TY - JOUR AU - Zhang, Le AU - El-Shabrawi, Mortada AU - Baur, Louise A AU - Byrne, Christopher D AU - Targher, Giovanni AU - Kehar, Mohit AU - Porta, Gilda AU - Lee, Way Seah AU - Lefere, Sander AU - Turan, Serap AU - Alisi, Anna AU - Weiss, Ram AU - Faienza, Maria Felicia AU - Ashraf, Ambika AU - Sundaram, Shikha S AU - Srivastava, Anshu AU - De Bruyne, Ruth AU - Kang, Yunkoo AU - Bacopoulou, Flora AU - Zhou, Yong-Hai AU - Darma, Andy AU - Lupsor-Platon, Monica AU - Hamaguchi, Masahide AU - Misra, Anoop AU - Méndez-Sánchez, Nahum AU - Ng, Nicholas Beng Hui AU - Marcus, Claude AU - Staiano, Amanda E AU - Waheed, Nadia AU - Alqahtani, Saleh A AU - Giannini, Cosimo AU - Ocama, Ponsiano AU - Nguyen, Mindie H AU - Arias-Loste, Maria Teresa AU - Ahmed, Mohamed Rabea AU - Sebastiani, Giada AU - Poovorawan, Yong AU - Al Mahtab, Mamun AU - Pericàs, Juan M AU - Reverbel da Silveira, Themis AU - Hegyi, Péter AU - Azaz, Amer AU - Isa, Hasan M AU - Lertudomphonwanit, Chatmanee AU - Farrag, Mona Issa AU - Nugud, Ahmed Abd Alwahab AU - Du, Hong-Wei AU - Qi, Ke-Min AU - Mouane, Nezha AU - Cheng, Xin-Ran AU - Al Lawati, Tawfiq AU - Fagundes, Eleonora D T AU - Ghazinyan, Hasmik AU - Hadjipanayis, Adamos AU - Fan, Jian-Gao AU - Gimiga, Nicoleta AU - Kamal, Naglaa M AU - Ștefănescu, Gabriela AU - Hong, Li AU - Diaconescu, Smaranda AU - Li, Ming AU - George, Jacob AU - Zheng, Ming-Hua TI - An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease JF - Med J2 - Med PY - 2024 SN - 2666-6340 DO - 10.1016/j.medj.2024.03.017 UR - https://m2.mtmt.hu/api/publication/34836460 ID - 34836460 AB - Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in children and adolescents, particularly those with obesity. NAFLD is considered a hepatic manifestation of the metabolic syndrome due to its close associations with abdominal obesity, insulin resistance, and atherogenic dyslipidemia. Experts have proposed an alternative terminology, metabolic dysfunction-associated fatty liver disease (MAFLD), to better reflect its pathophysiology. This study aimed to develop consensus statements and recommendations for pediatric MAFLD through collaboration among international experts.A group of 65 experts from 35 countries and six continents, including pediatricians, hepatologists, and endocrinologists, participated in a consensus development process. The process encompassed various aspects of pediatric MAFLD, including epidemiology, mechanisms, screening, and management.In round 1, we received 65 surveys from 35 countries and analyzed these results, which informed us that 73.3% of respondents agreed with 20 draft statements while 23.8% agreed somewhat. The mean percentage of agreement or somewhat agreement increased to 80.85% and 15.75%, respectively, in round 2. The final statements covered a wide range of topics related to epidemiology, pathophysiology, and strategies for screening and managing pediatric MAFLD.The consensus statements and recommendations developed by an international expert panel serve to optimize clinical outcomes and improve the quality of life for children and adolescents with MAFLD. These findings emphasize the need for standardized approaches in diagnosing and treating pediatric MAFLD.This work was funded by the National Natural Science Foundation of China (82070588, 82370577), the National Key R&D Program of China (2023YFA1800801), National High Level Hospital Clinical Research Funding (2022-PUMCH-C-014), the Wuxi Taihu Talent Plan (DJTD202106), and the Medical Key Discipline Program of Wuxi Health Commission (ZDXK2021007). LA - English DB - MTMT ER - TY - JOUR AU - Gantsetseg, Garmaa AU - Bunduc, Stefania AU - Kói, Tamás AU - Hegyi, Péter AU - Csupor, Dezső AU - Dariimaa, Ganbat AU - Dembrovszky, Fanni AU - Meznerics, Fanni Adél AU - Ailar, Nasirzadeh AU - Cristina, Barbagallo AU - Kökény, Gábor TI - A Systematic Review and Meta-Analysis of microRNA Profiling Studies in Chronic Kidney Diseases JF - NON-CODING RNA J2 - NON-CODING RNA VL - 10 PY - 2024 IS - 3 PG - 26 SN - 2311-553X DO - 10.3390/ncrna10030030 UR - https://m2.mtmt.hu/api/publication/34833996 ID - 34833996 LA - English DB - MTMT ER - TY - JOUR AU - Hamar, Balázs AU - Teutsch, Brigitta AU - Hoffmann, Eszter AU - Hegyi, Péter AU - Harnos, Andrea AU - Nyirády, Péter AU - Hunka, Zsombor Rezső AU - Ács, Nándor AU - Bánhidy, Ferenc AU - Melczer, Zsolt TI - Imiquimod Is Effective in Reducing Cervical Intraepithelial Neoplasia : A Systematic Review and Meta-Analysis JF - CANCERS J2 - CANCERS VL - 16 PY - 2024 IS - 8 PG - 15 SN - 2072-6694 DO - 10.3390/cancers16081610 UR - https://m2.mtmt.hu/api/publication/34825011 ID - 34825011 AB - Topical Imiquimod is an immune response modifier approved for the off-label use of vulvar intraepithelial neoplasia. We conducted this systematic review and meta-analysis to investigate the efficacy and safety of Imiquimod in treating cervical intraepithelial neoplasia (CIN) and human papillomavirus (HPV)-positive patients.The study was prospectively registered (CRD420222870) and involved a comprehensive systematic search of five medical databases on 10 October 2022. We included articles that assessed the use of Imiquimod in cervical dysplasia and HPV-positive patients. Pooled proportions, risk ratios (RRs), and corresponding 95% confidence intervals (CIs) were calculated using a random effects model to generate summary estimates. Statistical heterogeneity was assessed using I2 tested by the Cochran Q tests.Eight articles reported on 398 patients who received Imiquimod out of 672 patients. Among CIN-2-3 patients, we observed a pooled regression rate of 61% (CI: 0.46-0.75; I2: 77%). When compared, Imiquimod was inferior to conization (RR: 0.62; CI: 0.42-0.92; I2: 64%). The HPV clearance rate in women who completed Imiquimod treatment was 60% (CI: 0.31-0.81; I2: 57%). The majority of side effects reported were mild to moderate in severity.Our findings indicate that topical Imiquimod is safe and effective in reducing cervical intraepithelial neoplasia and promoting HPV clearance. However, it was found to be inferior compared to conization. Imiquimod could be considered a potential medication for high-grade CIN patients and should be incorporated into guidelines for treating cervical dysplasia. LA - English DB - MTMT ER - TY - JOUR AU - Kedves, András AU - Akay, M. AU - Akay, Y. AU - Kisiván, K. AU - Glavák, C. AU - Miovecz, Ádám AU - Schiffer, Ádám AU - Kisander, Zsolt AU - Lőrincz, Aba Tamás AU - Szőke, András AU - Sánta, B. AU - Freihat, Omar AU - Sipos, Dávid AU - Kovács, Árpád AU - Lakosi, Ferenc TI - Predictive value of magnetic resonance imaging diffusion parameters using artificial intelligence in low-and intermediate-risk prostate cancer patients treated with stereotactic ablative radiotherapy: A pilot study JF - RADIOGRAPHY J2 - RADIOGRAPHY VL - 30 PY - 2024 IS - 3 SP - 986 EP - 994 PG - 9 SN - 1078-8174 DO - 10.1016/j.radi.2024.03.015 UR - https://m2.mtmt.hu/api/publication/34824534 ID - 34824534 LA - English DB - MTMT ER - TY - CHAP AU - Garami, András ED - Vámos, Zoltán TI - Termoneutralitás T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó CY - Budapest SN - 9789632269177 PY - 2024 SP - 172 EP - 173 PG - 2 UR - https://m2.mtmt.hu/api/publication/34823724 ID - 34823724 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Garami, András ED - Vámos, Zoltán TI - Hőszabályozás T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó CY - Budapest SN - 9789632269177 PY - 2024 SP - 51 EP - 54 PG - 1 UR - https://m2.mtmt.hu/api/publication/34823695 ID - 34823695 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Rumbus, Zoltán AU - Fekete, Kata AU - Kelava, Leonardo AU - Gardos, Bibor AU - Klonfar, Krisztian AU - Kéringer, Patrik AU - Pintér, Erika AU - Pákai, Eszter AU - Garami, András TI - Ammonium chloride-induced hypothermia is attenuated by transient receptor potential channel vanilloid-1, but augmented by ankyrin-1 in rodents JF - LIFE SCIENCES J2 - LIFE SCI VL - 346 PY - 2024 PG - 12 SN - 0024-3205 DO - 10.1016/j.lfs.2024.122633 UR - https://m2.mtmt.hu/api/publication/34804165 ID - 34804165 N1 - Export Date: 22 April 2024; CODEN: LIFSA AB - Systemic administration of ammonium chloride (NH4Cl), an acidifying agent used in human patients and experimental conditions, causes hypothermia in mice, however, the mechanisms of the thermoregulatory response to NH4Cl and whether it develops in other species remained unknown.We studied body temperature (Tb) changes in rats and mice induced by intraperitoneal administration of NH4Cl after blockade of transient receptor potential vanilloid-1 (TRPV1) or ankyrin-1 (TRPA1) channels.In rats, NH4Cl decreased Tb by 0.4-0.8°C (p < 0.05). The NH4Cl-induced hypothermia also developed in Trpv1 knockout (Trpv1-/-) and wild-type (Trpv1+/+) mice, however, the Tb drop was exaggerated in Trpv1-/- mice compared to Trpv1+/+ controls with maximal decreases of 4.0 vs. 2.1°C, respectively (p < 0.05). Pharmacological blockade of TRPV1 channels with AMG 517 augmented the hypothermic response to NH4Cl in genetically unmodified mice and rats (p < 0.05 for both). In contrast, when NH4Cl was infused to mice genetically lacking the TRPA1 channel, the hypothermic response was significantly attenuated compared to wild-type controls with maximal mean Tb difference of 1.0°C between the genotypes (p = 0.008). Pretreatment of rats with a TRPA1 antagonist (A967079) also attenuated the NH4Cl-induced Tb drop with a maximal difference of 0.7°C between the pretreatment groups (p = 0.003).TRPV1 channels limit, whereas TRPA1 channels exaggerate the development of NH4Cl-induced hypothermia in rats and mice, but other mechanisms are also involved. Our results warrant for regular Tb control and careful consideration of NH4Cl treatment in patients with TRPA1 and TRPV1 channel dysfunctions. LA - English DB - MTMT ER - TY - JOUR AU - Farkas, B. AU - Borsos, M. AU - Resal, T. AU - Bacsur, P. AU - Szepes, Z. AU - Savarino, E. V. AU - Bertin, L. AU - Limdi, J. K. AU - Sethi-Arora, K. AU - Miheller, P. AU - Vilmos, F. AU - Castiglione, F. AU - Bonacci, L. AU - Lukas, M. AU - Maharshak, N. AU - Berman, G. AU - Krznaric, Z. AU - Wetwittayakhlang, P. AU - Lakatos, P. L. AU - Seidelin, J. B. AU - Attauabi, M. AU - Michalopoulos, G. AU - Ribaldone, D. G. AU - Kagramanova, A. AU - Chashkova, E. AU - Sarlós, Patrícia AU - Saibeni, S. AU - Shitrit, A. B. G. AU - Molnar, T. AU - Farkas, K. TI - Real-world data on sequential therapy in moderate-to-severe UC: Unveiling second-line strategies after anti-TNF failure JF - JOURNAL OF CROHNS & COLITIS J2 - J CROHNS COLITIS VL - 18 PY - 2024 SP - I1828 EP - I1829 PG - 2 SN - 1873-9946 UR - https://m2.mtmt.hu/api/publication/34803211 ID - 34803211 N1 - Supplement: 1 LA - English DB - MTMT ER - TY - JOUR AU - Vámos, Orsolya AU - Komora, Péter AU - Gede, Noémi AU - Hegyi, Péter AU - Kelemen, Kata AU - Varga, Gábor AU - Mikulás, Krisztina Ágnes AU - Kerémi, Beáta AU - Kispélyi, Ida Barbara TI - The effect of nicotine-containing products on peri-implant tissues : A systematic review and network meta-analysis JF - NICOTINE AND TOBACCO RESEARCH J2 - NICOTINE TOB RES PY - 2024 SN - 1462-2203 DO - 10.1093/ntr/ntae085 UR - https://m2.mtmt.hu/api/publication/34801787 ID - 34801787 AB - Smokers have a higher chance of developing peri-implant diseases and are therefore considered an at-risk population. Our aim was to compare peri-implant characteristics in users of electronic cigarettes (EC), waterpipes (WP), cigarettes (CS), smokeless tobacco (ST), and non-smokers (non-users of any nicotine and tobacco product; NS).A systematic search of four electronic databases (PubMed, EMBASE, Web of Science, CENTRAL) was performed until April 2023, restricted to English language. Thirty-nine observational studies were included in the qualitative synthesis, of which 32 studies were included in a Bayesian network meta-analysis. Using a predesigned form, two researchers independently collected data about marginal bone loss (MBL), probing pocket depth (PPD), plaque index (PI), bleeding on probing (BOP), modified plaque index (mPI), probing pocket depth > 4mm (PPD>4), gingival index (GI), peri-implant sulcular fluid (PISF) volume, and TNF-α and IL-1β levels. QUIPS and CINeMA were used to evaluate the risk of bias and certainty of evidence.NS had the smallest MBL. Most nicotine-containing product users had significantly higher MBL (CS, MD:1.34 CrI: 0.85, 1.79; WP, MD:1.58 CrI: 0.84, 2.35; ST, MD:2.53, CrI: 1.20, 3.87) than NS. EC did not show significant difference compared to NS (MD:0.52 CrI: -0.33, 1.36). In secondary outcomes NS were ranked in first place. Subset analysis based on smoking habit, implant duration, and maintenance control revealed no differences in ranking probability.Most nicotine-containing product users presented worse peri-implant parameters compared to non-smokers, while EC users did not show significant differences to NS in many outcomes.Alternative nicotine-containing products are gaining popularity and are often considered less harmful by the general public compared to traditional cigarettes. This is the first network meta-analysis comparing users of four nicotine-containing products and non-smokers. This study shows that CS, WP and ST have a detrimental effect on the overall health of peri-implant tissues. EC users also presented inferior parameters compared to NS, however, the difference was not significant in many outcomes. It is essential to educate patients who are using nicotine-containing products, and to provide proper maintenance and appropriate cessation support. Well-designed multi-armed studies are needed for direct comparison of different products, including heated tobacco products. Greater transparency of confounding factors is needed regarding smoking habit and oral hygiene. LA - English DB - MTMT ER - TY - JOUR AU - Olah, Csilla AU - Kubik, András AU - Mátrai, Péter AU - Engh, Marie Anne AU - Barna, Viktória AU - Hegyi, Péter AU - Reis, Henning AU - Nyirády, Péter AU - Szarvas, Tibor TI - Estimation of the incidence of urachal cancer : A systematic review and meta-analysis of registry-based studies JF - UROLOGIC ONCOLOGY: SEMINARS AND ORIGINAL INVESTIGATIONS J2 - UROL ONCOL SEMIN ORI INV PY - 2024 SN - 1078-1439 DO - 10.1016/j.urolonc.2024.03.011 UR - https://m2.mtmt.hu/api/publication/34801778 ID - 34801778 AB - Urachal cancer (UrC) is a rare disease with limited availability of representative incidence and clinical data. Although, the prevalence is accounting for less than 1% of bladder tumors, the 5-year survival rate is around only 50% for patients with resectable tumors, and even worse for patients with metastatic disease. Due to the lack of comprehensive prospective studies, our current knowledge of UrC is still limited.The present study aimed to summarize the available registry-based studies with unselected UrC patients to evaluate its incidence and clinicopathological characteristics.We conducted a systematic literature search of registry-based UrC publications on the 15th of May 2023 in 5 databases, which identified 4,748 publications. After duplicate removal and selection by 2 independent investigators, 6 publications proved to be appropriate for the final meta-analysis. Estimated incidence and clinicopathological parameters were extracted.Estimated incidence ranged between 0.022 and 0.060/ 100.000 person-years, with the highest occurrence in Japan and the lowest in Canada, while the random effect model calculated an overall incidence rate of 0.04 (95%CI: 0.03-0.05) 100.000 person-years. The median age at first diagnosis was 60 years (range: 58-64). The female to male ratio was 2:3. Lymph node or distant metastases were present in 9% and 14% of patients. The predominant tumour type was adenocarcinoma (86%) followed by urothelial carcinoma (12%) and squamous cell carcinoma (2%). The 5-year survival rate was 51.0% with 95%CI: 45.2-57.4.Our study provides an up-to-date comparison of estimated incidence rates between 6 countries of 3 continents based on rigorously selected registry-based studies. The results suggest low incidence rates for UrC with considerable geographic differences. The present meta-analysis provides unbiased registry-based data on the incidence, clinicopathological parameters and survival of UrC. LA - English DB - MTMT ER -