TY - JOUR AU - Radeleczki, Balázs AU - Nagy, Noémi AU - Percze-Mravcsik, Mariann AU - Szemerédi, Péter AU - Futó, Márton AU - Ware, Lara AU - Fehér, Melinda AU - Klauber, András AU - Cserháti, Péter AU - Laczkó, József AU - Zólyominé Botzheim, Lilla TI - A hibrid FES-kerékpározó terápia szerepe részleges gerincvelősérültek rehabilitációjában – esettanulmány JF - REHABILITÁCIÓ: A MAGYAR REHABILITÁCIÓS TÁRSASÁG FOLYÓIRATA J2 - REHABILITÁCIÓ VL - 34 PY - 2024 IS - 1 SP - 10 EP - 17 PG - 8 SN - 0866-479X UR - https://m2.mtmt.hu/api/publication/34773271 ID - 34773271 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kálovics, Máté AU - Szolgay, Péter AU - Iván, Kristóf AU - Szabó, Zsolt TI - Microwave Resonance Based Lab-on-a-Chip Local Pressure Sensing JF - IEEE SENSORS JOURNAL J2 - IEEE SENS J VL - XX. PY - 2024 SP - 1 EP - 1 PG - 1 SN - 1530-437X DO - 10.1109/JSEN.2024.3368366 UR - https://m2.mtmt.hu/api/publication/34764449 ID - 34764449 LA - English DB - MTMT ER - TY - JOUR AU - Rudner, Tamás AU - Porod, Wolfgang AU - Csaba, György TI - Design of oscillatory neural networks by machine learning JF - FRONTIERS IN NEUROSCIENCE J2 - FRONT NEUROSCI-SWITZ VL - 18 PY - 2024 SN - 1662-4548 DO - 10.3389/fnins.2024.1307525 UR - https://m2.mtmt.hu/api/publication/34764210 ID - 34764210 AB - We demonstrate the utility of machine learning algorithms for the design of oscillatory neural networks (ONNs). After constructing a circuit model of the oscillators in a machine-learning-enabled simulator and performing Backpropagation through time (BPTT) for determining the coupling resistances between the ring oscillators, we demonstrate the design of associative memories and multi-layered ONN classifiers. The machine-learning-designed ONNs show superior performance compared to other design methods (such as Hebbian learning), and they also enable significant simplifications in the circuit topology. We also demonstrate the design of multi-layered ONNs that show superior performance compared to single-layer ones. We argue that machine learning can be a valuable tool to unlock the true computing potential of ONNs hardware. LA - English DB - MTMT ER - TY - JOUR AU - Lippai, Zoltán AU - Péterfia, Bálint AU - Papp, Gergő AU - Dezső, Katalin AU - Bedics, Gábor AU - Pápai, Zsuzsanna AU - Lamers, Meindert H. AU - Kuin, Rosan CM AU - Szuhai, Károly AU - Sápi, Zoltán TI - A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas JF - EUROPEAN JOURNAL OF CANCER J2 - EUR J CANCER VL - 202 PY - 2024 PG - 9 SN - 0959-8049 DO - 10.1016/j.ejca.2024.114005 UR - https://m2.mtmt.hu/api/publication/34763713 ID - 34763713 LA - English DB - MTMT ER - TY - JOUR AU - Jász, Bálint AU - Ambrus, S. AU - Garay, Tamás AU - Schmidt, Péter AU - Hermann, Péter AU - Körmendi, Szandra Katalin AU - Jász, Máté TI - Different methods of determining centric relation – comparison with a digital mandibular motion analyser JF - BMC ORAL HEALTH J2 - BMC ORAL HEALTH VL - 24 PY - 2024 IS - 1 PG - 7 SN - 1472-6831 DO - 10.1186/s12903-024-04131-x UR - https://m2.mtmt.hu/api/publication/34760741 ID - 34760741 LA - English DB - MTMT ER - TY - THES AU - H. Zováthi, Örkény Ádám TI - Advanced Methods for Environment Analysis Based on Lidar Data PY - 2024 SP - 125 UR - https://m2.mtmt.hu/api/publication/34750920 ID - 34750920 LA - English DB - MTMT ER - TY - JOUR AU - Tresóné Takács, Virág AU - Bardóczi, Zsuzsanna AU - Orosz, Áron AU - Major, Ábel AU - Tar, Luca AU - Berki, Péter AU - Papp, Péter AU - Mayer, Márton István AU - Sebők, Hunor AU - Zsolt, Luca AU - Sós, Katalin Eszter AU - Káli, Szabolcs AU - Freund, Tamás AU - Nyíri, Gábor TI - Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons JF - PLOS BIOLOGY J2 - PLOS BIOL VL - 22 PY - 2024 IS - 3 PG - 54 SN - 1544-9173 DO - 10.1371/journal.pbio.3002539 UR - https://m2.mtmt.hu/api/publication/34749015 ID - 34749015 AB - GABAergic inhibitory neurons fundamentally shape the activity and plasticity of cortical circuits. A major subset of these neurons contains somatostatin (SOM); these cells play crucial roles in neuroplasticity, learning, and memory in many brain areas including the hippocampus, and are implicated in several neuropsychiatric diseases and neurodegenerative disorders. Two main types of SOM-containing cells in area CA1 of the hippocampus are oriens-lacunosum-moleculare (OLM) cells and hippocampo-septal (HS) cells. These cell types show many similarities in their soma-dendritic architecture, but they have different axonal targets, display different activity patterns in vivo, and are thought to have distinct network functions. However, a complete understanding of the functional roles of these interneurons requires a precise description of their intrinsic computational properties and their synaptic interactions. In the current study we generated, analyzed, and make available several key data sets that enable a quantitative comparison of various anatomical and physiological properties of OLM and HS cells in mouse. The data set includes detailed scanning electron microscopy (SEM)-based 3D reconstructions of OLM and HS cells along with their excitatory and inhibitory synaptic inputs. Combining this core data set with other anatomical data, patch-clamp electrophysiology, and compartmental modeling, we examined the precise morphological structure, inputs, outputs, and basic physiological properties of these cells. Our results highlight key differences between OLM and HS cells, particularly regarding the density and distribution of their synaptic inputs and mitochondria. For example, we estimated that an OLM cell receives about 8,400, whereas an HS cell about 15,600 synaptic inputs, about 16% of which are GABAergic. Our data and models provide insight into the possible basis of the different functionality of OLM and HS cell types and supply essential information for more detailed functional models of these neurons and the hippocampal network. LA - English DB - MTMT ER - TY - JOUR AU - Csomos, Attila AU - Madarász, Miklós AU - Turczel, Gábor AU - Cseri, Levente AU - Katona, Gergely AU - Rózsa J., Balázs AU - Kovács, Ervin AU - Mucsi, Zoltán TI - A Molecular Hybrid of the GFP Chromophore and 2,2′-Bipyridine: An Accessible Sensor for Zn2+ Detection with Fluorescence Microscopy JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 6 SN - 1661-6596 DO - 10.3390/ijms25063504 UR - https://m2.mtmt.hu/api/publication/34748236 ID - 34748236 N1 - Department of Chemistry, Femtonics Ltd, Tűzoltó utca 59, Budapest, H-1094, Hungary Hevesy György PhD School of Chemistry, Eötvös Loránd University, Pázmány Péter sétány 1/A, Budapest, H-1117, Hungary BrainVisionCenter, Liliom utca 43, Budapest, H-1094, Hungary NMR Research Laboratory, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok körútja 2, Budapest, H-1117, Hungary Department of Organic Chemistry & Technology, Budapest University of Technology & Economics, 3. Muegyetem rakpart, Budapest, H-1111, Hungary Two-Photon Measurement Technology Research Group, Pázmány Péter Catholic University, Práter utca 50/a, Budapest, H-1083, Hungary Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Szigony utca 43, Budapest, H-1083, Hungary Polymer Chemistry and Physics Research Group, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok körútja 2, Budapest, H-1117, Hungary Faculty of Materials and Chemical Sciences, University of Miskolc, Miskolc, H-3515, Hungary Export Date: 12 April 2024 Correspondence Address: Rózsa, B.; BrainVisionCenter, Liliom utca 43, Hungary; email: rozsabal@koki.hu Correspondence Address: Kovács, E.; Two-Photon Measurement Technology Research Group, Práter utca 50/a, Hungary; email: kovacs.ervin@ttk.hu AB - The few commercially available chemosensors and published probes for in vitro Zn2+ detection in two-photon microscopy are compromised by their flawed spectroscopic properties, causing issues in selectivity or challenging multistep syntheses. Herein, we present the development of an effective small molecular GFP chromophore-based fluorescent chemosensor with a 2,2′-bipyridine chelator moiety (GFZnP BIPY) for Zn2+ detection that has straightforward synthesis and uncompromised properties. Detailed experimental characterizations of the free and the zinc-bound compounds within the physiologically relevant pH range are presented. Excellent photophysical characteristics are reported, including a 53-fold fluorescence enhancement with excitation and emission maxima at 422 nm and 492 nm, respectively. A high two-photon cross section of 3.0 GM at 840 nm as well as excellent metal ion selectivity are reported. In vitro experiments on HEK 293 cell culture were carried out using two-photon microscopy to demonstrate the applicability of the novel sensor for zinc bioimaging. LA - English DB - MTMT ER - TY - JOUR AU - Kalivoda, Ágnes AU - Prószéky, Gábor TI - Hungarian auxiliaries revisited JF - ACTA LINGUISTICA ACADEMICA J2 - ACTA LING ACAD PY - 2024 SN - 2559-8201 DO - 10.1556/2062.2023.00701 UR - https://m2.mtmt.hu/api/publication/34738623 ID - 34738623 AB - This paper uses a corpus linguistic approach to investigate finite verbs co-occurring with infinitives. It aims to explore a range of similar verbs along a set of formal-distributional features based on Kálmán C. et al.'s (1989) study. We used hierarchical agglomerative clustering to analyze the data. The analysis identifies four clusters, two comprising verbs more auxiliary-like than the others. The results of this experiment are broadly similar to those of Kálmán C. et al. (1989); however, we also find remarkable differences. Most importantly, the so-called stress-avoiding verbs are likely to occur between the preverb and its associated infinitive, indicating that they are much closer to central auxiliaries than previously assumed. LA - English DB - MTMT ER - TY - JOUR AU - Csomos, Attila AU - Madarász, Miklós AU - Turczel, Gábor AU - Cseri, Levente AU - Bodor, Andrea AU - Anett, Matuscsák AU - Katona, Gergely AU - Kovács, Ervin AU - Rózsa J., Balázs AU - Mucsi, Zoltán TI - A GFP inspired 8-methoxyquinoline-derived fluorescent molecular sensor for the detection of Zn2+ by two-photon microscopy JF - CHEMISTRY-A EUROPEAN JOURNAL J2 - CHEM-EUR J PY - 2024 SN - 0947-6539 DO - 10.1002/chem.202400009 UR - https://m2.mtmt.hu/api/publication/34724516 ID - 34724516 N1 - Export Date: 22 April 2024 CODEN: CEUJE Correspondence Address: Mucsi, Z.; Femtonics Ltd., Tűzoltó utca 59, Hungary; email: zmucsi@femtonics.eu Correspondence Address: Rózsa, B.; BrainVisionCenter, Liliom utca 43–45, Hungary; email: rozsabal@koki.hu Correspondence Address: Kovács, E.; Two-Photon Measurement Technology Research Group, utca 50/a, Hungary; email: kovacs.ervin@ttk.hu AB - An effective, GFP-inspired fluorescent Zn2+ sensor is developed for two-photon microscopy and related biological application that featured an 8-methoxyquinoline moiety. Excellent photophysical characteristics including a 37-fold fluorescence enhancement with excitation and emission maxima at 440 nm and 505 nm, respectively, as well as a high two-photon cross-section of 73 GM at 880 nm are reported. Based on the experimental data, the relationship between the structure and properties was elucidated and explained backed up by DFT calculations, particularly to the observed PeT phenomenon for the turn-on process. Biological validation and detailed experimental and theoretical characterization of the free and the zinc-bound compounds are presented. LA - English DB - MTMT ER -