TY - JOUR AU - Ellis, Ian AU - Webster, Fleur AU - Allison, Kimberly H. AU - Dang, Chau AU - Gobbi, Helenice AU - Kulka, Janina AU - Lakhani, Sunil R. AU - Moriya, Takuya AU - Quinn, Cecily M. AU - Sapino, Anna AU - Schnitt, Stuart AU - Sibbering, D. Mark AU - Slodkowska, Elzbieta AU - Yang, Wentao AU - Tan, Puay H. TI - Dataset for reporting of the invasive carcinoma of the breast: recommendations from the International Collaboration on Cancer Reporting (ICCR) JF - HISTOPATHOLOGY J2 - HISTOPATHOLOGY PY - 2024 PG - 19 SN - 0309-0167 DO - 10.1111/his.15191 UR - https://m2.mtmt.hu/api/publication/34861184 ID - 34861184 AB - Background and ObjectivesCurrent national or regional guidelines for the pathology reporting on invasive breast cancer differ in certain aspects, resulting in divergent reporting practice and a lack of comparability of data. Here we report on a new international dataset for the pathology reporting of resection specimens with invasive cancer of the breast. The dataset was produced under the auspices of the International Collaboration on Cancer Reporting (ICCR), a global alliance of major (inter-)national pathology and cancer organizations.Methods and ResultsThe established ICCR process for dataset development was followed. An international expert panel consisting of breast pathologists, a surgeon, and an oncologist prepared a draft set of core and noncore data items based on a critical review and discussion of current evidence. Commentary was provided for each data item to explain the rationale for selecting it as a core or noncore element, its clinical relevance, and to highlight potential areas of disagreement or lack of evidence, in which case a consensus position was formulated. Following international public consultation, the document was finalized and ratified, and the dataset, which includes a synoptic reporting guide, was published on the ICCR website.ConclusionsThis first international dataset for invasive cancer of the breast is intended to promote high-quality, standardized pathology reporting. Its widespread adoption will improve consistency of reporting, facilitate multidisciplinary communication, and enhance comparability of data, all of which will help to improve the management of invasive breast cancer patients. The first International Collaboration on Cancer Reporting (ICCR) dataset for the pathology reporting of resection specimens with invasive cancer of the breast is intended to promote high-quality, standardized pathology reporting. Its widespread adoption will improve consistency of reporting, facilitate multidisciplinary communication, and enhance comparability of data, all of which will help to improve the management of invasive breast cancer patients. image LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Péter AU - Beloate, Lauren N. AU - Zhang, Nanyin TI - Perturbing cortical networks: in vivo electrophysiological consequences of pan-neuronal chemogenetic manipulations using deschloroclozapine JF - FRONTIERS IN NEUROSCIENCE J2 - FRONT NEUROSCI-SWITZ VL - 18 PY - 2024 PG - 15 SN - 1662-4548 DO - 10.3389/fnins.2024.1396978 UR - https://m2.mtmt.hu/api/publication/34861047 ID - 34861047 AB - Introduction: Chemogenetic techniques, specifically the use of Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), have become invaluable tools in neuroscience research. Yet, the understanding of how Gq- and Gicoupled DREADDs alter local field potential (LFP) oscillations in vivo remains incomplete. Methods: This study investigates the in vivo electrophysiological effects of DREADD actuation by deschloroclozapine, on spontaneous firing rate and LFP oscillations recorded from the anterior cingulate cortex in lightly anesthetized male rats. Results: Unexpectedly, in response to the administration of deschloroclozapine, we observed inhibitory effects with pan-neuronal hM3D(Gq) stimulation, and excitatory effects with pan-neuronal hM4D(Gi) stimulation in a significant portion of neurons. These results emphasize the need to account for indirect perturbation effects at the local neuronal network level in vivo, particularly when not all neurons express the chemogenetic receptors uniformly. In the current study, for instance, the majority of cells that were transduced with both hM3D(Gq) and hM4D(Gi) were GABAergic. Moreover, we found that panneuronal cortical chemogenetic modulation can profoundly alter oscillatory neuronal activity, presenting a potential research tool or therapeutic strategy in several neuropsychiatric models and diseases. Discussion: These findings help to optimize the use of chemogenetic techniques in neuroscience research and open new possibilities for novel therapeutic strategies. LA - English DB - MTMT ER - TY - JOUR AU - Németh, Zsuzsanna TI - "Kalória megvonás és fizikai aktivitás metabolikus hatásai - sejtektől a szervezetig". Beszámoló a Semmelweis Egyetem Obez Centrumának I. Obezitológia Továbbképzéséről (2024. április 27.) TS - Beszámoló a Semmelweis Egyetem Obez Centrumának I. Obezitológia Továbbképzéséről (2024. április 27.) JF - OBESITOLOGIA HUNGARICA J2 - OBESIT HUNG VL - in press PY - 2024 SP - in press SN - 1586-7935 UR - https://m2.mtmt.hu/api/publication/34860473 ID - 34860473 LA - Hungarian DB - MTMT ER - TY - GEN AU - Pál, Vanda AU - Kothencz, Ágnes AU - Nádor, Csaba AU - Szabó, Miklós AU - Zsidegh, Petra TI - Újszülöttkori extrém hyperlipidaemia PY - 2024 UR - https://m2.mtmt.hu/api/publication/34859105 ID - 34859105 N1 - {előadás} LA - Hungarian DB - MTMT ER - TY - GEN AU - Pál, Vanda TI - Assessment of neurodevelopmental outcome in infants born during the COVID-19 pandemic PY - 2024 UR - https://m2.mtmt.hu/api/publication/34859098 ID - 34859098 N1 - {előadás} LA - English DB - MTMT ER - TY - GEN AU - Pál, Vanda AU - Kothencz, Ágnes AU - Nádor, Csaba AU - Szabó, Miklós AU - Zsidegh, Petra TI - Extrém neonatális hyperlipidaemia PY - 2024 UR - https://m2.mtmt.hu/api/publication/34859065 ID - 34859065 N1 - {előadás} LA - Hungarian DB - MTMT ER - TY - GEN AU - Vojcek, Eszter TI - Perinatal stroke: brain territorial involvement, clinical risk factors and long-term outcome PY - 2024 UR - https://m2.mtmt.hu/api/publication/34858995 ID - 34858995 N1 - {előadás} LA - English DB - MTMT ER - TY - GEN AU - Csekő, Anna Judit TI - Rosszul lévő kis csecsemő PY - 2024 UR - https://m2.mtmt.hu/api/publication/34858984 ID - 34858984 N1 - {előadás} LA - Hungarian DB - MTMT ER - TY - GEN AU - Lódi, Csaba TI - Gyermekintenzív ellátás Magyarországon - itt tartunk most PY - 2024 UR - https://m2.mtmt.hu/api/publication/34858982 ID - 34858982 N1 - {előadás} LA - Hungarian DB - MTMT ER - TY - GEN AU - Pék, Tamás TI - Kit, mikor, hogyan izoláljunk? PY - 2024 UR - https://m2.mtmt.hu/api/publication/34858972 ID - 34858972 N1 - {előadás} LA - Hungarian DB - MTMT ER -