@article{MTMT:34819310,
	title = {The Outcomes of Patients with Omicron Variant Infection who Undergo Elective Surgery: A Propensity-score-matched Case-control Study},
	url = {https://m2.mtmt.hu/api/publication/34819310},
	author = {Xiong, X. and Li, R. and Yan, H. and Mao, Q.},
	doi = {10.7150/ijms.90695},
	journal-iso = {INT J MED SCI},
	journal = {INTERNATIONAL JOURNAL OF MEDICAL SCIENCES},
	volume = {21},
	unique-id = {34819310},
	issn = {1449-1907},
	abstract = {Aim: To investigate whether it is safe for patients with Omicron variant infection to undergo surgery during perioperative period. Methods: A total of 3,661 surgical patients were enrolled: 3,081 who were not infected with the Omicron variant and 580 who were infected with the Omicron variant. We conducted propensity score matching (PSM) with a ratio of 1:4 and a caliper value of 0.1 to match the infected and uninfected groups based on 13 variables. After PSM, we further divided the Infected group (560 cases) by the number of days between the preoperative Omicron variant infection and surgery: 0-7, 8-14, 15-30, and >30 days. Multivariate logistic regression analysis was subsequently conducted on the categorical variables and continuous variables with a P value below 0.05, thereby comparing the infected group (0-7, 8-14, 15-30, >30 days) and the uninfected group for perioperative complications. Results: Multivariate logistic regression analysis revealed that, compared to the uninfected group, among the four subgroups of the infected patients (0-7, 8-14, 15-30, >30 days), only renal insufficiency in the 8-14 days subgroup (OR: 0.09, 95%CI 0.01-0.74, P = 0.025) and anemia in the > 30 days subgroup (OR 0.6, 95%CI 0.4-0.9, P < 0.017) showed significant difference. However, there was no statistically significant difference in the incidence rate of blood transfusion, postoperative intensive care unit transfer, lung infection/pneumonia, pleural effusion, atelectasis, respiratory failure, sepsis, postoperative deep vein thrombosis, hypoalbuminemia, urinary tract infections, and medical expenses. Conclusion: Omicron infection does not significantly increase the risk of perioperative major complications. The Omicron infection may not be a sufficient risk factor to postpone elective surgery. © The author(s).},
	keywords = {Adult; Female; Middle Aged; Male; ARTICLE; human; Postoperative complications; Incidence; risk factor; major clinical study; controlled study; nonhuman; FRACTURE; Comorbidity; ANEMIA; retrospective study; Sepsis; blood transfusion; kidney failure; URINARY TRACT INFECTION; pleura effusion; case control study; respiratory failure; health care cost; elective surgery; intensive care unit; pneumonia; perioperative period; deep vein thrombosis; Clinical outcome; lung infection; hypoalbuminemia; Timing of surgery; malignant neoplasm; atelectasis; coronavirus disease 2019; SARS-CoV-2 Omicron; Omicron variant},
	year = {2024},
	eissn = {1449-1907},
	pages = {817-825}
}

@article{MTMT:34784294,
	title = {Respiratory pathogenic microbial infections: a narrative review},
	url = {https://m2.mtmt.hu/api/publication/34784294},
	author = {Long, Y. and Zheng, Y. and Li, C. and Guo, Z. and Li, P. and Zhang, F. and Liu, W. and Wang, Y.},
	doi = {10.7150/ijms.93628},
	journal-iso = {INT J MED SCI},
	journal = {INTERNATIONAL JOURNAL OF MEDICAL SCIENCES},
	volume = {21},
	unique-id = {34784294},
	issn = {1449-1907},
	year = {2024},
	eissn = {1449-1907},
	pages = {826-836}
}

@article{MTMT:34749074,
	title = {Impact of Omicron variant infection on the liver, kidney, and coagulation system in patients undergoing elective surgery: a retrospective case-control study},
	url = {https://m2.mtmt.hu/api/publication/34749074},
	author = {Xiong, X. and Li, R. and Pei, H. and Mao, Q.},
	doi = {10.7150/ijms.88727},
	journal-iso = {INT J MED SCI},
	journal = {INTERNATIONAL JOURNAL OF MEDICAL SCIENCES},
	volume = {21},
	unique-id = {34749074},
	issn = {1449-1907},
	abstract = {Purpose: We aimed to investigate the impact of Omicron variant infection on the perioperative organ function in patients undergoing elective surgery. Methods: A total of 5029 patients who underwent elective surgery between October 2022 and January 2023 at our hospital were enrolled. Among them, the patients who underwent elective surgery between October 2022 and November 2022 composed Group 1 (not infected with the Omicron variant) the control group; those who underwent elective surgery between December 2022 and January 2023 composed Group 2 (one month after Omicron variant infection) the experimental group. We further divided the patients into two subgroups for analysis: the tumor subgroup and the nontumor subgroup. Data on organ system function indicators, including coagulation parameters, liver function, complete blood count (CBC), and kidney function, were collected before and after surgery. Differences between the two groups were subsequently analyzed via binary logistic regression analysis. Results: Compared with those in the uninfected patient group, the following changes were observed in patients with Omicron variant infection who underwent elective surgery one month after infection: prothrombin activity (PTa), prothrombin time (PT), fibrinogen, albumin/globulin, alanine aminotransferase (ALT), mean corpuscular hemoglobin concentration (MCHC), platelet (PLT), and anemia were increased AST/ALT, indirect bilirubin (IBILI), eosinophils, and uric acid were decreased before surgery; and lung infection/pneumonia and fibrinogen were increased, while AST/ALT, globulin, total bilirubin (TBIL), white blood cell count (WBC), and uric acid were decreased after surgery. There was no significant difference in the mortality rate or length of hospital stay (LOS) between the two groups. Subgroup analysis revealed elevated monocyte, PLT, and fibrinogen classification, levels and decreased globulin, prealbumin (PBA), eosinophil, and uric acid levels in the tumor subgroup of patients who underwent elective surgery one month after Omicron infection compared with those in the uninfected patients. Compared with the nontumor subgroup, fibrinogen levels, lung infection/pneumonia, TBIL, and PLT count were increased in the uninfected patients, while the globulin and eosinophil levels were decreased. Conclusion: Compared with uninfected patients, patients who underwent elective surgery one month after Omicron variant infection exhibited minimal changes in perioperative coagulation parameters, liver function, CBC counts, and kidney function. Additionally, no significant differences in postoperative mortality or LOS were observed between the two groups. © The author(s).},
	year = {2024},
	eissn = {1449-1907},
	pages = {742-754}
}

@article{MTMT:34784788,
	title = {Novel model of pyroptosis-related molecular signatures for prognosis prediction of clear cell renal cell carcinoma patients},
	url = {https://m2.mtmt.hu/api/publication/34784788},
	author = {Chen, J. and Jiang, R. and Guan, W. and Cao, Q. and Tian, Y. and Dong, K. and Pan, X. and Cui, X.},
	doi = {10.7150/ijms.88301},
	journal-iso = {INT J MED SCI},
	journal = {INTERNATIONAL JOURNAL OF MEDICAL SCIENCES},
	volume = {21},
	unique-id = {34784788},
	issn = {1449-1907},
	year = {2024},
	eissn = {1449-1907},
	pages = {496-507}
}

@article{MTMT:34563347,
	title = {Metabolomics Analysis and Diagnosis of Lung Cancer: Insights from Diverse Sample Types},
	url = {https://m2.mtmt.hu/api/publication/34563347},
	author = {Liang, S. and Cao, X. and Wang, Y. and Leng, P. and Wen, X. and Xie, G. and Luo, H. and Yu, R.},
	doi = {10.7150/ijms.85704},
	journal-iso = {INT J MED SCI},
	journal = {INTERNATIONAL JOURNAL OF MEDICAL SCIENCES},
	volume = {21},
	unique-id = {34563347},
	issn = {1449-1907},
	abstract = {Lung cancer is a highly fatal disease that poses a significant global health burden. The absence of characteristic clinical symptoms frequently results in the diagnosis of most patients at advanced stages of lung cancer. Although low-dose computed tomography (LDCT) screening has become increasingly prevalent in clinical practice, its high rate of false positives continues to present a significant challenge. In addition to LDCT screening, tumor biomarker detection represents a critical approach for early diagnosis of lung cancer; unfortunately, no tumor marker with optimal sensitivity and specificity is currently available. Metabolomics has recently emerged as a promising field for developing novel tumor biomarkers. In this paper, we introduce metabolic pathways, instrument platforms, and a wide variety of sample types for lung cancer metabolomics. Specifically, we explore the strengths, limitations, and distinguishing features of various sample types employed in lung cancer metabolomics research. Additionally, we present the latest advances in lung cancer metabolomics research that utilize diverse sample types. We summarize and enumerate research studies that have investigated lung cancer metabolomics using different metabolomic sample types. Finally, we provide a perspective on the future of metabolomics research in lung cancer. Our discussion of the potential of metabolomics in developing new tumor biomarkers may inspire further study and innovation in this dynamic field. © The author(s).},
	keywords = {Humans; CHROMATOGRAPHY; CHROMATOGRAPHY; CELLS; PLASMA; metabolism; SERUM; SKIN; review; human; Sensitivity and Specificity; Sensitivity and Specificity; Biomarkers; TISSUES; GLUCOSE; nonhuman; Tomography, X-Ray Computed; biological marker; Mass spectrometry; Mass spectrometry; lipid metabolism; lipid; glucose metabolism; blood sampling; amino acid; saliva; lung cancer; lung cancer; lung tumor; lung tumor; Lung Neoplasms; Lung Neoplasms; cancer diagnosis; metabolomics; metabolomics; metabolomics; metabolomics; tumor marker; tumor marker; Bronchoalveolar Lavage Fluid; Nuclear magnetic resonance spectroscopy; mass fragmentography; breathing; cancer tissue; cancer research; Liquid chromatography-Mass spectrometry; amino acid metabolism; volatile organic compound; procedures; X-ray computed tomography; Biomarkers, Tumor; Metabonomics; dried blood spot testing; urine sampling; Sweat; capillary electrophoresis-mass spectrometry},
	year = {2024},
	eissn = {1449-1907},
	pages = {234-252}
}

@article{MTMT:34479861,
	title = {NAD+-A Hub of Energy Metabolism in Heart Failure},
	url = {https://m2.mtmt.hu/api/publication/34479861},
	author = {Wu, Y. and Pei, Z. and Qu, P.},
	doi = {10.7150/ijms.89370},
	journal-iso = {INT J MED SCI},
	journal = {INTERNATIONAL JOURNAL OF MEDICAL SCIENCES},
	volume = {21},
	unique-id = {34479861},
	issn = {1449-1907},
	abstract = {Heart failure is a condition where reduced levels of adenosine triphosphate (ATP) affect energy supply in myocardial cells. Nicotinamide adenine dinucleotide (NAD+) plays a crucial role as a coenzyme for electron transfer in energy metabolism. Decreased NAD+ levels in myocardial cells lead to inadequate ATP production and increased susceptibility to heart failure. Researchers are exploring ways to increase NAD+ levels to alleviate heart failure. Targets such as sirtuin2 (sirt2), sirtuin3 (sirt3), Poly (ADP-ribose) polymerase (PARP), and diastolic regulatory proteins are being investigated. NAD+ supplementation has shown promise, even in heart failure with preserved ejection fraction (HFpEF). By focusing on NAD+ as a central component of energy metabolism, it is possible to improve myocardial activity, heart function, and address energy deficiency in heart failure. © The author(s).},
	keywords = {review; human; disease predisposition; Mitochondria; nonhuman; protein phosphorylation; enzyme activity; diet supplementation; Electron Transport; heart failure; heart failure; systolic blood pressure; diastolic blood pressure; protein expression; Adenosine Triphosphate; heart function; protein targeting; reactive oxygen metabolite; energy metabolism; energy metabolism; protein modification; sirtuin 1; nicotinamide adenine dinucleotide; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; enzyme synthesis; sirtuin 3; sirtuin 2; Heart failure with preserved ejection fraction; NAD+; nicotinamide riboside; cardiac muscle cell; sirtuin 4; sirtuin 5; sirtuin 6; sirtuin 7; flavine adenine nucleotide; ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1},
	year = {2024},
	eissn = {1449-1907},
	pages = {369-375}
}

@article{MTMT:34594111,
	title = {Bibliometric Analysis of Stem Cells in Ischemic Stroke (2001-2022): Trends, Hotspots and Prospects},
	url = {https://m2.mtmt.hu/api/publication/34594111},
	author = {Yang, Ting and Jiang, Nan and Han, Hongxia and Shui, Jing and Hou, Miaomiao and Kumar, Gajendra and Tian, Hao and Song, Lijuan and Ma, Cungen and Li, Xinyi and Ding, Zhibin},
	doi = {10.7150/ijms.86591},
	journal-iso = {INT J MED SCI},
	journal = {INTERNATIONAL JOURNAL OF MEDICAL SCIENCES},
	volume = {21},
	unique-id = {34594111},
	issn = {1449-1907},
	abstract = {Background: Ischemic stroke is a common cerebrovascular accident with a high risk of neurological deficits. Stem cell therapy has progressively attracted the interest of scientists and clinicians due to the benefits of promoting neural regeneration and regulating the microenvironment surrounding the lesion after ischemic stroke. Our study aimed to evaluate the development trends and research hotspots in the field of stem cells and ischemic stroke. Materials and methods: Publications related to stem cells and ischemic stroke were retrieved from the Web of Science from 2001 to 2022. Data analysis and mapping were performed using VOSviewer, Citespace and ImageGP. Results: In total, 1932 papers were included in the analysis. Publications have steadily increased over the past 22 years. China has contributed the maximum number of publications, whereas the USA ranked first in the total number of citations and was considered the center of the international collaboration network. University of South Florida, Henry Ford Hospital, and Oakland University were the most influential institutions. Stroke, Brain Research, and Neural Regeneration Research were the most productive journals. The research in this field was primarily focused on the effects of stem cells on neurogenesis, inflammation, and angiogenesis following ischemic stroke, as well as their therapeutic potential for the disease. In addition, neural stem cells and mesenchymal stem cells are the most commonly utilized stem cells. The topics related to miRNA, extracellular vesicles, exosomes, mesenchymal stem cells, neuroinflammation, and autophagy are current research hotspots. Conclusion: Our bibliometric study provides a novel perspective on the research trends in the field of stem cells and ischemic stroke. The outcome of this study may benefit scientists to identify research hotspots and development directions, thereby advancing the application of stem cell-based therapy for ischemic stroke.},
	keywords = {Stem Cells; TRANSLATION; bibliometric analysis; ischemic stroke; NEUROGENESIS; paracrine effects},
	year = {2024},
	eissn = {1449-1907},
	pages = {151-168}
}

@article{MTMT:34581946,
	title = {Status of research on the development and regeneration of hair follicles},
	url = {https://m2.mtmt.hu/api/publication/34581946},
	author = {Liu, Dan and Xu, Qi and Meng, Xiangyuan and Liu, Xiaomei and Liu, Jinyu},
	doi = {10.7150/ijms.88508},
	journal-iso = {INT J MED SCI},
	journal = {INTERNATIONAL JOURNAL OF MEDICAL SCIENCES},
	volume = {21},
	unique-id = {34581946},
	issn = {1449-1907},
	abstract = {Hair loss, or alopecia, is a prevalent condition in modern society that imposes substantial mental and psychological burden on individuals. The types of hair loss, include androgenetic alopecia, alopecia areata, and telogen effluvium; of them, androgenetic alopecia is the most common condition. Traditional treatment modalities mainly involve medical options, such as minoxidil, finasteride and surgical interventions, such as hair transplantation. However, these treatments still have many limitations. Therefore, exploring the pathogenesis of hair loss, specifically focusing on the development and regeneration of hair follicles (HFs), and developing new strategies for promoting hair regrowth are essential. Some emerging therapies for hair loss have gained prominence; these therapies include low-level laser therapy, micro needling, fractional radio frequency, platelet-rich plasma, and stem cell therapy. The aforementioned therapeutic strategies appear promising for hair loss management. In this review, we investigated the mechanisms underlying HF development and regeneration. For this, we studied the structure, development, cycle, and cellular function of HFs. In addition, we analyzed the symptoms, types, and causes of hair loss as well as its current conventional treatments. Our study provides an overview of the most effective regenerative medicine-based therapies for hair loss.},
	keywords = {Stem cell therapy; hair loss; hair follicle growth; Hair follicle regeneration},
	year = {2024},
	eissn = {1449-1907},
	pages = {80-94}
}

@article{MTMT:34515285,
	title = {Anlotinib suppresses the DNA damage response by disrupting SETD1A and inducing p53-dependent apoptosis in Transformed Follicular Lymphoma},
	url = {https://m2.mtmt.hu/api/publication/34515285},
	author = {Zhuang, Xinguo and Yao, Jingwei and Li, Xun and Jiang, Yuelong and Zhong, Mengya and Tan, Jinshui and Zhou, Hui and Li, Genhong and Zha, Jie and Xu, Bing},
	doi = {10.7150/ijms.84952},
	journal-iso = {INT J MED SCI},
	journal = {INTERNATIONAL JOURNAL OF MEDICAL SCIENCES},
	volume = {21},
	unique-id = {34515285},
	issn = {1449-1907},
	abstract = {Purpose: The high tumor mutational burden (TMB) of transformed follicular lymphoma (tFL) leads to tumor heterogeneity and poor prognosis in follicular lymphoma, in which endogenous DNA damage and epigenetic modification are the key factors. This study aims to evaluate the efficacy of anlotinib in tFL and to investigate its potential therapeutic mechanism.Methods: Cell viability and apoptosis were tested with CCK-8 and annexin V/PI staining kits, respectively. The tumorigenicity test in mice was utilized to further confirm the efficacy of anlotinib in vivo. Western blotting was utilized to explore the molecular mechanisms. Results: Anlotinib induced G2/M phase arrest in tFL cells, inhibited the proliferation of tFL cells and promoted the apoptosis of tFL cells in a dose-dependent manner. Administration of anlotinib markedly reduced tumor mass and weight in an FL xenograft mouse model. The western blot and immunohistochemistry staining results confirmed that the mechanism by which anlotinib promoted tumor cell apoptosis was DNA damage. Further results showed that anlotinib significantly downregulated the expression of SETD1A, leading to its destruction. Anlotinib administration resulted in a significant dose-dependent increase in the level of p-p53. Furthermore, anlotinib greatly downregulated the antiapoptotic proteins Mcl-1 and in parallel upregulated the proapoptotic element BAX and Bak, accompanied by caspase-3 activation and PARP degradation.Conclusion: Anlotinib has a good proapoptotic effect on tumor cells in vitro and in vivo, and its possible mechanism is related to the inhibition of the DNA damage response by disrupting SETD1A.},
	keywords = {CLASSIFICATION; REPAIR; Histone modifications; DNA damage response; SETD1A; anlotinib; Transformed follicular lymphoma (tFL)},
	year = {2024},
	eissn = {1449-1907},
	pages = {70-79}
}

@article{MTMT:34341363,
	title = {Lnc NR2F1-AS1 Promotes Breast Cancer Metastasis by Targeting the MiR-25-3p/ZEB2 Axis},
	url = {https://m2.mtmt.hu/api/publication/34341363},
	author = {Zhai, Duanyang and Zhou, Yu and Kuang, Xiaying and Shao, Fangyuan and Zhen, Tiantian and Lin, Ying and Wang, Qing and Shao, Nan},
	doi = {10.7150/ijms.86969},
	journal-iso = {INT J MED SCI},
	journal = {INTERNATIONAL JOURNAL OF MEDICAL SCIENCES},
	volume = {20},
	unique-id = {34341363},
	issn = {1449-1907},
	abstract = {Background: Long noncoding RNAs (lncRNAs) substantially affect tumor metastasis and are aberrantly expressed in various cancers. However, its role in breast cancer (BC) remains unclear.Methods: A microarray assay of differentially expressed lncRNAs in epithelial-mesenchymal transition (EMT) and non-EMT cells was performed. The prognostic value of lnc NR2F1-AS1 expression in patients with BC was analyzed using The Cancer Genome Atlas database. Lnc NR2F1-AS1 expression levels in different BC cell lines were assessed using quantitative real-time PCR. The role of lnc NR2F1-AS1 in BC cell metastasis was investigated in vitro and in vivo. Dual luciferase reporter assay and RNA immunoprecipitation were performed to investigate the relationship between lnc NR2F1-AS1, miR-25-3p, and ZEB2.Results: High levels of lnc NR2F1-AS1 were observed in BC cells undergoing EMT and were closely correlated with adverse prognosis in patients with BC. Lnc NR2F1-AS1 knockdown significantly inhibited BC cell migration, invasiveness in vitro, and metastasis in vivo. Mechanistically, lnc NR2F1-AS1 competitively binds to miR-25-3p to impede ZEB2 degradation, a positive EMT transcription factor in BC.Conclusions: Our study revealed a novel lnc NR2F1-AS1/miR-25-3p/ZEB2 axis in BC metastasis and that lnc NR2F1-AS1 may serve as a potential therapeutic target for BC metastasis.},
	keywords = {METASTASIS; breast cancer; miR-25-3p; ZEB2},
	year = {2023},
	eissn = {1449-1907},
	pages = {1152-1162}
}