TY - JOUR AU - Shlimon, Kristian AU - Lindenberger, Marcus AU - De Basso, Rachel AU - Cinthio, Magnus AU - Bjarnegard, Niclas TI - Increased diameter and stiffness of elastic but not muscular arteries in men with abdominal aortic aneurysm JF - JOURNAL OF APPLIED PHYSIOLOGY J2 - J APPL PHYSIOL VL - 136 PY - 2024 IS - 6 SP - 1410 EP - 1417 PG - 8 SN - 8750-7587 DO - 10.1152/japplphysiol.00875.2023 UR - https://m2.mtmt.hu/api/publication/35337795 ID - 35337795 LA - English DB - MTMT ER - TY - JOUR AU - Menon, Nithin J. AU - Sun, Clara AU - Chhina, Jashnoor AU - Halvorson, Brayden D. AU - Frisbee, Jefferson C. AU - Frisbee, Stephanie J. TI - Cerebrovascular dysfunction and depressive symptoms in preclinical models: insights from a scoping review JF - JOURNAL OF APPLIED PHYSIOLOGY J2 - J APPL PHYSIOL VL - 136 PY - 2024 IS - 6 SP - 1352 EP - 1363 PG - 12 SN - 8750-7587 DO - 10.1152/japplphysiol.00031.2024 UR - https://m2.mtmt.hu/api/publication/35319024 ID - 35319024 LA - English DB - MTMT ER - TY - JOUR AU - Williams, Zander J. AU - Orton, Christopher M. AU - Garner, Justin L. AU - Chan, Ley T. AU - Tana, Anand AU - Shah, Pallav L. AU - Polkey, Michael I. AU - Semple, Thomas AU - Hull, James H. TI - Feasibility of continuous bronchoscopy during exercise in the assessment of large airway movement in healthy subjects JF - JOURNAL OF APPLIED PHYSIOLOGY J2 - J APPL PHYSIOL VL - 136 PY - 2024 IS - 6 SP - 1429 EP - 1439 PG - 11 SN - 8750-7587 DO - 10.1152/japplphysiol.00746.2023 UR - https://m2.mtmt.hu/api/publication/35289918 ID - 35289918 LA - English DB - MTMT ER - TY - JOUR AU - Bao, Yuki AU - Frisbee, Amelia C. AU - Frisbee, Jefferson C. AU - Goldman, Daniel TI - A constrained constructive optimization model of branching arteriolar networks in rat skeletal muscle JF - JOURNAL OF APPLIED PHYSIOLOGY J2 - J APPL PHYSIOL VL - 136 PY - 2024 IS - 6 SP - 1303 EP - 1321 PG - 19 SN - 8750-7587 DO - 10.1152/japplphysiol.00896.2023 UR - https://m2.mtmt.hu/api/publication/35280192 ID - 35280192 LA - English DB - MTMT ER - TY - JOUR AU - Paterson, Craig AU - Stone, Keeron AU - Turner, Louise AU - Moinuddin, Arsalan AU - Stoner, Lee AU - Fryer, Simon TI - The effect of cardiorespiratory fitness and habitual physical activity on cardiovascular responses to 2 h of uninterrupted sitting JF - JOURNAL OF APPLIED PHYSIOLOGY J2 - J APPL PHYSIOL VL - 136 PY - 2024 IS - 5 SP - 1087 EP - 1096 PG - 10 SN - 8750-7587 DO - 10.1152/japplphysiol.00361.2023 UR - https://m2.mtmt.hu/api/publication/35289919 ID - 35289919 LA - English DB - MTMT ER - TY - JOUR AU - Sullivan, Brian P. AU - Collins, Brittany C. AU - McMillin, Shawna L. AU - Toussaint, Elise AU - Stein, Clara Z. AU - Spangenburg, Espen E. AU - Lowe, Dawn A. TI - Ablation of skeletal muscle estrogen receptor alpha impairs contractility in male mice JF - JOURNAL OF APPLIED PHYSIOLOGY J2 - J APPL PHYSIOL VL - 136 PY - 2024 IS - 4 SP - 764 EP - 773 PG - 10 SN - 8750-7587 DO - 10.1152/japplphysiol.00714.2023 UR - https://m2.mtmt.hu/api/publication/34828355 ID - 34828355 AB - Estradiol and estrogen receptor α (ERα) have been shown to be important for the maintenance of skeletal muscle strength in females; however, little is known about the roles of estradiol and ERα in male muscle. The purpose of this study was to determine if skeletal muscle ERα is required for optimal contractility in male mice. We hypothesize that reduced ERα in skeletal muscle impairs contractility in male mice. Skeletal muscle-specific knockout (skmERαKO) male mice exhibited reduced strength across multiple muscles and several contractile parameters related to force generation and kinetics compared with wild-type littermates (skmERαWT). Isolated EDL muscle-specific isometric tetanic force, peak twitch force, peak concentric and peak eccentric forces, as well as the maximal rates of force development and relaxation were 11%–21% lower in skmERαKO compared with skmERαWT mice. In contrast, isolated soleus muscles from skmERαKO mice were not affected. In vivo peak torque of the anterior crural muscles was 20% lower in skmERαKO compared with skmERαWT mice. Muscle masses, contractile protein contents, fiber types, phosphorylation of the myosin regulatory light chain, and caffeine-elicited force did not differ between muscles of skmERαKO and skmERαWT mice, suggesting that strength deficits were not due to size, composition, or calcium release components of muscle contraction. These results indicate that in male mice, reduced skeletal muscle ERα blunts contractility to a magnitude similar to that previously reported in females; however, the mechanism may be sexually dimorphic.NEW & NOTEWORTHY We comprehensively measured in vitro and in vivo contractility of leg muscles with reduced estrogen receptor α (ERα) in male mice and reported that force generation and contraction kinetics are impaired. In contrast to findings in females, phosphorylation of myosin regulatory light chain cannot account for low force production in male skeletal muscle ERα knockout mice. These results indicate that ERα is required for optimal contractility in males and females but via sexually dimorphic means. LA - English DB - MTMT ER - TY - JOUR AU - Peták, Ferenc AU - Südy, Roberta AU - Diaper, John AU - Fontao, Fabienne AU - Bizzotto, Davide AU - Dellacà, Raffaele L. AU - Habre, Walid AU - Schranc, Álmos TI - Benefits of intratracheal and extrathoracic high-frequency percussive ventilation in a model of capnoperitoneum JF - JOURNAL OF APPLIED PHYSIOLOGY J2 - J APPL PHYSIOL VL - 136 PY - 2024 IS - 4 SP - 928 EP - 937 PG - 10 SN - 8750-7587 DO - 10.1152/japplphysiol.00881.2023 UR - https://m2.mtmt.hu/api/publication/34798171 ID - 34798171 N1 - Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary Unit for Anesthesiological Investigations, Department of Acute Medicine, University of Geneva, Geneva, Switzerland Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy Export Date: 15 May 2024 CODEN: JAPHE Correspondence Address: Peták, F.; Department of Medical Physics and Informatics, Hungary; email: petak.ferenc@med.u-szeged.hu Chemicals/CAS: carbon dioxide, 124-38-9, 58561-67-4; Carbon Dioxide Funding details: OTKA-NKFIH K138032 Funding text 1: This work was supported by a Hungarian Basic Research Council Grant OTKA-NKFIH K138032. AB - The present study examines an alternative and innovative mechanical ventilation modality in improving oxygen delivery, CO 2 clearance, and respiratory mechanical abnormalities in a clinically relevant experimental model of capnoperitoneum. Our data reveal that high-frequency oscillations combined with conventional ventilation improve gas exchange, with intratracheal oscillations being more effective than extrathoracic oscillations in this clinically relevant translational model. LA - English DB - MTMT ER - TY - JOUR AU - Rodrigues, P. AU - Orssatto, L.B.R. AU - Gagnon, D. AU - Dahhak, A. AU - Hecksteden, A. AU - Stewart, I.B. AU - Minett, G.M. TI - Passive heat therapy: a promising preventive measure for people at risk of adverse health outcomes during heat extremes JF - JOURNAL OF APPLIED PHYSIOLOGY J2 - J APPL PHYSIOL VL - 136 PY - 2024 IS - 4 SP - 677 EP - 694 PG - 18 SN - 8750-7587 DO - 10.1152/japplphysiol.00701.2023 UR - https://m2.mtmt.hu/api/publication/34778140 ID - 34778140 N1 - Institute of Physiology, Medical University of Innsbruck, Innsbruck, Austria Institute of Sport Science, Leopold-Franzens-University of Innsbruck, Innsbruck, Austria School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, QLD, Australia Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, VIC, Australia Montreal Heart Institute, Montréal, QC, Canada School of Kinesiology and Exercise Science, Université de Montréal, Montréal, QC, Canada Export Date: 8 April 2024 CODEN: JAPHE Correspondence Address: Rodrigues, P.; Institute of Physiology, Austria; email: patrick.rodrigues@uibk.ac.at LA - English DB - MTMT ER - TY - JOUR AU - Beck, Owen N. AU - Schroeder, Jordyn N. AU - Sawicki, Gregory S. TI - Habitually wearing high heels may improve user walking economy in any footwear JF - JOURNAL OF APPLIED PHYSIOLOGY J2 - J APPL PHYSIOL VL - 136 PY - 2024 IS - 3 SP - 567 EP - 572 PG - 6 SN - 8750-7587 DO - 10.1152/japplphysiol.00016.2024 UR - https://m2.mtmt.hu/api/publication/35019073 ID - 35019073 LA - English DB - MTMT ER - TY - JOUR AU - Minten, Lennert AU - Langenaeken, Tom AU - McCutcheon, Keir AU - Bennett, Johan AU - Van Hecke, Manon AU - Algoet, Michiel AU - Bezy, Stephanie AU - Duchenne, Jurgen AU - Puvrez, Alexis AU - Wouters, Laurine AU - Voigt, Jens-Uwe AU - Adriaenssens, Tom AU - Desmet, Walter AU - Sinnaeve, Peter AU - Verbrugghe, Peter AU - Oosterlinck, Wouter AU - Claus, Piet AU - Meuris, Bart AU - Dubois, Christophe TI - An interventional sheep model of severe aortic valve stenosis hemodynamics for the evaluation of alterations in coronary physiology and microvascular function JF - JOURNAL OF APPLIED PHYSIOLOGY J2 - J APPL PHYSIOL VL - 136 PY - 2024 IS - 3 SP - 606 EP - 617 PG - 12 SN - 8750-7587 DO - 10.1152/japplphysiol.00737.2023 UR - https://m2.mtmt.hu/api/publication/35001200 ID - 35001200 LA - English DB - MTMT ER -