TY - JOUR AU - Bunda, Szilvia AU - Kálmán-Szabó, Ibolya AU - Lihi, Norbert AU - Képes, Zita AU - Szikra, Dezső AU - Péliné Szabó, Judit AU - Timári, István AU - Szücs, Dániel AU - May, Nóra Veronika AU - Papp, Gábor Csaba AU - Trencsényi, György AU - Kálmán, Ferenc Krisztián TI - Diagnosis of Melanoma with 61 Cu-Labeled PET Tracer JF - JOURNAL OF MEDICINAL CHEMISTRY J2 - J MED CHEM PY - 2024 SN - 0022-2623 DO - 10.1021/acs.jmedchem.4c00479 UR - https://m2.mtmt.hu/api/publication/34861986 ID - 34861986 LA - English DB - MTMT ER - TY - JOUR AU - Kastal, Zsuzsa AU - Balabán, Adrienn AU - Vida, Szilvia AU - Kállay, Csilla AU - Nagy, Lajos AU - Várnagy, Katalin AU - Sóvágó, Imre TI - Copper(II), Nickel(II) and Zinc(II) Complexes of Peptide Fragments of Tau Protein JF - MOLECULES J2 - MOLECULES VL - 29 PY - 2024 IS - 10 PG - 18 SN - 1420-3049 DO - 10.3390/molecules29102171 UR - https://m2.mtmt.hu/api/publication/34860740 ID - 34860740 AB - Copper(II), nickel(II) and zinc(II) complexes of various peptide fragments of tau protein were studied by potentiometric and spectroscopic techniques. All peptides contained one histidyl residue and represented the sequences of tau(91–97) (Ac-AQPHTEI-NH2), tau(385–390) (Ac-KTDHGA-NH2) and tau(404–409) (Ac-SPRHLS-NH2). Imidazole-N donors of histidine were the primary metal binding sites for all peptides and all metal ions, but in the case of copper(II) and nickel(II), the deprotonated amide groups were also involved in metal binding by increasing pH. The most stable complexes were formed with copper(II) ions, but the presence of prolyl residues resulted in significant changes in the thermodynamic stability and speciation of the systems. It was also demonstrated that nickel(II) and especially zinc(II) complexes have relatively low thermodynamic stability with these peptides. The copper(II)-catalyzed oxidation of the peptides was also studied. In the presence of H2O2, the fragmentation of peptides was detected in all cases. In the simultaneous presence of H2O2 and ascorbic acid, the fragmentation of the peptide is less preferred, and the formation of 2-oxo-histidine also occurs. LA - English DB - MTMT ER - TY - JOUR AU - Vishwakarma, Gayatri AU - Andrási, Melinda AU - Szabó, Dávid Ruben AU - Hajdu, Péter Béla AU - Petrilla, Vladimir AU - Petrillová, Monika AU - Legath, Jaroslav AU - Gáspár, Attila TI - Analysis of intact venom proteins with capillary zone electrophoresis - mass spectrometry JF - MICROCHEMICAL JOURNAL J2 - MICROCHEM J VL - 200 PY - 2024 PG - 8 SN - 0026-265X DO - 10.1016/j.microc.2024.110290 UR - https://m2.mtmt.hu/api/publication/34774200 ID - 34774200 N1 - Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem ter 1., Debrecen, 4032, Hungary Department of Dental Biochemistry and Department of Biophysics and Cell Biology, University of Debrecen, Egyetem tér 1., Debrecen, 4032, Hungary Department of Biology and Physiology, University of Veterinary Medicine and Pharmacy, Košice, Slovakia Zoological Department, Zoological Garden Košice, Košice-Kavečany, Slovakia Department of General Competencies, University of Veterinary Medicine and Pharmacy, Košice, Slovakia Department of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy, Košice, Slovakia Department of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, Rzeszow, Poland Export Date: 6 April 2024 CODEN: MICJA Correspondence Address: Gaspar, A.; Department of Inorganic and Analytical Chemistry, Egyetem ter 1., Hungary; email: gaspar@science.unideb.hu Funding details: Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K142134, K128525, 2022_526066, APVV - 22-0101 Funding text 1: The authors acknowledge the financial support provided for this project by the National Research, Development and Innovation Office, Hungary (K142134 (AG), K128525 (HP)), Stipendium Hungaricum (#2022_526066) and by the project APVV-22-0101 (Slovak Research and Development Agency Departmental Organization of the Ministry of Education, Science, Research and Sports of the Slovak Republic). LA - English DB - MTMT ER - TY - JOUR AU - Ecsédi, Bertold AU - Forgács, Attila AU - Balogh, Zoltán AU - Fábián, István AU - Kalmár, József TI - Hydration and wetting mechanism of borosilicate – Polyvinyl alcohol (PVA) hybrid aerogels of potential bioactivity JF - JOURNAL OF MOLECULAR LIQUIDS J2 - J MOL LIQ VL - 401 PY - 2024 PG - 8 SN - 0167-7322 DO - 10.1016/j.molliq.2024.124605 UR - https://m2.mtmt.hu/api/publication/34763386 ID - 34763386 LA - English DB - MTMT ER - TY - JOUR AU - Simon, Fruzsina AU - Fábián, István AU - Szabó, Mária TI - Oxidation of branched chain amino acids by HOCl: kinetics and mechanism JF - JOURNAL OF HAZARDOUS MATERIALS J2 - J HAZARD MATER VL - 470 PY - 2024 SN - 0304-3894 DO - 10.1016/j.jhazmat.2024.134145 UR - https://m2.mtmt.hu/api/publication/34763028 ID - 34763028 N1 - Department of Inorganic and Analytical Chemistry, University of Debrecen, Debrecen, Hungary HUN-REN-UD Mechanisms of Complex Homogeneous and Heterogeneous Chemical, Reactions Research Group, University of Debrecen, Debrecen, Hungary Export Date: 8 May 2024 CODEN: JHMAD Correspondence Address: Szabó, M.; Department of Inorganic and Analytical Chemistry, Hungary; email: szabo.maria@science.unideb.hu Funding details: Debreceni Egyetem, DE Funding details: OTKA-139140 Funding text 1: This study was supported by the National Research, Development and Innovation Found of Hungary under grant number OTKA-139140 and by the University of Debrecen Program for Scientific Publication. LA - English DB - MTMT ER - TY - JOUR AU - Dibello, Estefanía AU - Oddone, Natalia AU - Franco, Jaime AU - Tóthné Illyés, Tünde Zita AU - Medeiros, Andrea AU - Kiss, Attila AU - Hőgye, Fanni AU - E Kövér, Katalin AU - Szilágyi, László AU - Comini, Marcelo A. TI - Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity JF - INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE J2 - INT J PARASITOL-DRUG VL - 24 PY - 2024 PG - 6 SN - 2211-3207 DO - 10.1016/j.ijpddr.2024.100529 UR - https://m2.mtmt.hu/api/publication/34743720 ID - 34743720 AB - Earlier evidences showed that diglycosyl diselenides are active against the infective stage of African trypanosomes (top hits IC50 0.5 and 1.5 μM) but poorly selective (selectivity index <10). Here we extended the study to 33 new seleno-glycoconjugates with the aim to improve potency and selectivity. Three selenoglycosides and three glycosyl selenenylsulfides displayed IC50 against bloodstream Trypanosoma brucei in the sub-μM range (IC50 0.35–0.77 μM) and four of them showed an improved selectivity (selectivity index >38-folds vs. murine and human macrohages). For the glycosyl selenylsulfides, the anti-trypanosomal activity was not significantly influenced by the nature of the moiety attached to the sulfur atom. Except for a quinoline-, and to a minor extent a nitro-derivative, the most selective hits induced a rapid (within 60 min) and marked perturbation of the LMWTredox homeostasis. The formation of selenenylsulfide glycoconjugates with free thiols has been identified as a potential mechanism involved in this process. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Balázs István AU - Bahar, Bazeli AU - Annelies, Janssens AU - Lisztes, Erika AU - Racskó, Márk AU - Kelemen, Balázs AU - Herczeg, Mihály AU - Nagy, Tamás Milán AU - E Kövér, Katalin AU - Argha, Mitra AU - Attila, Borics AU - Bíró, Tamás AU - Thomas, Voets TI - Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants JF - ELIFE J2 - ELIFE PY - 2024 SN - 2050-084X UR - https://m2.mtmt.hu/api/publication/34722559 ID - 34722559 N1 - preprint DOI-ja: 10.1101/2024.02.01.578392 LA - English DB - MTMT ER - TY - JOUR AU - Balogh, Zoltán AU - Kalmár, József AU - Gommes, Cedric J. TI - Wetting of alginate aerogels, from mesoporous solids to hydrogels: a small-angle scattering analysis JF - JOURNAL OF APPLIED CRYSTALLOGRAPHY J2 - J APPL CRYSTALLOGR VL - 57 PY - 2024 IS - 2 SP - 369 EP - 379 PG - 11 SN - 0021-8898 DO - 10.1107/S1600576724001705 UR - https://m2.mtmt.hu/api/publication/34655160 ID - 34655160 N1 - Accepted on 20-Febr-2024. Published on-line on 21-March-2024. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Dávid Ruben AU - Nagy, Cynthia Nóra AU - Gáspár, Attila TI - Direct Injection Electrospray Ionization Mass Spectrometry (ESI-MS) Analysis of Proteins with High Matrix Content:Utilizing Taylor–Aris Dispersion JF - ANGEWANDTE CHEMIE-INTERNATIONAL EDITION J2 - ANGEW CHEM INT EDIT VL - 63 PY - 2024 IS - 15 PG - 8 SN - 1433-7851 DO - 10.1002/anie.202318225 UR - https://m2.mtmt.hu/api/publication/34654115 ID - 34654115 N1 - Export Date: 21 February 2024; Cited By: 0; Correspondence Address: A. Gaspar; Department of Inorganic and Analytical Chemistry, Institute of Chemistry, University of Debrecen, Debrecen, 4032, Hungary; email: gaspar@science.unideb.hu; CODEN: ACIEF AB - This is the first work demonstrating the utility of the Taylor–Aris (TA) dispersion in avoiding serious interference issues commonly occurring in the electrospray ionization-mass spectrometric (ESI-MS) determination of therapeutic protein pharmaceuticals undergoing no pre-separation or sample purification. It was also pointed out that the TA dispersion conditions and its analytical utilization for proteomics can be easily accomplished in a commercial CE-MS instrument. In the proposed Taylor–Aris dispersion-assisted mass spectrometry (TADA-MS) analysis 0.5 μL sample is injected into a 65 cm long 50 μm i.d. capillary and pumped with 1 bar toward the MS. The procedure is efficient for the direct injection analysis of components having low diffusion coefficients (proteins) that are present in complex matrices of small organic and inorganic compounds. © 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH. LA - English DB - MTMT ER - TY - JOUR AU - Duong, Thoa AU - Vivero-Lopez, Maria AU - Ardao, Inés AU - Alvarez-Lorenzo, Carmen AU - Forgács, Attila AU - Kalmár, József AU - García-González, Carlos A. TI - Alginate aerogels by spray gelation for enhanced pulmonary delivery and solubilization of beclomethasone dipropionate JF - CHEMICAL ENGINEERING JOURNAL J2 - CHEM ENG J VL - 485 PY - 2024 PG - 15 SN - 1385-8947 DO - 10.1016/j.cej.2024.149849 UR - https://m2.mtmt.hu/api/publication/34629003 ID - 34629003 N1 - Accepted on 18-February-2024. Published online on 20-February-2024. LA - English DB - MTMT ER -