@article{MTMT:34798171,
	title = {Benefits of intratracheal and extrathoracic high-frequency percussive ventilation in a model of capnoperitoneum},
	url = {https://m2.mtmt.hu/api/publication/34798171},
	author = {Peták, Ferenc and Südy, Roberta and Diaper, John and Fontao, Fabienne and Bizzotto, Davide and Dellacà, Raffaele L. and Habre, Walid and Schranc, Álmos},
	doi = {10.1152/japplphysiol.00881.2023},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {136},
	unique-id = {34798171},
	issn = {8750-7587},
	abstract = {The present study examines an alternative and innovative mechanical ventilation modality in improving oxygen delivery, CO 2 clearance, and respiratory mechanical abnormalities in a clinically relevant experimental model of capnoperitoneum. Our data reveal that high-frequency oscillations combined with conventional ventilation improve gas exchange, with intratracheal oscillations being more effective than extrathoracic oscillations in this clinically relevant translational model.},
	year = {2024},
	eissn = {1522-1601},
	pages = {928-937},
	orcid-numbers = {Peták, Ferenc/0000-0001-6249-9327; Bizzotto, Davide/0000-0002-0631-6925; Dellacà, Raffaele L./0000-0002-3672-4591; Schranc, Álmos/0000-0002-9955-9116}
}

@article{MTMT:34778140,
	title = {Passive heat therapy: a promising preventive measure for people at risk of adverse health outcomes during heat extremes},
	url = {https://m2.mtmt.hu/api/publication/34778140},
	author = {Rodrigues, P. and Orssatto, L.B.R. and Gagnon, D. and Dahhak, A. and Hecksteden, A. and Stewart, I.B. and Minett, G.M.},
	doi = {10.1152/japplphysiol.00701.2023},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {136},
	unique-id = {34778140},
	issn = {8750-7587},
	year = {2024},
	eissn = {1522-1601},
	pages = {677-694}
}

@article{MTMT:34661776,
	title = {Cortical microglia dynamics are conserved during voluntary wheel running},
	url = {https://m2.mtmt.hu/api/publication/34661776},
	author = {Strohm, Alexandra O. and O'Connor, Thomas N. and Oldfield, Sadie and Young, Sala and Hammond, Christian and Mccall, Matthew and Dirksen, Robert T. and Majewska, Ania K.},
	doi = {10.1152/japplphysiol.00311.2023},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {136},
	unique-id = {34661776},
	issn = {8750-7587},
	keywords = {microglia; Two-photon microscopy; voluntary wheel running},
	year = {2024},
	eissn = {1522-1601},
	pages = {89-108}
}

@article{MTMT:34629819,
	title = {Combined changes in temperature and pH mimicking exercise result in decreased efficiency in muscle mitochondria},
	url = {https://m2.mtmt.hu/api/publication/34629819},
	author = {Flensted-Jensen, Mathias and Kleis-Olsen, Ann-Sofie and Hasso, Rasmus Kinimond and Lindtofte, Soren and Perez, Juan Corral and Ortega-Gomez, Sonia and Larsen, Steen},
	doi = {10.1152/japplphysiol.00293.2023},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {136},
	unique-id = {34629819},
	issn = {8750-7587},
	keywords = {PH; TEMPERATURE; Mitochondria; Exercise; mitochondrial efficiency},
	year = {2024},
	eissn = {1522-1601},
	pages = {79-88},
	orcid-numbers = {Flensted-Jensen, Mathias/0000-0002-5288-9783; Larsen, Steen/0000-0002-5170-4337}
}

@article{MTMT:34649722,
	title = {The impact of life-long strength versus endurance training on muscle fiber morphology and phenotype composition in older men},
	url = {https://m2.mtmt.hu/api/publication/34649722},
	author = {Toien, Tiril and Nielsen, Jakob Lindberg and Berg, Ole Kristian and Brobakken, Mathias Forsberg and Nyberg, Stian Kwak and Espedal, Lars and Malmo, Thomas and Frandsen, Ulrik and Aagaard, Per and Wang, Eivind},
	doi = {10.1152/japplphysiol.00208.2023},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {135},
	unique-id = {34649722},
	issn = {8750-7587},
	keywords = {OLDER ADULTS; Denervation; neural cell adhesion molecule (NCAM); fast-twitch type II fibers; nuclear clumps},
	year = {2023},
	eissn = {1522-1601},
	pages = {1360-1371},
	orcid-numbers = {Aagaard, Per/0000-0002-9773-7361}
}

@article{MTMT:34637756,
	title = {The ventilatory response to modified rebreathing is unchanged by hyperoxic severity: implications for the hyperoxic hyperventilation paradox},
	url = {https://m2.mtmt.hu/api/publication/34637756},
	author = {Huggard, Joshua D. and Guluzade, Nasimi A. and Duffin, James and Keir, Daniel A.},
	doi = {10.1152/japplphysiol.00455.2023},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {135},
	unique-id = {34637756},
	issn = {8750-7587},
	keywords = {HYPEROXIA; breathing; Ventilation; chemoreceptor; chemoreflex},
	year = {2023},
	eissn = {1522-1601},
	pages = {1446-1456}
}

@article{MTMT:34597754,
	title = {Augmented sympathoexcitation slows postexercise heart rate recovery},
	url = {https://m2.mtmt.hu/api/publication/34597754},
	author = {Boyes, Natasha G. and Mannozzi, Joseph and Rapin, Nicole and Alvarez, Alberto and Al-Hassan, Mohamed-Hussein and Lessanework, Beruk and Lahti, Dana S. and Olver, T. Dylan and O'Leary, Donal S. and Tomczak, Corey R.},
	doi = {10.1152/japplphysiol.00549.2023},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {135},
	unique-id = {34597754},
	issn = {8750-7587},
	abstract = {Slow heart rate recovery following exercise may be influenced by persistent sympathoexcitation. This study examined 1) the effect of muscle metaboreflex activation (MMA) on heart rate recovery following dynamic exercise; and 2) whether the effect of MMA on heart rate recovery is reversible by reducing sympathoexcitation [baroreflex activation via phenylephrine (PE)] in canines. Twenty-two young adults completed control and MMA protocols during cycle ergometry at 110% ventilatory threshold with 5 min recovery. Heart rate recovery kinetics [tau (tau), amplitude, end-exercise, and end-recovery heart rate] and root mean square of successive differences (RMSSD) were measured. Five chronically instrumented canines completed control, MMA (50%-60% imposed reduction in hindlimb blood flow), and MMA with end-exercise PE infusion (MMA + PE) protocols during moderate exercise (6.4 km<middle dot>h(-1)) and 3 min recovery. Heart rate recovery kinetics and MAP were measured. MAP increased during MMA versus control in canines (P < 0.001). Heart rate recovery tau was slower during MMA versus control in humans (17% slower; P = 0.011) and canines (150% slower; P = 0.002). Heart rate recovery tau was faster during MMA + PE versus MMA (40% faster; P = 0.034) and was similar to control in canines (P = 0.426). Amplitude, end-exercise, and end-recovery heart rate were similar between conditions in humans (all P >= 0.122) and in canines (all P >= 0.084). MMA decreased RMSSD in early recovery (P = 0.004). MMA-induced sympathoexcitation slows heart rate recovery and this effect is markedly attenuated with PE. Therefore, elevated sympathoexcitation via MMA impairs heart rate recovery and inhibition of this stimulus normalizes, in part, heart rate recovery. NEW & NOTEWORTHY Augmented sympathoexcitation, via muscle metaboreflex activation, functionally slows heart rate recovery in both young healthy adults and chronically instrumented canines. Furthermore, elevated sympathoexcitation corresponded with lower parasympathetic activity, as assessed by heart rate variability, during the first 3 min of recovery. Finally, sympathoinhibition, via phenylephrine infusion, normalizes heart rate recovery during muscle metaboreflex activation.},
	keywords = {Autonomic function; PHENYLEPHRINE; sympathoexcitation; muscle metaboreflex; heart rate kinetics},
	year = {2023},
	eissn = {1522-1601},
	pages = {1300-1311},
	orcid-numbers = {Mannozzi, Joseph/0000-0002-0815-6355; Olver, T. Dylan/0000-0003-1263-680X}
}

@article{MTMT:34595619,
	title = {Altered accumulation of hepatic mitochondrial antioxidant proteins with age and environmental heat stress},
	url = {https://m2.mtmt.hu/api/publication/34595619},
	author = {Haak, Jodie L. and Kregel, Kevin C. and Bloomer, Steven A.},
	doi = {10.1152/japplphysiol.00610.2023},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {135},
	unique-id = {34595619},
	issn = {8750-7587},
	abstract = {Aging impairs overall physiological function, particularly the response to environmental stressors. Repeated heat stress elevates reactive oxygen species and macromolecular damage in the livers of aged animals, likely due to mitochondrial dysfunction. The goal of this investigation was to determine potential mechanisms for mitochondrial dysfunction after heat stress by evaluating key redox-sensitive and antioxidant proteins (Sirt-3, MnSOD, Trx-2, and Ref-1). We hypothesized that heat stress would result in greater mitochondrial abundance of these proteins, but that aging would attenuate this response. For this purpose, young (6 mo) and old (24 mo) Fisher 344 rats were exposed to heat stress on two consecutive days. During each heating trial, colonic temperature was elevated to 41 degrees C during the first 60 min, and then clamped at this temperature for 30 min. Nonheated animals served as controls. At 2 and 24 h after the second heat stress, hepatic mitochondria were isolated from each animal, and then immunoblotted for Sirt-3, acetylated lysine residues (Ac-K), MnSOD, Trx-2, and Ref-1. Aging increased Sirt-3 and lowered Ac-K. In response to heat stress, Sirt-3, Ac-K, MnSOD, and Ref-1 increased in mitochondrial fractions in both young and old animals. At 2 h after the second heat stress, mitochondrial Trx-2 declined in old, but not in young animals. Our results suggest that some components of the response to heat stress are preserved with aging. However, the decline in Trx-2 represents a potential mechanism for age-related mitochondrial damage and dysfunction after heat stress.},
	keywords = {Aging; HYPERTHERMIA; Ref-1; SIRT-3; Trx-2},
	year = {2023},
	eissn = {1522-1601},
	pages = {1339-1347}
}

@article{MTMT:34588387,
	title = {The effect of low-frequency fatigue on the torque-velocity relationship in human quadriceps},
	url = {https://m2.mtmt.hu/api/publication/34588387},
	author = {Herskind, Jon and Gravholt, Anders and Hvid, Lars G. and Overgaard, Kristian},
	doi = {10.1152/japplphysiol.00637.2022},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {135},
	unique-id = {34588387},
	issn = {8750-7587},
	abstract = {Low-frequency fatigue (LFF) is usually defined as the decline in low:high-frequency force of electrically evoked isometric muscle contractions. The influence of LFF on dynamic muscle function is not well studied. Our aim was to assess the effect of LFF on the electrically evoked torque-velocity relationship in humans. Sixteen participants underwent a series of electrically evoked knee extensions in an isokinetic dynamometer to establish torque-velocity relationships at 15 and 50 Hz using isokinetic contractions. Hereafter, fatigue was induced by five sets of 10 repetitions of maximal voluntary dynamic knee extensions. After 30 min of rest, torque-velocity tests were repeated. Maximal torque (F-max) was measured, whereas maximal contraction velocity (V-max) and maximal power (P-max) were estimated using Hill's force-velocity equation, 15:50 Hz ratios were calculated for F-max, V-max, and P(max )as markers of LFF. F(max )decreased by 40% at 15 Hz (P = 0.001) and by 15% at 50 Hz (P = 0.001) in the fatigued state. No significant change was detected for V(max )at 15 Hz [-2%, (P = 0.349)] or 50 Hz [+3% (P = 0.763)], whereas 15 and 50 Hz P-max decreased by 30% (P = 0.004) and 10% (P = 0.008), respectively. Following the fatigue protocol, the 15:50 Hz F-max ratio decreased by 31% (P < 0.001), indicating LFF. The 15:50 Hz P-max ratio also decreased by 23% (P = 0.002), whereas the 15:50 Hz Vmax ratio was unchanged (P = 0.313). In conclusion, fatiguing contractions decreased Fmax and Pmax at both high and low stimulation frequencies, whereas Vmax appeared unaffected. Nevertheless, LFF influences power production during human dynamic contractions at a range of submaximal velocities.NEW & NOTEWORTHY Force-velocity relationships were established using either low- or high-frequency electrical stimulation before and after fatiguing voluntary eccentric/concentric contractions of the knee extensors. Low-frequency fatigue was assessed by the relative decrease in low- and high-frequency maximal torque, maximal shortening velocity, and maximal power estimated by the force-velocity relationship. Low-frequency fatigue manifests itself as a large decrease in low-frequency maximal force and power with a modest decrease in high-frequency maximal force and power. Contraction velocity does not seem to decrease in the same manner.},
	keywords = {electrical stimulation; muscle power; Force-velocity; prolonged low-frequency force depression; force-frequency relationship},
	year = {2023},
	eissn = {1522-1601},
	pages = {1457-1466},
	orcid-numbers = {Overgaard, Kristian/0000-0002-3204-509X}
}

@article{MTMT:34585642,
	title = {Potentiation of active force by cyclic strain in sheep carotid arterial smooth muscle},
	url = {https://m2.mtmt.hu/api/publication/34585642},
	author = {Wang, Lu and Dong, Shoujin and Chitano, Pasquale and Seow, Chun Y.},
	doi = {10.1152/japplphysiol.00162.2023},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {135},
	unique-id = {34585642},
	issn = {8750-7587},
	abstract = {The ability to generate force in large arteries is known to be augmented by cyclic strain that mimics the mechanically dynamic in vivo environment associated with blood pressure fluctuation experienced by these arteries. Cyclic strain does not induce a contractile response, like that observed in the myogenic response seen in small arteries, but prompts a substantial increase in the response to electrical stimulation. We coined this phenomenon "force potentiation." Because protein kinase C (PKC) and rho-kinase (ROCK) are known to play a role in increasing contractility of arterial smooth muscle by inhibition of myosin light chain phosphatase, and integrin-link kinase (ILK) is crucial in mechanotransduction, we examined how inhibition of these kinases affected force potentiation in sheep carotid artery. We found that phosphorylation of the regulatory myosin light chain was enhanced by cyclic strain, but the enhancement was observed only in activated, not in relaxed muscle. Inhibition of ROCK diminished force potentiation and active isometric force, likely due to the disinhibition of myosin light chain phosphatase. Inhibition of PKC abolished force potentiation without an effect on active force, suggesting a more exclusive role of PKC (compared with ROCK) in mediating force potentiation. Inhibition of ILK had a similar effect as PKC inhibition, suggesting that ILK may be an upstream kinase for PKC activation by mechanical stimuli. Taken together, the findings suggest that ILK, PKC, and ROCK are important kinases in the signal transduction pathway that mediate the effect of mechanical strain on force potentiation.},
	keywords = {INTEGRIN-LINKED KINASE; Protein kinase C; Rho-kinase; muscle mechanics; myosin light chain phosphorylation},
	year = {2023},
	eissn = {1522-1601},
	pages = {1243-1254}
}