TY - JOUR AU - Dehghani, M. AU - Sadeghi, M. AU - Barzkar, F. AU - Maghsoomi, Z. AU - Janani, L. AU - Motevalian, S.A. AU - Loke, Y.K. AU - Ismail-Beigi, F. AU - Baradaran, H.R. AU - Khamseh, M.E. TI - Efficacy and safety of basal insulins in people with type 2 diabetes mellitus: a systematic review and network meta-analysis of randomized clinical trials JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1286827 UR - https://m2.mtmt.hu/api/publication/34814768 ID - 34814768 N1 - Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Department of Epidemiology, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran Imperial Clinical Trials Unit, Imperial College London, London, United Kingdom Norwich Medical School, University of East Anglia, Norwich, United Kingdom Department of Medicine, Case Western Reserve University, Cleveland, OH, United States Ageing Clinical and Experimental Research Team, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom Export Date: 23 April 2024 Correspondence Address: Baradaran, H.R.; Department of Epidemiology, Iran; email: baradaran.hr@iums.ac.ir Correspondence Address: Khamseh, M.E.; Endocrine Research Center, Iran; email: khamseh.m@iums.ac.ir Chemicals/CAS: C peptide, 59112-80-0; hemoglobin A1c, 62572-11-6; insulin, 9004-10-8; insulin degludec, 844439-96-9; insulin detemir, 169148-63-4, 201305-44-4, 270588-25-5; insulin glargine, 160337-95-1; insulin lispro, 133107-64-9; isophane insulin, 9004-17-5; mesoglycan, 80455-95-4 AB - Aim: The comparative effectiveness of basal insulins has been examined in several studies. However, current treatment algorithms provide a list of options with no clear differentiation between different basal insulins as the optimal choice for initiation. Methods: A comprehensive search of MEDLINE, Embase, Cochrane Library, ISI, and Scopus, and a reference list of retrieved studies and reviews were performed up to November 2023. We identified phase III randomized controlled trials (RCTs) comparing the efficacy and safety of basal insulin regimens. The primary outcomes evaluated were HbA1c reduction, weight change, and hypoglycemic events. The revised Cochrane ROB-2 tool was used to assess the methodological quality of the included studies. A random-effects frequentist network meta-analysis was used to estimate the pooled weighted mean difference (WMD) and odds ratio (OR) with 95% confidence intervals considering the critical assumptions in the networks. The certainty of the evidence and confidence in the rankings was assessed using the GRADE minimally contextualized approach. Results: Of 20,817 retrieved studies, 44 RCTs (23,699 participants) were eligible for inclusion in our network meta-analysis. We found no significant difference among various basal insulins (including Neutral Protamine Hagedorn (NPH), ILPS, insulin glargine, detemir, and degludec) in reducing HbA1c. Insulin glargine, 300 U/mL (IGlar-300) was significantly associated with less weight gain (mean difference ranged from 2.9 kg to 4.1 kg) compared to other basal insulins, namely thrice-weekly insulin degludec (IDeg-3TW), insulin degludec, 100 U/mL (IDeg-100), insulin degludec, 200 U/mL (IDeg-200), NPH, and insulin detemir (IDet), but with low to very low certainty regarding most comparisons. IDeg-100, IDeg-200, IDet, and IGlar-300 were associated with significantly lower odds of overall, nocturnal, and severe hypoglycemic events than NPH and insulin lispro protamine (ILPS) (moderate to high certainty evidence). NPH was associated with the highest odds of overall and nocturnal hypoglycemia compared to others. Network meta-analysis models were robust, and findings were consistent in sensitivity analyses. Conclusion: The efficacy of various basal insulin regimens is comparable. However, they have different safety profiles. IGlar-300 may be the best choice when weight gain is a concern. In contrast, IDeg-100, IDeg-200, IDet, and IGlar-300 may be preferred when hypoglycemia is the primary concern. Copyright © 2024 Dehghani, Sadeghi, Barzkar, Maghsoomi, Janani, Motevalian, Loke, Ismail-Beigi, Baradaran and Khamseh. LA - English DB - MTMT ER - TY - JOUR AU - Ming, A. AU - Lorek, E. AU - Wall, J. AU - Schubert, T. AU - Ebert, N. AU - Galatzky, I. AU - Baum, A.-K. AU - Glanz, W. AU - Stober, S. AU - Mertens, P.R. TI - Unveiling peripheral neuropathy and cognitive dysfunction in diabetes: an observational and proof-of-concept study with video games and sensor-equipped insoles JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1310152 UR - https://m2.mtmt.hu/api/publication/34801695 ID - 34801695 N1 - University Clinic for Nephrology and Hypertension, Diabetology and Endocrinology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany University Clinic for Neurology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany Artificial Intelligence Lab, Otto-von-Guericke University Magdeburg, Magdeburg, Germany Export Date: 19 April 2024 Correspondence Address: Mertens, P.R.; University Clinic for Nephrology and Hypertension, Germany; email: peter.mertens@med.ovgu.de Tradenames: caret version: 6.0-94; ggplot2 version: 3.4.2; glmnet version: 4.1-7 AB - Background: Proactive screening for cognitive dysfunction (CD) and peripheral neuropathy (PNP) in elderly patients with diabetes mellitus is essential for early intervention, yet clinical examination is time-consuming and prone to bias. Objective: We aimed to investigate PNP and CD in a diabetes cohort and explore the possibility of identifying key features linked with the respective conditions by machine learning algorithms applied to data sets obtained in playful games controlled by sensor-equipped insoles. Methods: In a cohort of patients diagnosed with diabetes (n=261) aged over 50 years PNP and CD were diagnosed based on complete physical examination (neuropathy symptom and disability scores, and Montreal Cognitive Assessment). In an observational and proof-of-concept study patients performed a 15 min lasting gaming session encompassing tutorials and four video games with 5,244 predefined features. The steering of video games was solely achieved by modulating plantar pressure values, which were measured by sensor-equipped insoles in real-time. Data sets were used to identify key features indicating game performance with correlation regarding CD and PNP findings. Thereby, machine learning models (e.g. gradient boosting and lasso and elastic-net regularized generalized linear models) were set up to distinguish patients in the different groups. Results: PNP was diagnosed in 59% (n=153), CD in 34% (n=89) of participants, and 23% (n=61) suffered from both conditions. Multivariable regression analyses suggested that PNP was positively associated with CD in patients with diabetes (adjusted odds ratio = 1.95; 95% confidence interval: 1.03-3.76; P=0.04). Predictive game features were identified that significantly correlated with CD (n=59), PNP (n=40), or both (n=59). These features allowed to set up classification models that were enriched by individual risk profiles (i.e. gender, age, weight, BMI, diabetes type, and diabetes duration). The obtained models yielded good predictive performance with the area under the receiver-operating-characteristic curves reaching 0.95 for CD without PNP, 0.83 for PNP without CD, and 0.84 for CD and PNP combined. Conclusions: The video game-based assessment was able to categorize patients with CD and/or PNP with high accuracy. Future studies with larger cohorts are needed to validate these results and potentially enhance the discriminative power of video games. Copyright © 2024 Ming, Lorek, Wall, Schubert, Ebert, Galatzky, Baum, Glanz, Stober and Mertens. LA - English DB - MTMT ER - TY - JOUR AU - Horinouchi, S. AU - Deguchi, T. AU - Mukai, M. AU - Ijuin, A. AU - Kawamoto, Y. AU - Nishio, Y. TI - Assessment of the severity of diabetic polyneuropathy aids in predicting the risk of developing diabetic complications in patients with untreated diabetes JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1380970 UR - https://m2.mtmt.hu/api/publication/34801693 ID - 34801693 N1 - Department of Diabetes and Endocrine Medicine, Kagoshima City Hospital, Kagoshima, Japan Department of Diabetes and Endocrine Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan Export Date: 19 April 2024 Correspondence Address: Horinouchi, S.; Department of Diabetes and Endocrine Medicine, Japan; email: shuhori501@yahoo.co.jp Chemicals/CAS: ethambutol, 10054-05-4, 1070-11-7, 3577-94-4, 74-55-5; hemoglobin A1c, 62572-11-6; insulin, 9004-10-8 Tradenames: Excel 2021, Microsoft, United States; EZR, Saitama medical center, Japan; software Statcel 3, OMS, Japan; Viking Select, Nicolet, Japan Manufacturers: Nicolet, Japan; OMS, Japan; Saitama medical center, Japan; Microsoft, United States AB - This study aimed to determine the efficacy of assessing the severity of diabetic polyneuropathy (DPN) in patients with untreated diabetes. Seventy-two patients with untreated type 2 diabetes who were hospitalized for glycemic control were enrolled and divided into the following two groups: patients who had no prior diagnosis and patients who were unattended or had discontinued treatment. Electrophysiological criteria consistent with Baba’s classification were used to diagnose and assess the severity of DPN. The patients were divided into three subgroups: no DPN (stage 0), mild DPN (stage 1), and moderate or more-severe DPN (stages 2–4). Intergroup comparisons were performed for the clinical characteristics and the results of the nerve conduction studies. Twenty-two (30%), 25 (35%), and 25 (35%) patients were categorized into the no DPN, mild DPN, and moderate or more-severe DPN subgroups, respectively. The number of patients who were unattended or had discontinued treatment in the moderate or more-severe DPN subgroup was significantly higher than that in the no DPN subgroup. The patients in the moderate or more-severe DPN subgroup had an increased risk of developing diabetic retinopathy and nephropathy, with odds ratios of 19.5 and 11.0 for advanced stages of retinopathy and nephropathy, respectively. Thus, the assessment of the severity of DPN could aid in the prediction of the risk of developing diabetic complications in patients with untreated diabetes. Copyright © 2024 Horinouchi, Deguchi, Mukai, Ijuin, Kawamoto and Nishio. LA - English DB - MTMT ER - TY - JOUR AU - Sun, X. AU - Yang, X. AU - Zhu, X. AU - Ma, Y. AU - Li, X. AU - Zhang, Y. AU - Liu, Q. AU - Fan, C. AU - Zhang, M. AU - Xu, B. AU - Xu, Y. AU - Gao, X. AU - Dong, J. AU - Xia, M. AU - Bian, H. TI - Association of vitamin D deficiency and subclinical diabetic peripheral neuropathy in type 2 diabetes patients JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1354511 UR - https://m2.mtmt.hu/api/publication/34801692 ID - 34801692 N1 - Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China Institute of Metabolic Disease, Fudan University, Shanghai, China Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China Institute of Metabolism &Integrative Biology (IMIB), Fudan University, Shanghai, China Department of Geriatrics, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China Export Date: 19 April 2024 Correspondence Address: Xia, M.; Department of Endocrinology, China; email: dr_xiamingfeng@163.com Correspondence Address: Bian, H.; Department of Endocrinology, China; email: zhongshan_bh@126.com Correspondence Address: Dong, J.; Department of Neurology, China; email: dong.jihong@zs-hospital.sh.cn Chemicals/CAS: 25 hydroxyvitamin D, 64719-49-9; calcium, 7440-70-2, 14092-94-5; cholesterol, 57-88-5; creatinine, 19230-81-0, 60-27-5; glycated hemoglobin, 9062-63-9; hemoglobin A1c, 62572-11-6; parathyroid hormone, 12584-96-2, 68893-82-3, 9002-64-6; phosphorus, 7723-14-0; uric acid, 69-93-2 Tradenames: 7600-020, Hitachi, Japan; R version 4.0.3, R Foundation; Variant II machine, Biorad, United States Manufacturers: Hitachi, Japan; Biorad, United States; R Foundation AB - Background: Diabetic peripheral neuropathy (DPN) contributes to disability and imposes heavy burdens, while subclinical DPN is lack of attention so far. We aimed to investigate the relationship between vitamin D and distinct subtypes of subclinical DPN in type 2 diabetes (T2DM) patients. Methods: This cross-sectional study included 3629 T2DM inpatients who undertook nerve conduction study to detect subclinical DPN in Zhongshan Hospital between March 2012 and December 2019. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D (25(OH)D) level < 50 nmol/L. Results: 1620 (44.6%) patients had subclinical DPN and they were further divided into subgroups: distal symmetric polyneuropathy (DSPN) (n=685), mononeuropathy (n=679) and radiculopathy (n=256). Compared with non-DPN, DPN group had significantly lower level of 25(OH)D (P < 0.05). In DPN subtypes, only DSPN patients had significantly lower levels of 25(OH)D (36.18 ± 19.47 vs. 41.03 ± 18.47 nmol/L, P < 0.001) and higher proportion of vitamin D deficiency (78.54% vs. 72.18%, P < 0.001) than non-DPN. Vitamin D deficiency was associated with the increased prevalence of subclinical DPN [odds ratio (OR) 1.276, 95% confidence interval (CI) 1.086-1.501, P = 0.003] and DSPN [OR 1. 646, 95% CI 1.31-2.078, P < 0.001], independent of sex, age, weight, blood pressure, glycosylated hemoglobin, T2DM duration, calcium, phosphorus, parathyroid hormone, lipids and renal function. The association between vitamin D deficiency and mononeuropathy or radiculopathy was not statistically significant. A negative linear association was observed between 25(OH)D and subclinical DSPN. Vitamin D deficiency maintained its significant association with subclinical DSPN in all age groups. Conclusions: Vitamin D deficiency was independently associated with subclinical DSPN, rather than other DPN subtypes. Copyright © 2024 Sun, Yang, Zhu, Ma, Li, Zhang, Liu, Fan, Zhang, Xu, Xu, Gao, Dong, Xia and Bian. LA - English DB - MTMT ER - TY - JOUR AU - Xia, Y. AU - Wang, Y. AU - Yuan, S. AU - Hu, J. AU - Zhang, L. AU - Xie, J. AU - Zhao, Y. AU - Hao, J. AU - Ren, Y. AU - Wu, S. TI - Development and validation of nomograms to predict clinical outcomes of preeclampsia JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1292458 UR - https://m2.mtmt.hu/api/publication/34801054 ID - 34801054 N1 - Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou, China Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China Department of Gynaecology and Obstetrics, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China Export Date: 19 April 2024 Correspondence Address: Wu, S.; Department of Clinical Laboratory, China; email: 263809227@qq.com Correspondence Address: Ren, Y.; Department of Gynaecology and Obstetrics, China; email: 3202107@zju.edu.cn Chemicals/CAS: alanine aminotransferase, 9000-86-6, 9014-30-6; aspartate aminotransferase, 9000-97-9; creatinine, 19230-81-0, 60-27-5; hemoglobin, 9008-02-0; lactate dehydrogenase, 9001-60-9; lactate dehydrogenase A Funding details: Medical Science and Technology Project of Zhejiang Province, 2023KY811 Funding details: National Natural Science Foundation of China, NSFC, 82102476 Funding details: Natural Science Foundation of Zhejiang Province, ZJNSF, LQ21H190005 Funding text 1: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Project supported by Medical and Health Science and Technology Program of Zhejiang Province (Grant No. 2023KY811), National Natural Science Foundation of China (Grant No. 82102476) and Natural Science Foundation of Zhejiang province (Grant No. LQ21H190005). AB - Background: Preeclampsia (PE) is one of the most severe pregnancy-related diseases; however, there is still a lack of reliable biomarkers. In this study, we aimed to develop models for predicting early-onset PE, severe PE, and the gestation duration of patients with PE. Methods: Eligible patients with PE were enrolled and divided into a training (n = 253) and a validation (n = 108) cohort. Multivariate logistic and Cox models were used to identify factors associated with early-onset PE, severe PE, and the gestation duration of patients with PE. Based on significant factors, nomograms were developed and evaluated using the area under the curve (AUC) and a calibration curve. Results: In the training cohort, multiple gravidity experience (p = 0.005), lower albumin (ALB; p < 0.001), and higher lactate dehydrogenase (LDH; p < 0.001) were significantly associated with early-onset PE. Abortion history (p = 0.017), prolonged thrombin time (TT; p < 0.001), and higher aspartate aminotransferase (p = 0.002) and LDH (p = 0.003) were significantly associated with severe PE. Abortion history (p < 0.001), gemellary pregnancy (p < 0.001), prolonged TT (p < 0.001), higher mean platelet volume (p = 0.014) and LDH (p < 0.001), and lower ALB (p < 0.001) were significantly associated with shorter gestation duration. Three nomograms were developed and validated to predict the probability of early-onset PE, severe PE, and delivery time for each patient with PE. The AUC showed good predictive performance, and the calibration curve and decision curve analysis demonstrated clinical practicability. Conclusion: Based on the clinical features and peripheral blood laboratory indicators, we identified significant factors and developed models to predict early-onset PE, severe PE, and the gestation duration of pregnant women with PE, which could help clinicians assess the clinical outcomes early and design appropriate strategies for patients. Copyright © 2024 Xia, Wang, Yuan, Hu, Zhang, Xie, Zhao, Hao, Ren and Wu. LA - English DB - MTMT ER - TY - JOUR AU - Găloiu, S. AU - Toma, I.-D. AU - Tănasie, D.I. AU - Bărbulescu, A. AU - Baciu, I. AU - Niculescu, D.A. AU - Trifănescu, R.A. AU - Căpăţînă, C. AU - Radian, Ş. AU - Poiană, C. TI - High mortality risk among women with acromegaly still persists JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1348972 UR - https://m2.mtmt.hu/api/publication/34798521 ID - 34798521 N1 - Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Department of Endocrinology I, C. I. Parhon National Institute of Endocrinology, Bucharest, Romania Export Date: 18 April 2024 Correspondence Address: Găloiu, S.; Department of Endocrinology, Romania; email: simona.galoiu@umfcd.ro Chemicals/CAS: growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6; somatomedin C, 67763-96-6; somatostatin, 38916-34-6, 51110-01-1 Tradenames: Data Science Workbench version 14, STATISTICA Manufacturers: Diasorin, Italy; STATISTICA; TIBCO Software AB - Introduction: The mortality ratio in patients with acromegaly has improved over the last few decades. We aimed to determine the mortality rate and correlated factors in patients with acromegaly before and after the introduction of national protocols for treatment. In addition, we determined whether there are sex-related differences in mortality of patients with acromegaly. Methods: This observational retrospective study included 399 consecutive patients with acromegaly between January 2001–December 2022. Paraclinical data included random growth hormone (GH) and insulin-like growth factor-I (IGF1) levels, maximal pituitary tumor diameter at diagnosis, first visit, and last evaluation. Standardized mortality ratio (SMR) was calculated by dividing the observed and expected mortality rates. Cox regression analysis revealed the independent factors associated with mortality. Results: At the last visit, 31.07% (124) of patients were cured, 22.05% (88) had controlled acromegaly with medication, and 45.31% (181) had not controlled acromegaly. During follow-up (13.03 ± 5.65 years, 5216.62 person-years), 89 patients died (0.017%), resulting in an SMR of 1.18 [95% CI 0.95–1.45]. The independent factors associated with mortality were the last IGF1 level/last random GH level, absence of surgery, gonadotropin deficiency, and age. Patients with normal IGF1 after treatment showed an SMR of 0.71, whereas patients with IGF1 ratio > 1 showed SMR=1.51. Patients diagnosed between 1975–2007 and 2008–2022 had SMR = 1.25 [95% CI 0.97–1.58] and SMR = 1.09 [95% CI 0.68–1.65], respectively. In females with acromegaly, SMR was 1.63 [95% CI 1.24–2.11]; 1.76 [95% CI 1.30–2.34] in women diagnosed before 2008 and 1.33 [95% CI 0.69–2.33] in those diagnosed after 2008. Males with acromegaly had a mortality ratio similar to males from the general population (SMR = 0.99, [95% CI 0.66–1.41]). Conclusion: Patients diagnosed with acromegaly in the last 15 years had lower mortality rates than those diagnosed before 2008, due to the availability of new medications, primarily somatostatin receptor analogs and to a higher proportion of patients undergoing surgery. Females still have a high mortality ratio owing to older age at diagnosis and higher risk of metabolic complications. Therefore, efforts should be made for early diagnosis of acromegaly in women. Copyright © 2024 Găloiu, Toma, Tănasie, Bărbulescu, Baciu, Niculescu, Trifănescu, Căpăţînă, Radian and Poiană. LA - English DB - MTMT ER - TY - JOUR AU - Tang, Yuanyuan AU - Yang, Zhaoxia AU - Wen, Jinyang AU - Tang, Dazhong AU - Luo, Yi AU - Xiang, Chunlin AU - Huang, Lu AU - Xia, Liming TI - Association of serum uric acid with right cardiac chamber remodeling assessed by cardiovascular magnetic resonance feature tracking in patients with connective tissue disease JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1351197 UR - https://m2.mtmt.hu/api/publication/34795202 ID - 34795202 N1 - Export Date: 24 April 2024 Correspondence Address: Xia, L.; Department of Radiology, Hubei, China; email: xialiming2017@outlook.com LA - English DB - MTMT ER - TY - JOUR AU - Xu, Z. AU - Qi, L. AU - Zhang, H. AU - Yu, D. AU - Shi, Y. AU - Yu, Y. AU - Zhu, T. TI - Smoking and BMI mediate the causal effect of education on lower back pain: observational and Mendelian randomization analyses JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1288170 UR - https://m2.mtmt.hu/api/publication/34790366 ID - 34790366 N1 - Department of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu, China Department of Sports Medicine, Sichuan Province Orthopedic Hospital, Sichuan, Chengdu, China Department of Medical Laboratory, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong, Jinan, China Export Date: 15 April 2024 Correspondence Address: Zhu, T.; Department of Health Preservation and Rehabilitation, Sichuan, China; email: tianminzhu@cdutcm.edu.cn Correspondence Address: Yu, Y.; Department of Sports Medicine, Sichuan, China; email: yym2016@163.com LA - English DB - MTMT ER - TY - JOUR AU - He, Y. AU - Liu, S. AU - Lin, H. AU - Ding, F. AU - Shao, Z. AU - Xiong, L. TI - Roles of organokines in intervertebral disc homeostasis and degeneration JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1340625 UR - https://m2.mtmt.hu/api/publication/34790292 ID - 34790292 N1 - Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Orthopaedics, JingMen Central Hospital, Jingmen, China Hubei Minzu University, Enshi, China Export Date: 15 April 2024 Correspondence Address: Shao, Z.; Department of Orthopaedics, China; email: szwpro@163.com Correspondence Address: Xiong, L.; Department of Orthopaedics, China; email: xiongliming@hust.edu.cn Correspondence Address: Ding, F.; Department of Orthopaedics, China; email: jmyydf@163.com LA - English DB - MTMT ER - TY - JOUR AU - Wei, H. AU - Ren, J. AU - Li, R. AU - Qi, X. AU - Yang, F. AU - Li, Q. TI - Global, regional, and national burden of chronic kidney disease attributable to high fasting plasma glucose from 1990 to 2019: a systematic analysis from the global burden of disease study 2019 JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1379634 UR - https://m2.mtmt.hu/api/publication/34790263 ID - 34790263 N1 - School of Pharmaceutical Science, Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan, China Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, Shanxi University of Chinese Medicine, Taiyuan, China Export Date: 15 April 2024 Correspondence Address: Yang, F.; School of Pharmaceutical Science, China; email: fanfan42@sxmu.edu.cn Correspondence Address: Li, Q.; School of Pharmaceutical Science, China; email: sxlqs2012@163.com LA - English DB - MTMT ER -