TY - JOUR AU - Yang, Jun AU - Yan, Caihong AU - Chen, Shaolin AU - Li, Min AU - Miao, Yanmei AU - Ma, Xinglong AU - Zeng, Junfa AU - Xie, Peng TI - The possible mechanisms of ferroptosis in sepsis-associated acquired weakness JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 15 PY - 2024 SP - 1 EP - 8 PG - 8 SN - 1664-042X DO - 10.3389/fphys.2024.1380992 UR - https://m2.mtmt.hu/api/publication/34759191 ID - 34759191 AB - Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and its morbidity and mortality rates are increasing annually. It is an independent risk factor for intensive care unit-acquired weakness (ICU-AW), which is a common complication of patients in ICU. This situation is also known as sepsis-associated acquired weakness (SAW), and it can be a complication in more than 60% of patients with sepsis. The outcomes of SAW are often prolonged mechanical ventilation, extended hospital stays, and increased morbidity and mortality of patients in ICUs. The pathogenesis of SAW is unclear, and an effective clinical treatment is not available. Ferroptosis is an iron-dependent type of cell death with unique morphological, biochemical, and genetic features. Unlike other forms of cell death such as autophagy, apoptosis, and necrosis, ferroptosis is primarily driven by lipid peroxidation. Cells undergo ferroptosis during sepsis, which further enhances the inflammatory response. This process leads to increased cell death, as well as multi-organ dysfunction and failure. Recently, there have been sporadic reports suggesting that SAW is associated with ferroptosis, but the exact pathophysiological mechanisms remain unclear. Therefore, we reviewed the possible pathogenesis of ferroptosis that leads to SAW and offer new strategies to prevent and treat SAW. LA - English DB - MTMT ER - TY - JOUR AU - Lei, Ming AU - Salvage, Samantha C. AU - Jackson, Antony P. AU - Huang, Christopher L.-H. TI - Cardiac arrhythmogenesis: roles of ion channels and their functional modification JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 15 PY - 2024 PG - 23 SN - 1664-042X DO - 10.3389/fphys.2024.1342761 UR - https://m2.mtmt.hu/api/publication/34755119 ID - 34755119 N1 - Edited by: Mona El Refaey, The Ohio State University, United States Reviewed by: - Richard Ang, University College London, United Kingdom - Hyun Seok Hwang, Florida State University, United States AB - Cardiac arrhythmias cause significant morbidity and mortality and pose a major public health problem. They arise from disruptions in the normally orderly propagation of cardiac electrophysiological activation and recovery through successive cardiomyocytes in the heart. They reflect abnormalities in automaticity, initiation, conduction, or recovery in cardiomyocyte excitation. The latter properties are dependent on surface membrane electrophysiological mechanisms underlying the cardiac action potential. Their disruption results from spatial or temporal instabilities and heterogeneities in the generation and propagation of cellular excitation. These arise from abnormal function in their underlying surface membrane, ion channels, and transporters, as well as the interactions between them. The latter, in turn, form common regulatory targets for the hierarchical network of diverse signaling mechanisms reviewed here. In addition to direct molecular-level pharmacological or physiological actions on these surface membrane biomolecules, accessory, adhesion, signal transduction, and cytoskeletal anchoring proteins modify both their properties and localization. At the cellular level of excitation–contraction coupling processes, Ca 2+ homeostatic and phosphorylation processes affect channel activity and membrane excitability directly or through intermediate signaling. Systems -level autonomic cellular signaling exerts both acute channel and longer-term actions on channel expression. Further upstream intermediaries from metabolic changes modulate the channels both themselves and through modifying Ca 2+ homeostasis. Finally, longer-term organ -level inflammatory and structural changes, such as fibrotic and hypertrophic remodeling, similarly can influence all these physiological processes with potential pro-arrhythmic consequences. These normal physiological processes may target either individual or groups of ionic channel species and alter with particular pathological conditions. They are also potentially alterable by direct pharmacological action, or effects on longer-term targets modifying protein or cofactor structure, expression, or localization. Their participating specific biomolecules, often clarified in experimental genetically modified models, thus constitute potential therapeutic targets. The insights clarified by the physiological and pharmacological framework outlined here provide a basis for a recent modernized drug classification. Together, they offer a translational framework for current drug understanding. This would facilitate future mechanistically directed therapeutic advances, for which a number of examples are considered here. The latter are potentially useful for treating cardiac, in particular arrhythmic, disease. LA - English DB - MTMT ER - TY - JOUR AU - He, H. AU - Zhou, J. AU - Xu, X. AU - Zhou, P. AU - Zhong, H. AU - Liu, M. TI - Piezo channels in the intestinal tract JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 15 PY - 2024 SN - 1664-042X DO - 10.3389/fphys.2024.1356317 UR - https://m2.mtmt.hu/api/publication/34749450 ID - 34749450 N1 - School of Acupuncture-Moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Hunan, Changsha, China Key Laboratory of Acupuncture and Moxibustion Bioinformatics, Education Department of Hunan Province, Hunan, Changsha, China Export Date: 21 March 2024 Correspondence Address: Liu, M.; School of Acupuncture-Moxibustion, Hunan, China; email: newmean@hnucm.edu.cn LA - English DB - MTMT ER - TY - JOUR AU - Cao, Meng AU - Yang, Baiquan AU - Tang, Yucheng AU - Wang, Chun AU - Yin, Lijun TI - Effects of low-volume functional and running high-intensity interval training on physical fitness in young adults with overweight/obesity JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 15 PY - 2024 PG - 11 SN - 1664-042X DO - 10.3389/fphys.2024.1325403 UR - https://m2.mtmt.hu/api/publication/34733337 ID - 34733337 N1 - Funding Agency and Grant Number: Science and Technology Innovation Project of General Administration of Sport of China [22KJCX035]; Guangdong Planning Office of Philosophy and Social Science [GD20YTY02] Funding text: The present study was supported by Shenzhen University. The authors would like to thank all participants who took part in the study for their genuine efforts.r The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by Science and Technology Innovation Project of General Administration of Sport of China (ID: 22KJCX035) and the Guangdong Planning Office of Philosophy and Social Science (ID: GD20YTY02). AB - Objectives: This study examined and compared the effects of functional and running high-intensity interval training (HIIT) on body composition, cardiorespiratory fitness, and muscular fitness of young adults with overweight or obesity. Methods: Forty-five participants (22.1 +/- 2.1 years, BMI = 25.2 +/- 1.0 kg/m(2)) were assigned to functional HIIT (HIIT-F; n = 15), running HIIT (HIIT-R; n = 15), or non-training control group (CON; n = 15). Participants in HIIT-F and HIIT-R performed functional exercise based-HIIT (four sets of all-out whole-body exercises including jumping jacks, squats, twist jumps and mountain climbers, et al.) and running HIIT (four sets of running on a treadmill) for 12 weeks, respectively. Body composition, muscular fitness, and cardiorespiratory fitness were assessed pre and post intervention. Results: Both HIIT-F and HIIT-R significantly improved the body composition and cardiorespiratory fitness, with HIIT-F induced greater improvements in lean mass (+1.623 vs. -1.034 kg, p < 0.001), back strength (+6.007 vs. +3.333 kg, p < 0.01), and push-ups (+5.692 vs. 1.923 reps, p < 0.001) than that in HIIT-R. HIIT-R reduced more visceral fat area (VFA) (-11.416 vs. -4.338 cm(2), p = 0.052) and induced similar improvement in cardiorespiratory fitness (VO2max, +2.192 vs. +2.885 mL/kg/min, p = 0.792) with HIIT-F. Conclusion: Twelve weeks of HIIT-R or HIIT-F improved physical fitness among young adults with overweight or obesity. Despite the similar impact on cardiorespiratory fitness, HIIT-F generates a better positive effect on muscular fitness relative to HIIT-R, which could be partly explained by the greater increase in lean mass after HIIT-F intervention. LA - English DB - MTMT ER - TY - JOUR AU - Mould, Rhys R. AU - Mackenzie, Alasdair M. AU - Kalampouka, Ifigeneia AU - Nunn, Alistair V. W. AU - Thomas, E. Louise AU - Bell, Jimmy D. AU - Botchway, Stanley W. TI - Ultra weak photon emission—a brief review JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 15 PY - 2024 SP - 1348915 SN - 1664-042X DO - 10.3389/fphys.2024.1348915 UR - https://m2.mtmt.hu/api/publication/34726955 ID - 34726955 AB - Cells emit light at ultra-low intensities: photons which are produced as by-products of cellular metabolism, distinct from other light emission processes such as delayed luminescence, bioluminescence, and chemiluminescence. The phenomenon is known by a large range of names, including, but not limited to, biophotons, biological autoluminescence, metabolic photon emission and ultraweak photon emission (UPE), the latter of which shall be used for the purposes of this review. It is worth noting that the photons when produced are neither ‘weak’ nor specifically biological in characteristics. Research of UPE has a long yet tattered past, historically hamstrung by a lack of technology sensitive enough to detect it. Today, as technology progresses rapidly, it is becoming easier to detect and image these photons, as well as to describe their function. In this brief review we will examine the history of UPE research, their proposed mechanism, possible biological role, the detection of the phenomenon, and the potential medical applications. LA - English DB - MTMT ER - TY - JOUR AU - Zhang, Yu AU - Cui, Jiangbo AU - Cang, Zhengqiang AU - Pei, Jiaomiao AU - Zhang, Xi AU - Song, Baoqiang AU - Fan, Xing AU - Ma, Xianjie AU - Li, Yang TI - Hair follicle stem cells promote epidermal regeneration under expanded condition JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 15 PY - 2024 PG - 11 SN - 1664-042X DO - 10.3389/fphys.2024.1306011 UR - https://m2.mtmt.hu/api/publication/34688735 ID - 34688735 N1 - Edited by: Bin Yao, Tianjin University, China Reviewed by: - Ryan O'Shaughnessy, Queen Mary University of London, United Kingdom - Yiming Zhang, Xinqiao Hospital, China - Yuzhen Wang, People’s Liberation Army General Hospital, China AB - Skin soft tissue expansion is the process of obtaining excess skin mixed with skin development, wound healing, and mechanical stretching. Previous studies have reported that tissue expansion significantly induces epidermal proliferation throughout the skin. However, the mechanisms underlying epidermal regeneration during skin soft tissue expansion are yet to be clarified. Hair follicle stem cells (HFSCs) have been recognized as a promising approach for epidermal regeneration. This study examines HFSC-related epidermal regeneration mechanisms under expanded condition and proposes a potential method for its cellular and molecular regulation. LA - English DB - MTMT ER - TY - JOUR AU - Petrusic, Tanja AU - Novak, Dario TI - A 16-week school-based intervention improves physical fitness in Slovenian children: a randomized controlled trial JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 15 PY - 2024 PG - 10 SN - 1664-042X DO - 10.3389/fphys.2024.1311046 UR - https://m2.mtmt.hu/api/publication/34666780 ID - 34666780 LA - English DB - MTMT ER - TY - JOUR AU - Pimenta, Ricardo AU - Antunes, Hugo AU - Bruno, Paula AU - Veloso, A. P. TI - Hamstrings mechanical properties profiling in football players of different competitive levels and positions after a repeated sprint protocol JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 14 PY - 2024 PG - 7 SN - 1664-042X DO - 10.3389/fphys.2023.1315564 UR - https://m2.mtmt.hu/api/publication/34661821 ID - 34661821 LA - English DB - MTMT ER - TY - JOUR AU - Fathima, Shahna AU - Al Hakeem, Walid Ghazi AU - Selvaraj, Ramesh K. AU - Shanmugasundaram, Revathi TI - Beyond protein synthesis: the emerging role of arginine in poultry nutrition and host-microbe interactions JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 14 PY - 2024 PG - 16 SN - 1664-042X DO - 10.3389/fphys.2023.1326809 UR - https://m2.mtmt.hu/api/publication/34661813 ID - 34661813 LA - English DB - MTMT ER - TY - JOUR AU - Geng, Zhizhong AU - Wang, Jinhao AU - Cao, Guohuan AU - Tan, Chenhao AU - Li, Longji AU - Qiu, Jun TI - Differential impact of heat and hypoxia on dynamic oxygen uptake and deoxyhemoglobin parameters during incremental exhaustive exercise JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 14 PY - 2024 PG - 14 SN - 1664-042X DO - 10.3389/fphys.2023.1247659 UR - https://m2.mtmt.hu/api/publication/34659147 ID - 34659147 LA - English DB - MTMT ER -