@inproceedings{MTMT:33645223, title = {Novel Copper Complexes with Glyoximes, Amines, Schiff Bases, Semi- and Thiosemicarbazones; Synthesis and Physico-Chemical Analysis}, url = {https://m2.mtmt.hu/api/publication/33645223}, author = {Várhelyi, Csaba, ifj. and Szalay, Roland and Pokol, György and Madarász, János and Szilágyi, Imre Miklós and Huszthy, Péter and Simon-Várhelyi, Melinda and Tötös, Róbert and RALUCA-ANCA, MEREU and ALEXANDRA, AVRAM and Korecz, László and May, Nóra Veronika and Mihály, Judith}, booktitle = {Proceedings of the 28th International Symposium on Analytical and Environmental Problems}, unique-id = {33645223}, year = {2022}, pages = {46-50}, orcid-numbers = {Szalay, Roland/0000-0003-3535-5365; Pokol, György/0000-0003-1597-9808; Huszthy, Péter/0000-0001-7305-3312; May, Nóra Veronika/0000-0003-4770-4681} } @CONFERENCE{MTMT:33645214, title = {Glioximokkal, aminokkal, bórsav-észterekkel és Schiff-bázisokkal képzett új vas(II)-komplexek fizikai-kémiai elemzése, és biológiai tulajdonságainak vizsgálata (Novel Iron(II) Complexes with Glyoximes, Amines, Borate Esters and Schiff-Bases, their Physico-Chemical Analysis and Biological Properties Study)}, url = {https://m2.mtmt.hu/api/publication/33645214}, author = {Várhelyi, Csaba, ifj. and Szalay, Roland and Kuzmann, Ernő and Homonnay, Zoltán and Pokol, György and Madarász, János and PAPP, JUDIT and MEREU, RALUCA-ANCA and Huszthy, Péter and Simon-Várhelyi, Melinda and AVRAM, ALEXANDRA and Mihály, Judith}, booktitle = {XXVIII. Nemzetközi Vegyészkonferencia = 28th International Conference on Chemistry}, unique-id = {33645214}, year = {2022}, pages = {44-44}, orcid-numbers = {Szalay, Roland/0000-0003-3535-5365; Kuzmann, Ernő/0000-0002-0183-6649; Homonnay, Zoltán/0000-0001-5299-5394; Pokol, György/0000-0003-1597-9808; Huszthy, Péter/0000-0001-7305-3312} } @article{MTMT:33644922, title = {Platina-komplexek szintézise aminokkal, alfa-dioximokkal, Schiff-bázisokkal, valamint fizikai-kémiai és biológiai sajátosságainak vizsgálata (Platinum Complexes Synthesis with Amines, alpha-dioximes, Schiff bases and their Physical-Chemical and Biological Study)}, url = {https://m2.mtmt.hu/api/publication/33644922}, author = {Várhelyi, Csaba, ifj. and Pokol, György and Szalay, Roland and F., GOGA and Simon-Várhelyi, Melinda and L.-M., GOLBAN and A., BOGDAN and Huszthy, Péter and Madarász, János and J., PAPP and J.-N., BÁLINT-TROMBITÁS and Mihály, Judith}, journal-iso = {ACTA SCI TRANSYLVANICA}, journal = {ACTA SCIENTIARUM TRANSYLVANICA - MÚZEUMI FÜZETEK (2006-)}, volume = {28 (2020)}, unique-id = {33644922}, issn = {1842-5070}, year = {2022}, pages = {5-18}, orcid-numbers = {Pokol, György/0000-0003-1597-9808; Szalay, Roland/0000-0003-3535-5365; Huszthy, Péter/0000-0001-7305-3312} } @article{MTMT:33077292, title = {Diverging enantiopreferences: insights into the phenylalanine aminomutase mechanism and evolution}, url = {https://m2.mtmt.hu/api/publication/33077292}, author = {Molnár, Zsófia Klára and Poppe, László and Vértessy, Beáta (Grolmuszné)}, journal-iso = {FEBS OPEN BIO}, journal = {FEBS OPEN BIO}, volume = {12}, unique-id = {33077292}, issn = {2211-5463}, year = {2022}, eissn = {2211-5463}, pages = {245-246}, orcid-numbers = {Poppe, László/0000-0002-8358-1378} } @article{MTMT:32561115, title = {Mössbauer study of some novel iron-bis-glyoxime and iron-tris-glyoxime complexes}, url = {https://m2.mtmt.hu/api/publication/32561115}, author = {Várhelyi, Csaba, ifj. and Homonnay, Zoltán and Szalay, Roland and Pokol, György and Szilágyi, Imre Miklós and Huszthy, Péter and KUBUKI, Shiro and GOGA, Firuța and Tötös, Róbert and Simon-Várhelyi, Melinda and Kuzmann, Ernő}, doi = {10.1007/s10751-021-01738-2}, journal-iso = {HYPERFINE INTERACT}, journal = {HYPERFINE INTERACTIONS}, volume = {243}, unique-id = {32561115}, issn = {0304-3843}, abstract = {Dioximes as ligands are used as analytical reagents and serve as models for biological systems as well as catalysts in chemical processes. A number of novel mixed complexes of the type [Fe(DioxH)2(amine)2] have been prepared and characterised by FTIR, 57Fe Mössbauer and mass spectroscopy by us. We have found strong Fe–N donor acceptor interactions and iron occurred in low-spin FeII state in all complexes. Later, we have also found that the incorporation of branching alkyl chains (isopropyl) in the complexes alters the Fe–N bond length and results in high-spin iron(II) state [1, 2]. The question arises: can the spin state of iron be manipulated generally by replacing the short alkyl chains with high volume demand ones in Fe-azomethine-amine complexes? To answer the question we have synthetized novel iron-bis-glioxime and iron-tris-gloxime complexes when long chain alkyl or aromatic ligands replaced the short alkyl ones and studied by 57Fe Mössbauer spectroscopy, MS, FTIR, UV-VIS, TG-DTA-DTG and XRD methods. Novel iron-bis-glyoxime and iron-tris-glyoxime type complexes, [Fe(Diethyl-Diox)3(BOH)2], [Fe(Diethyl-Diox)3(BOEt)2] and [Fe(phenyl-Me-Diox)3(BOEt)2], were synthesized similarly as described in [2]. The FTIR, UV-VIS, TG-DTA-DTG and MS measurements indicated that the expected novel complexes could be successfully synthesized.}, year = {2022}, eissn = {1572-9540}, orcid-numbers = {Homonnay, Zoltán/0000-0001-5299-5394; Szalay, Roland/0000-0003-3535-5365; Pokol, György/0000-0003-1597-9808; Huszthy, Péter/0000-0001-7305-3312; Kuzmann, Ernő/0000-0002-0183-6649} } @inproceedings{MTMT:32761176, title = {Novel Iron Complexes with Gglyoximes, Schiff Bases and Boric Acid Derivatives: Synthesis, Physico-Chemical Analysis and Biological Study}, url = {https://m2.mtmt.hu/api/publication/32761176}, author = {Várhelyi, Csaba, ifj. and Kuzmann, Ernő and Homonnay, Zoltán and Szalay, Roland and Pokol, György and FIRUŢA, GOGA and Huszthy, Péter and PAPP, JUDIT and Simon-Várhelyi, Melinda and Tötös, Róbert and AVRAM, ALEXANDRA}, booktitle = {Proceedings of the 27th International Symposium on Analytical and Environmental Problems}, unique-id = {32761176}, abstract = {Iron(II) clathrochelate complexes obtained with glyoximes are macrobicyclic ligand systems, which completely encapsulate the metal ion, and are formed under mild conditions with high yields. In particular, the riblike-functionalized clatrochelates both with the inherent and with the terminal closo-borate substituents synthesized recently have been proposed as new radiopharmaceuticals for boron neutron capture therapy of cancer. In our research work new iron(II) complexes were synthesized with alpha-glyoximes, boric acid derivatives, amines, Schiff bases, such as [Fe(Me-Pr-Glyox)3(BO–Et)2], [Fe(Et-Bu-Glyox)3(BO–R)2] (R = methyl, propyl, butyl), [Fe(phenyl-Me-GlyoxH)2(amine)2], [Fe(Et-Bu-GlyoxH)2(amine)2], [Fe(2-heptanone)2(en)(amine)2], where GlyoxH, Glyox = mono- or bi-deprotonated glyoxime, en = ethylenediamine and the used amines: dibutylamine, 3-picoline, 4-aminopyridine, 6-amino-3-picoline, 3-amino-1-propanol, imidazole, 2-aminopyrimidine, 3-methylpiperidine, 3-amino-1H-1,2,4-triazole. For preparation ironII-sulfate was dissolved in water and mixed with alcoholic solution of the glyoxime, then the corresponding amines and the other complexing agents were added. The mixture so obtained was refluxed under inert atmosphere. The molecular structures of our products were studied by IR, Mössbauer and UV–VIS spectroscopies, mass spectrometry (MS) and thermoanalytical measurements (TG-DTG-DTA). The biological activity, like antimicrobial effect, was studied for a few bacteria.}, year = {2021}, pages = {61-66}, orcid-numbers = {Kuzmann, Ernő/0000-0002-0183-6649; Homonnay, Zoltán/0000-0001-5299-5394; Szalay, Roland/0000-0003-3535-5365; Pokol, György/0000-0003-1597-9808; Huszthy, Péter/0000-0001-7305-3312} } @CONFERENCE{MTMT:32761146, title = {Réz-komplexek glioximokkal, Schiff-bázisokkal, szemi- és tioszemi-karbazonokkal, valamint fizikai-kémiai és biológiai vizsgálatuk (Copper Complexes with Glyoximes, Schiff Bases, Semi- and Thiosemicarbazones, and their Physical-Chemical and Biological Study)}, url = {https://m2.mtmt.hu/api/publication/32761146}, author = {Várhelyi, Csaba, ifj. and Korecz, László and Pokol, György and Szalay, Roland and GOGA, FIRUŢA and Simon-Várhelyi, Melinda and Tötös, Róbert and Huszthy, Péter and Madarász, János and PAPP, JUDIT and Mihály, Judith}, booktitle = {EME – A Magyar Tudomány Napja Erdélyben, 20. fórum, ÉRTÉKTEREMTŐ TUDOMÁNY - Természettudományi szakosztály}, unique-id = {32761146}, abstract = {Kutatásunk során a következő típusú réz(II)-komplexeket állítottuk elő glioximokkal, aminokkal, Schiff-bázisokkal, valamint szemi (SC)- és tioszemikarbazonokkal (TSC): [Cu(GlioxH)2(amin)2], [Cu(2-heptanon)2A], [Cu(2-heptanon)2A(amin)2], [Cu(2-heptanon-SC)2], [Cu(2-heptanon-TSC)2], ahol GlioxH2: etil-butil-glioxim, metil-butil-glioxim, fenil-metil-glioxim; amin: dibutil-amin, 6-amino-3-pikolin, 1-amino-pentán, difenil-amin, 3-metil-piperidin, 3-pikolin, 3-aminofenol, diizopropil-amin, 2-pikolin, 3-amino-1,2,4-triazol, imidazol; A: 1,2-diaminoetán, 1,2- és 1,3-diaminopropán, o-fenilén-diamin. A felhasználási lehetőségek bemutatása után tárgyaljuk komplexeink kémiai és biológiai sajátosságait, szerkezetét FTIR, ESR, UV-VIS spektroszkópiai, valamint termoanalitikai (TG, DTA, DTG), tömegspektrometriai és por-röntgen diffrakciós (XRD) módszerek segítségével. A réz-komplexeket széles körben tanulmányozzák potenciális antibakteriális, maláriaellenes és gombaellenes hatásuk szempontjából. Számos képviselőjük az Alzheimer- és Parkinson-kór, valamint cél-specifikus újgenerációs rákellenes és gyulladáscsökkentő gyógyszerek.}, year = {2021}, pages = {28-30}, orcid-numbers = {Pokol, György/0000-0003-1597-9808; Szalay, Roland/0000-0003-3535-5365; Huszthy, Péter/0000-0001-7305-3312} } @CONFERENCE{MTMT:32760654, title = {Etil-propil-glioxim halogenidekkel, aziddal és aminokkal képzett új kobalt(III)-komplexeinek fizikai-kémiai elemzése, és biológiai tulajdonságainak vizsgálata (Novel Cobalt(III) Complexes with Ethyl-Propyl-Glyoxime, Halides, Azide and Amines, their Physico-Chemical Analysis and Biological Properties Study)}, url = {https://m2.mtmt.hu/api/publication/32760654}, author = {Várhelyi, Csaba, ifj. and Szalay, Roland and Pokol, György and Madarász, János and Mihály, Judith and PAPP, JUDIT and GOGA, FIRUŢA and Huszthy, Péter and Simon-Várhelyi, Melinda and AVRAM, ALEXANDRA}, booktitle = {XXVII. Nemzetközi Vegyészkonferencia / 27th International Conference on Chemistry}, unique-id = {32760654}, abstract = {Az utóbbi időben egyre nagyobb az érdeklődés az átmenetifém-komplex katalizátorok iránt, amelyek szerves vegyületeket oxidálnak. Ezen túlmenően a kobalt-komplexek nagy jelentőséggel bírnak a rákkutatás területén is. Kobalt-komplexek segítségével olyan gyógyszereket fejlesztettek ki, amelyeken hipoxiás körülmények között szelektíven redukció megy végbe Co(II) formába, ami kiváltja a gyógyszer aktív formáját. Ezen kívül antimikrobás szerekként is használatosak. Kutatásaink célja etil-propil-glioximmal képzett [Co(Et-Pr-Gliox.H)2(X)(amin)] típusú kobalt(III)-komplexek előállítása különböző aminokkal, halogenidekkel és aziddal (X: Br, I, N3, amin: 2,2’-bipiridil, imidazol, 2-brómpiridin, 4-klóranilin, 1H-1,2,4-triazol-amin, 3-pikolin, 4-amino-piridin, 2-amino-pirimidin). A felhasználási lehetőségek bemutatása után tárgyaljuk a komplexek szerkezetét FTIR-, NMR-, UV-VIS-spektroszkópiai, valamint termoanalitikai (TG, DTA, DTG), tömegspektrometriai és por-röntgen diffrakciós (XRD) módszerekkel jellemezve. Tanulmányoztuk komplexeink antibakteriális hatását is különböző baktérium-törzsekre.}, year = {2021}, pages = {57-57}, orcid-numbers = {Szalay, Roland/0000-0003-3535-5365; Pokol, György/0000-0003-1597-9808; Huszthy, Péter/0000-0001-7305-3312} } @article{MTMT:2888122, title = {New synthesis of naratriptan}, url = {https://m2.mtmt.hu/api/publication/2888122}, author = {Poszávácz, László and Simig, Gyula and Fetter, József and Bertha, Ferenc}, doi = {10.3987/COM-06-10670}, journal-iso = {HETEROCYCLES}, journal = {HETEROCYCLES}, volume = {68}, unique-id = {2888122}, issn = {0385-5414}, abstract = {A new synthesis of N-methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide (naratriptan, 1a) has been elaborated starting from 1-benzyl-1H-indole-5-carbaldehyde (14b). The 1-benzyl group proved to be an advantageous protecting group in the course of the construction of the ethanesulfonamide and methylpipieridinyl side-chains and it was removed in the last step of the synthesis.}, year = {2006}, eissn = {1881-0942}, pages = {713-719}, orcid-numbers = {Simig, Gyula/0000-0002-2569-6476} } @inproceedings{MTMT:2668317, title = {Furo[2,3-f]izokinolinok egyszerű szintézise}, url = {https://m2.mtmt.hu/api/publication/2668317}, author = {Mészárosné Tőrincsi, Mercédesz and Kolonits, Pál and Pálosi, Endre and Novák, Lajos}, booktitle = {XII. Nemzetközi Vegyészkonferencia = Proceedings of 12th International Conference of Chemistry}, unique-id = {2668317}, year = {2006}, pages = {83} }