@article{MTMT:34850199,
	title = {Effect of the 35 nm and 70 nm Size Exclusion Chromatography (SEC) Column and Plasma Storage Time on Separated Extracellular Vesicles},
	url = {https://m2.mtmt.hu/api/publication/34850199},
	author = {György, Bernadett and Pálóczi, Krisztina and Balbisi, Mirjam and Turiák, Lilla and Drahos, László and Visnovitz, Tamás and Koltai, Erika and Radák, Zsolt},
	doi = {10.3390/cimb46050264},
	journal-iso = {CURR ISSUES MOL BIOL},
	journal = {CURRENT ISSUES IN MOLECULAR BIOLOGY},
	volume = {46},
	unique-id = {34850199},
	issn = {1467-3037},
	abstract = {The technical difficulty of separating extracellular vesicles (EVs) from plasma proteins in human blood presents a significant hurdle in EV research, particularly during nano ultra-high-performance liquid chromatography–tandem mass spectrometric (UHPLC-MS/MS) analysis, where detecting “vesicular” proteins among abundant plasma proteins is challenging. Standardisation is a pressing issue in EV research, prompting collaborative global efforts to address it. While the MISEV guidelines offer valuable recommendations, unanswered questions remain, particularly regarding sample storage. We compared size exclusion chromatography (SEC) columns with pore sizes of 35 nm and 70 nm to identify fractions with minimal contaminating proteins and the highest concentration of small EVs (sEVs). Following column selection, we explored potential differences in the quality and quantity of sEVs isolated from platelet-free plasma (PFP) after long-term storage at −80 °C (>2.5 years) compared to freshly drawn blood. Our methodologically rigorous study indicates that prolonged storage, under correct storage and processing conditions, does not compromise sEV quality. Both columns effectively isolated vesicles, with the 70 nm column exhibiting a higher abundance of “vesicular” proteins. We propose a relatively rapid and moderately efficient protocol for obtaining a comparatively pure sEV fraction from plasma, facilitating sEV processing in clinical trials.},
	year = {2024},
	eissn = {1467-3045},
	pages = {4337-4357},
	orcid-numbers = {György, Bernadett/0000-0002-3787-7338; Pálóczi, Krisztina/0000-0001-7065-3582; Balbisi, Mirjam/0000-0002-6917-6974; Turiák, Lilla/0000-0002-2139-8156; Drahos, László/0000-0001-9589-6652; Visnovitz, Tamás/0000-0002-7962-5083; Koltai, Erika/0000-0002-1370-2955; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34850193,
	title = {Reactive oxygen species promote endurance exercise-induced adaptations in skeletal muscles},
	url = {https://m2.mtmt.hu/api/publication/34850193},
	author = {Powers, Scott K. and Radák, Zsolt and Ji, Li Li and Jackson, Malcolm},
	doi = {10.1016/j.jshs.2024.05.001},
	journal-iso = {JSHS},
	journal = {JOURNAL OF SPORT AND HEALTH SCIENCE},
	unique-id = {34850193},
	issn = {2095-2546},
	abstract = {The discovery that contracting skeletal muscle generates reactive oxygen species (ROS) was first reported over 40 years ago. The prevailing view in the 1980s was that exercise-induced ROS production promotes oxidation of proteins and lipids resulting in muscle damage. However, a paradigm shift occurred in the 1990s as growing research revealed that ROS are signaling molecules, capable of activating transcriptional activators/coactivators and promoting exercise-induced muscle adaptation. Growing evidence supports the notion that reduction-oxidation (redox) signaling pathways play an important role in the muscle remodeling that occurs in response to endurance exercise training. This review examines the specific role that redox signaling plays in this endurance exercise-induced skeletal muscle adaptation. We begin with a discussion of the primary sites of ROS production in contracting muscle fibers followed by a summary of the antioxidant enzymes involved in the regulation of ROS levels in the cell. We then discuss which redox-sensitive signaling pathways promote endurance exercise-induced muscle adaptation and debate the strength of the evidence supporting the notion that redox signaling plays an essential role in muscle adaptation to endurance exercise training. In hopes of stimulating future research, we highlight several important unanswered questions in this field.},
	year = {2024},
	eissn = {2213-2961},
	orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34829424,
	title = {Organ specificity and commonality of epigenetic aging in low- and high-running capacity rats},
	url = {https://m2.mtmt.hu/api/publication/34829424},
	author = {Kawamura, T. and Kerepesi, C. and Torma, Ferenc Gergely and Bori, Z. and Zhou, L. and Bakonyi, Péter and Radák, Zsolt},
	doi = {10.1101/2024.04.21.590009},
	journal = {bioRxive},
	volume = {2024},
	unique-id = {34829424},
	year = {2024},
	eissn = {2692-8205},
	orcid-numbers = {Bakonyi, Péter/0000-0002-6120-3384; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34776881,
	title = {Accelerated Fear Extinction by Regular Light-Intensity Exercise: A Possible Role of Hippocampal BDNF-TrkB Signaling},
	url = {https://m2.mtmt.hu/api/publication/34776881},
	author = {OKAMOTO, MASAHIRO and SHIMODA, RYO and AMAYA, YUKI and SOYA, SHINGO and SOYA, MARIKO and KOIZUMI, HIKARU and NAKAMURA, KENGO and HIRAGA, TAICHI and Torma, Ferenc Gergely and SOYA, HIDEAKI},
	doi = {10.1249/MSS.0000000000003312},
	journal-iso = {MED SCI SPORT EXER},
	journal = {MEDICINE AND SCIENCE IN SPORTS AND EXERCISE},
	volume = {56},
	unique-id = {34776881},
	issn = {0195-9131},
	year = {2024},
	eissn = {1530-0315},
	pages = {221-229}
}

@article{MTMT:34775640,
	title = {Harmony in Motion: Unraveling the Nexus of Sports, Plant-Based Nutrition, and Antioxidants for Peak Performance},
	url = {https://m2.mtmt.hu/api/publication/34775640},
	author = {Ayaz, Asma and Zaman, Wajid and Radák, Zsolt and Gu, Yaodong},
	doi = {10.3390/antiox13040437},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {13},
	unique-id = {34775640},
	abstract = {The intricate interplay between plant-based nutrition, antioxidants, and their impact on athletic performance forms the cornerstone of this comprehensive review. Emphasizing the pivotal importance of dietary choices in the realm of sports, this paper sets the stage for an in-depth exploration of how stress and physical performance are interconnected through the lens of nutrition. The increasing interest among athletes in plant-based diets presents an opportunity with benefits for health, performance, and recovery. It is essential to investigate the connection between sports, plants, and antioxidants. Highlighting the impact of nutrition on recovery and well-being, this review emphasizes how antioxidants can help mitigate oxidative stress. Furthermore, it discusses the growing popularity of plant-based diets among athletes. It elaborates on the importance of antioxidants in combating radicals addressing stress levels while promoting cellular health. By identifying rich foods, it emphasizes the role of a balanced diet in ensuring sufficient intake of these beneficial compounds. Examining stress within the context of sports activities, this review provides insights into its mechanisms and its impact on athletic performance as well as recovery processes. This study explores the impact of plant-based diets on athletes including their types, potential advantages and challenges. It also addresses the drawbacks of relying on plant-based diets, concerns related to antioxidant supplementation and identifies areas where further research is needed. Furthermore, the review suggests directions for research and potential innovations in sports nutrition. Ultimately it brings together the aspects of sports, plant-based nutrition, and antioxidants to provide a perspective for athletes, researchers and practitioners. By consolidating existing knowledge, it offers insights that can pave the way for advancements in the ever-evolving field of sports nutrition.},
	year = {2024},
	eissn = {2076-3921},
	pages = {437},
	orcid-numbers = {Ayaz, Asma/0000-0002-7596-8513; Zaman, Wajid/0000-0001-6864-2366; Radák, Zsolt/0000-0003-1297-6804; Gu, Yaodong/0000-0003-2187-9440}
}

@article{MTMT:34743288,
	title = {Combined NAD(P)H and lipofuscin FLIM revealed the development of metabolic syndrome in the liver of epigenetically altered rats},
	url = {https://m2.mtmt.hu/api/publication/34743288},
	author = {Kolonics, Attila and Kawamura, Takuji and Szipőcs, Róbert and Radák, Zsolt},
	doi = {10.1117/12.3005632},
	journal-iso = {PROCEEDINGS OF SPIE},
	journal = {PROCEEDINGS OF SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING},
	volume = {12849},
	unique-id = {34743288},
	issn = {0277-786X},
	year = {2024},
	eissn = {1996-756X},
	orcid-numbers = {Kolonics, Attila/0000-0003-3990-5336; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34718895,
	title = {Current knowledge about pyruvate supplementation: A brief review},
	url = {https://m2.mtmt.hu/api/publication/34718895},
	author = {Olek, Robert A. and Kujach, Sylwester and Radák, Zsolt},
	doi = {10.1016/j.smhs.2024.02.007},
	journal-iso = {SPORTS MED HEALTH SCI},
	journal = {SPORTS MEDICINE AND HEALTH SCIENCE},
	volume = {2024},
	unique-id = {34718895},
	issn = {2666-3376},
	year = {2024},
	orcid-numbers = {Olek, Robert A./0000-0002-3714-7386; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34714793,
	title = {Whole body vibration ameliorates anxiety-like behavior and memory functions in 30 months old senescent male rats},
	url = {https://m2.mtmt.hu/api/publication/34714793},
	author = {Oroszi, Tamás and Felszeghy, Klára and Luiten, Paul G.M. and Schoemaker, Regien G. and van der Zee, Eddy A. and Nyakas, Csaba},
	doi = {10.1016/j.heliyon.2024.e26608},
	journal-iso = {HELIYON},
	journal = {HELIYON},
	volume = {10},
	unique-id = {34714793},
	year = {2024},
	eissn = {2405-8440},
	orcid-numbers = {Oroszi, Tamás/0000-0003-2327-9959; Felszeghy, Klára/0000-0002-3539-1457; van der Zee, Eddy A./0000-0002-6471-7938; Nyakas, Csaba/0000-0003-3756-0186}
}

@article{MTMT:34693196,
	title = {Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness},
	url = {https://m2.mtmt.hu/api/publication/34693196},
	author = {Torma, Ferenc Gergely and Kerepesi, Csaba and Jókai, Mátyás and Bábszky, Gergely and Koltai, Erika and Ligeti, Balázs and Kalcsevszki, Regina and McGreevy, Kristen M. and Horvath, Steve and Radák, Zsolt},
	doi = {10.1111/acel.14101},
	journal-iso = {AGING CELL},
	journal = {AGING CELL},
	volume = {23},
	unique-id = {34693196},
	issn = {1474-9718},
	abstract = {Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various diseases and during the aging process, yet their relation to epigenetic clocks is not explored. To fill this gap, we collected metagenomic (from stool), epigenetic (from blood), and exercise‐related data from physically active individuals and, by applying epigenetic clocks, we examined the relationship between gut flora, blood‐based epigenetic age acceleration, and physical fitness. We revealed that an increased entropy in the gut microbiome of physically active middle‐aged/old individuals is associated with accelerated epigenetic aging, decreased fitness, or impaired health status. We also observed that a slower epigenetic aging and higher fitness level can be linked to altered abundance of some bacterial species often linked to anti‐inflammatory effects. Overall our data suggest that alterations in the microbiome can be associated with epigenetic age acceleration and physical fitness.},
	year = {2024},
	eissn = {1474-9726},
	orcid-numbers = {Kerepesi, Csaba/0000-0001-9541-246X; Bábszky, Gergely/0000-0002-5939-8434; Koltai, Erika/0000-0002-1370-2955; Horvath, Steve/0000-0002-4110-3589; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34596630,
	title = {Impact of differing eccentric-concentric phase durations on muscle damage and anabolic hormones},
	url = {https://m2.mtmt.hu/api/publication/34596630},
	author = {Kizilay, F. and Emin, Kafkas M. and Çagatay, Tąskapan M. and Haydar, Demirel A. and Radák, Zsolt},
	doi = {10.3233/IES-220078},
	journal-iso = {ISOKINET EXERC SCI},
	journal = {ISOKINETICS AND EXERCISE SCIENCE},
	volume = {32},
	unique-id = {34596630},
	issn = {0959-3020},
	year = {2024},
	eissn = {1878-5913},
	pages = {29-39},
	orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804}
}