TY - JOUR AU - Tomita, N. AU - Katayama, H. AU - Kurihara, Y. AU - Takahashi, T. AU - Shibata, S. AU - Mima, T. AU - Osu, R. AU - Kumano, H. TI - Tackling social anxiety with targeted brain stimulation: investigating the effects of transcranial static magnetic field stimulation on self-focused attention JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 18 PY - 2024 SN - 1662-5153 DO - 10.3389/fnbeh.2024.1373564 UR - https://m2.mtmt.hu/api/publication/34780176 ID - 34780176 N1 - Export Date: 10 April 2024 Correspondence Address: Tomita, N.; Educational Psychology, Japan; email: ntomita@u-gakugei.ac.jp Funding details: Japan Society for the Promotion of Science, JSPS, 19H01091, 23K18440, 20K14231, 23H00459, 23K12901, 21K17671, 22H04788, 21H04425 Funding text 1: The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was partly supported by JSPS KAKENHI 23K12901 and 20K14231 (to NT), JSPS KAKENHI 21K17671 (to SS), Grant-in-Aid for Scientific Research (A) 19H01091, 23H00459, Grant-in-Aid for Challenging Research (Exploratory) 23K18440 and Grant-in-Aid for Scientific Research on Innovative Areas 22H04788 (to TM), Grant-in-Aid for Scientific Research (A) 21H04425 (to RO). AB - Previous studies suggested that self-focused attention (SFA), implicated in social anxiety disorder (SAD), correlates with heightened activity in the right frontopolar area (rFPA), which is the right prefrontal cortex just behind the forehead. Transcranial static magnetic field stimulation (tSMS) is a non-invasive brain stimulation method capable of temporarily suppressing brain function beneath the magnet. We explored whether tSMS on individuals with tendencies toward SAD elicited (1) suppressing rFPA activation during the resting-state and (2) reducing SFA during a subsequent speech task. Twenty-three university students with social anxiety performed two speech tasks. Between tasks, the tSMS group received neodymium magnet stimulation while the sham group received fake magnet stimulation on the rFPA for 20 min. Resting-state rFPA activities was measured using functional near-infrared spectroscopy (fNIRS), while SFA (body sensations and observer perspective), field perspective, and detached mindfulness (DM) perspective were assessed via questionnaires during both speech tasks. The observer perspective means SFA to self-imagery from others’ viewpoint, while the field and DM perspectives mean appropriately focusing on the external environment. The results indicated that tSMS intervention decreased rFPA activity from pre- to post-intervention rest. Then, tSMS reduced SFA to bodily sensations and increased DM perspective from pre- to post-intervention speech, especially in those with high levels of social anxiety. Furthermore, tSMS enhanced the field perspective regardless of social anxiety tendency. The results suggest that tSMS may suppress overactivity in rFPA, reduce SFA to body sensation, and increase adaptive attention in highly socially anxious individuals. Our study suggests the possibility of the clinical application of tSMS for treating SAD. Copyright © 2024 Tomita, Katayama, Kurihara, Takahashi, Shibata, Mima, Osu and Kumano. LA - English DB - MTMT ER - TY - JOUR AU - Stevens, M. AU - Ní, Mhurchú S. AU - Corley, E. AU - Egan, C. AU - Hallahan, B. AU - McDonald, C. AU - Donohoe, G. AU - Burke, T. TI - Uncinate fasciculus microstructural organisation and emotion recognition in schizophrenia: controlling for hit rate bias JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 18 PY - 2024 SN - 1662-5153 DO - 10.3389/fnbeh.2024.1302916 UR - https://m2.mtmt.hu/api/publication/34779023 ID - 34779023 AB - Introduction: Schizophrenia (SCZ) is a complex neurodevelopmental disorder characterised by functional and structural brain dysconnectivity and disturbances in perception, cognition, emotion, and social functioning. In the present study, we investigated whether the microstructural organisation of the uncinate fasciculus (UF) was associated with emotion recognition (ER) performance. Additionally, we investigated the usefulness of an unbiased hit rate (UHR) score to control for response biases (i.e., participant guessing) during an emotion recognition task (ERT). Methods: Fifty-eight individuals diagnosed with SCZ were included. The CANTAB ERT was used to measure social cognition. Specific ROI manual tract segmentation was completed using ExploreDTI and followed the protocol previously outlined by Coad et al. (2020). Results: We found that the microstructural organisation of the UF was significantly correlated with physical neglect and ER outcomes. Furthermore, we found that the UHR score was more sensitive to ERT subscale emotion items than the standard HR score. Finally, given the association between childhood trauma (in particular childhood neglect) and social cognition in SCZ, a mediation analysis found evidence that microstructural alterations of the UF mediated an association between childhood trauma and social cognitive performance. Discussion: The mediating role of microstructural alterations in the UF on the association between childhood trauma and social cognitive performance suggests that early life adversity impacts both brain development and social cognitive outcomes for people with SCZ. Limitations of the present study include the restricted ability of the tensor model to correctly assess multi-directionality at regions where fibre populations intersect. Copyright © 2024 Stevens, Ní Mhurchú, Corley, Egan, Hallahan, McDonald, Donohoe and Burke. LA - English DB - MTMT ER - TY - JOUR AU - Kiuchi, Masataka AU - Uno, Tadashi AU - Hasegawa, Tatsuya AU - Koyama, Katsuhiro AU - Horiuchi, Masahiro TI - Influence of short-term hypoxic exposure on spatial learning and memory function and brain-derived neurotrophic factor in rats—A practical implication to human's lost way JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 18 PY - 2024 SN - 1662-5153 DO - 10.3389/fnbeh.2024.1330596 UR - https://m2.mtmt.hu/api/publication/34686273 ID - 34686273 AB - The present study aimed to investigate the effects of a short period of normobaric hypoxic exposure on spatial learning and memory, and brain-derived neurotrophic factor (BDNF) levels in the rat hippocampus. Hypoxic conditions were set at 12.5% O 2 . We compared all variables between normoxic trials (Norm), after 24 h (Hypo-24 h), and after 72 h of hypoxic exposure (Hypo-72 h). Spatial learning and memory were evaluated by using a water-finding task in an open field. Time to find water drinking fountains was significantly extended in Hypo 24 h (36.2 ± 21.9 s) compared to those in Norm (17.9 ± 12.8 s; P < 0.05), whereas no statistical differences between Norm and Hypo-72 h (22.7 ± 12.3 s). Moreover, hippocampal BDNF level in Hypo-24 h was significantly lower compared to Norm (189.4 ± 28.4 vs. 224.9 ± 47.7 ng/g wet tissue, P < 0.05), whereas no statistically differences in those between Norm and Hypo-72 h (228.1 ± 39.8 ng/g wet tissue). No significant differences in the changes in corticosterone and adrenocorticotropic hormone levels were observed across the three conditions. When data from Hypo-24 h and Hypo-72 h of hypoxia were pooled, there was a marginal negative relationship between the time to find drinking fountains and BDNF ( P < 0.1), and was a significant negative relationship between the locomotor activities and BDNF ( P < 0.05). These results suggest that acute hypoxic exposure (24 h) may impair spatial learning and memory; however, it recovered after 72 h of hypoxic exposure. These changes in spatial learning and memory may be associated with changes in the hippocampal BDNF levels in rats. LA - English DB - MTMT ER - TY - JOUR AU - Lu, Huanhua AU - Song, Yiying AU - Wang, Xu AU - Liu, Jia TI - The neural correlates of perceived social support and its relationship to psychological well-being JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 17 PY - 2024 PG - 8 SN - 1662-5153 DO - 10.3389/fnbeh.2023.1295668 UR - https://m2.mtmt.hu/api/publication/34656298 ID - 34656298 LA - English DB - MTMT ER - TY - JOUR AU - Lipp, Hans-Peter AU - Krackow, Sven AU - Turkes, Emir AU - Benner, Seico AU - Endo, Toshihiro AU - Russig, Holger TI - IntelliCage: the development and perspectives of a mouse- and user-friendly automated behavioral test system JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 17 PY - 2024 PG - 34 SN - 1662-5153 DO - 10.3389/fnbeh.2023.1270538 UR - https://m2.mtmt.hu/api/publication/34643506 ID - 34643506 N1 - Cited By :2 Export Date: 10 April 2024 Correspondence Address: Lipp, H.-P.; Faculty of Medicine, Switzerland; email: hans-peter.lipp@iem.uzh.ch LA - English DB - MTMT ER - TY - JOUR AU - Horka, Petra AU - Langova, Veronika AU - Hubeny, Jan AU - Vales, Karel AU - Chrtkova, Ivana AU - Horacek, Jiri TI - Open field test for the assessment of anxiety-like behavior in Gnathonemus petersii fish JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 17 PY - 2024 PG - 11 SN - 1662-5153 DO - 10.3389/fnbeh.2023.1280608 UR - https://m2.mtmt.hu/api/publication/34583572 ID - 34583572 N1 - Funding Agency and Grant Number: Czech Health Research Council [AZV CR NU21 04-00405]; Charles University Grant Agency [GA UK 131 3820]; Charles University research program Cooperatio-Neurosciences Funding text: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Czech Health Research Council (grant number AZV CR NU21 04-00405); and the Charles University Grant Agency (grant number GA UK 131 3820) and the Charles University research program Cooperatio-Neurosciences (grant number Cooperatio 207038 - Neurosciences, Charles University, Third Faculty of Medicine, Prague). AB - The open field test (OFT) is a basic and most widely used test for investigation in animal studies of the neurobiological basis of anxiety and screening for novel drug targets. Here, we present the results of an OFT for weakly electric fish Gnathonemus petersii. This study aimed to describe the behavioral response of G. petersii exposed to an OFT, simultaneously with an evaluation of electrical organ discharges (EOD), to determine whether any association between EOD and patterns of motor behavior in the OFT exists. Treatment of OFT activity and its temporal patterning was assessed for the whole 6-min trial as well as per-minute distributions of activity using a near-infrared camera and an EOD data acquisition system. Our results demonstrated that the time spent, distance moved, and time of activity were significantly higher in the periphery of the OFT arena. The zone preference pattern over the 6-min test session showed that G. petersii prefer the outer zone (83.61%) over the center of the arena (16.39%). The motor behavior of fish measured as distance moved, active time, and swim speed were correlated with the number of EODs; however, no relationship was found between EOD and acceleration. LA - English DB - MTMT ER - TY - JOUR AU - Horii-Hayashi, Noriko AU - Masuda, Kazuya AU - Kato, Taika AU - Kobayashi, Kenta AU - Inutsuka, Ayumu AU - Nambu, Miyu F. AU - Tanaka, Kazumasa Z. AU - Inoue, Koichi AU - Nishi, Mayumi TI - Entrance-sealing behavior in the home cage: a defensive response to potential threats linked to the serotonergic system and manifestation of repetitive/stereotypic behavior in mice JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 17 PY - 2024 PG - 15 SN - 1662-5153 DO - 10.3389/fnbeh.2023.1289520 UR - https://m2.mtmt.hu/api/publication/34577860 ID - 34577860 AB - The security of animal habitats, such as burrows and nests, is vital for their survival and essential activities, including eating, mating, and raising offspring. Animals instinctively exhibit defensive behaviors to protect themselves from imminent and potential threats. In 1963, researchers reported wild rats sealing the entrances to their burrows from the inside using materials such as mud, sand, and vegetation. This behavior, known as "entrance sealing (ES)," involves repetitive movements of their nose/mouth and forepaws and is likely a proactive measure against potential intruders, which enhances burrow security. These observations provide important insights into the animals' ability to anticipate potential threats that have not yet occurred and take proactive actions. However, this behavior lacks comprehensive investigation, and the neural mechanisms underpinning it remain unclear. Hypothalamic perifornical neurons expressing urocortin-3 respond to novel objects/potential threats and modulate defensive responses to the objects in mice, including risk assessment and burying. In this study, we further revealed that chemogenetic activation of these neurons elicited ES-like behavior in the home-cage. Furthermore, behavioral changes caused by activating these neurons, including manifestations of ES-like behavior, marble-burying, and risk assessment/burying of a novel object, were effectively suppressed by selective serotonin-reuptake inhibitors. The c-Fos analysis indicated that ES-like behavior was potentially mediated through GABAergic neurons in the lateral septum. These findings underscore the involvement of hypothalamic neurons in the anticipation of potential threats and proactive defense against them. The links of this security system with the manifestation of repetitive/stereotypic behaviors and the serotonergic system provide valuable insights into the mechanisms underlying the symptoms of obsessive-compulsive disorder. LA - English DB - MTMT ER - TY - JOUR AU - Kohn, Brooke H. AU - Cui, Zehua AU - Candelaria, Margo A. AU - Buckingham-Howes, Stacy AU - Black, Maureen M. AU - Riggins, Tracy TI - Early emotional caregiving environment and associations with memory performance and hippocampal volume in adolescents with prenatal drug exposure JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 17 PY - 2023 PG - 16 SN - 1662-5153 DO - 10.3389/fnbeh.2023.1238172 UR - https://m2.mtmt.hu/api/publication/34635460 ID - 34635460 LA - English DB - MTMT ER - TY - JOUR AU - Randolph, Eric C. AU - Fieber, Lynne A. TI - Improvements in operant memory of Aplysia are correlated with age and specific gene expression JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 17 PY - 2023 PG - 12 SN - 1662-5153 DO - 10.3389/fnbeh.2023.1221794 UR - https://m2.mtmt.hu/api/publication/34632776 ID - 34632776 LA - English DB - MTMT ER - TY - JOUR AU - Smith, Lucille Lakier TI - Similarities and differences regarding acute anorexia nervosa and semi-starvation: does behavioral thermoregulation play a central role? JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 17 PY - 2023 PG - 14 SN - 1662-5153 DO - 10.3389/fnbeh.2023.1243572 UR - https://m2.mtmt.hu/api/publication/34630536 ID - 34630536 LA - English DB - MTMT ER -