@article{MTMT:35696920, title = {Relationship of Thyroid Volume and Function with Ankle-Brachial Index, Toe-Brachial Index, and Toe Pressure in Euthyroid People Aged 18–65}, url = {https://m2.mtmt.hu/api/publication/35696920}, author = {Jakubiak, G.K. and Pawlas, N. and Morawiecka-Pietrzak, M. and Zalejska-Fiolka, J. and Stanek, A. and Cieślar, G.}, doi = {10.3390/medicina60091445}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {60}, unique-id = {35696920}, issn = {1010-660X}, abstract = {Background and Objectives: The interrelationship between thyroid function and the state of the cardiovascular system has been investigated both in preclinical and human studies. However, it remains unclear whether there is any association between thyroid hormones and features of subclinical cardiovascular dysfunction in euthyroid patients. Material and Methods: This study involved 45 people (females: 57.8%) with no thyroid disease who, during planned hospitalization, underwent thyroid ultrasound, determination of biochemical parameters of thyroid function, and measurement of ankle-brachial index (ABI) and toe-brachial index (TBI). People with signs of acute illness or a deterioration of their health were excluded. Results: Significant correlations were found between free triiodothyronine (FT3) and several parameters of both ABI (R = 0.347; p = 0.019 for the mean ABI taken from right side and left side values) and TBI (R = 0.396; p = 0.007 for the mean TBI taken from right side and left side values), as well as the maximal toe pressure (TP) taken from right side and left side values (R = 0.304; p = 0.045). Thyrotropin (TSH) was shown to be significantly correlated only with the maximal TBI value (taken from right side and left side values) (R = 0.318; p = 0.033), whereas free thyroxin (FT4) was shown to be significantly correlated only with the minimal TBI value (taken from right side and left side values) (R = 0.381; p = 0.01). Thyroid volume (TV) was shown to be correlated with TP (R = 0.4; p = 0.008 for the mean TP taken from right side and left side values) and some parameters of TBI value (R = 0.332; p = 0.028 for the mean TBI taken from right side and left side values), but no significant correlations were found between TVand ABI parameters. Patients with a mean ABI value ≤ 1.0 or a mean TBI value ≤ 0.75 have lower TSH, FT3, FT4, and TV than the rest of the study population, but the difference was statistically significant only for FT3. Conclusions: Even in a population of euthyroid patients with no diagnosed thyroid disease, there are some significant correlations between the volume and function of the thyroid gland and the selected features of subclinical cardiovascular dysfunction such as ABI and TBI. © 2024 by the authors.}, keywords = {thyroxine; Triiodothyronine; Thyrotropin; ANKLE-BRACHIAL INDEX; thyroid volume; toe-brachial index; Toe pressure; subclinical cardiovascular dysfunction}, year = {2024}, eissn = {1648-9144} } @article{MTMT:35689546, title = {Evaluation of Amiodarone Administration in Patients with New-Onset Atrial Fibrillation in Septic Shock}, url = {https://m2.mtmt.hu/api/publication/35689546}, author = {Oprea, A. and Marina, V. and Ciobotaru, O.R. and Popescu, C.-M.}, doi = {10.3390/medicina60091436}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {60}, unique-id = {35689546}, issn = {1010-660X}, abstract = {Background and Objective: New-onset atrial fibrillation (NOAF) is a common cardiac condition often observed in intensive care units. When amiodarone is used to treat this condition, either to maintain sinus rhythm after electrical cardioversion or to control heart rate, complications can arise when a systemic pathology is present. Systemic pathology can result in a decrease in cardiac output and blood pressure, making the management of NOAF and septic shock challenging. Limited international research exists on the coexistence of NOAF and septic shock, making it difficult to determine the optimal course of treatment. While amiodarone is not the primary choice of antiarrhythmic drug for patients in septic shock, it may be considered for those with underlying cardiac issues. This paper aims to investigate the safety of administering amiodarone to patients with septic shock and explore whether another antiarrhythmic drug may be more effective, especially considering the cardiac conditions that patients may have. Materials and Methods: To write this article, we searched electronic databases for studies where authors used amiodarone and other medications for heart rate control or sinus rhythm restoration. Results: The studies reviewed in this work have shown that for the patients with septic shock and NOAF along with a pre-existing cardiac condition like a dilated left atrium, the use of amiodarone may provide greater benefits compared to other antiarrhythmic drugs. For patients with NOAF and septic shock without underlying heart disease, the initial use of propafenone has been found to be advantageous. However, a challenge arises when deciding between rhythm or heart rate control using various drug classes. Unfortunately, there is limited literature available on this specific scenario. Conclusions: NOAF is a frequent and potentially life-threatening complication occurring in one out of seven patients with sepsis, and its incidence is rising among patients with septic shock. © 2024 by the authors.}, keywords = {Humans; PATHOPHYSIOLOGY; human; Calcium Channel Blockers; SEPTIC SHOCK; Shock, Septic; Complication; Drug therapy; amiodarone; amiodarone; amiodarone; Anti-Arrhythmia Agents; antiarrhythmic agent; Atrial Fibrillation; Atrial Fibrillation; new-onset atrial fibrillation}, year = {2024}, eissn = {1648-9144} } @article{MTMT:35630226, title = {Withdrawal/Withholding of Life-Sustaining Therapies: Limitation of Therapeutic Effort in the Intensive Care Unit}, url = {https://m2.mtmt.hu/api/publication/35630226}, author = {Becerra-Bolaños, Á. and Ramos-Ahumada, D.F. and Herrera-Rodríguez, L. and Valencia-Sola, L. and Ojeda-Betancor, N. and Rodríguez-Pérez, A.}, doi = {10.3390/medicina60091461}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {60}, unique-id = {35630226}, issn = {1010-660X}, year = {2024}, eissn = {1648-9144} } @article{MTMT:35617434, title = {Metabolic proteins expression up-regulated in blood-borne extensively drug-resistant Salmonella typhi isolates from Pakistan}, url = {https://m2.mtmt.hu/api/publication/35617434}, author = {Yasin, Nusrat and Rahman, Hazir and Qasim, Muhammad and Nisa, Iqbal and Sarwar, Yasra and Khan, Niamat and Alzahrani, Khalid J. and Alsuwat, Meshari A. and Alzahrani, Fuad M. and Aljohani, Abrar}, doi = {10.3390/medicina60091404}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {60}, unique-id = {35617434}, issn = {1010-660X}, keywords = {proteome; MDR and XDR S. Typhi; orbitrap MS analysis; functional and antigenic annotation}, year = {2024}, eissn = {1648-9144}, orcid-numbers = {Alzahrani, Khalid J./0000-0002-6688-0106; Aljohani, Abrar/0000-0003-2378-4234} } @article{MTMT:35512918, title = {The Neuroprotective Role of Indole-3-Propionic Acid in Migraine Pathophysiology}, url = {https://m2.mtmt.hu/api/publication/35512918}, author = {Agircan, D. and Taskin, S. and Cekic, M. and Celik, H.}, doi = {10.3390/medicina60091417}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {60}, unique-id = {35512918}, issn = {1010-660X}, abstract = {Background and Objectives: Migraine is a leading cause of disability worldwide, with complex pathophysiological mechanisms involving oxidative and nitrosative stress. Recent research suggests that Indole-3-Propionic Acid (IPA) may have a neuroprotective role in reducing nitrosative stress. This study aims to elucidate the roles of IPA and nitrosative stress biomarkers in migraine patients, focusing on their potential as therapeutic targets. Materials and Methods: This cross-sectional, case-control study included 57 migraine patients and 30 healthy controls. Patients were categorized into episodic migraine (EM) and chronic migraine (CM) groups. Socio-demographic and clinical characteristics were documented through structured interviews. Validated scales such as the Visual Analog Score (VAS), Headache Impact Test 6 (HIT-6), Migraine Disability Assessment Test (MIDAS), Migraine 24 h Quality of Life Scale (24 h QoL), Mini-Mental State Examination (MMSE), and Migraine Attacks–Subjective Cognitive Impairments Scale (Mig-SCog) were administered. Venous blood samples were collected, and serum levels of IPA, Nitric Oxide (NO), Nitric Oxide Synthase (NOS), and Peroxynitrite (ONOO−) were measured using ELISA and spectrophotometric methods. Results: Significant differences in serum IPA and NO levels were observed between migraine patients and controls. Specifically, higher serum IPA levels were found in the EM group, while higher serum NO levels were observed in the CM group. Elevated NO levels correlated with increased migraine attack frequency. Conversely, serum IPA levels showed a negative correlation with attack frequency, suggesting a protective role. Specifically, NO levels were positively correlated with the number of painful days, NSAID usage, VAS scores, HIT-6 scores, and MIDAS scores, while negatively correlated with 24 h QoL scores. Conclusions: The study highlights the significant involvement of IPA and nitrosative stress in migraine pathophysiology. Elevated IPA levels, particularly in EM patients, suggest its potential neuroprotective role. These findings underscore the importance of targeting oxidative and nitrosative stress pathways in developing effective migraine therapies. © 2024 by the authors.}, keywords = {Adult; Adult; Female; Female; Middle Aged; Middle Aged; Male; Male; Humans; BLOOD; PATHOPHYSIOLOGY; MIGRAINE; MIGRAINE; human; Case-Control Studies; Quality of Life; Quality of Life; Biomarkers; physiology; drug effect; Psychology; Cross-Sectional Studies; biological marker; Indoles; disability; nitric oxide; nitric oxide; case control study; Migraine Disorders; Neuroprotective Agents; cross-sectional study; Drug therapy; neuroprotective agent; peroxynitrous acid; peroxynitrous acid; nitrosative stress; indole derivative; prevention and control; pain severity; Oxidative stress; Oxidative stress; Indole-3-propionic acid}, year = {2024}, eissn = {1648-9144} } @article{MTMT:35497202, title = {Insights into the Two Most Common Cancers of Primitive Gut-Derived Structures and Their Microbial Connections}, url = {https://m2.mtmt.hu/api/publication/35497202}, author = {Ray, Amitabha and Moore, Thomas F. and Naik, Dayalu S. L. and Borsch, Daniel M.}, doi = {10.3390/medicina60091515}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {60}, unique-id = {35497202}, issn = {1010-660X}, keywords = {Escherichia coli; colorectal cancer; PHAGE THERAPY; pulmonary neoplasm; Chlamydia species}, year = {2024}, eissn = {1648-9144} } @article{MTMT:35470243, title = {Transplacental Transmission of SARS-CoV-2: A Narrative Review}, url = {https://m2.mtmt.hu/api/publication/35470243}, author = {Bui, M.T. and Nguyen, Le C.A. and Duong, K.L. and Hoang, V.T. and Nguyen, T.K.}, doi = {10.3390/medicina60091517}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {60}, unique-id = {35470243}, issn = {1010-660X}, abstract = {Background and Objectives: The study aims to explore the potential for transplacental transmission of SARS-CoV-2, focusing on its pathophysiology, placental defense mechanisms, and the clinical implications for maternal and neonatal health. Materials and Methods: A comprehensive review of the current literature was conducted, analyzing studies on SARS-CoV-2 infection in pregnancy, the expression of key viral receptors (ACE2 and TMPRSS2) in placental cells, and the immune responses involved in placental defense. The review also examined the clinical outcomes related to maternal and neonatal health, including adverse pregnancy outcomes and neonatal infection. Results: The expression of ACE2 and TMPRSS2 in the placenta supports the biological plausibility of SARS-CoV-2 transplacental transmission. Histopathological findings from the infected placentas reveal inflammation, vascular changes, and the evidence of viral particles in placental tissues. Clinical reports indicate an increased risk of preterm birth, intrauterine growth restriction, and neonatal infection in pregnancies affected by COVID-19. However, the frequency and mechanisms of vertical transmission remain variable across studies, highlighting the need for standardized research protocols. Conclusions: SARS-CoV-2 can potentially infect placental cells, leading to adverse pregnancy outcomes and neonatal infection. While evidence of transplacental transmission has been documented, the risk and mechanisms are not fully understood. Ongoing research is essential to clarify these aspects and inform obstetric care practices to improve maternal and neonatal outcomes during the COVID-19 pandemic. © 2024 by the authors.}, keywords = {Female; Female; Humans; metabolism; human; newborn; pregnancy; pregnancy; Infant, Newborn; placenta; placenta; virology; serine proteinase; Infectious Disease Transmission, Vertical; Pregnancy Outcome; Pregnancy Outcome; Serine Endopeptidases; Pregnancy Complications, Infectious; Vertical transmission; angiotensin converting enzyme 2; Angiotensin-converting enzyme 2; Transplacental transmission; COVID-19; COVID-19; coronavirus disease 2019; Severe acute respiratory syndrome coronavirus 2; SARS-CoV-2; SARS-CoV-2; TMPRSS2 protein, human; ACE2 protein, human; infectious pregnancy complication}, year = {2024}, eissn = {1648-9144} } @article{MTMT:35459744, title = {Lipid-Lowering Treatment Gaps in Patients after Acute Myocardial Infarction: Using Global Database TriNetX}, url = {https://m2.mtmt.hu/api/publication/35459744}, author = {Talviste, G. and Leinsalu, M. and Ross, P. and Viigimaa, M.}, doi = {10.3390/medicina60091433}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {60}, unique-id = {35459744}, issn = {1010-660X}, abstract = {Background and Objectives: Patients with previous acute myocardial infarction are at significantly higher risk of recurrent events. Early and intensive lipid-lowering therapy targeting low-density lipoprotein cholesterol is a key strategy for reducing cardiovascular risk in post-acute myocardial infarction patients worldwide. This study aimed to assess patients’ real-life lipid-lowering treatment gaps after acute myocardial infarction using a global network, TriNetX, of anonymous, real-time patient data. The uniqueness of the study was the use of the novel, evolving, and constantly improving TriNetX platform and the evaluation of its feasibility for clinical research. Materials and Methods: A retrospective study was conducted on global repository patients in 2020, diagnosed with acute myocardial infarction, with a three-year follow-up. Results: After acute myocardial infarction, the prescribing rate of lipid-lowering medication (statins, ezetimibe and PCSK9I) was insufficient to reach target LDL-C values. The mean LDL-C level decreased from 2.7 mmol/L (103 mg/dL) as measured on the day of AMI to 1.97 mmol/L (76 mg/dL) between 31D and 3M. During the second and third years, the mean LDL-C value was stable (around 2.0 mmol/L (78 mg/dL)). LDL-C goals were not sufficiently reached, as only 7–12% of patients were reported to have LDL-C values < 55 mg/dL (1.4 mmol/L) and 13–20% of patients were reported to have LDL-C values < 70 mg/dL (1.8 mmol/L) during the follow-up periods. This means that a substantial number of patients remain at a very high risk for CV complications and mortality. Most cardiovascular complications happen within three months after acute myocardial infarction. Conclusions: Gaps remain between the recommendations for managing LDL-C in guidelines and what occurs in real life. The TriNetX platform is an innovative platform with significant potential and should be further developed for clinical research, as it enables the use of valuable interinstitutional data. © 2024 by the authors.}, keywords = {Aged; Aged; Female; Female; Middle Aged; Middle Aged; Male; Male; Humans; BLOOD; MORTALITY; human; Retrospective Studies; Databases, Factual; retrospective study; low density lipoprotein cholesterol; Cholesterol, LDL; Acute myocardial infarction; myocardial infarction; heart infarction; antilipemic agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; ezetimibe; ezetimibe; Drug therapy; factual database; Hydroxymethylglutaryl-CoA Reductase Inhibitors; LDL CHOLESTEROL; Cardiovascular complications; Hypolipidemic Agents; Lipid-lowering treatment; TriNetX}, year = {2024}, eissn = {1648-9144} } @article{MTMT:35450715, title = {PREVENT Equation: The Black Sheep among Cardiovascular Risk Scores? A Comparative Agreement Analysis of Nine Prediction Models in High-Risk Lithuanian Women}, url = {https://m2.mtmt.hu/api/publication/35450715}, author = {Navickas, P. and Lukavičiūtė, L. and Glaveckaitė, S. and Baranauskas, A. and Šatrauskienė, A. and Badarienė, J. and Laucevičius, A.}, doi = {10.3390/medicina60091511}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {60}, unique-id = {35450715}, issn = {1010-660X}, year = {2024}, eissn = {1648-9144} } @article{MTMT:35446972, title = {Relationship between Cancer and Intention to Leave Work among Older Workers: A Cross-Sectional Internet-Based Study}, url = {https://m2.mtmt.hu/api/publication/35446972}, author = {Matsugaki, R. and Matsuda, S. and Ogami, A.}, doi = {10.3390/medicina60091506}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {60}, unique-id = {35446972}, issn = {1010-660X}, year = {2024}, eissn = {1648-9144} }