@article{MTMT:34791243,
	title = {Expression Analysis of Phenylpropanoid Pathway Genes and Phenylpropanoid Accumulation in Different Organs of Chelidonium majus L.},
	url = {https://m2.mtmt.hu/api/publication/34791243},
	author = {Kwon, Haejin and Sathasivam, Ramaraj and Yoon, Jiwon and Park, Chanung and Park, Nam Il and Chung, Yong Suk and Park, Sang Un},
	doi = {10.1177/1934578X241239835},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {19},
	unique-id = {34791243},
	issn = {1934-578X},
	keywords = {Gene Expression; Chelidonium majus; phenolic compounds; metabolic profiling},
	year = {2024},
	eissn = {1555-9475}
}

@article{MTMT:34517938,
	title = {Garcinia Biflavonoid 1 from Garcinia kola Ameliorates Glycolipid Metabolism Disorder in Type 2 Diabetic db/db Mice},
	url = {https://m2.mtmt.hu/api/publication/34517938},
	author = {Fu, Ting-Dan and Zhang, Wen-Li and Zhang, Ying and Deng, Chang-Sheng and Qi, Wang and Xu, Qin and Song, Jian-Ping and Guo, Wen-Feng and Yang, Rui-Yi and Huang, Xin-An},
	doi = {10.1177/1934578X231224993},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {19},
	unique-id = {34517938},
	issn = {1934-578X},
	abstract = {Background: Garcinia kola is recommended in African folk medicine for the treatment of diabetes and its associated complications. In this study, we investigated the effects of Garcinia biflavonoid 1 (GB1), an active chemical component of Garcinia kola, on blood glucose and lipid in db/db mice with type 2 diabetes. Methods: Db/db mice were divided into 4 groups: vehicle, low-dose GB1 (50 mg/kg), high-dose GB1 (100 mg/kg), and rosiglitazone, and treated for 4 weeks. Body weight, fasting blood glucose (FBG), fasting insulin, oral glucose tolerance test (OGTT), insulin tolerance test (ITT), hepatic glycogen, serum and liver biochemical parameters, and histological morphology of the pancreas, heart, and kidneys were evaluated. Results: GB1 significantly reduced FBG, the area under the curve value of OGTT and ITT, and the homeostasis model assessment of insulin resistance, increased the homeostasis model assessment of beta-cell function, quantitative insulin sensitivity check index, and the level of hepatic glycogen. Lower triglyceride and free fatty acid level, and a lower triglyceride-glucose index were also observed in the GB1 groups. In addition, no significant changes in alanine aminotransferase and aspartate aminotransferase levels, or in the histopathology of the pancreas, heart, or kidney were observed after GB1 treatment. Conclusion: These findings indicate that GB1 exerts an antidiabetic effect in db/db mice, by improving hyperglycemia, insulin resistance, and lipid dysregulation without evidence of adverse reactions.},
	keywords = {MELLITUS; RESISTANCE; COMPLEX; Insulin Resistance; hyperglycemia; Flavonoids; rosiglitazone; Type 2 diabetes; Chemistry, Medicinal; kolaviron; Garcinia biflavonoid 1; hyperlipidema; QUANTITATIVE INSULIN SENSITIVITY; CHECK INDEX},
	year = {2024},
	eissn = {1555-9475}
}

@article{MTMT:34327176,
	title = {Anti-inflammatory Mechanism of Morin Hydrate by Suppressing the NF-κB/MAPKs Mediated Cell Migration and Modulating Src/FAK and β-Catenin},
	url = {https://m2.mtmt.hu/api/publication/34327176},
	author = {Jayakumar, Thanasekaran and Sheu, Joen-Rong and Yuan, Kuo-Ching and Yen, Ting-Lin and Hsia, Chih-Wei and Huang, Wei-Chieh and Tseng, Li-Ning and Chen, Chun-Han and Hsia, Chih-Hsuan},
	doi = {10.1177/1934578X231201029},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {18},
	unique-id = {34327176},
	issn = {1934-578X},
	abstract = {Background: Macrophage migration plays a critical role in inflammation and the development of pathological processes. Thus, inhibiting macrophage migration is a potential approach for reducing inflammation. Besides, mitigation of inflammatory mediators also inhibits macrophage migration. Morin hydrate (MH), a bioflavonoid found in fruits, vegetables, and herbs, has demonstrated various pharmacological effects, including anti-inflammatory and immunosuppressive properties. However, the specific molecular mechanisms underlying MH's anti-inflammatory effects and its impact on macrophage migration remain unclear. This study focused on MH's anti-inflammatory molecular mechanism and also elucidated how it is associated with inhibiting macrophage migration. Methods: The anti-inflammatory and antimigration effects of MH were investigated in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, a murine macrophage cell line. The production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS) were assessed by various assays. Additionally, the expression of key signaling molecules, such as extracellular signal-regulated kinase (ERK), JNK, p65, pSrc, focal adhesion kinase (FAK), beta-catenin, COX-2, p-p38, and p-Akt, was analyzed in response to MH treatment. Results: MH treatment reduced LPS-induced NO production and downregulated the mRNA and protein expression of iNOS in RAW264.7 cells. It concentration dependently inhibited the expression of ERK and JNK. At a high concentration of 20 mu M, MH also suppressed the expression of p65, pSrc, and pFAK. Moreover, MH effectively attenuated LPS-induced beta-catenin expression, while it did not exhibit a significant effect on COX-2, p-p38, and p-Akt expressions in LPS-stimulated RAW264.7 cells. Furthermore, MH pretreatment inhibited the migration of LPS-induced macrophages. Conclusion: This study reveals that MH exerts its anti-inflammatory effects by inhibiting NO production, downregulating iNOS expression, and modulating ERK/JNK and p65 phosphorylation. Additionally, MH suppresses Src/FAK phosphorylation and downregulates beta-catenin expression induced by LPS. The findings demonstrate a complex interplay between the inflammatory response and MH's impact on macrophage migration being intertwined with its anti-inflammatory properties.},
	keywords = {MIGRATION; Morin hydrate; inflammatory; iNOS/COX-2; ERK/JNK; Src/FAK pathways},
	year = {2023},
	eissn = {1555-9475}
}

@article{MTMT:34141610,
	title = {Bioactive Ingredients of Helleborus niger L. (Christmas Rose): The Renaissance of an Old Medicinal Herb—A Review},
	url = {https://m2.mtmt.hu/api/publication/34141610},
	author = {Cuny, Eckehard},
	doi = {10.1177/1934578X231201053},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {18},
	unique-id = {34141610},
	issn = {1934-578X},
	abstract = {The medicinal plant Helleborus nig er L. (Ranunculaceae) found in the European Alps has been valued as an effective remedy for numerous diseases for centuries. Recent preclinical evaluations showed pharmacologic potential of the plant extract for cancer treatment. Furthermore, several compounds extracted from H niger exhibited potent pharmacological effects. Thus, the renaissance of this old and proven medicinal herb requires better knowledge of its bioactive ingredients. A key ingredient of H niger is protoanemonin which is responsible for its burning hot taste and vesicant effect. Protoanemonin possesses antibacterial, antifungal, cytotoxic, and antimutagenic activity, and its isolation, synthesis, and preparation as a therapeutically valuable medicinal product are well elaborated. Anemonin, the dimer of protoanemonin, has antimicrobial, anti-inflammatory, and antimalarial activity, whereas (−)-ranunculin, a protoanemonin glycoside, possesses cytotoxicity and antimutagenic activity. (+)-Ranuncoside, another protoanemonin glycoside, has a spiro acetal molecular scaffold, a feature that is responsible for the biological activity of a multitude of natural products. Furthermore, the flavonoids kaempferol glycoside, quercetin glycoside, and glucosyl-phenyllactic acid have been isolated, and other phenolics with complex structures were detected as well. The main active ingredient of H niger rhizomes is the bufadienolide hellebrin. It is a steroidal cardiac diglycoside with utility for heart failure treatment. Hellebrin and its aglycon hellebrigenin are patented as lead compounds to treat cancer. Recently, additional bufadienolides as well as ecdysteroids were isolated from H niger whole plants and showed potent cytotoxicity on human cancer cell lines. Finally, various saponins have been determined by mass spectrometry, of which 4 compounds isolated from the rhizome are awaiting pharmacological assessment. This review gives an overview of the current knowledge of the isolation, synthesis, structure elucidation, derivatization, and biological activities of known H niger constituents. Furthermore, recent advances concerning the development of pharmaceuticals from these constituents and their derivatives are described.},
	year = {2023},
	eissn = {1555-9475},
	orcid-numbers = {Cuny, Eckehard/0000-0003-2077-9536}
}

@article{MTMT:34286684,
	title = {New Sesterterpenoid from the Marine Fungus Penicillium oxalicum M893},
	url = {https://m2.mtmt.hu/api/publication/34286684},
	author = {Nguyen, Thi Hoang Anh and Do, Thi Quynh and Nguyen, Thuy Linh and Thi, Hong Minh Le and Nguyen, Mai Anh and Murphy, Brian T. and Dam, Thanh Xuan and Huong, Doan Thi Mai and Cuong, Pham Van},
	doi = {10.1177/1934578X231191636},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {18},
	unique-id = {34286684},
	issn = {1934-578X},
	abstract = {Objectives: The aim of the project was the isolation, structural elucidation, and antimicrobial and antifungal activities of compounds from the culture broth of the marine fungus Penicillium oxalicum M893 (isolated from the marine brown alga Spatoglossum sp.). Methods: Combined chromatographic techniques were used to isolate antibacterial and antifungal compounds from the MeOH extract Penicillium oxalicum M893. The structures were elucidated by analyses of high-resolution electrospray ionization mass spectral and nuclear magnetic resonance data. The antimicrobial and antifungal effects of compounds were evaluated using the dilution turbidimetric broth method. Results: One new sesterterpenoid, oxaliterpenoid (1), and six known compounds, aspergillusidone C (2), nidulin (3), emeguisin B (4), aspergillusether A (5), aspergillusether J (6), and guisinol (7) were isolated from the methanol extract of the culture broth of Penicillium oxalicum M893. All compounds showed potent antibacterial activities against Gram-(+) bacteria, E. faecalis (ATCC299212), S. aureus (ATCC25923), and B. cereus (ATCC14579), and the yeast Candida albicans (ATCC10231), with MIC values ranging from 2 to 128 mu g/mL.},
	keywords = {ANTIBACTERIAL; ANTIFUNGAL; Marine fungi; Penicillium oxalicum; sesterterpenoid; oxaliterpenoid},
	year = {2023},
	eissn = {1555-9475}
}

@article{MTMT:34248333,
	title = {Phytochemical Analysis, Antioxidant, and Antihyperglycemic Activities of Crataegus monogyna Jacq Aqueous Extract},
	url = {https://m2.mtmt.hu/api/publication/34248333},
	author = {Radi, Fatima Z. and Bencheikh, Noureddine and Bouhrim, Mohamed and Saleh, Asmaa and Al Kamaly, Omkulthom and Parvez, Mohammad K. and Elbouzidi, Amine and Bnouham, Mohamed and Zair, Touriya},
	doi = {10.1177/1934578X231195157},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {18},
	unique-id = {34248333},
	issn = {1934-578X},
	abstract = {Objective: This study aims to evaluate the phytochemical composition, antioxidant, and antihyperglycemic (in vivo, in vitro, and in silico) activities and acute toxicity of Crataegus monogyna Jacq (C monogyna) aqueous extracts. Methods: The study analyzed the aqueous extract of C monogyna through various methods such as phytochemical screening, and the high-performance liquid chromatography-ultraviolet (HPLC-UV)-visible analysis. The extract was also tested for antioxidant potential, acute toxicity, antihyperglycemic effect, and inhibitory effect on the pancreatic alpha-amylase enzyme. Additionally, the study used the molecular docking approach to identify the most potent ligands in the extract. Results: The phytochemical screening of the aqueous extract of C monogyna showed the presence of flavonoids, tannins, coumarins, sterol, and triterpene. The extract was rich in total polyphenols (1.65 +/- 0.04 mg gallic acid equivalent per gram of extract [GAE/g] DM), total flavonoids (0.33 +/- 0.03 EQ/g DM), and condensed tannins (0.28 +/- 0.01 EC/mg DM). HPLC-UV-visible analysis identified 9 phenolic compounds, with high levels of gallic acid and caffeic acid. The C monogyna extract has a high antioxidant activity with an IC50 of 9.23 +/- 0.01 mg/mL by DPPH and 8.32 +/- 0.02 mg/mL by FRAP. The aqueous extract of C monogyna was not toxic to albino mice. The glucose tolerance test showed a significant antihyperglycemic effect, with an IC50 of 0.070 +/- 0.008 mg/mL for the inhibition of pancreatic a-amylase activity by the aqueous extract of C monogyna. The in vivo inhibitory effect of the extract on the pancreatic alpha-amylase enzyme was confirmed. Two flavonoids, catechin, and rutin, were identified as potent inhibitors of the activity of alpha-amylase in the in silico part of the study, compared to the native ligand, Acarbose. Conclusion: The study found that C monogyna has significant antioxidant and antihyperglycemic properties. The presence of catechin and rutin may contribute to these effects. The results suggest that C monogyna could be used as a dietary supplement to prevent and treat diabetes.},
	keywords = {antioxidant activity; phytochemistry; PANCREATIC ALPHA-AMYLASE; PHENOLICS; acute toxicity; antihyperglycemic activity; C monogyna},
	year = {2023},
	eissn = {1555-9475},
	orcid-numbers = {Elbouzidi, Amine/0000-0003-0314-8484}
}

@article{MTMT:34215963,
	title = {Quercetin Suppresses Ferroptosis in Chondrocytes via Activating the Nrf2/ GPX4 Signaling Pathway},
	url = {https://m2.mtmt.hu/api/publication/34215963},
	author = {Xu, G. and Lu, M. and Fang, L. and Tian, F. and Zhu, H. and Zhou, L. and Zhou, X.},
	doi = {10.1177/1934578X231194837},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {18},
	unique-id = {34215963},
	issn = {1934-578X},
	abstract = {Background: Osteoarthritis is a progressive chronic disease that lacks effective treatment strategies. Ferroptosis features may be involved in the development and progression of osteoarthritis. Quercetin, a widely studied flavonoid compound, is considered a potential candidate for osteoarthritis therapies, although its anti-ferroptosis effect remains uncertain. This research aimed to investigate the regulatory impact of quercetin on ferroptosis and Nrf2 signaling in RSL3-induced C28/I2 cells. Methods: Cell viability was measured using the CCK-8 assay. Cellular lipid reactive oxygen species (ROS) were detected using fluorescence microscopy and flow cytometry combined with C11-BODIPY 581/591 staining. The level of malondialdehyde (MDA) was measured using an MDA assay kit. The level of GPX4 protein was determined by immunofluorescence staining and Western blotting. The protein levels of nuclear-Nrf2 and HO-1 were confirmed using Western blotting. Results: Quercetin improved cell viability, reduced the accumulation of lipid ROS, decreased MDA levels, elevated the protein levels of GPX4 and HO-1, and enhanced nuclear-Nrf2 protein levels in the ferroptosis cell model induced by RSL3. Additionally, the Nrf2 agonist TBHQ reversed ferroptosis in chondrocytes by activating the Nrf2/HO-1 pathway, while the Nrf2 inhibitor ML385 failed to protect against RSL3-induced ferroptosis in chondrocytes. Conclusion: Quercetin suppresses RSL3-induced ferroptosis in chondrocytes by activating the Nrf2/GPX4 signaling pathway, providing a promising therapeutic option for osteoarthritis. © The Author(s) 2023.},
	keywords = {Quercetin; Flavonoids; osteoarthritis; Nrf2; Ferroptosis; GPX4; C28/I2 cells},
	year = {2023},
	eissn = {1555-9475}
}

@article{MTMT:34276109,
	title = {A Literature Review of Meleagrins},
	url = {https://m2.mtmt.hu/api/publication/34276109},
	author = {El-Sawy, Eslam R. and Abdel-Aziz, Mohamed S. and Kirsch, Gilbert},
	doi = {10.1177/1934578X231186206},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {18},
	unique-id = {34276109},
	issn = {1934-578X},
	abstract = {Fungal bioactive secondary metabolites are considered promising sources for the production of unique compounds with exceptional chemical structures. Of these bioactive secondary metabolites, meleagrins are prenylated indole alkaloids characterized by a triazaspirocyclic skeleton that is generally obtained from Penicillium species. Meleagrins are alkaloids with promising biological activities. Here is a survey of previously published research on meleagrins: their sources, biosynthetic pathways, synthesis, and bioactivities.},
	keywords = {synthesis; BIOACTIVITY; Biosynthetic gene cluster; Penicillium species; meleagrins},
	year = {2023},
	eissn = {1555-9475}
}

@article{MTMT:34268430,
	title = {Fingerprint and Chemometric Analysis of Arabinogalactan Derived From Lycium barbarum Fruit},
	url = {https://m2.mtmt.hu/api/publication/34268430},
	author = {Huang, Wenqi and Sun, Jing and Liu, Tingting and Zhao, Tong and Dong, Xinling and Xu, Xiaojing and Lu, Yu and Lin, Xiaoliang and Gong, Guiping},
	doi = {10.1177/1934578X231168467},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {18},
	unique-id = {34268430},
	issn = {1934-578X},
	abstract = {Purpose: Arabinogalactan is the main active ingredient of Lycium barbarum polysaccharides, possessing various bioactivities. However, the physicochemical properties of arabinogalactans differ between fruit varieties, provenance, and harvest seasons. The study aimed at distinguishing these differences between the main active ingredient (arabinogalactans) of fruit varieties, provenance, and harvest seasons. Methods: We obtained 27 batches L. barbarum fruit arabinogalactans using hot water extraction, fractional precipitation, and their monosaccharide composition and molecular weight fingerprints were established. The similarity between multiple fingerprinting profiles was evaluated using chemometrics. Results: These results showed that the summer fruits (NQ1 and MQ1) from Xianfeng (Inner Mongolia), varieties NQ1 and NQ9 from Jingyuan (Gansu), varieties NQ7 and NQ9 from Zhongning (Ningxia), variety NQ1 from Nanliang farm, Yinchuan (Ningxia) and Guazhou (Gansu), as well as autumn fruits (NQ1, NQ7, and Xiao JianJiao) from Jinghe (Xinjiang) were similar to the summer fruits of variety NQ1 (Zhongning, Ningxia). The quality of L. barbarum fruit was related to locations and varieties. Conclusion: The preparation of the main active ingredient was the key for quality control analysis of L. barbarum fruit. This study provides a theoretical basis for the quality control of L. barbarum polysaccharides, and for the development and utilization of L. barbarum fruit.},
	keywords = {PHYSICOCHEMICAL PROPERTIES; chemometrics; arabinogalactan; Lycium barbarum fruit; fingerprinting profiles},
	year = {2023},
	eissn = {1555-9475}
}

@article{MTMT:34076156,
	title = {Preventive Effect of 1-Methoxylespeflorin G11 on Nitrite Release in Lipopolysaccharide-Stimulated Glial Cells},
	url = {https://m2.mtmt.hu/api/publication/34076156},
	author = {Paing, Y.M.M. and Valencia, M. and Cho, N. and Lee, S.H.},
	doi = {10.1177/1934578X231176150},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {18},
	unique-id = {34076156},
	issn = {1934-578X},
	year = {2023},
	eissn = {1555-9475}
}