@article{MTMT:34727376,
	title = {Mental health in the two years following hypertensive and normotensive pregnancy: The Postpartum, Physiology, Psychology and Paediatric follow-up (P4) cohort study},
	url = {https://m2.mtmt.hu/api/publication/34727376},
	author = {Shang, J. and Hackett, M.L. and Harris, K. and Woodward, M. and Roberts, L.M. and Zhang, P. and Henry, A.},
	doi = {10.1016/j.preghy.2023.12.008},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {35},
	unique-id = {34727376},
	issn = {2210-7789},
	year = {2024},
	eissn = {2210-7797},
	pages = {43-50}
}

@article{MTMT:34570274,
	title = {Effect of short-term changes in salt intake on plasma cytokines in women with healthy and hypertensive pregnancies},
	url = {https://m2.mtmt.hu/api/publication/34570274},
	author = {Thangaraj, Sai Sindhu and Gunlund, Tina-Signe Gissel and Stubbe, Jane and Palarasah, Yaseelan and Svenningsen, Per and Nielsen, Lise Hald and Ovesen, Per Glud and Jensen, Boye L.},
	doi = {10.1016/j.preghy.2024.01.135},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {35},
	unique-id = {34570274},
	issn = {2210-7789},
	year = {2024},
	eissn = {2210-7797},
	pages = {82-87},
	orcid-numbers = {Stubbe, Jane/0000-0002-2703-453X; Svenningsen, Per/0000-0001-6590-7103; Jensen, Boye L./0000-0001-7607-213X}
}

@article{MTMT:34593044,
	title = {Treatment of acute-onset hypertension in pregnancy: A network meta-analysis of randomized controlled trials comparing anti-hypertensives and route of administration},
	url = {https://m2.mtmt.hu/api/publication/34593044},
	author = {Bhat, Adithya D. and Keasler, Paige M. and Kolluru, Lavanya and Dombrowski, Michael M. and Palanisamy, Arvind and Singh, Preet Mohinder},
	doi = {10.1016/j.preghy.2023.10.005},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {34},
	unique-id = {34593044},
	issn = {2210-7789},
	abstract = {Background: Consensus on the relative efficacy of available antihypertensive agents used in pregnancy is lacking. Objective: To compare treatment success with antihypertensives and categorize by route of administration. Search strategy: MEDLINE, Embase, PubMed, Web of Science, Scopus, CINAHL, and clinicaltrials.gov were searched without date restriction.Data collection: Peer-reviewed randomized controlled trials (RCTs) comparing pharmacologic agents used to treat hypertension in parturients were included. Evaluated treatment groups included IV-labetalol (BBIV), IV-hydralazine (DIV), oral-nifedipine (CCBPO), sublingual nifedipine (CCBSL), IV-calcium channel blocker (nonspecific)(CCBIV), IV-nitroglycerine (NTG), epoprostenol infusion (PRO), IV-ketanserin (5HT2B), IV-diazoxide (BZO), oral-nifedipine + methyldopa (CCBAG), oral-methyl-dopa (AAG), and oral prazosin (ABPO). Analysis: Seventy-four studies (8324 patients) were eligible post PRISMA guidelines screening. Results were pooled using a Bayesian-approach for success of treatment (study defined target blood pressure), time to achieve target pressure, and neonatal intensive-care admissions.Results: Treatment success (primary outcome, 55 trials with 5518 patients) was analyzed. Surface under the cumulative ranking curve (SUCRA) was categorized for 13 drugs, CCBPO (0.84) followed by CCBSL (0.78) were most likely to be effective in achieving target blood pressure. After sub-grouping by presence/absence of pre-eclampsia, CCB-PO ranked highest for both [(0.82) vs. (0.77), respectively]. Serotonin antagonists (0.99) and nitroglycerin (0.88) ranked highest for time to target pressure. NICU admissions were lowest for alpha-2 agonists (0.89), followed by BB PO (0.82) and hydralazine IV (0.49).Conclusion: Oral calcium-channel blockers ranked highest for treatment success. Ketanserin achieved target blood pressure fastest, warranting additional research. The results should be interpreted with caution as SUCRA values may not indicate whether the differences between interventions have clinically meaningful effect sizes.},
	keywords = {HYPERTENSION; network meta-analysis; Antihypertensives},
	year = {2023},
	eissn = {2210-7797},
	pages = {74-82},
	orcid-numbers = {Palanisamy, Arvind/0000-0001-8460-1759}
}

@article{MTMT:34302899,
	title = {RUPP Th17s cause hypertension and mitochondrial dysfunction in the kidney and placenta during pregnancy},
	url = {https://m2.mtmt.hu/api/publication/34302899},
	author = {Fitzgerald, Sarah and Deer, Evangeline and Hogg, James and Cornelius, Denise C. and Turner, Ty and Amaral, Lorena M. and Hoang, Ngoc and Edwards, Kristin and Herrock, Owen and Campbell, Nathan and Ibrahim, Tarek and LaMarca, Babbette},
	doi = {10.1016/j.preghy.2023.04.002},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {32},
	unique-id = {34302899},
	issn = {2210-7789},
	abstract = {Background: Preeclampsia (PE), new-onset hypertension (HTN), and organ dysfunction during the second half of pregnancy, is associated with an increase in inflammatory immune cells, including T helper 17 (Th17) cells. Studies have demonstrated that mitochondrial (mt) dysfunction is important in the pathogenesis of PE though causative factors have yet to be fully identified. Although Th17 cells, natural killer (NK) cells, and mt dysfunction contribute to HTN in the reduced uterine perfusion pressure (RUPP) rat model, the role of Th17 cells or IL-17 in mt dysfunction is unknown. Therefore, we hypothesize that RUPP stimulated Th17 cells cause HTN and mt dysfunction, which is alleviated with the blockade of IL-17. Methods: On gestational day 12 (GD12), RUPP Th17 cells were transferred into normal pregnant (NP) Sprague Dawley rats. A subset of NP + RUPPTh17 rats received IL-17RC (100 pg/day) on GD14-19. Blood pressure (MAP), NK cells, and mt function were measured on GD19 in all groups. Results: MAP increased in response to NP + RUPP Th17 compared to NP rats and was lowered with IL-17RC. Circulating and placental NK cells increased with NP + RUPP Th17 compared to NP and were lowered with IL-17RC. Renal mtROS increased in NP + RUPP Th17 compared to NP and was normalized with IL-17RC. Similar to PE women, placental mtROS decreased in NP + RUPP Th17 and was normalized with IL-17RC. Conclusion: Our results indicate that IL-17RC inhibition normalizes HTN, NK cell activation, and multi-organ mt dysfunction caused by Th17 cells stimulated in response to placental ischemia.},
	keywords = {PREECLAMPSIA; T helper cells; Oxidative stress},
	year = {2023},
	eissn = {2210-7797},
	pages = {50-56},
	orcid-numbers = {Deer, Evangeline/0000-0001-8004-5978; Edwards, Kristin/0000-0002-2168-8241; Campbell, Nathan/0000-0003-0518-4219}
}

@article{MTMT:34237733,
	title = {Letter to editor - Placental basal plate myofibers and risk of hypertensive disorders of pregnancy},
	url = {https://m2.mtmt.hu/api/publication/34237733},
	author = {Hessami, Kamran and Espinoza, Jimmy and Salmanian, Bahram and Castro, Eumenia and Shamshirsaz, Alireza A. and Shamshirsaz, Amir A.},
	doi = {10.1016/j.preghy.2023.07.001},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {33},
	unique-id = {34237733},
	issn = {2210-7789},
	year = {2023},
	eissn = {2210-7797},
	pages = {32-33}
}

@article{MTMT:33767856,
	title = {Pre-eclampsia is associated with complement pathway activation in the maternal and fetal circulation, and placental tissue},
	url = {https://m2.mtmt.hu/api/publication/33767856},
	author = {Blakey, Hannah and Sun, Ruyue and Xie, Long and Russell, Rebecca and Sarween, Nadia and Hodson, James and Hargitai, Beata and Marton, Tamás and A H Neil, Desley and Wong, Edwin and Sheerin, Neil S and Bramham, Kate and Harris, Claire L and Knox, Ellen and Drayson, Mark and Lipkin, Graham},
	doi = {10.1016/j.preghy.2023.04.001},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {32},
	unique-id = {33767856},
	issn = {2210-7789},
	year = {2023},
	eissn = {2210-7797},
	pages = {43-49},
	orcid-numbers = {Blakey, Hannah/0000-0003-4979-5599; Xie, Long/0000-0002-2138-888X; Hodson, James/0000-0003-3487-0090; Marton, Tamás/0000-0001-5585-2276; Sheerin, Neil S/0000-0002-3743-2371; Bramham, Kate/0000-0002-6272-7921; Harris, Claire L/0000-0003-0845-1730}
}

@article{MTMT:33334444,
	title = {Upregulation of exofacial peroxiredoxin-thioredoxin system of lymphocytes and monocytes in preeclampsia},
	url = {https://m2.mtmt.hu/api/publication/33334444},
	author = {Alasztics, Bálint and Kovács, Árpád Ferenc and Pállinger, Éva and Szabó-Taylor, Katalin and Szabó, Gábor and Molvarec, Attila and Koller, Ákos and Rigó, János},
	doi = {10.1016/j.preghy.2022.12.002},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {31},
	unique-id = {33334444},
	issn = {2210-7789},
	year = {2023},
	eissn = {2210-7797},
	pages = {54-59},
	orcid-numbers = {Alasztics, Bálint/0000-0002-4011-8439; Kovács, Árpád Ferenc/0000-0002-7742-160X; Pállinger, Éva/0000-0002-5789-0951; Szabó-Taylor, Katalin/0000-0002-4763-3521; Szabó, Gábor/0000-0002-8573-8260; Molvarec, Attila/0000-0002-3229-3034; Koller, Ákos/0000-0003-3256-8701; Rigó, János/0000-0003-2762-6516}
}

@article{MTMT:34177601,
	title = {PO6_22. Exofacial expression of peroxiredoxin-1 on peripheral blood mononuclear cells in preeclampsia},
	url = {https://m2.mtmt.hu/api/publication/34177601},
	author = {Alasztics, B. and Kovács, Árpád Ferenc and Koller, A. and Pállinger, Éva and Rigo, J.},
	doi = {10.1016/j.preghy.2023.07.079},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {33},
	unique-id = {34177601},
	issn = {2210-7789},
	year = {2023},
	eissn = {2210-7797},
	pages = {e39},
	orcid-numbers = {Kovács, Árpád Ferenc/0000-0002-7742-160X; Pállinger, Éva/0000-0002-5789-0951}
}

@article{MTMT:33510390,
	title = {The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice*},
	url = {https://m2.mtmt.hu/api/publication/33510390},
	author = {Magee, Laura A. and Brown, Mark A. and Hall, David R. and Gupte, Sanjay and Hennessy, Annemarie and Karumanchi, S. Ananth and Kenny, Louise C. and McCarthy, Fergus and Myers, Jenny and Poon, Liona C. and Rana, Sarosh and Saito, Shigeru and Staff, Anne Cathrine and Tsigas, Eleni and von Dadelszen, Peter},
	doi = {10.1016/j.preghy.2021.09.008},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {27},
	unique-id = {33510390},
	issn = {2210-7789},
	abstract = {All units managing hypertensive pregnant women should maintain and review uniform departmental management protocols and conduct regular audits of maternal & fetal outcomes. The cause(s) of pre-eclampsia and the optimal clinical management of the hypertensive disorders of pregnancy remain uncertain; therefore, we recommend that every hypertensive pregnant woman be offered an opportunity to participate in research, clinical trials and follow-up studies.},
	keywords = {HYPERTENSION; pregnancy; Pre-Eclampsia; outcome; perinatal; Maternal},
	year = {2022},
	eissn = {2210-7797},
	pages = {148-169},
	orcid-numbers = {von Dadelszen, Peter/0000-0003-4136-3070}
}

@article{MTMT:33235420,
	title = {Galectin-7 dysregulates renin-angiotensin-aldosterone and NADPH oxide synthase pathways in preeclampsia},
	url = {https://m2.mtmt.hu/api/publication/33235420},
	author = {Menkhorst, Ellen and Zhou, Wei and Santos, Leilani and Zhang, Jian-Guo and St-Pierre, Yves and Young, Morag J. and Dimitriadis, Evdokia},
	doi = {10.1016/j.preghy.2022.09.008},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {30},
	unique-id = {33235420},
	issn = {2210-7789},
	abstract = {Objectives: Preeclampsia is a life-threatening disorder of pregnancy unique to humans. Poor placentation in the first trimester of pregnancy is widely accepted to be an underlying cause of preeclampsia. Galectin-7 is abnormally elevated in chorionic villous samples and serum from women that subsequently develop pre-term preeclampsia. Administration of exogenous galectin-7 to pregnant mice causes preeclampsia-like features (hypertension, proteinuria), associated with dysregulation of the renin-angiotensin system (RAS). In this study investigated the mechanism by which galectin-7 induces alterations to tissue RAS homeostasis and ROS production. We hypothesized that galectin-7 induces alterations in the production of either placental RAS or NADPH oxidases (or both) to drive the dysregulated RAS and ROS production seen in preeclampsia.Study Design: Mated female mice (n = 5-6/group) received single (embryonic day [E]12/13) or multiple (E8-12) subcutaneous injections of 400 mu g/kg/day galectin-7 or vehicle control and killed on E13 or E18. Human first trimester placental villous and decidual tissue (n = 11) was cultured under 8 % oxygen with 1 mu g/mL galectin-7 or vehicle control for 16 h.Results: Galectin-7 administration to pregnant mice impaired placental labyrinth formation, suppressed circulating aldosterone and altered placental RAS (Agt, Renin) and NADPH oxidase (Cyba, Cybb and Icam1) mRNA expression. In vitro, galectin-7 regulated human placental villous RAS (AGT) and NADPH oxidase (CYBA, ICAM1 and VCAM1) mRNA expression.Conclusions: Overall, galectin-7 likely drives hypertension in preeclampsia via its direct regulation of multiple pathways associated with preeclampsia in the placenta. Galectin-7 may therefore be a therapeutic target to improve placental function and prevent preeclampsia.},
	keywords = {RENIN-ANGIOTENSIN SYSTEM; placenta; Reactive oxygen species; PREECLAMPSIA; galectin-7},
	year = {2022},
	eissn = {2210-7797},
	pages = {130-136},
	orcid-numbers = {Zhou, Wei/0000-0001-9636-7963}
}