@article{MTMT:34883229,
	title = {LINE-1 ORF1p is a Promising Biomarker in Cervical Intraepithelial Neoplasia Degree Assessment},
	url = {https://m2.mtmt.hu/api/publication/34883229},
	author = {Karkas, Réka and Abdullah, Khaldoon Sadiq Ahmed and Kaizer, László and Ürmös, A and Raya, May and Tiszlavicz, Lilla Györgyi and Pankotai, Tibor and Nagy, István and Mátés, Lajos and Sükösd, Farkas},
	doi = {10.1097/PGP.0000000000001035},
	journal-iso = {INT J GYNECOL PATHOL},
	journal = {INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY},
	volume = {44},
	unique-id = {34883229},
	issn = {0277-1691},
	abstract = {Cervical intraepithelial neoplasia (CIN) represents a spectrum of preinvasive squamous lesions within the cervical epithelium, whose identification is a diagnostic challenge due to subtle histomorphological differences among its categories. This study explores ORF1p, a nucleic acid-binding protein derived from long interspersed nuclear element-1 (LINE-1), as a potential biomarker for enhancing CIN diagnosis. A comprehensive analysis of 143 cervical specimens, encompassing CIN I (n=20), CIN II (n=46), CIN III (n=14), invasive cancer (n=32), and nondysplastic cases (normal cervical epithelia (n=24) and atrophy (n=7) were conducted. ORF1p, Ki67, and p16 expressions were evaluated using immunohistochemistry. ORF1p immunopositivity was detected in the vast majority [110/112 (98.2%)] of dysplastic and neoplastic (CIN and invasive cancer) specimens, whereas 19/24 (79.2%) of normal cervical specimens lacked ORF1p expression. The observed pattern of ORF1p expression showed a progressively increasing extent and intensity with advancing CIN grades. CIN I exhibited mild ORF1p expression in the lower one or two-thirds of the cervical epithelium [14/16 (87.5%)], whereas CIN II demonstrated moderate to strong ORF1p expression spanning the lower two-thirds [29/46 (63.0%)]. Pronounced transepithelial ORF1p immunopositivity characterized CIN III cases [13/14 (92.8%)] and cervical cancer [30/32 (93.8%)]. These findings propose ORF1p as a valuable indicator even for detecting CIN I, effectively discerning them from normal cervical tissue (p < 0.0001). Our findings underscore the potential of ORF1p as an early diagnostic marker for cervical neoplasia.},
	year = {2025},
	eissn = {1538-7151},
	pages = {22-30},
	orcid-numbers = {Pankotai, Tibor/0000-0001-9810-5465}
}

@mastersthesis{MTMT:35064816,
	title = {Current clinicopathological challenges of lung cancer [A tüdődaganatok aktuális klinikopatológiai kihívásai]},
	url = {https://m2.mtmt.hu/api/publication/35064816},
	author = {Zombori-Tóth, Noémi},
	doi = {10.14232/phd.12169},
	publisher = {Universití of Szeged},
	unique-id = {35064816},
	year = {2025}
}

@article{MTMT:35680190,
	title = {Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance},
	url = {https://m2.mtmt.hu/api/publication/35680190},
	author = {Martins, Ana and Judák, Fanni Orsolya and Farkas, Zoltán and Szili, Petra and Grézal, Gábor and Csörgő, Bálint and Czikkely, Márton Simon and Maharramov, Elvin and Daruka, Lejla and Spohn, Réka and Balogh, Dávid and Daraba, Andreea and Juhász, Szilvia and Vágvölgyi, Máté and Hunyadi, Attila and Cao, Yihui and Sun, Zhenquan and Li, Xuechen and Papp, Balázs and Pál, Csaba},
	doi = {10.1126/scitranslmed.adl2103},
	journal-iso = {SCI TRANSL MED},
	journal = {SCIENCE TRANSLATIONAL MEDICINE},
	volume = {17},
	unique-id = {35680190},
	issn = {1946-6234},
	abstract = {Several antibiotic candidates are in development against Gram-positive bacterial pathogens, but their long-term utility is unclear. To investigate this issue, we studied the laboratory evolution of resistance to antibiotics that have not yet reached the market. We found that, with the exception of compound SCH79797, antibiotic resistance generally readily evolves in Staphylococcus aureus . Cross-resistance was detected between such candidates and antibiotics currently in clinical use, including vancomycin, daptomycin, and the promising antibiotic candidate teixobactin. These patterns were driven by overlapping molecular mechanisms through mutations in regulatory systems. In particular, teixobactin-resistant bacteria displayed clinically relevant multidrug resistance and retained their virulence in an invertebrate infection model, raising concerns. More generally, we demonstrate that putative resistance mutations against candidate antibiotics are already present in natural bacterial populations. Therefore, antibiotic resistance in nature may evolve readily from the selection of preexisting genetic variants. Our work highlights the importance of predicting future evolution of resistance to antibiotic candidates at an early stage of drug development.},
	year = {2025},
	eissn = {1946-6242},
	orcid-numbers = {Martins, Ana/0000-0002-8541-7440; Judák, Fanni Orsolya/0009-0008-5729-1634; Grézal, Gábor/0000-0003-1685-4791; Csörgő, Bálint/0000-0003-0397-6845; Czikkely, Márton Simon/0009-0008-6123-9927; Vágvölgyi, Máté/0000-0002-2233-9422; Hunyadi, Attila/0000-0003-0074-3472; Cao, Yihui/0009-0001-6573-1942; Sun, Zhenquan/0000-0003-0877-9015; Li, Xuechen/0000-0001-5465-7727}
}

@article{MTMT:35685373,
	title = {ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro},
	url = {https://m2.mtmt.hu/api/publication/35685373},
	author = {Daruka, Lejla and Czikkely, Márton Simon and Szili, Petra and Farkas, Zoltán and Balogh, Dávid and Grézal, Gábor and Maharramov, Elvin and Vu, Thu-Hien and Sipos, Levente and Juhász, Szilvia and Dunai, Anett and Daraba, Andreea and Számel, Mónika and Sári, Tóbiás and Stirling, Tamás and Vásárhelyi, Bálint Márk and Ari, Eszter and Christodoulou, Chryso and Manczinger, Máté and Enyedi, Márton Zsolt and Jaksa, Gábor and Kovács, Károly and van Houte, Stineke and Pursey, Elizabeth and Pintér, Lajos and Haracska, Lajos and Kintses, Bálint and Papp, Balázs and Pál, Csaba},
	doi = {10.1038/s41564-024-01891-8},
	journal-iso = {NAT MICROBIOL},
	journal = {NATURE MICROBIOLOGY},
	volume = {10},
	unique-id = {35685373},
	issn = {2058-5276},
	year = {2025},
	eissn = {2058-5276},
	pages = {313-331},
	orcid-numbers = {Czikkely, Márton Simon/0009-0008-6123-9927; Grézal, Gábor/0000-0003-1685-4791; Sipos, Levente/0009-0004-3926-4721; Stirling, Tamás/0000-0002-8964-6443; Vásárhelyi, Bálint Márk/0000-0003-1782-8691; Ari, Eszter/0000-0001-7774-1067; Manczinger, Máté/0000-0003-0831-9617; van Houte, Stineke/0000-0001-7047-1308}
}

@mastersthesis{MTMT:36134328,
	title = {Bridging the gap between experimental and human sepsis: Porcine models for sepsis research with improved clinical relevance [Klinikailag releváns sertésmodell kifejlesztése a kísérletes és humán szepszis közötti eltérések áthidalására]},
	url = {https://m2.mtmt.hu/api/publication/36134328},
	author = {Zsikai, Bettina Ágnes},
	doi = {10.14232/phd.12367},
	publisher = {Universití of Szeged},
	unique-id = {36134328},
	year = {2025}
}

@mastersthesis{MTMT:36134774,
	title = {Effects of goal-directed fluid therapy on microcirculation during human study and animal experiment [A célzott folyadékterápia hatásai a mikrocirkulációra: állat kísérletben és klinikai vizsgálatban]},
	url = {https://m2.mtmt.hu/api/publication/36134774},
	author = {László, Ildikó},
	doi = {10.14232/phd.12358},
	publisher = {Universití of Szeged},
	unique-id = {36134774},
	abstract = {Fluid resuscitation remains one of the cornerstone’s in the management of acute bleeding. According to Starling's “Three-compartment model”, four-times more crystalloids (Cryst) have the same volume-replacement (VR) effect as colloids (Coll). However, this VR ratio remains a controversial issue as it may be affected by the degradation of the endothelial glycocalyx layer (GX), a situation often found in the critically ill. On the other hand, macro- and microcirculatory effects of solutions are difficult to compare, because the endpoints of resuscitation seldom based on similar criteria. Our aims were: (1) to compare the effects of Coll and Cryst based fluid resuscitation during an experimental stroke volume index (SVI) guided haemorrhage and resuscitation animal model; (2) to investigate the effects of Cryst and Coll’s on the microcirculation during free flap surgery when management was guided by detailed haemodynamic assessment. In our animal experiment, anesthetized and mechanically ventilated pigs were randomised to receive Coll or Cryst infusion. Animals were bled until baseline SVI (Tbsl) dropped by 50% (T0), followed by resuscitation until initial SVI was reached (T4) in four steps. In our clinical trial patients undergoing maxillofacial tumour resection and free flap reconstruction were randomised into groups treated with either intra-operative Cryst or Coll solutions. In the animal experiment, hemodynamic changes and GX degradation products serum levels followed similar pattern without significant difference between the groups. Animals received significantly less resuscitation fluid in the Coll as compared to the Cryst-group. In the clinical trial there was no difference between the groups regarding patient characteristics. Both groups remained haemodynamically stable throughout, but patients in the Cryst group required approximately 1.5 times more total fluid volume than in the Coll group. There was no significant difference in the microcirculatory blood flow between the groups as indicated by laser-Doppler flowmetry. We concluded that: (1) volume-replacement ratio for solutions follows the Starling's principle when the GX is intact, and (2) when fluid management is guided by detailed haemodynamic assessment there was no difference between the effects of solutions on the microcirculation, hence it may not be the type of the fluid, but the appropriate VR caused haemodynamic stability and perfusion that is responsible for microcirculatory blood flow.},
	year = {2025}
}

@mastersthesis{MTMT:36136239,
	title = {Temporal changes of the microcirculatory-mitochondrial functions in experimental rodent sepsis [A mikrokeringési és mitokondriális funkciók időbeli változásainak vizsgálata kísérletes rágcsáló szepszis modellben]},
	url = {https://m2.mtmt.hu/api/publication/36136239},
	author = {Fejes, Roland},
	doi = {10.14232/phd.12377},
	publisher = {Universití of Szeged},
	unique-id = {36136239},
	year = {2025}
}

@mastersthesis{MTMT:36137015,
	title = {The role of preserved spontaneous breathing during thoracic surgery [A megtartott spontán légzés szerepe mellkassebészeti beavatkozások során]},
	url = {https://m2.mtmt.hu/api/publication/36137015},
	author = {Fabó, Csongor},
	doi = {10.14232/phd.11975},
	publisher = {Universití of Szeged},
	unique-id = {36137015},
	year = {2025}
}

@mastersthesis{MTMT:36137071,
	title = {Clinical and genetic analysis of rare ion channel diseases [Ritka ioncsatorna betegségek klinikai és genetikai elemzése]},
	url = {https://m2.mtmt.hu/api/publication/36137071},
	author = {Borbás, János},
	doi = {10.14232/phd.12255},
	publisher = {Universití of Szeged},
	unique-id = {36137071},
	year = {2025}
}

@mastersthesis{MTMT:36137111,
	title = {Investigation of potential tocolytic combinations of terbutaline with magnesium sulfate and sildenafil in pregnant rat model [A terbutalin magnézium-szulfáttal és szildenafillal történő vizsgálata patkánymodellen, mint új, potenciális tokolitikus kombinációk]},
	url = {https://m2.mtmt.hu/api/publication/36137111},
	author = {Barna, Tamara},
	doi = {10.14232/phd.12225},
	publisher = {Universití of Szeged},
	unique-id = {36137111},
	year = {2025}
}