TY - JOUR AU - Venditti, P AU - Zhang, Y AU - Radák, Zsolt AU - Magalhaes, J TI - Exercise in the Prevention and Management of Oxidative Stress-Linked Diseases JF - OXIDATIVE MEDICINE AND CELLULAR LONGEVITY J2 - OXID MED CELL LONGEV PY - 2018 PG - 2 SN - 1942-0900 DO - 10.1155/2018/7643721 UR - https://m2.mtmt.hu/api/publication/3380328 ID - 3380328 LA - English DB - MTMT ER - TY - JOUR AU - Négyesi, János AU - Váczi, Márk AU - Magyar, Olivér Mátyás AU - Pantovic, Milan AU - Tihanyi, József AU - Rácz, Levente TI - Adaptation mechanisms of the knee extensors contractile properties in response to short-term stretch-shortening exercise training JF - ISOKINETICS AND EXERCISE SCIENCE J2 - ISOKINET EXERC SCI VL - 25 PY - 2017 IS - 1 SP - 65 EP - 72 PG - 8 SN - 0959-3020 DO - 10.3233/IES-160646 UR - https://m2.mtmt.hu/api/publication/3207798 ID - 3207798 N1 - Department of Biomechanics, Kinesiology and Informatics, University of Physical Education, Alkotás 44, Budapest, 1123, Hungary Fájdalom Ambulancia, Budapest, Hungary Institute of Sport Sciences and Physical Education, University of Pécs, Pécs, Hungary Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia Research Institute of Sport Science, University of Physical Education, Budapest, Hungary Export Date: 4 June 2023 CODEN: IESCE Correspondence Address: Négyesi, J.; Department of Biomechanics, Alkotás 44, Hungary; email: j.negyesi88@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Radák, Zsolt AU - Suzuki, K AU - Higuchi, M AU - Balogh, László AU - Boldogh, I AU - Koltai, Erika TI - Physical exercise, reactive oxygen species and neuroprotection JF - FREE RADICAL BIOLOGY AND MEDICINE J2 - FREE RADICAL BIO MED VL - 98 PY - 2016 SP - 187 EP - 196 PG - 10 SN - 0891-5849 DO - 10.1016/j.freeradbiomed.2016.01.024 UR - https://m2.mtmt.hu/api/publication/3031729 ID - 3031729 AB - Regular exercise has systemic beneficial effects, including the promotion of brain function. The adaptive response to regular exercise involves the up-regulation of the enzymatic antioxidant system and modulation of oxidative damage. Reactive oxygen species (ROS) are important regulators of cell signaling. Exercise, via intensity-dependent modulation of metabolism and/or directly activated ROS generating enzymes, regulates the cellular redox state of the brain. ROS are also involved in the self-renewal and differentiation of neuronal stem cells and the exercise-mediated neurogenesis could be partly associated with ROS production. Exercise has strong effects on the immune system and readily alters the production of cytokines. Certain cytokines, especially IL-6, IL-1, TNF-alpha, IL-18 and IFN gamma, are actively involved in the modulation of synaptic plasticity and neurogenesis. Cytokines can also contribute to ROS production. ROS-mediated alteration of lipids, protein, and DNA could directly affect brain function, while exercise modulates the accumulation of oxidative damage. Oxidative alteration of macromolecules can activate signaling processes, membrane remodeling, and gene transcription. The well known neuroprotective effects of exercise are partly due to redox-associated adaptation. LA - English DB - MTMT ER - TY - JOUR AU - Powers, SK AU - Radák, Zsolt AU - Ji, LL TI - Exercise-induced oxidative stress: past, present and future JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 594 PY - 2016 IS - 18 SP - 5081 EP - 5092 PG - 12 SN - 0022-3751 DO - 10.1113/JP270646 UR - https://m2.mtmt.hu/api/publication/3031728 ID - 3031728 AB - The existence of free radicals in living cells was first reported in 1954 and this important finding helped launch the field of free radical biology. However, the discovery that muscular exercise is associated with increased biomarkers of oxidative stress did not occur until 1978. Following the initial report that exercise promotes oxidative stress in humans, many studies have confirmed that prolonged or short-duration high intensity exercise results in increased radical production in active skeletal muscles resulting in the formation of oxidized lipids and proteins in the working muscles. Since these early descriptive studies, the investigation of radicals and redox biology related to exercise and skeletal muscle has grown as a discipline and the importance of this research in the biomedical sciences is widely recognized. This review will briefly summarize the history of research in exercise-induced oxidative stress and will discuss the major paradigm shifts that the field has undergone and continues to experience. We conclude with a discussion of future directions in the hope of stimulating additional research in this important field. LA - English DB - MTMT ER - TY - CHAP AU - Radák, Zsolt TI - Posttranslational modification of proteins T2 - Physical Activity, Exercise, Sedentary Behavior and Health PB - Springer Japan SN - 9784431553335 PY - 2015 SP - 165 EP - 169 PG - 5 DO - 10.1007/978-4-431-55333-5_14 UR - https://m2.mtmt.hu/api/publication/25972590 ID - 25972590 LA - English DB - MTMT ER - TY - JOUR AU - Felszeghy, Klára AU - Pósa, Anikó AU - Varga, Csaba AU - Nyakas, Csaba TI - Interaction between high vs. low calorie intake and physical exercise on cognition in rats JF - OBESITOLOGIA HUNGARICA J2 - OBESIT HUNG VL - 14 PY - 2015 IS - S2 SP - 42 EP - 43 PG - 2 SN - 1586-7935 UR - https://m2.mtmt.hu/api/publication/3090079 ID - 3090079 LA - English DB - MTMT ER - TY - CHAP AU - Dobák, Z AU - Kovács, P AU - Nyakas, Csaba ED - Borbély, Attila ED - Hamar, Pál ED - Kotányi, Magdolna TI - A hazai és nemzetközi labdarúgó játékosok sporttáplálkozása napjainkban T2 - Színes sporttudomány PB - Debreceni Campus Nonprofit Közhasznú Kft. CY - Debrecen SN - 9789639822382 PY - 2015 SP - 156 EP - 160 PG - 5 UR - https://m2.mtmt.hu/api/publication/3060597 ID - 3060597 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Suwa, M AU - Nakano, H AU - Radák, Zsolt AU - Kumagai, S TI - Effects of nitric oxide synthase inhibition on fiber-type composition, mitochondrial biogenesis, and SIRT1 expression in rat skeletal muscle JF - JOURNAL OF SPORTS SCIENCE AND MEDICINE J2 - J SPORT SCI MED VL - 14 PY - 2015 IS - 3 SP - 548 EP - 555 PG - 8 SN - 1303-2968 UR - https://m2.mtmt.hu/api/publication/2990840 ID - 2990840 AB - It was hypothesized that nitric oxide synthases (NOS) regulated SIRT1 expression and lead to a corresponding changes of contractile and metabolic properties in skeletal muscle. The purpose of the present study was to investigate the influence of long-term inhibition of nitric oxide synthases (NOS) on the fiber-type composition, metabolic regulators such as and silent information regulator of transcription 1 (SIRT1) and peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha), and components of mitochondrial biogenesis in the soleus and plantaris muscles of rats. Rats were assigned to two groups: control and NOS inhibitor (N (omega)-nitro-L-arginine methyl ester hydrochloride (L-NAME), ingested for 8 weeks in drinking water)-treated groups. The percentage of Type I fibers in the L-NAME group was significantly lower than that in the control group, and the percentage of Type IIA fibers was concomitantly higher in soleus muscle. In plantaris muscle, muscle fiber composition was not altered by L-NAME treatment. L-NAME treatment decreased the cytochrome C protein expression and activity of mitochondrial oxidative enzymes in the plantaris muscle but not in soleus muscle. NOS inhibition reduced the SIRT1 protein expression level in both the soleus and plantaris muscles, whereas it did not affect the PGC-1alpha protein expression. L-NAME treatment also reduced the glucose transporter 4 protein expression in both muscles. These results suggest that NOS plays a role in maintaining SIRT1 protein expression, muscle fiber composition and components of mitochondrial biogenesis in skeletal muscle. Key pointsNOS inhibition by L-NAME treatment decreased the SIRT1 protein expression in skeletal muscle.NOS inhibition induced the Type I to Type IIA fiber type transformation in soleus muscle.NOS inhibition reduced the components of mitochondrial biogenesis and glucose metabolism in skeletal muscle. LA - English DB - MTMT ER - TY - JOUR AU - Téglás, Tímea AU - Bretz, Károly AU - Nyakas, Csaba TI - Egy passzív testedzési forma, a pulzáló elektromágneses terápia (EMF) hatásai idős patkányokban JF - MAGYAR SPORTTUDOMÁNYI SZEMLE J2 - M SPORTTUD SZLE VL - 16 PY - 2015 IS - 2 (62) SP - 68 SN - 1586-5428 UR - https://m2.mtmt.hu/api/publication/2919751 ID - 2919751 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Felszeghy, Klára AU - Pósa, Anikó AU - Varga, Csaba AU - Nyakas, Csaba TI - Magas illetve csökkentett kalória-tartalmú táplálék és az önkéntes fizikai tréning kölcsönhatása a kognitív teljesítményre patkányban JF - MAGYAR SPORTTUDOMÁNYI SZEMLE J2 - M SPORTTUD SZLE VL - 16 PY - 2015 IS - 2 (62) SP - 30 SN - 1586-5428 UR - https://m2.mtmt.hu/api/publication/2908128 ID - 2908128 LA - Hungarian DB - MTMT ER -