TY - JOUR AU - Jakubiak, G.K. AU - Pawlas, N. AU - Morawiecka-Pietrzak, M. AU - Zalejska-Fiolka, J. AU - Stanek, A. AU - Cieślar, G. TI - Relationship of Thyroid Volume and Function with Ankle-Brachial Index, Toe-Brachial Index, and Toe Pressure in Euthyroid People Aged 18–65 JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 60 PY - 2024 IS - 9 SN - 1010-660X DO - 10.3390/medicina60091445 UR - https://m2.mtmt.hu/api/publication/35696920 ID - 35696920 N1 - Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Zabrze, 41-800, Poland Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Zabrze, 41-800, Poland Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Zabrze, 41-800, Poland Department of Internal Medicine, Angiology and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Bytom, 41-902, Poland Cited By :1 Export Date: 16 January 2025 Correspondence Address: Jakubiak, G.K.; Department of Pharmacology, Poland; email: grzegorz.k.jakubiak@gmail.com AB - Background and Objectives: The interrelationship between thyroid function and the state of the cardiovascular system has been investigated both in preclinical and human studies. However, it remains unclear whether there is any association between thyroid hormones and features of subclinical cardiovascular dysfunction in euthyroid patients. Material and Methods: This study involved 45 people (females: 57.8%) with no thyroid disease who, during planned hospitalization, underwent thyroid ultrasound, determination of biochemical parameters of thyroid function, and measurement of ankle-brachial index (ABI) and toe-brachial index (TBI). People with signs of acute illness or a deterioration of their health were excluded. Results: Significant correlations were found between free triiodothyronine (FT3) and several parameters of both ABI (R = 0.347; p = 0.019 for the mean ABI taken from right side and left side values) and TBI (R = 0.396; p = 0.007 for the mean TBI taken from right side and left side values), as well as the maximal toe pressure (TP) taken from right side and left side values (R = 0.304; p = 0.045). Thyrotropin (TSH) was shown to be significantly correlated only with the maximal TBI value (taken from right side and left side values) (R = 0.318; p = 0.033), whereas free thyroxin (FT4) was shown to be significantly correlated only with the minimal TBI value (taken from right side and left side values) (R = 0.381; p = 0.01). Thyroid volume (TV) was shown to be correlated with TP (R = 0.4; p = 0.008 for the mean TP taken from right side and left side values) and some parameters of TBI value (R = 0.332; p = 0.028 for the mean TBI taken from right side and left side values), but no significant correlations were found between TVand ABI parameters. Patients with a mean ABI value ≤ 1.0 or a mean TBI value ≤ 0.75 have lower TSH, FT3, FT4, and TV than the rest of the study population, but the difference was statistically significant only for FT3. Conclusions: Even in a population of euthyroid patients with no diagnosed thyroid disease, there are some significant correlations between the volume and function of the thyroid gland and the selected features of subclinical cardiovascular dysfunction such as ABI and TBI. © 2024 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Oprea, A. AU - Marina, V. AU - Ciobotaru, O.R. AU - Popescu, C.-M. TI - Evaluation of Amiodarone Administration in Patients with New-Onset Atrial Fibrillation in Septic Shock JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 60 PY - 2024 IS - 9 SN - 1010-660X DO - 10.3390/medicina60091436 UR - https://m2.mtmt.hu/api/publication/35689546 ID - 35689546 N1 - Export Date: 14 January 2025 Correspondence Address: Marina, V.; Doctoral School of Faculty of Medicine and Pharmacy, 47 Str. Domnească, Romania; email: virginia.marina@ugal.ro Chemicals/CAS: amiodarone, 1951-25-3, 19774-82-4, 62067-87-2; Amiodarone; Anti-Arrhythmia Agents AB - Background and Objective: New-onset atrial fibrillation (NOAF) is a common cardiac condition often observed in intensive care units. When amiodarone is used to treat this condition, either to maintain sinus rhythm after electrical cardioversion or to control heart rate, complications can arise when a systemic pathology is present. Systemic pathology can result in a decrease in cardiac output and blood pressure, making the management of NOAF and septic shock challenging. Limited international research exists on the coexistence of NOAF and septic shock, making it difficult to determine the optimal course of treatment. While amiodarone is not the primary choice of antiarrhythmic drug for patients in septic shock, it may be considered for those with underlying cardiac issues. This paper aims to investigate the safety of administering amiodarone to patients with septic shock and explore whether another antiarrhythmic drug may be more effective, especially considering the cardiac conditions that patients may have. Materials and Methods: To write this article, we searched electronic databases for studies where authors used amiodarone and other medications for heart rate control or sinus rhythm restoration. Results: The studies reviewed in this work have shown that for the patients with septic shock and NOAF along with a pre-existing cardiac condition like a dilated left atrium, the use of amiodarone may provide greater benefits compared to other antiarrhythmic drugs. For patients with NOAF and septic shock without underlying heart disease, the initial use of propafenone has been found to be advantageous. However, a challenge arises when deciding between rhythm or heart rate control using various drug classes. Unfortunately, there is limited literature available on this specific scenario. Conclusions: NOAF is a frequent and potentially life-threatening complication occurring in one out of seven patients with sepsis, and its incidence is rising among patients with septic shock. © 2024 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Becerra-Bolaños, Á. AU - Ramos-Ahumada, D.F. AU - Herrera-Rodríguez, L. AU - Valencia-Sola, L. AU - Ojeda-Betancor, N. AU - Rodríguez-Pérez, A. TI - Withdrawal/Withholding of Life-Sustaining Therapies: Limitation of Therapeutic Effort in the Intensive Care Unit JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 60 PY - 2024 IS - 9 SN - 1010-660X DO - 10.3390/medicina60091461 UR - https://m2.mtmt.hu/api/publication/35630226 ID - 35630226 LA - English DB - MTMT ER - TY - JOUR AU - Yasin, Nusrat AU - Rahman, Hazir AU - Qasim, Muhammad AU - Nisa, Iqbal AU - Sarwar, Yasra AU - Khan, Niamat AU - Alzahrani, Khalid J. AU - Alsuwat, Meshari A. AU - Alzahrani, Fuad M. AU - Aljohani, Abrar TI - Metabolic proteins expression up-regulated in blood-borne extensively drug-resistant Salmonella typhi isolates from Pakistan JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 60 PY - 2024 IS - 9 PG - 12 SN - 1010-660X DO - 10.3390/medicina60091404 UR - https://m2.mtmt.hu/api/publication/35617434 ID - 35617434 LA - English DB - MTMT ER - TY - JOUR AU - Agircan, D. AU - Taskin, S. AU - Cekic, M. AU - Celik, H. TI - The Neuroprotective Role of Indole-3-Propionic Acid in Migraine Pathophysiology JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 60 PY - 2024 IS - 9 SN - 1010-660X DO - 10.3390/medicina60091417 UR - https://m2.mtmt.hu/api/publication/35512918 ID - 35512918 N1 - Department of Neurology, Harran Faculty of Medicine, Harran University, Sanliurfa, 63290, Turkey Department of Physiology, Harran Faculty of Medicine, Harran University, Sanliurfa, 63290, Turkey Export Date: 8 November 2024 Correspondence Address: Agircan, D.; Department of Neurology, Turkey; email: cekicdr@gmail.com Chemicals/CAS: nitric oxide, 10102-43-9; peroxynitrous acid, 14691-52-2; Biomarkers; Indoles; Neuroprotective Agents; Nitric Oxide; Peroxynitrous Acid AB - Background and Objectives: Migraine is a leading cause of disability worldwide, with complex pathophysiological mechanisms involving oxidative and nitrosative stress. Recent research suggests that Indole-3-Propionic Acid (IPA) may have a neuroprotective role in reducing nitrosative stress. This study aims to elucidate the roles of IPA and nitrosative stress biomarkers in migraine patients, focusing on their potential as therapeutic targets. Materials and Methods: This cross-sectional, case-control study included 57 migraine patients and 30 healthy controls. Patients were categorized into episodic migraine (EM) and chronic migraine (CM) groups. Socio-demographic and clinical characteristics were documented through structured interviews. Validated scales such as the Visual Analog Score (VAS), Headache Impact Test 6 (HIT-6), Migraine Disability Assessment Test (MIDAS), Migraine 24 h Quality of Life Scale (24 h QoL), Mini-Mental State Examination (MMSE), and Migraine Attacks–Subjective Cognitive Impairments Scale (Mig-SCog) were administered. Venous blood samples were collected, and serum levels of IPA, Nitric Oxide (NO), Nitric Oxide Synthase (NOS), and Peroxynitrite (ONOO−) were measured using ELISA and spectrophotometric methods. Results: Significant differences in serum IPA and NO levels were observed between migraine patients and controls. Specifically, higher serum IPA levels were found in the EM group, while higher serum NO levels were observed in the CM group. Elevated NO levels correlated with increased migraine attack frequency. Conversely, serum IPA levels showed a negative correlation with attack frequency, suggesting a protective role. Specifically, NO levels were positively correlated with the number of painful days, NSAID usage, VAS scores, HIT-6 scores, and MIDAS scores, while negatively correlated with 24 h QoL scores. Conclusions: The study highlights the significant involvement of IPA and nitrosative stress in migraine pathophysiology. Elevated IPA levels, particularly in EM patients, suggest its potential neuroprotective role. These findings underscore the importance of targeting oxidative and nitrosative stress pathways in developing effective migraine therapies. © 2024 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Ray, Amitabha AU - Moore, Thomas F. AU - Naik, Dayalu S. L. AU - Borsch, Daniel M. TI - Insights into the Two Most Common Cancers of Primitive Gut-Derived Structures and Their Microbial Connections JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 60 PY - 2024 IS - 9 PG - 20 SN - 1010-660X DO - 10.3390/medicina60091515 UR - https://m2.mtmt.hu/api/publication/35497202 ID - 35497202 LA - English DB - MTMT ER - TY - JOUR AU - Bui, M.T. AU - Nguyen, Le C.A. AU - Duong, K.L. AU - Hoang, V.T. AU - Nguyen, T.K. TI - Transplacental Transmission of SARS-CoV-2: A Narrative Review JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 60 PY - 2024 IS - 9 SN - 1010-660X DO - 10.3390/medicina60091517 UR - https://m2.mtmt.hu/api/publication/35470243 ID - 35470243 N1 - Export Date: 18 October 2024 Correspondence Address: Nguyen, T.K.; Thai Binh University of Medicine and Pharmacy, Thai Binh 410000, Viet Nam; email: trungkiendhytb@gmail.com AB - Background and Objectives: The study aims to explore the potential for transplacental transmission of SARS-CoV-2, focusing on its pathophysiology, placental defense mechanisms, and the clinical implications for maternal and neonatal health. Materials and Methods: A comprehensive review of the current literature was conducted, analyzing studies on SARS-CoV-2 infection in pregnancy, the expression of key viral receptors (ACE2 and TMPRSS2) in placental cells, and the immune responses involved in placental defense. The review also examined the clinical outcomes related to maternal and neonatal health, including adverse pregnancy outcomes and neonatal infection. Results: The expression of ACE2 and TMPRSS2 in the placenta supports the biological plausibility of SARS-CoV-2 transplacental transmission. Histopathological findings from the infected placentas reveal inflammation, vascular changes, and the evidence of viral particles in placental tissues. Clinical reports indicate an increased risk of preterm birth, intrauterine growth restriction, and neonatal infection in pregnancies affected by COVID-19. However, the frequency and mechanisms of vertical transmission remain variable across studies, highlighting the need for standardized research protocols. Conclusions: SARS-CoV-2 can potentially infect placental cells, leading to adverse pregnancy outcomes and neonatal infection. While evidence of transplacental transmission has been documented, the risk and mechanisms are not fully understood. Ongoing research is essential to clarify these aspects and inform obstetric care practices to improve maternal and neonatal outcomes during the COVID-19 pandemic. © 2024 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Talviste, G. AU - Leinsalu, M. AU - Ross, P. AU - Viigimaa, M. TI - Lipid-Lowering Treatment Gaps in Patients after Acute Myocardial Infarction: Using Global Database TriNetX JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 60 PY - 2024 IS - 9 SN - 1010-660X DO - 10.3390/medicina60091433 UR - https://m2.mtmt.hu/api/publication/35459744 ID - 35459744 N1 - Department of Health Technologies, School of Information Technologies, Tallinn University of Technology, Ehitajate Street 5, Tallinn, 19086, Estonia National Institute for Health Development, Paldiski Highway 80, Tallinn, 10617, Estonia North Estonia Medical Centre, J. Sütiste Road 19, Tallinn, 13419, Estonia Export Date: 15 October 2024 Correspondence Address: Talviste, G.; Department of Health Technologies, Ehitajate Street 5, Estonia; email: grete.talviste@taltech.ee AB - Background and Objectives: Patients with previous acute myocardial infarction are at significantly higher risk of recurrent events. Early and intensive lipid-lowering therapy targeting low-density lipoprotein cholesterol is a key strategy for reducing cardiovascular risk in post-acute myocardial infarction patients worldwide. This study aimed to assess patients’ real-life lipid-lowering treatment gaps after acute myocardial infarction using a global network, TriNetX, of anonymous, real-time patient data. The uniqueness of the study was the use of the novel, evolving, and constantly improving TriNetX platform and the evaluation of its feasibility for clinical research. Materials and Methods: A retrospective study was conducted on global repository patients in 2020, diagnosed with acute myocardial infarction, with a three-year follow-up. Results: After acute myocardial infarction, the prescribing rate of lipid-lowering medication (statins, ezetimibe and PCSK9I) was insufficient to reach target LDL-C values. The mean LDL-C level decreased from 2.7 mmol/L (103 mg/dL) as measured on the day of AMI to 1.97 mmol/L (76 mg/dL) between 31D and 3M. During the second and third years, the mean LDL-C value was stable (around 2.0 mmol/L (78 mg/dL)). LDL-C goals were not sufficiently reached, as only 7–12% of patients were reported to have LDL-C values < 55 mg/dL (1.4 mmol/L) and 13–20% of patients were reported to have LDL-C values < 70 mg/dL (1.8 mmol/L) during the follow-up periods. This means that a substantial number of patients remain at a very high risk for CV complications and mortality. Most cardiovascular complications happen within three months after acute myocardial infarction. Conclusions: Gaps remain between the recommendations for managing LDL-C in guidelines and what occurs in real life. The TriNetX platform is an innovative platform with significant potential and should be further developed for clinical research, as it enables the use of valuable interinstitutional data. © 2024 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Navickas, P. AU - Lukavičiūtė, L. AU - Glaveckaitė, S. AU - Baranauskas, A. AU - Šatrauskienė, A. AU - Badarienė, J. AU - Laucevičius, A. TI - PREVENT Equation: The Black Sheep among Cardiovascular Risk Scores? A Comparative Agreement Analysis of Nine Prediction Models in High-Risk Lithuanian Women JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 60 PY - 2024 IS - 9 SN - 1010-660X DO - 10.3390/medicina60091511 UR - https://m2.mtmt.hu/api/publication/35450715 ID - 35450715 N1 - Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, Vilnius, 03101, Lithuania State Research Institute Centre for Innovative Medicine, Vilnius, 08410, Lithuania Export Date: 11 October 2024 Correspondence Address: Navickas, P.; Faculty of Medicine, Lithuania; email: petras.navickas@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Matsugaki, R. AU - Matsuda, S. AU - Ogami, A. TI - Relationship between Cancer and Intention to Leave Work among Older Workers: A Cross-Sectional Internet-Based Study JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 60 PY - 2024 IS - 9 SN - 1010-660X DO - 10.3390/medicina60091506 UR - https://m2.mtmt.hu/api/publication/35446972 ID - 35446972 N1 - Department of Work Systems and Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan Export Date: 10 October 2024 Correspondence Address: Matsugaki, R.; Department of Work Systems and Health, Japan; email: pt-matsugaki@med.uoeh-u.ac.jp LA - English DB - MTMT ER -