@article{MTMT:34801695,
	title = {Unveiling peripheral neuropathy and cognitive dysfunction in diabetes: an observational and proof-of-concept study with video games and sensor-equipped insoles},
	url = {https://m2.mtmt.hu/api/publication/34801695},
	author = {Ming, A. and Lorek, E. and Wall, J. and Schubert, T. and Ebert, N. and Galatzky, I. and Baum, A.-K. and Glanz, W. and Stober, S. and Mertens, P.R.},
	doi = {10.3389/fendo.2024.1310152},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34801695},
	issn = {1664-2392},
	abstract = {Background: Proactive screening for cognitive dysfunction (CD) and peripheral neuropathy (PNP) in elderly patients with diabetes mellitus is essential for early intervention, yet clinical examination is time-consuming and prone to bias. Objective: We aimed to investigate PNP and CD in a diabetes cohort and explore the possibility of identifying key features linked with the respective conditions by machine learning algorithms applied to data sets obtained in playful games controlled by sensor-equipped insoles. Methods: In a cohort of patients diagnosed with diabetes (n=261) aged over 50 years PNP and CD were diagnosed based on complete physical examination (neuropathy symptom and disability scores, and Montreal Cognitive Assessment). In an observational and proof-of-concept study patients performed a 15 min lasting gaming session encompassing tutorials and four video games with 5,244 predefined features. The steering of video games was solely achieved by modulating plantar pressure values, which were measured by sensor-equipped insoles in real-time. Data sets were used to identify key features indicating game performance with correlation regarding CD and PNP findings. Thereby, machine learning models (e.g. gradient boosting and lasso and elastic-net regularized generalized linear models) were set up to distinguish patients in the different groups. Results: PNP was diagnosed in 59% (n=153), CD in 34% (n=89) of participants, and 23% (n=61) suffered from both conditions. Multivariable regression analyses suggested that PNP was positively associated with CD in patients with diabetes (adjusted odds ratio = 1.95; 95% confidence interval: 1.03-3.76; P=0.04). Predictive game features were identified that significantly correlated with CD (n=59), PNP (n=40), or both (n=59). These features allowed to set up classification models that were enriched by individual risk profiles (i.e. gender, age, weight, BMI, diabetes type, and diabetes duration). The obtained models yielded good predictive performance with the area under the receiver-operating-characteristic curves reaching 0.95 for CD without PNP, 0.83 for PNP without CD, and 0.84 for CD and PNP combined. Conclusions: The video game-based assessment was able to categorize patients with CD and/or PNP with high accuracy. Future studies with larger cohorts are needed to validate these results and potentially enhance the discriminative power of video games. Copyright © 2024 Ming, Lorek, Wall, Schubert, Ebert, Galatzky, Baum, Glanz, Stober and Mertens.},
	keywords = {Aged; Female; Male; ARTICLE; human; diabetes mellitus; diabetes mellitus; logistic regression analysis; major clinical study; controlled study; machine learning; machine learning; heart arrhythmia; Peripheral neuropathy; Peripheral neuropathy; vascular disease; urine incontinence; dizziness; COGNITIVE DYSFUNCTION; cognitive defect; observational study; receiver operating characteristic; nerve cell network; diagnostic test accuracy study; Video Games; Proof of concept; support vector machine; New York Heart Association class; NEUROPSYCHOLOGICAL ASSESSMENT; Montreal Cognitive Assessment; video game; Neuropathy Symptom Score; neuropathy disability score; Disability assessment; sensor-equipped insoles; neuropathy symptom and disability score},
	year = {2024},
	eissn = {1664-2392}
}

@article{MTMT:34801693,
	title = {Assessment of the severity of diabetic polyneuropathy aids in predicting the risk of developing diabetic complications in patients with untreated diabetes},
	url = {https://m2.mtmt.hu/api/publication/34801693},
	author = {Horinouchi, S. and Deguchi, T. and Mukai, M. and Ijuin, A. and Kawamoto, Y. and Nishio, Y.},
	doi = {10.3389/fendo.2024.1380970},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34801693},
	issn = {1664-2392},
	abstract = {This study aimed to determine the efficacy of assessing the severity of diabetic polyneuropathy (DPN) in patients with untreated diabetes. Seventy-two patients with untreated type 2 diabetes who were hospitalized for glycemic control were enrolled and divided into the following two groups: patients who had no prior diagnosis and patients who were unattended or had discontinued treatment. Electrophysiological criteria consistent with Baba’s classification were used to diagnose and assess the severity of DPN. The patients were divided into three subgroups: no DPN (stage 0), mild DPN (stage 1), and moderate or more-severe DPN (stages 2–4). Intergroup comparisons were performed for the clinical characteristics and the results of the nerve conduction studies. Twenty-two (30%), 25 (35%), and 25 (35%) patients were categorized into the no DPN, mild DPN, and moderate or more-severe DPN subgroups, respectively. The number of patients who were unattended or had discontinued treatment in the moderate or more-severe DPN subgroup was significantly higher than that in the no DPN subgroup. The patients in the moderate or more-severe DPN subgroup had an increased risk of developing diabetic retinopathy and nephropathy, with odds ratios of 19.5 and 11.0 for advanced stages of retinopathy and nephropathy, respectively. Thus, the assessment of the severity of DPN could aid in the prediction of the risk of developing diabetic complications in patients with untreated diabetes. Copyright © 2024 Horinouchi, Deguchi, Mukai, Ijuin, Kawamoto and Nishio.},
	keywords = {Adult; Female; Middle Aged; Male; IMMUNOREACTIVITY; ARTICLE; DIABETIC NEUROPATHY; human; diabetes mellitus; risk factor; major clinical study; GLYCEMIC CONTROL; HYPERTENSION; INSULIN; Japan; disease severity; computer assisted tomography; mean corpuscular volume; diabetic retinopathy; diabetic nephropathy; hyperglycemia; hemoglobin A1c; resuscitation; polyneuropathy; kidney transplantation; non insulin dependent diabetes mellitus; kidney injury; Diabetic complications; Ankle Brachial Index; muscle action potential; electroneurography; Estimated glomerular filtration rate; DAS28; Diabetic polyneuropathy; nerve conduction study; diabetic complication; ethambutol; Diabetic Foot; proliferative diabetic retinopathy; ABTS radical scavenging assay; somatosensory evoked potential; motor nerve conduction; Baba's classification; untreated diabetes},
	year = {2024},
	eissn = {1664-2392}
}

@article{MTMT:34801692,
	title = {Association of vitamin D deficiency and subclinical diabetic peripheral neuropathy in type 2 diabetes patients},
	url = {https://m2.mtmt.hu/api/publication/34801692},
	author = {Sun, X. and Yang, X. and Zhu, X. and Ma, Y. and Li, X. and Zhang, Y. and Liu, Q. and Fan, C. and Zhang, M. and Xu, B. and Xu, Y. and Gao, X. and Dong, J. and Xia, M. and Bian, H.},
	doi = {10.3389/fendo.2024.1354511},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34801692},
	issn = {1664-2392},
	abstract = {Background: Diabetic peripheral neuropathy (DPN) contributes to disability and imposes heavy burdens, while subclinical DPN is lack of attention so far. We aimed to investigate the relationship between vitamin D and distinct subtypes of subclinical DPN in type 2 diabetes (T2DM) patients. Methods: This cross-sectional study included 3629 T2DM inpatients who undertook nerve conduction study to detect subclinical DPN in Zhongshan Hospital between March 2012 and December 2019. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D (25(OH)D) level < 50 nmol/L. Results: 1620 (44.6%) patients had subclinical DPN and they were further divided into subgroups: distal symmetric polyneuropathy (DSPN) (n=685), mononeuropathy (n=679) and radiculopathy (n=256). Compared with non-DPN, DPN group had significantly lower level of 25(OH)D (P < 0.05). In DPN subtypes, only DSPN patients had significantly lower levels of 25(OH)D (36.18 ± 19.47 vs. 41.03 ± 18.47 nmol/L, P < 0.001) and higher proportion of vitamin D deficiency (78.54% vs. 72.18%, P < 0.001) than non-DPN. Vitamin D deficiency was associated with the increased prevalence of subclinical DPN [odds ratio (OR) 1.276, 95% confidence interval (CI) 1.086-1.501, P = 0.003] and DSPN [OR 1. 646, 95% CI 1.31-2.078, P < 0.001], independent of sex, age, weight, blood pressure, glycosylated hemoglobin, T2DM duration, calcium, phosphorus, parathyroid hormone, lipids and renal function. The association between vitamin D deficiency and mononeuropathy or radiculopathy was not statistically significant. A negative linear association was observed between 25(OH)D and subclinical DSPN. Vitamin D deficiency maintained its significant association with subclinical DSPN in all age groups. Conclusions: Vitamin D deficiency was independently associated with subclinical DSPN, rather than other DPN subtypes. Copyright © 2024 Sun, Yang, Zhu, Ma, Li, Zhang, Liu, Fan, Zhang, Xu, Xu, Gao, Dong, Xia and Bian.},
	keywords = {Blood Pressure; Body Weight; Aged; Adult; Female; Male; calcium; PREVALENCE; ARTICLE; DIABETIC NEUROPATHY; AGE; PHOSPHORUS; human; major clinical study; nerve conduction; cholesterol; body mass; triacylglycerol; high density lipoprotein cholesterol; hemoglobin A1c; creatinine; low density lipoprotein cholesterol; polyneuropathy; kidney function; vitamin D; cross-sectional study; non insulin dependent diabetes mellitus; impaired glucose tolerance; uric acid; 25 hydroxyvitamin D; vitamin D deficiency; Parathyroid Hormone; diabetic patient; Type 2 diabetes; Radiculopathy; Estimated glomerular filtration rate; neurologic disease assessment; diabetic peripheral neuropathy; mononeuropathy; glycated hemoglobin; needle electromyography; ELECTROCHEMILUMINESCENCE IMMUNOASSAY; Distal symmetric polyneuropathy; Distal symmetric polyneuropathy; Nerve conduction study (NCS); neuropathy assessment},
	year = {2024},
	eissn = {1664-2392}
}

@article{MTMT:34801054,
	title = {Development and validation of nomograms to predict clinical outcomes of preeclampsia},
	url = {https://m2.mtmt.hu/api/publication/34801054},
	author = {Xia, Y. and Wang, Y. and Yuan, S. and Hu, J. and Zhang, L. and Xie, J. and Zhao, Y. and Hao, J. and Ren, Y. and Wu, S.},
	doi = {10.3389/fendo.2024.1292458},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34801054},
	issn = {1664-2392},
	abstract = {Background: Preeclampsia (PE) is one of the most severe pregnancy-related diseases; however, there is still a lack of reliable biomarkers. In this study, we aimed to develop models for predicting early-onset PE, severe PE, and the gestation duration of patients with PE. Methods: Eligible patients with PE were enrolled and divided into a training (n = 253) and a validation (n = 108) cohort. Multivariate logistic and Cox models were used to identify factors associated with early-onset PE, severe PE, and the gestation duration of patients with PE. Based on significant factors, nomograms were developed and evaluated using the area under the curve (AUC) and a calibration curve. Results: In the training cohort, multiple gravidity experience (p = 0.005), lower albumin (ALB; p < 0.001), and higher lactate dehydrogenase (LDH; p < 0.001) were significantly associated with early-onset PE. Abortion history (p = 0.017), prolonged thrombin time (TT; p < 0.001), and higher aspartate aminotransferase (p = 0.002) and LDH (p = 0.003) were significantly associated with severe PE. Abortion history (p < 0.001), gemellary pregnancy (p < 0.001), prolonged TT (p < 0.001), higher mean platelet volume (p = 0.014) and LDH (p < 0.001), and lower ALB (p < 0.001) were significantly associated with shorter gestation duration. Three nomograms were developed and validated to predict the probability of early-onset PE, severe PE, and delivery time for each patient with PE. The AUC showed good predictive performance, and the calibration curve and decision curve analysis demonstrated clinical practicability. Conclusion: Based on the clinical features and peripheral blood laboratory indicators, we identified significant factors and developed models to predict early-onset PE, severe PE, and the gestation duration of pregnant women with PE, which could help clinicians assess the clinical outcomes early and design appropriate strategies for patients. Copyright © 2024 Xia, Wang, Yuan, Hu, Zhang, Xie, Zhao, Hao, Ren and Wu.},
	keywords = {Adult; Female; ARTICLE; human; major clinical study; cohort analysis; clinical feature; HEMOGLOBIN; HYPERTENSION; biological marker; Gestational Age; systolic blood pressure; albumin; diastolic blood pressure; retrospective study; menstrual irregularity; creatinine; area under the curve; lactate dehydrogenase; PREECLAMPSIA; training; biomarker; aspartate aminotransferase; Pre-Eclampsia; pregnant woman; predictive model; alanine aminotransferase; thrombin time; abortion; Clinical outcome; nomogram; nomogram; Mean platelet volume; peripheral biomarkers; multigravida},
	year = {2024},
	eissn = {1664-2392}
}

@article{MTMT:34798521,
	title = {High mortality risk among women with acromegaly still persists},
	url = {https://m2.mtmt.hu/api/publication/34798521},
	author = {Găloiu, S. and Toma, I.-D. and Tănasie, D.I. and Bărbulescu, A. and Baciu, I. and Niculescu, D.A. and Trifănescu, R.A. and Căpăţînă, C. and Radian, Ş. and Poiană, C.},
	doi = {10.3389/fendo.2024.1348972},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34798521},
	issn = {1664-2392},
	abstract = {Introduction: The mortality ratio in patients with acromegaly has improved over the last few decades. We aimed to determine the mortality rate and correlated factors in patients with acromegaly before and after the introduction of national protocols for treatment. In addition, we determined whether there are sex-related differences in mortality of patients with acromegaly. Methods: This observational retrospective study included 399 consecutive patients with acromegaly between January 2001–December 2022. Paraclinical data included random growth hormone (GH) and insulin-like growth factor-I (IGF1) levels, maximal pituitary tumor diameter at diagnosis, first visit, and last evaluation. Standardized mortality ratio (SMR) was calculated by dividing the observed and expected mortality rates. Cox regression analysis revealed the independent factors associated with mortality. Results: At the last visit, 31.07% (124) of patients were cured, 22.05% (88) had controlled acromegaly with medication, and 45.31% (181) had not controlled acromegaly. During follow-up (13.03 ± 5.65 years, 5216.62 person-years), 89 patients died (0.017%), resulting in an SMR of 1.18 [95% CI 0.95–1.45]. The independent factors associated with mortality were the last IGF1 level/last random GH level, absence of surgery, gonadotropin deficiency, and age. Patients with normal IGF1 after treatment showed an SMR of 0.71, whereas patients with IGF1 ratio > 1 showed SMR=1.51. Patients diagnosed between 1975–2007 and 2008–2022 had SMR = 1.25 [95% CI 0.97–1.58] and SMR = 1.09 [95% CI 0.68–1.65], respectively. In females with acromegaly, SMR was 1.63 [95% CI 1.24–2.11]; 1.76 [95% CI 1.30–2.34] in women diagnosed before 2008 and 1.33 [95% CI 0.69–2.33] in those diagnosed after 2008. Males with acromegaly had a mortality ratio similar to males from the general population (SMR = 0.99, [95% CI 0.66–1.41]). Conclusion: Patients diagnosed with acromegaly in the last 15 years had lower mortality rates than those diagnosed before 2008, due to the availability of new medications, primarily somatostatin receptor analogs and to a higher proportion of patients undergoing surgery. Females still have a high mortality ratio owing to older age at diagnosis and higher risk of metabolic complications. Therefore, efforts should be made for early diagnosis of acromegaly in women. Copyright © 2024 Găloiu, Toma, Tănasie, Bărbulescu, Baciu, Niculescu, Trifănescu, Căpăţînă, Radian and Poiană.},
	keywords = {Adult; Female; Male; SOMATOSTATIN; ARTICLE; GROWTH HORMONE; MORTALITY; human; major clinical study; sex difference; systolic blood pressure; somatomedin C; dyslipidemia; body mass; retrospective study; Acromegaly; Acromegaly; tumor volume; observational study; neurosurgery; neurosurgery; mortality risk; somatostatin analogs; Pituitary tumor; immunoradiometric assay; pituitary radiotherapy; maximal pituitary tumor diameter},
	year = {2024},
	eissn = {1664-2392}
}

@article{MTMT:34795202,
	title = {Association of serum uric acid with right cardiac chamber remodeling assessed by cardiovascular magnetic resonance feature tracking in patients with connective tissue disease},
	url = {https://m2.mtmt.hu/api/publication/34795202},
	author = {Tang, Yuanyuan and Yang, Zhaoxia and Wen, Jinyang and Tang, Dazhong and Luo, Yi and Xiang, Chunlin and Huang, Lu and Xia, Liming},
	doi = {10.3389/fendo.2024.1351197},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34795202},
	issn = {1664-2392},
	year = {2024},
	eissn = {1664-2392}
}

@article{MTMT:34790366,
	title = {Smoking and BMI mediate the causal effect of education on lower back pain: observational and Mendelian randomization analyses},
	url = {https://m2.mtmt.hu/api/publication/34790366},
	author = {Xu, Z. and Qi, L. and Zhang, H. and Yu, D. and Shi, Y. and Yu, Y. and Zhu, T.},
	doi = {10.3389/fendo.2024.1288170},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34790366},
	issn = {1664-2392},
	year = {2024},
	eissn = {1664-2392}
}

@article{MTMT:34790292,
	title = {Roles of organokines in intervertebral disc homeostasis and degeneration},
	url = {https://m2.mtmt.hu/api/publication/34790292},
	author = {He, Y. and Liu, S. and Lin, H. and Ding, F. and Shao, Z. and Xiong, L.},
	doi = {10.3389/fendo.2024.1340625},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34790292},
	issn = {1664-2392},
	year = {2024},
	eissn = {1664-2392}
}

@article{MTMT:34790263,
	title = {Global, regional, and national burden of chronic kidney disease attributable to high fasting plasma glucose from 1990 to 2019: a systematic analysis from the global burden of disease study 2019},
	url = {https://m2.mtmt.hu/api/publication/34790263},
	author = {Wei, H. and Ren, J. and Li, R. and Qi, X. and Yang, F. and Li, Q.},
	doi = {10.3389/fendo.2024.1379634},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34790263},
	issn = {1664-2392},
	year = {2024},
	eissn = {1664-2392}
}

@article{MTMT:34789382,
	title = {Global trends in burden of type 2 diabetes attributable to physical inactivity across 204 countries and territories, 1990-2019},
	url = {https://m2.mtmt.hu/api/publication/34789382},
	author = {Yang, X. and Sun, J. and Zhang, W.},
	doi = {10.3389/fendo.2024.1343002},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34789382},
	issn = {1664-2392},
	year = {2024},
	eissn = {1664-2392}
}