TY  - JOUR
AU  - Christodoulou, C.
AU  - Diab, S.
AU  - Bano, G.
AU  - Aroniada, M.
AU  - Hodnett, N.
AU  - Zomer, S.
TI  - The Integration of Drug Substance and Drug Product Manufacturing Models: The Missing Link for Model-based End-to-End Process Development
JF  - COMPUTER-AIDED CHEMICAL ENGINEERING
J2  - COMPAIDED CHEMI ENG
VL  - 52
PY  - 2023
SP  - 2101
EP  - 2106
PG  - 6
SN  - 1570-7946
DO  - 10.1016/B978-0-443-15274-0.50334-6
UR  - https://m2.mtmt.hu/api/publication/34696305
ID  - 34696305
N1  - GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom            
            GlaxoSmithKline, Park Road, Ware, SG12 0DP, United Kingdom            
            GlaxoSmithKline, 1250 S Collegeville Rd, Collegeville (PA), 19426, United States            
            Export Date: 29 February 2024            
            Funding details: GlaxoSmithKline, GSK            
            Funding text 1: This study was funded by a Digital Design capability project at GlaxoSmithKine (GSK).
AB  - Demonstrations of pharmaceutical process modelling have been made in the literature in the pursuit of accelerated development. Modelling activities for drug substance (DS) and product (DP) manufacturing are often conducted separately, as project time constraints often require that the DS and DP processes be developed simultaneously, each with fixed decision criteria and requirements. We illustrate how connecting DS and DP process models is essential for a full process understanding and how key attributes of an isolated DS can propagate through a DP tableting line to impact the DP dissolution. We do so by performing an uncertainty analysis on a flowsheet model of a crystallization and direct compression line. The dissolution sensitivity highlights the need for end-to-end flowsheet modelling to realize the full benefits of modelling. We also discuss the key technical and regulatory obstacles that must be overcome to achieve this. © 2023 Elsevier B.V.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Diwekar, Urmila
AU  - Nisal, Apoorva
AU  - Shastri, Yogendra
AU  - Cabezas, Heriberto
TI  - Optimal Control for Deriving Policies for Global Sustainability
JF  - COMPUTER-AIDED CHEMICAL ENGINEERING
J2  - COMPAIDED CHEMI ENG
VL  - 52
PY  - 2023
SP  - 2471
EP  - 2476
PG  - 6
SN  - 1570-7946
DO  - 10.1016/B978-0-443-15274-0.50393-0
UR  - https://m2.mtmt.hu/api/publication/34094867
ID  - 34094867
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Gani, Rafiqul
AU  - Chen, Xi
AU  - Eden, Mario R
AU  - Mansouri, Seyed S
AU  - Martin, Mariano
AU  - Mujtaba, Iqbal M
AU  - Padungwatanaroj, Orakotch
AU  - Roh, Kosan
AU  - Ricardez-Sandoval, Luis
AU  - Sugiyama, Hirokazu
TI  - Challenges and opportunities for process systems engineering in a changed world
JF  - COMPUTER-AIDED CHEMICAL ENGINEERING
J2  - COMPAIDED CHEMI ENG
VL  - 49
PY  - 2022
SP  - 7
EP  - 20
PG  - 14
SN  - 1570-7946
UR  - https://m2.mtmt.hu/api/publication/34568377
ID  - 34568377
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tóth, András József
TI  - Modelling of Organophilic Pervaporation for Separation of Acetone-Butanol-Ethanol Mixture
JF  - COMPUTER-AIDED CHEMICAL ENGINEERING
J2  - COMPAIDED CHEMI ENG
VL  - 51
PY  - 2022
SP  - 43
EP  - 48
PG  - 6
SN  - 1570-7946
DO  - 10.1016/B978-0-323-95879-0.50008-4
UR  - https://m2.mtmt.hu/api/publication/32662429
ID  - 32662429
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Romero-García, A.G.
AU  - Ramírez-Corona, N.
AU  - Sánchez-Ramírez, E.
AU  - Alcocer-García, H.
AU  - Segovia-Hernandez, J.G.
TI  - Integration of CO2 capture to power plants: the effect of fuel and gas composition in process configuration
JF  - COMPUTER-AIDED CHEMICAL ENGINEERING
J2  - COMPAIDED CHEMI ENG
VL  - 50
PY  - 2021
SP  - 1529
EP  - 1534
PG  - 6
SN  - 1570-7946
DO  - 10.1016/B978-0-323-88506-5.50236-9
UR  - https://m2.mtmt.hu/api/publication/32172190
ID  - 32172190
N1  - Departamen to de Ingeniería Química, Universidad de Guanajuato, Noria Alta s/n, Guanajuato, Gto., 36050, Mexico            
            Departamento de IngenieríaQuímica, Alimentos y Ambiental, Universidad de lasAméricas Puebla. ExHda, Santa CatarinaMártir s/n, San Andrés Cholula, Puebla, 72820, Mexico            
            Export Date: 2 September 2021
AB  - In recent years, electricity demand has been increasing, according to the International Energy Agency, the energy sector is the biggest producer of greenhouse gas emissions (CO2), having terrible environmental consequences. Various alternatives have been sought to reduce CO2 emissions, highlighting the implementation of CO2 capture and storage plants. In this work, it is shown an environmental and energetic analysis of a CO2capture plant coupled to a power plant. The analysis considered two different operating cases with different fuels in the power plant each case: biogas, coal, non- associated gas, and associated gas. The first one considers a constant fuel feed flow in the power plant. The second one, considers a constant energy demand. The results indicate that, for the first case, the fuel with the lowest environmental impact was the non-associated gas with 2.14 kEcopoints and 1083 MJ per kg of CO2 recovered. For a constant energy demand, the fuel with the lowest environmental impact was the biogas with 0.57 kEcopoints and 193 MJ per kg of CO2 recovered. For the systems here considered, those processes working with associated and non-associated gases remain the most efficient in terms of net energy produced. © 2021 Elsevier B.V.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kummer, Alex
AU  - Nagy, Lajos
AU  - Varga, Tamás
TI  - NMPC based Temperature Control in Fed-batch Reactor to Avoid Thermal Runaway
JF  - COMPUTER-AIDED CHEMICAL ENGINEERING
J2  - COMPAIDED CHEMI ENG
VL  - 48
PY  - 2020
SP  - 1087
EP  - 1092
PG  - 6
SN  - 1570-7946
DO  - 10.1016/B978-0-12-823377-1.50182-8
UR  - https://m2.mtmt.hu/api/publication/33079517
ID  - 33079517
N1  - cited By 1
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Theodoridis, K.
AU  - Stergiopoulos, F.
AU  - Bechtsis, D.
AU  - Nikolaidis, N.
AU  - Triantafyllidis, D.
AU  - Tsagaris, A.
AU  - Filelis, A.
AU  - Papaikonomou, A.
TI  - An Innovative and Fully Automated System for Gel Electrophoresis
JF  - COMPUTER-AIDED CHEMICAL ENGINEERING
J2  - COMPAIDED CHEMI ENG
VL  - 48
PY  - 2020
SP  - 847
EP  - 852
PG  - 6
SN  - 1570-7946
DO  - 10.1016/B978-0-12-823377-1.50142-7
UR  - https://m2.mtmt.hu/api/publication/33077060
ID  - 33077060
N1  - cited By 0
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Frias, J.M.
AU  - Wang, S.-J.
AU  - Wong, D.S.-H.
AU  - Chou, C.-H.
AU  - Jang, S.-S.
AU  - Lee, E.-K.
TI  - Floating Pressure Control of Vapor Recompression Distillation in Propane-propylene Separation
JF  - COMPUTER-AIDED CHEMICAL ENGINEERING
J2  - COMPAIDED CHEMI ENG
VL  - 48
PY  - 2020
SP  - 1315
EP  - 1320
PG  - 6
SN  - 1570-7946
DO  - 10.1016/B978-0-12-823377-1.50220-2
UR  - https://m2.mtmt.hu/api/publication/32099220
ID  - 32099220
N1  - Department of Chemical Engineering, National Tsing Hua University, Taiwan, Hsinchu, 30013, Taiwan            
            Center for Energy and Environmental Research, Natioinal Tsing Hua UniversityTaiwan 30013, Taiwan            
            Export Date: 9 July 2021
AB  - The separation of propylene from propane is an energy-intensive distillation process. Vapor recompression is commonly used for the separation of propylene and propane. Most studies of vapor recompression were carried out at a given pressure. It is well known that the lower the pressure, the higher the volatility difference and less energy is required to perform the separation. In a traditional column, energy of the distillation can be minimized by operating at the lowest pressure possible. The limit is usually determined by the maximum cooling capacity in the condenser, which is in turn determined by the temperature of the cooling water. Such a practice is known as floating pressure control. In a vapor-recompression column, the condenser and reboiler were replaced by a heat exchanger. Auxiliary condenser and reboiler may or may not be present. The operating constraint is determined by the anti-surge control of the compressor. Furthermore, it is necessary to ensure that the compressed vapor which acts as steam in the reboiler is not substantially subcooled to avoid the vibration of the heat exchanger. In this study, the implementation of floating pressure control for a vapor-recompression propane-propylene column with an auxiliary condenser is studied using ASPEN Plus dynamics. A control scheme that includes basic inventory control and quality control was proposed. To keep the operation within safe region of the compressor surge curve, the split of the compressed vapor going to the bottom as heating medium and passing through the auxiliary condenser is adjusted. It is shown that the column can be operated under product purity requirements of top and bottom when column pressure is reduced by 1 kg/cm2. © 2020 Elsevier B.V.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Romero-García, A.G.
AU  - Ramírez-Corona, N.
AU  - Sánchez-Ramírez, E.
AU  - Alcocer-García, H.
AU  - Segovia-Hernández, J.G.
TI  - Effect of Flue Gas Composition on the Design of a CO2 Capture Plant
JF  - COMPUTER-AIDED CHEMICAL ENGINEERING
J2  - COMPAIDED CHEMI ENG
VL  - 48
PY  - 2020
SP  - 835
EP  - 840
PG  - 6
SN  - 1570-7946
DO  - 10.1016/B978-0-12-823377-1.50140-3
UR  - https://m2.mtmt.hu/api/publication/32090527
ID  - 32090527
N1  - Departamento de Ingeniería Química, Universidad de Guanajuato, Noria Alta s/n, Guanajuato, Gto. 36050, Mexico            
            Departamento de Ingeniería Química, Alimentos y Ambiental, Universidad de las Américas Puebla. ExHda. Santa Catarina Mártir s/n, San Andrés Cholula, Puebla, 72820, Mexico            
            Export Date: 3 July 2021
AB  - According to studies conducted by the International Energy Agency, the energy sector is the biggest producer of greenhouse gas emissions (CO2), having important environmental consequences. Various alternatives have been sought to reduce CO2 emissions during electric production, highlighting as an alternative, the implementation of CO2 capture and storage plants. In this work, it is shown the global optimization of a coupling CO2 capture plant to an electric power plant, having as objective function minimize the energetic requirements of the process. For this study, it was considered four different fuels in the power plant; biogas, coal, non- associated natural gas, and associated natural gas. Two operating scenarios are considered: in the first, generate the same combustion gas flow for all the proposed fuels and in second, obtain the same energy demand with the 4 fuels. For the design and simulation, the software ASPEN Plus simulator was used. © 2020 Elsevier B.V.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Fechtner, Marcus
AU  - Kienle, Achim
TI  - Rational Design of Ion Exchange Simulated Moving Bed Processes
JF  - COMPUTER-AIDED CHEMICAL ENGINEERING
J2  - COMPAIDED CHEMI ENG
VL  - 48
PY  - 2020
SP  - 733
EP  - 738
PG  - 6
SN  - 1570-7946
DO  - 10.1016/B978-0-12-823377-1.50123-3
UR  - https://m2.mtmt.hu/api/publication/32081128
ID  - 32081128
AB  - Triangle theory, a powerful tool for the rational design of simulated moving bed processes, was developed by the group of Morbidelli, see (Migliorini et al., 1998) and references therein. In this paper, we extend this theory to classical ion exchange processes by applying the generalized approach of Migliorini et al. (2000). Results are verified by simulations of the related true moving bed process. For this purpose, our numerical approach for single column processes introduced in (Fechtner and Kienle, 2017) is extended to these types of processes while preserving all its advantages.
LA  - English
DB  - MTMT
ER  -