@article{MTMT:34833183,
	title = {Different states of synaptic vesicle priming explain target cell type–dependent differences in neurotransmitter release},
	url = {https://m2.mtmt.hu/api/publication/34833183},
	author = {Aldahabi, Mohammad and Neher, Erwin and Nusser, Zoltán},
	doi = {10.1073/pnas.2322550121},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {121},
	unique-id = {34833183},
	issn = {0027-8424},
	abstract = {Pronounced differences in neurotransmitter release from a given presynaptic neuron, depending on the synaptic target, are among the most intriguing features of cortical networks. Hippocampal pyramidal cells (PCs) release glutamate with low probability to somatostatin expressing oriens-lacunosum-moleculare (O-LM) interneurons (INs), and the postsynaptic responses show robust short-term facilitation, whereas the release from the same presynaptic axons onto fast-spiking INs (FSINs) is ~10-fold higher and the excitatory postsynaptic currents (EPSCs) display depression. The mechanisms underlying these vastly different synaptic behaviors have not been conclusively identified. Here, we applied a combined functional, pharmacological, and modeling approach to address whether the main difference lies in the action potential-evoked fusion or else in upstream priming processes of synaptic vesicles (SVs). A sequential two-step SV priming model was fitted to the peak amplitudes of unitary EPSCs recorded in response to complex trains of presynaptic stimuli in acute hippocampal slices of adult mice. At PC–FSIN connections, the fusion probability (P fusion ) of well-primed SVs is 0.6, and 44% of docked SVs are in a fusion-competent state. At PC–O-LM synapses, P fusion is only 40% lower (0.36), whereas the fraction of well-primed SVs is 6.5-fold smaller. Pharmacological enhancement of fusion by 4-AP and priming by PDBU was recaptured by the model with a selective increase of P fusion and the fraction of well-primed SVs, respectively. Our results demonstrate that the low fidelity of transmission at PC–O-LM synapses can be explained by a low occupancy of the release sites by well-primed SVs.},
	keywords = {hippocampal interneurons; Synaptic modeling; short-term plasticity; synaptic diversity; active zone},
	year = {2024},
	eissn = {1091-6490},
	orcid-numbers = {Neher, Erwin/0000-0002-9758-7922}
}

@article{MTMT:34749015,
	title = {Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons},
	url = {https://m2.mtmt.hu/api/publication/34749015},
	author = {Tresóné Takács, Virág and Bardóczi, Zsuzsanna and Orosz, Áron and Major, Ábel and Tar, Luca and Berki, Péter and Papp, Péter and Mayer, Márton István and Sebők, Hunor and Zsolt, Luca and Sós, Katalin Eszter and Káli, Szabolcs and Freund, Tamás and Nyíri, Gábor},
	doi = {10.1371/journal.pbio.3002539},
	journal-iso = {PLOS BIOL},
	journal = {PLOS BIOLOGY},
	volume = {22},
	unique-id = {34749015},
	issn = {1544-9173},
	abstract = {GABAergic inhibitory neurons fundamentally shape the activity and plasticity of cortical circuits. A major subset of these neurons contains somatostatin (SOM); these cells play crucial roles in neuroplasticity, learning, and memory in many brain areas including the hippocampus, and are implicated in several neuropsychiatric diseases and neurodegenerative disorders. Two main types of SOM-containing cells in area CA1 of the hippocampus are oriens-lacunosum-moleculare (OLM) cells and hippocampo-septal (HS) cells. These cell types show many similarities in their soma-dendritic architecture, but they have different axonal targets, display different activity patterns in vivo, and are thought to have distinct network functions. However, a complete understanding of the functional roles of these interneurons requires a precise description of their intrinsic computational properties and their synaptic interactions. In the current study we generated, analyzed, and make available several key data sets that enable a quantitative comparison of various anatomical and physiological properties of OLM and HS cells in mouse. The data set includes detailed scanning electron microscopy (SEM)-based 3D reconstructions of OLM and HS cells along with their excitatory and inhibitory synaptic inputs. Combining this core data set with other anatomical data, patch-clamp electrophysiology, and compartmental modeling, we examined the precise morphological structure, inputs, outputs, and basic physiological properties of these cells. Our results highlight key differences between OLM and HS cells, particularly regarding the density and distribution of their synaptic inputs and mitochondria. For example, we estimated that an OLM cell receives about 8,400, whereas an HS cell about 15,600 synaptic inputs, about 16% of which are GABAergic. Our data and models provide insight into the possible basis of the different functionality of OLM and HS cell types and supply essential information for more detailed functional models of these neurons and the hippocampal network.},
	year = {2024},
	eissn = {1545-7885},
	orcid-numbers = {Tresóné Takács, Virág/0000-0002-3276-4131}
}

@article{MTMT:34714189,
	title = {Working memory features are embedded in hippocampal place fields},
	url = {https://m2.mtmt.hu/api/publication/34714189},
	author = {Varga, Viktor and Petersen, Peter and Zutshi, Ipshita and Huszar, Roman and Zhang, Yiyao and Buzsáki, György},
	doi = {10.1016/j.celrep.2024.113807},
	journal-iso = {CELL REP},
	journal = {CELL REPORTS},
	volume = {43},
	unique-id = {34714189},
	issn = {2211-1247},
	year = {2024},
	eissn = {2211-1247},
	pages = {113807}
}

@article{MTMT:34400320,
	title = {Author Correction: The medial septum controls hippocampal supra-theta oscillations},
	url = {https://m2.mtmt.hu/api/publication/34400320},
	author = {Király, Bálint and Domonkos, Andor and Jelitai, Márta and Lopes-dos-Santos, Vítor and Martínez-Bellver, Sergio and Kocsis, Barnabás and Schlingloff, Dániel and Joshi, Abhilasha and Salib, Minas and Fiáth, Richárd and Barthó, Péter and Ulbert, István and Freund, Tamás and Viney, Tim J. and Dupret, David and Varga, Viktor and Hangya, Balázs},
	doi = {10.1038/s41467-023-43190-6},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {14},
	unique-id = {34400320},
	issn = {2041-1723},
	year = {2023},
	eissn = {2041-1723},
	orcid-numbers = {Lopes-dos-Santos, Vítor/0000-0002-1858-0125; Joshi, Abhilasha/0000-0002-0511-3747; Salib, Minas/0000-0001-9938-7978; Fiáth, Richárd/0000-0001-8732-2691; Ulbert, István/0000-0001-9941-9159; Viney, Tim J./0000-0001-6444-1188; Dupret, David/0000-0002-0040-1766}
}

@article{MTMT:34237484,
	title = {Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus},
	url = {https://m2.mtmt.hu/api/publication/34237484},
	author = {Barth, Albert and Jelitai, Márta and Vasarhelyi-Nagy, Maria Flora and Varga, Viktor},
	doi = {10.1038/s41467-023-42611-w},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {14},
	unique-id = {34237484},
	issn = {2041-1723},
	abstract = {Throughout life animals inevitably encounter unforeseen threatening events. Activity of principal cells in the hippocampus is tuned for locations and for salient stimuli in the animals’ environment thus forming a map known to be pivotal for guiding behavior. Here, we explored if a code of threatening stimuli exists in the CA1 region of the dorsal hippocampus of mice by recording neuronal response to aversive stimuli delivered at changing locations. We have discovered a rapidly emerging, location independent response to innoxious aversive stimuli composed of the coordinated activation of subgroups of pyramidal cells and connected interneurons. Activated pyramidal cells had higher basal firing rate, more probably participated in ripples, targeted more interneurons than place cells and many of them lacked place fields. We also detected aversive stimulus-coupled assemblies dominated by the activated neurons. Notably, these assemblies could be observed even before the delivery of the first aversive event. Finally, we uncovered the systematic shift of the spatial code from the aversive to, surprisingly, the reward location during the fearful stimulus. Our results uncovered components of the dorsal CA1 circuit possibly key for re-sculpting the spatial map in response to abrupt aversive events.},
	year = {2023},
	eissn = {2041-1723}
}

@article{MTMT:34207759,
	title = {Several ways to wake you up by the thalamus},
	url = {https://m2.mtmt.hu/api/publication/34207759},
	author = {Acsády, László and Mátyás, Ferenc},
	doi = {10.1016/j.neuron.2023.09.020},
	journal-iso = {NEURON},
	journal = {NEURON},
	volume = {111},
	unique-id = {34207759},
	issn = {0896-6273},
	year = {2023},
	eissn = {1097-4199},
	pages = {3140-3142},
	orcid-numbers = {Mátyás, Ferenc/0000-0002-3903-8896}
}

@article{MTMT:34188237,
	title = {The medial septum controls hippocampal supra-theta oscillations},
	url = {https://m2.mtmt.hu/api/publication/34188237},
	author = {Király, Bálint and Domonkos, Andor and Jelitai, Márta and Lopes-dos-Santos, Vítor and Martínez-Bellver, Sergio and Kocsis, Barnabás and Schlingloff, Dániel and Joshi, Abhilasha and Salib, Minas and Fiáth, Richárd and Barthó, Péter and Ulbert, István and Freund, Tamás and Viney, Tim J. and Dupret, David and Varga, Viktor and Hangya, Balázs},
	doi = {10.1038/s41467-023-41746-0},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {14},
	unique-id = {34188237},
	issn = {2041-1723},
	abstract = {Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval.},
	keywords = {NEURONS; hippocampus; Theta rhythm; ENTORHINAL CORTEX; Action Potentials; HIPPOCAMPAL; Parvalbumins; CA1 region},
	year = {2023},
	eissn = {2041-1723},
	orcid-numbers = {Király, Bálint/0000-0001-8483-8780; Lopes-dos-Santos, Vítor/0000-0002-1858-0125; Joshi, Abhilasha/0000-0002-0511-3747; Salib, Minas/0000-0001-9938-7978; Fiáth, Richárd/0000-0001-8732-2691; Ulbert, István/0000-0001-9941-9159; Viney, Tim J./0000-0001-6444-1188; Dupret, David/0000-0002-0040-1766}
}

@article{MTMT:34125713,
	title = {Structural organisation of perisomatic inhibition in the mouse medial prefrontal cortex},
	url = {https://m2.mtmt.hu/api/publication/34125713},
	author = {Nagy-Pál, Petra and Veres, Judit and Fekete, Zsuzsanna and Karlócai, Rita and Filippo, Weisz and Barabás, Bence and Reéb, Zsófia and Hájos, Norbert},
	doi = {10.1523/JNEUROSCI.0432-23.2023},
	journal-iso = {J NEUROSCI},
	journal = {JOURNAL OF NEUROSCIENCE},
	volume = {43},
	unique-id = {34125713},
	issn = {0270-6474},
	year = {2023},
	eissn = {1529-2401},
	pages = {6972-6987}
}

@CONFERENCE{MTMT:34084378,
	title = {Examination of the density of macro- and microglia coverage of the bloodbrain barrier in human patients with focal cortical dysplasia-associated epilepsy.},
	url = {https://m2.mtmt.hu/api/publication/34084378},
	author = {Tóth, Katalin Zsófia and Szekeres-Paraczky, Cecília Kata and Erőss, Loránd and Fabó, Dániel and Orsolya, Salamonné Mihály and Maglóczky, Zsófia and Szocsics, Péter},
	booktitle = {Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA)},
	unique-id = {34084378},
	year = {2023},
	orcid-numbers = {Erőss, Loránd/0000-0002-5796-5546; Fabó, Dániel/0000-0001-5141-5351}
}

@CONFERENCE{MTMT:34023858,
	title = {Modelling the intracellular biochemical mechanisms of long term potentiation in a CA1 pyramidal cell spine head},
	url = {https://m2.mtmt.hu/api/publication/34023858},
	author = {Farkas, Gábor and Tar, Luca and Sáray, Sára and Káli, Szabolcs},
	booktitle = {Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA)},
	unique-id = {34023858},
	year = {2023},
	pages = {156-156}
}