@article{MTMT:34846015, title = {Recurrence Patterns after Radiotherapy for Glioblastoma with [(11)C]methionine Positron Emission Tomography-Guided Irradiation for Target Volume Optimization}, url = {https://m2.mtmt.hu/api/publication/34846015}, author = {Debreczeni-Máté, Zsanett and Törő, Imre and Simon, Mihály and Gál, Kristóf and Barabás, Marton and Sipos, Dávid and Kovács, Árpád}, doi = {10.3390/diagnostics14090964}, journal-iso = {DIAGNOSTICS}, journal = {DIAGNOSTICS}, volume = {14}, unique-id = {34846015}, issn = {2075-4418}, abstract = {11C methionine (11C-MET) is increasingly being used in addition to contrast-enhanced MRI to plan for radiotherapy of patients with glioblastomas. This study aimed to assess the recurrence pattern quantitatively. Glioblastoma patients undergoing 11C-MET PET examination before primary radiotherapy from 2018 to 2023 were included in the analysis. A clinical target volume was manually created and fused with MRI-based gross tumor volumes and MET PET-based biological target volume. The recurrence was noted as an area of contrast enhancement on the first MRI scan, which showed progression. The recurrent tumor was identified on the radiological MR images in terms of recurrent tumor volume, and recurrences were classified as central, in-field, marginal, or ex-field tumors. We then compared the MET-PET-defined biological target volume with the MRI-defined recurrent tumor volume regarding spatial overlap (the Dice coefficient) and the Hausdorff distance. Most recurrences occurred locally within the primary tumor area (64.8%). The mean Hausdorff distance was 39.4 mm (SD 32.25), and the mean Dice coefficient was 0.30 (SD 0.22). In patients with glioblastoma, the analysis of the recurrence pattern has been mainly based on FET-PET. Our study confirms that the recurrence pattern after gross tumor volume-based treatment contoured by MET-PET is consistent with the FET-PET-based treatment described in the literature.}, year = {2024}, eissn = {2075-4418}, orcid-numbers = {Sipos, Dávid/0000-0001-9615-1740; Kovács, Árpád/0000-0002-8469-5764} } @article{MTMT:34818503, title = {A Rheopheresis kezelés komplex angiológiai hatásai}, url = {https://m2.mtmt.hu/api/publication/34818503}, author = {Gál, Kristóf and Németh, Norbert and Gálné Remenyik, Judit and Soltész, Pál}, journal-iso = {METABOLIZMUS}, journal = {METABOLIZMUS}, volume = {22}, unique-id = {34818503}, issn = {1589-7311}, year = {2024}, pages = {62-65}, orcid-numbers = {Németh, Norbert/0000-0002-1162-3778} } @article{MTMT:34799242, title = {The role of chemoradiotherapy and immunotherapy in stage III NSCLC}, url = {https://m2.mtmt.hu/api/publication/34799242}, author = {Orosz, Zsuzsanna and Kovács, Árpád}, doi = {10.3389/pore.2024.1611716}, journal-iso = {PATHOL ONCOL RES}, journal = {PATHOLOGY AND ONCOLOGY RESEARCH}, volume = {30}, unique-id = {34799242}, issn = {1219-4956}, abstract = {Locally advanced non-small lung cancer encompasses a diverse range of tumors. In the last few years, the treatment of stage III unresectable non-small lung cancer has evolved significantly. The PACIFIC trial opened a new therapeutic era in the treatment of locally advanced NSCLC, establishing durvalumab consolidation therapy as the new standard of care worldwide. A careful evaluation of this type of lung cancer and a discussion of the management of these patients within a multidisciplinary team represents a crucial step in defining the best treatment strategy for each patient. For unresectable stage III NSCLC, definitive concurrent chemoradiotherapy (CCRT) was historically recommended as a treatment with a 5-year survival rate ranging from 20% to 30%. The PACIFIC study conducted in 2017 compared the use of chemoradiotherapy and maintenance therapy with the anti-PD-L1 monoclonal antibody durvalumab to a placebo in patients with locally advanced NSCLC who had not experienced disease progression. The study was prospective, randomized, and phase III. The administration of this medication in patients with locally advanced non-small cell lung cancer (NSCLC) has demonstrated a notable improvement in overall survival. Multiple clinical trials are currently exploring various immune checkpoint inhibition regimens to enhance the treatment efficacy in patients with stage III cancer. Our goal is to offer an up-to-date summary of the planned clinical trials for treatment options, focusing on the significant obstacles and prospects in the post-PACIFIC era.}, year = {2024}, eissn = {1532-2807}, pages = {1-6}, orcid-numbers = {Kovács, Árpád/0000-0002-8469-5764} } @article{MTMT:34688477, title = {Stereotactic body radiotherapy in lung cancer: a contemporary review}, url = {https://m2.mtmt.hu/api/publication/34688477}, author = {Csiki, Emese and Simon, Mihály and Papp, Judit and Barabás, Márton and Mikáczó, Johanna and Gál, Kristóf and Sipos, Dávid and Kovács, Árpád}, doi = {10.3389/pore.2024.1611709}, journal-iso = {PATHOL ONCOL RES}, journal = {PATHOLOGY AND ONCOLOGY RESEARCH}, volume = {30}, unique-id = {34688477}, issn = {1219-4956}, abstract = {The treatment of early stage non-small cell lung cancer (NSCLC) has improved enormously in the last two decades. Although surgery is not the only choice, lobectomy is still the gold standard treatment type for operable patients. For inoperable patients stereotactic body radiotherapy (SBRT) should be offered, reaching very high local control and overall survival rates. With SBRT we can precisely irradiate small, well-defined lesions with high doses. To select the appropriate fractionation schedule it is important to determine the size, localization and extent of the lung tumor. The introduction of novel and further developed planning (contouring guidelines, diagnostic image application, planning systems) and delivery techniques (motion management, image guided radiotherapy) led to lower rates of side effects and more conformal target volume coverage. The purpose of this study is to summarize the current developments, randomised studies, guidelines about lung SBRT, with emphasis on the possibility of increasing local control and overall rates in “fit,” operable patients as well, so SBRT would be eligible in place of surgery.}, year = {2024}, eissn = {1532-2807}, orcid-numbers = {Papp, Judit/0000-0001-6066-6187; Sipos, Dávid/0000-0001-9615-1740} } @article{MTMT:34492606, title = {Occupational Stress Levels among Radiologists and Radiographers in Hungary during the COVID-19 Era}, url = {https://m2.mtmt.hu/api/publication/34492606}, author = {Sipos, Dávid and Kövesdi, Orsolya Liza and Raposa, Bence and Ferkai, Luca Anna and Deutsch, Krisztina and Pandur, Attila and Kovács, Árpád and Petőné Csima, Melinda}, doi = {10.3390/healthcare12020160}, journal-iso = {HEALTHCARE-BASEL}, journal = {HEALTHCARE}, volume = {12}, unique-id = {34492606}, keywords = {radiologist; OCCUPATIONAL STRESS; effort-reward imbalance; radiographer; COVID-19}, year = {2024}, eissn = {2227-9032}, orcid-numbers = {Sipos, Dávid/0000-0001-9615-1740; Kövesdi, Orsolya Liza/0009-0006-2992-6503; Raposa, Bence/0000-0001-9551-8440; Ferkai, Luca Anna/0000-0003-4976-1516; Kovács, Árpád/0000-0002-8469-5764} } @article{MTMT:34478121, title = {Sleep Quality and Perceived Stress among Health Science Students during Online Education—A Single Institution Study}, url = {https://m2.mtmt.hu/api/publication/34478121}, author = {Busa, Flóra and Petőné Csima, Melinda and Törzsökné Márton, Johanna Andrea and Rozmann, Nóra and Pandur, Attila and Ferkai, Luca Anna and Deutsch, Krisztina and Kovács, Árpád and Sipos, Dávid}, doi = {10.3390/healthcare12010075}, journal-iso = {HEALTHCARE-BASEL}, journal = {HEALTHCARE}, volume = {12}, unique-id = {34478121}, abstract = {Recently, online education has been gaining prominence in university life. Our survey aimed to examine sleep quality and perceived stress levels among students at the University of Pécs Faculty of Health Sciences. A cross-sectional, quantitative, descriptive survey was conducted between February and March 2023. The online survey included the Hungarian versions of the internationally validated Athens Insomnia Scale (AIS) and Perceived Stress Scale (PSS). Statistical analysis involved descriptive statistics, independent t-tests, analysis of variance (ANOVA), and Mann–Whitney and Kruskal–Wallis tests (p < 0.05). We analyzed 304 responses, and females dominated (n = 270; 88.8%). Students in a relationship had significantly higher AIS scores (t = −2.470; p = 0.014). Medium average (2.50–3.49) students and those who rarely/never exercise showed significantly higher AIS and PSS (p ≤ 0.05). Students on the phone/watching a series during online education, daily laptop/TV use for more than 2 h, and pre-sleep use of smart devices for more than 60 min also negatively affected AIS and PSS scores (p ≤ 0.05). Nursing, physiotherapy, and radiography students were the most affected regarding insomnia and perceived stress (p ≤ 0.05). Our survey shows that excessive smart device use and lack of exercise are associated with higher stress levels and poorer sleep quality.}, year = {2024}, eissn = {2227-9032}, orcid-numbers = {Rozmann, Nóra/0000-0002-5621-4935; Ferkai, Luca Anna/0000-0003-4976-1516; Kovács, Árpád/0000-0002-8469-5764; Sipos, Dávid/0000-0001-9615-1740} } @article{MTMT:34506935, title = {Impact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and Radiotherapy Planning in Head and Neck Squamous Carcinoma: A Retrospective Study of 46 Patients}, url = {https://m2.mtmt.hu/api/publication/34506935}, author = {Pham, Anh and Garai, Ildikó and Kovács, Árpád and Dér, Ádám and Szántó, Erika and Hascsi, Zsolt and Bátyi, Ferenc and Berényi, Ervin László and Pham, Thong Minh}, doi = {10.12659/MSM.942122}, journal-iso = {MED SCI MONIT}, journal = {MEDICAL SCIENCE MONITOR}, volume = {30}, unique-id = {34506935}, issn = {1234-1010}, year = {2023}, eissn = {1643-3750}, pages = {1-7}, orcid-numbers = {Kovács, Árpád/0000-0002-8469-5764} } @article{MTMT:34415940, title = {Editorial: LINAC-based stereotactic radiosurgery in daily practice}, url = {https://m2.mtmt.hu/api/publication/34415940}, author = {Kovács, Árpád and Lakosi, Ferenc}, doi = {10.3389/fonc.2023.1306329}, journal-iso = {FRONT ONCOL}, journal = {FRONTIERS IN ONCOLOGY}, volume = {13}, unique-id = {34415940}, issn = {2234-943X}, year = {2023}, eissn = {2234-943X}, orcid-numbers = {Kovács, Árpád/0000-0002-8469-5764} } @article{MTMT:34395861, title = {Reduced burnout in medical and health science students during the pandemic COVID-19 - a follow-up study of a single institution in Hungary}, url = {https://m2.mtmt.hu/api/publication/34395861}, author = {Sipos, Dávid and Biro, Anett Anna and Busa, Flora and Freihat, Omar and Tollár, József and Pandur, Attila and Kovács, Árpád and Deutsch, Krisztina and Petőné Csima, Melinda}, doi = {10.1186/s12909-023-04867-0}, journal-iso = {BMC MED EDUC}, journal = {BMC MEDICAL EDUCATION}, volume = {23}, unique-id = {34395861}, keywords = {student; burnout; COVID-19; Secondment; Maslach burnout inventory general survey for students scale}, year = {2023}, eissn = {1472-6920}, orcid-numbers = {Sipos, Dávid/0000-0001-9615-1740; Tollár, József/0000-0001-7607-6739; Kovács, Árpád/0000-0002-8469-5764} } @article{MTMT:33655329, title = {Burnout and occupational stress among Hungarian radiographers working in emergency and non-emergency departments during COVID-19 pandemic}, url = {https://m2.mtmt.hu/api/publication/33655329}, author = {Sipos, Dávid and Jenei, Timea and Kövesdi, Orsolya Liza and Novák, Pál and Freihat, Omar and Tollár, József and Pandur, Attila and Kovács, Árpád and Repa, Imre and Petőné Csima, Melinda}, doi = {10.1016/j.radi.2023.02.013}, journal-iso = {RADIOGRAPHY}, journal = {RADIOGRAPHY}, volume = {29}, unique-id = {33655329}, issn = {1078-8174}, abstract = {Introduction: The increased workload caused by the coronavirus pandemic may have had a significant impact on the mental health of radiographers. The aim of our study was to investigate burnout and occupational stress in radiographers working in emergency departments (ED) and non-emergency departments (NED). Methods: Quantitative, cross-sectional, descriptive research was carried out among radiographers working in the public health sector in Hungary. Due to the cross-sectional nature of our survey, there was no overlap between the ED and NED groups. For data collection, we used simultaneously the Maslach Burnout Inventory (MBI), the Effort-Reward Imbalance questionnaire (ERI), and our self-designed questionnaire. Results: We excluded incomplete questionnaires from our survey; finally, 439 responses were evaluated. Significantly higher scores for depersonalisation (DP; 8.43 (SD = 6.69) vs. 5.63 (SD = 4.21) and emotional exhaustion (EE; 25.07 (SD = 11.41) vs. 19.72 (SD = 11.72)) were observed in radiographers working in ED (p = 0.001; p = 0.001) when compared to NED. Male radiographers working in ED aged 20–29 and 30–39 years with experience of 1–9 years were more affected by DP (p ≤ 0.05). Worrying about one's own health had a negative effect on DP and EE (p ≤ 0.05). Having close friend with a COVID-19 infection had a negative effect on EE (p ≤ 0.05); not being infected with coronavirus, not being quarantined and relocating within the workplace had a positive effect on personal accomplishment (PA); radiographers who were 50 years or older with 20–29 years of experience were more affected by depersonalisation (DP); and those who worried about their health had significantly higher stress scores (p ≤ 0.05) in both ED and NED settings. Conclusion: Male radiographers at the beginning of their careers were more affected by burnout. Employment in EDs had a negative impact on DP and EE. Implications for practice: Our results support the implementation of interventions to counter the effects of occupational stress and burnout among radiographers working in ED.}, keywords = {STRESS; emergency; mental health; burnout; CORONAVIRUS; MBI; radiographer}, year = {2023}, pages = {466-472}, orcid-numbers = {Sipos, Dávid/0000-0001-9615-1740; Kövesdi, Orsolya Liza/0009-0006-2992-6503; Tollár, József/0000-0001-7607-6739; Kovács, Árpád/0000-0002-8469-5764} }