@article{MTMT:34853427, title = {Violens és nem-violens öngyilkossági kísérletet elkövető személyek demográfiai jellemzői: átfogó adatelemzés a 2016-2021-es évekre vonatkozóan}, url = {https://m2.mtmt.hu/api/publication/34853427}, author = {Szeifert, Noémi and Sebők, Barbara and Szilágyi, Simon and Bérdi, Márk and Gonda, Xénia}, journal-iso = {PSYCHIATRIA HUNG}, journal = {PSYCHIATRIA HUNGARICA}, volume = {39}, unique-id = {34853427}, issn = {0237-7896}, year = {2024}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203} } @article{MTMT:34853425, title = {A depresszív, szorongó és ciklotím affektív temperamentumok csökkentik a meddőségi kezelések sikerének e}, url = {https://m2.mtmt.hu/api/publication/34853425}, author = {Szabó, Georgina and Szigeti, F Judit and Sipos, Miklós and Várbíró, Szabolcs and Gonda, Xénia}, journal-iso = {PSYCHIATRIA HUNG}, journal = {PSYCHIATRIA HUNGARICA}, volume = {39}, unique-id = {34853425}, issn = {0237-7896}, year = {2024}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203} } @article{MTMT:34853391, title = {A virtuális valóság alapú terápia szisztematikus szakirodalom-kutatása és -elemzése krónikus megbetegedéssel küzdő páciensek körében szomatikus tünet zavar kezelésében}, url = {https://m2.mtmt.hu/api/publication/34853391}, author = {Márton, Lilla and Gadó, Klára and Fekete, Márta and Lajkó, Patrícia and Gonda, Xénia}, journal-iso = {PSYCHIATRIA HUNG}, journal = {PSYCHIATRIA HUNGARICA}, volume = {39}, unique-id = {34853391}, issn = {0237-7896}, year = {2024}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203} } @article{MTMT:34853345, title = {Innovatív lehetőségek a geriátriai páciensek mentális egészségének és jólétének javítására: a virtuális valóság terápia hatásainak multidiszciplináris vizsgálata}, url = {https://m2.mtmt.hu/api/publication/34853345}, author = {Lajkó, Patricia and Gadó, Klára and Fekete, Márta and Márton, Lilla and Gonda, Xénia}, journal-iso = {PSYCHIATRIA HUNG}, journal = {PSYCHIATRIA HUNGARICA}, volume = {39}, unique-id = {34853345}, issn = {0237-7896}, year = {2024}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203} } @article{MTMT:34853295, title = {A Korai Trauma Kérdőív (ETI-SR) magyar nyelvű változatának pszichometriai jellemzői}, url = {https://m2.mtmt.hu/api/publication/34853295}, author = {Szeifert, Noémi Mónika and Sebők, Barbara and Szabó, Brigitta and Miklósi, Mónika and Lénárt, Ágota and Schmelowszky, Ágoston and Gonda, Xénia}, journal-iso = {PSYCHIATRIA HUNG}, journal = {PSYCHIATRIA HUNGARICA}, volume = {39}, unique-id = {34853295}, issn = {0237-7896}, year = {2024}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203} } @article{MTMT:34853242, title = {A Korai Trauma Kérdőív Rövidített Változatának (ETISR-SF) magyar nyelvű adaptálásának és pszichometriai jellemzőinek a bemutatása}, url = {https://m2.mtmt.hu/api/publication/34853242}, author = {Szeifert, Noémi Mónika and Sebők, Barbara and Szabó, Brigitta and Miklósi, Mónika and Lénárt, Ágota and Schmelowszky, Ágoston and Gonda, Xénia}, journal-iso = {PSYCHIATRIA HUNG}, journal = {PSYCHIATRIA HUNGARICA}, volume = {39}, unique-id = {34853242}, issn = {0237-7896}, year = {2024}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203} } @article{MTMT:34852653, title = {Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission}, url = {https://m2.mtmt.hu/api/publication/34852653}, author = {Stern, S. and Zhang, L. and Wang, M. and Wright, R. and Rosh, I. and Hussein, Y. and Stern, T. and Choudhary, A. and Tripathi, U. and Reed, P. and Sadis, H. and Nayak, R. and Shemen, A. and Agarwal, K. and Cordeiro, D. and Peles, D. and Hang, Y. and Mendes, A.P.D. and Baul, T.D. and Roth, J.G. and Coorapati, S. and Boks, M.P. and McCombie, W.R. and Hulshoff, Pol H. and Brennand, K.J. and Réthelyi, János and Kahn, R.S. and Marchetto, M.C. and Gage, F.H.}, doi = {10.1038/s41380-024-02561-1}, journal-iso = {MOL PSYCHIATR}, journal = {MOLECULAR PSYCHIATRY}, unique-id = {34852653}, issn = {1359-4184}, year = {2024}, eissn = {1476-5578}, orcid-numbers = {Réthelyi, János/0000-0002-3641-012X} } @article{MTMT:34850748, title = {Minimum spanning tree analysis of EEG resting-state functional networks in schizophrenia}, url = {https://m2.mtmt.hu/api/publication/34850748}, author = {Becske, Melinda and Marosi, Csilla and Molnár, Hajnalka and Fodor, Zsuzsanna and Farkas, Kinga and Rácz, Frigyes Sámuel and Baradits, Máté and Csukly, Gábor}, doi = {10.1038/s41598-024-61316-8}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34850748}, issn = {2045-2322}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Becske, Melinda/0000-0002-3265-4039; Marosi, Csilla/0000-0001-6467-175X; Molnár, Hajnalka/0000-0002-3555-1692; Fodor, Zsuzsanna/0000-0001-9335-4921; Farkas, Kinga/0000-0002-1125-3957; Rácz, Frigyes Sámuel/0000-0001-9077-498X; Baradits, Máté/0000-0003-1131-4550; Csukly, Gábor/0000-0002-5006-9407} } @article{MTMT:34847005, title = {Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia}, url = {https://m2.mtmt.hu/api/publication/34847005}, author = {Spathopoulou, Angeliki and Sauerwein, Gabriella A. and Marteau, Valentin and Podlesnic, Martina and Lindlbauer, Theresa and Kipura, Tobias and Hotze, Madlen and Gabassi, Elisa and Kruszewski, Katharina and Koskuvi, Marja and Réthelyi, János and Apáti, Ágota and Conti, Luciano and Ku, Manching and Koal, Therese and Mueller, Udo and Talmazan, Radu A. and Ojansuu, Ilkka and Vaurio, Olli and Lahteenvuo, Markku and Lehtonen, Sarka and Mertens, Jerome and Kwiatkowski, Marcel and Gunther, Katharina and Tiihonen, Jari and Koistinaho, Jari and Trajanoski, Zlatko and Edenhofer, Frank}, doi = {10.1038/s41380-024-02568-8}, journal-iso = {MOL PSYCHIATR}, journal = {MOLECULAR PSYCHIATRY}, unique-id = {34847005}, issn = {1359-4184}, abstract = {Schizophrenia (SCZ) is a neuropsychiatric disorder, caused by a combination of genetic and environmental factors. The etiology behind the disorder remains elusive although it is hypothesized to be associated with the aberrant response to neurotransmitters, such as dopamine and glutamate. Therefore, investigating the link between dysregulated metabolites and distorted neurodevelopment holds promise to offer valuable insights into the underlying mechanism of this complex disorder. In this study, we aimed to explore a presumed correlation between the transcriptome and the metabolome in a SCZ model based on patient-derived induced pluripotent stem cells (iPSCs). For this, iPSCs were differentiated towards cortical neurons and samples were collected longitudinally at various developmental stages, reflecting neuroepithelial-like cells, radial glia, young and mature neurons. The samples were analyzed by both RNA-sequencing and targeted metabolomics and the two modalities were used to construct integrative networks in silico. This multi-omics analysis revealed significant perturbations in the polyamine and gamma-aminobutyric acid (GABA) biosynthetic pathways during rosette maturation in SCZ lines. We particularly observed the downregulation of the glutamate decarboxylase encoding genes GAD1 and GAD2, as well as their protein product GAD65/67 and their biochemical product GABA in SCZ samples. Inhibition of ornithine decarboxylase resulted in further decrease of GABA levels suggesting a compensatory activation of the ornithine/putrescine pathway as an alternative route for GABA production. These findings indicate an imbalance of cortical excitatory/inhibitory dynamics occurring during early neurodevelopmental stages in SCZ. Our study supports the hypothesis of disruption of inhibitory circuits to be causative for SCZ and establishes a novel in silico approach that enables for integrative correlation of metabolic and transcriptomic data of psychiatric disease models.}, keywords = {FIBROBLASTS; GABA; Neurosciences; pluripotent; Biochemistry & Molecular Biology}, year = {2024}, eissn = {1476-5578}, orcid-numbers = {Réthelyi, János/0000-0002-3641-012X} } @{MTMT:34842665, title = {Attention Deficit Hyperactivity Disorder in Adults: From Research to Clinical Practice}, url = {https://m2.mtmt.hu/api/publication/34842665}, author = {Asherson, Philip and Balázs, Judit and Bitter, István and Carpentier, Pieter-Jan and Jaeschke, Rafał and Mohr, Pavel and Ramos-Quiroga, Josep Antoni and Rossi, Pietro De and Semerci, Benji and Kooij, Sandra}, booktitle = {Mental Health Research and Practice}, doi = {10.1017/9781009067287.010}, unique-id = {34842665}, year = {2024}, pages = {135-157}, orcid-numbers = {Balázs, Judit/0000-0001-6397-1419; Bitter, István/0000-0002-9464-4709} }