@article{MTMT:34831627,
	title = {[52Mn]Mn-BPPA-Trastuzumab: A Promising HER2-Specific PET Radiotracer},
	url = {https://m2.mtmt.hu/api/publication/34831627},
	author = {Toàn, Ngô Minh and Vágner, Adrienn and Nagy, Gábor and Ország, Gábor and Nagy, Tamás and Csikos, Csaba and Váradi, Balázs and Sajtos, Gergő Zoltán and Kapus, István and Szoboszlai, Zoltán and Szikra, Dezső and Trencsényi, György and Tircsó, Gyula and Garai, Ildikó},
	doi = {10.1021/acs.jmedchem.4c00344},
	journal-iso = {J MED CHEM},
	journal = {JOURNAL OF MEDICINAL CHEMISTRY},
	volume = {67},
	unique-id = {34831627},
	issn = {0022-2623},
	abstract = {This study aimed to develop a novel radiotracer using trastuzumab and the long-lived [52Mn]Mn isotope for HER2-targeted therapy selection and monitoring. A new Mn(II) chelator, BPPA, synthesized from a rigid bispyclen platform possessing a picolinate pendant arm, formed a stable and inert Mn(II) complex with favorable relaxation properties. BPPA was converted into a bifunctional chelator (BFC), conjugated to trastuzumab, and labeled with [52Mn]Mn isotope. In comparison to DOTA-GA-trastuzumab, the BPPA-trastuzumab conjugate exhibits a labeling efficiency with [52Mn]Mn approximately 2 orders of magnitude higher. In female CB17 SCID mice bearing 4T1 (HER2−) and MDA-MB-HER2+ (HER2+) xenografts, [52Mn]Mn-BPPA-trastuzumab demonstrated superior uptake in HER2+ cells on day 3, with a 3–4 fold difference observed on day 7. Overall, the hexadentate BPPA chelator proves to be exceptional in binding Mn(II). Upon coupling with trastuzumab as a BFC ligand, it becomes an excellent imaging probe for HER2-positive tumors. [52Mn]Mn-BPPA-trastuzumab enables an extended imaging time window and earlier detection of HER2-positive tumors with superior tumor-to-background contrast.},
	year = {2024},
	eissn = {1520-4804},
	pages = {1},
	orcid-numbers = {Trencsényi, György/0000-0001-6456-6212}
}

@article{MTMT:34831051,
	title = {A rheumatoid arthritis etiopatogenezise - újdonságok},
	url = {https://m2.mtmt.hu/api/publication/34831051},
	author = {Szekanecz, Zoltán and Kacsándi, Dorottya and Soós, Boglárka},
	journal-iso = {IMMUNOLÓGIAI SZEMLE},
	journal = {IMMUNOLÓGIAI SZEMLE},
	volume = {16},
	unique-id = {34831051},
	issn = {2061-0203},
	year = {2024},
	pages = {4-14}
}

@article{MTMT:34829474,
	title = {A JAK-gátlók alkalmazásának jövőbeli lehetőségei krónikus gyulladásos kórképekben},
	url = {https://m2.mtmt.hu/api/publication/34829474},
	author = {Szekanecz, Zoltán},
	journal-iso = {ORVOSTOVÁBBKÉPZŐ SZLE},
	journal = {ORVOSTOVÁBBKÉPZŐ SZEMLE},
	unique-id = {34829474},
	issn = {1218-2583},
	year = {2024}
}

@article{MTMT:34827495,
	title = {A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association ( HFA ) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function},
	url = {https://m2.mtmt.hu/api/publication/34827495},
	author = {Ameri, Pietro and Mercurio, Valentina and Pollesello, Piero and Anker, Markus S. and Backs, Johannes and Bayes‐Genis, Antoni and Borlaug, Barry A. and Burkhoff, Daniel and Caravita, Sergio and Chan, Stephen Y. and de Man, Frances and Giannakoulas, George and González, Aránzazu and Guazzi, Marco and Hassoun, Paul M. and Hemnes, Anna R. and Maack, Cristoph and Madden, Brendan and Melenovsky, Vojtech and Müller, Oliver J. and Papp, Zoltán and Pullamsetti, Soni Savai and Rainer, Peter P. and Redfield, Margaret M. and Rich, Stuart and Schiattarella, Gabriele G. and Skaara, Hall and Stellos, Kostantinos and Tedford, Ryan J. and Thum, Thomas and Vachiery, Jean Luc and van der Meer, Peter and Van Linthout, Sophie and Pruszczyk, Piotr and Seferovic, Petar and Coats, Andrew J.S. and Metra, Marco and Rosano, Giuseppe and Rosenkranz, Stephan and Tocchetti, Carlo Gabriele},
	doi = {10.1002/ejhf.3236},
	journal-iso = {EUR J HEART FAIL},
	journal = {EUROPEAN JOURNAL OF HEART FAILURE},
	unique-id = {34827495},
	issn = {1388-9842},
	abstract = {Pulmonary hypertension (PH) associated with left heart failure (LHF) (PH‐LHF) is one of the most common causes of PH. It directly contributes to symptoms and reduced functional capacity and negatively affects right heart function, ultimately leading to a poor prognosis. There are no specific treatments for PH‐LHF, despite the high number of drugs tested so far. This scientific document addresses the main knowledge gaps in PH‐LHF with emphasis on pathophysiology and clinical trials. Key identified issues include better understanding of the role of pulmonary venous versus arteriolar remodelling, multidimensional phenotyping to recognize patient subgroups positioned to respond to different therapies, and conduct of rigorous pre‐clinical studies combining small and large animal models. Advancements in these areas are expected to better inform the design of clinical trials and extend treatment options beyond those effective in pulmonary arterial hypertension. Enrichment strategies, endpoint assessments, and thorough haemodynamic studies, both at rest and during exercise, are proposed to play primary roles to optimize early‐stage development of candidate therapies for PH‐LHF.},
	year = {2024},
	eissn = {1879-0844}
}

@article{MTMT:34824919,
	title = {Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model},
	url = {https://m2.mtmt.hu/api/publication/34824919},
	author = {Horváth, Ádám and Steib, Anita and Nehr-Majoros, Andrea Kinga and Kántás, Boglárka and Király, Ágnes and Racskó, Márk and Tóth, Balázs István and Szánti-Pintér, Eszter and Kudová, Eva and Skodáné Földes, Rita and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.3390/ijms25094637},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34824919},
	issn = {1661-6596},
	abstract = {The thermo- and pain-sensitive Transient Receptor Potential Melastatin 3 and 8 (TRPM3 and TRPM8) ion channels are functionally associated in the lipid rafts of the plasma membrane. We have already described that cholesterol and sphingomyelin depletion, or inhibition of sphingolipid biosynthesis decreased the TRPM8 but not the TRPM3 channel opening on cultured sensory neurons. We aimed to test the effects of lipid raft disruptors on channel activation on TRPM3- and TRPM8-expressing HEK293T cells in vitro, as well as their potential analgesic actions in TRPM3 and TRPM8 channel activation involving acute pain models in mice. CHO cell viability was examined after lipid raft disruptor treatments and their effects on channel activation on channel expressing HEK293T cells by measurement of cytoplasmic Ca2+ concentration were monitored. The effects of treatments were investigated in Pregnenolone-Sulphate-CIM-0216-evoked and icilin-induced acute nocifensive pain models in mice. Cholesterol depletion decreased CHO cell viability. Sphingomyelinase and methyl-beta-cyclodextrin reduced the duration of icilin-evoked nocifensive behavior, while lipid raft disruptors did not inhibit the activity of recombinant TRPM3 and TRPM8. We conclude that depletion of sphingomyelin or cholesterol from rafts can modulate the function of native TRPM8 receptors. Furthermore, sphingolipid cleavage provided superiority over cholesterol depletion, and this method can open novel possibilities in the management of different pain conditions.},
	keywords = {PAIN; cholesterol; Sphingomyelinase; lipid raft; methyl-beta-cyclodextrin; transient receptor potential},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Szánti-Pintér, Eszter/0000-0001-8263-9884; Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:34821280,
	title = {Cardio-ankle vascular index for predicting cardiovascular morbimortality and determinants for its progression in the prospective advanced approach to arterial stiffness (TRIPLE-A-Stiffness) study},
	url = {https://m2.mtmt.hu/api/publication/34821280},
	author = {Bäck, Magnus and Topouchian, Jirar and Labat, Carlos and Gautier, Sylvie and Blacher, Jacques and Cwynar, Marcin and de la Sierra, Alejandro and Páll, Dénes and Duarte, Kevin and Fantin, Francesco and Farkas, Katalin and Garcia-Ortiz, Luis and Hakobyan, Zoya and Jankowski, Piotr and Jelakovic, Ana and Kotsani, Marina and Konradi, Alexandra and Mikhailova, Oksana and Mintale, Iveta and Plunde, Oscar and Ramos, Rafael and Rogoza, Anatoly and Sirenko, Yuriy and Tasic, Nebojsa and Rudyk, Iurii and Urazalina, Saule and Wohlfahrt, Peter and Zelveian, Parounak and Asmar, Roland and Benetos, Athanase},
	doi = {10.1016/j.ebiom.2024.105107},
	journal-iso = {EBIOMEDICINE},
	journal = {EBIOMEDICINE},
	unique-id = {34821280},
	issn = {2352-3964},
	year = {2024},
	eissn = {2352-3964},
	orcid-numbers = {Bäck, Magnus/0000-0003-0853-5141; Topouchian, Jirar/0009-0006-4297-9810}
}

@article{MTMT:34820678,
	title = {Metabolic Syndrome and Biotherapeutic Activity of Dairy (Cow and Buffalo) Milk Proteins and Peptides: Fast Food-Induced Obesity Perspective—A Narrative Review},
	url = {https://m2.mtmt.hu/api/publication/34820678},
	author = {Abdisa, Kenbon Beyene and Némethné Szerdahelyi, Emőke and Molnár, Máté András and Friedrich, László and Lakner, Zoltán and Koris, András and Tóth, Attila and Nath, Arijit},
	doi = {10.3390/biom14040478},
	journal-iso = {BIOMOLECULES},
	journal = {BIOMOLECULES},
	volume = {14},
	unique-id = {34820678},
	issn = {2218-273X},
	abstract = {Metabolic syndrome (MS) is defined by the outcome of interconnected metabolic factors that directly increase the prevalence of obesity and other metabolic diseases. Currently, obesity is considered one of the most relevant topics of discussion because an epidemic heave of the incidence of obesity in both developing and underdeveloped countries has been reached. According to the World Obesity Atlas 2023 report, 38% of the world population are presently either obese or overweight. One of the causes of obesity is an imbalance of energy intake and energy expenditure, where nutritional imbalance due to consumption of high-calorie fast foods play a pivotal role. The dynamic interactions among different risk factors of obesity are highly complex; however, the underpinnings of hyperglycemia and dyslipidemia for obesity incidence are recognized. Fast foods, primarily composed of soluble carbohydrates, non-nutritive artificial sweeteners, saturated fats, and complexes of macronutrients (protein-carbohydrate, starch-lipid, starch-lipid-protein) provide high metabolic calories. Several experimental studies have pointed out that dairy proteins and peptides may modulate the activities of risk factors of obesity. To justify the results precisely, peptides from dairy milk proteins were synthesized under in vitro conditions and their contributions to biomarkers of obesity were assessed. Comprehensive information about the impact of proteins and peptides from dairy milks on fast food-induced obesity is presented in this narrative review article.},
	year = {2024},
	eissn = {2218-273X},
	pages = {478},
	orcid-numbers = {Abdisa, Kenbon Beyene/0000-0002-4641-2823; Némethné Szerdahelyi, Emőke/0000-0003-2419-5802; Koris, András/0000-0002-2284-8139}
}

@article{MTMT:34820368,
	title = {In Vivo Imaging of Acute Hindlimb Ischaemia in Rat Model: A Pre-Clinical PET Study},
	url = {https://m2.mtmt.hu/api/publication/34820368},
	author = {Farkasinszky, Gergely and Péliné Szabó, Judit and Károlyi, Péter and Rácz, Szilvia and Dénes, Noémi and Papp, Tamás and Király, József and Szabó, Zsuzsanna and Kertész, István and Mező, Gábor and Halmos, Gábor and Képes, Zita and Trencsényi, György},
	doi = {10.3390/pharmaceutics16040542},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {16},
	unique-id = {34820368},
	issn = {1999-4923},
	abstract = {Background: To better understand ischaemia-related molecular alterations, temporal changes in angiogenic Aminopeptidase N (APN/CD13) expression and glucose metabolism were assessed with PET using a rat model of peripheral arterial disease (PAD). Methods: The mechanical occlusion of the base of the left hindlimb triggered using a tourniquet was applied to establish the ischaemia/reperfusion injury model in Fischer-344 rats. 2-[18F]FDG and [68Ga]Ga-NOTA-c(NGR) PET imaging performed 1, 3, 5, 7, and 10 days post-ischaemia induction was followed by Western blotting and immunohistochemical staining for APN/CD13 in ischaemic and control muscle tissue extracts. Results: Due to a cellular adaptation to hypoxia, a gradual increase in [68Ga]Ga-NOTA-c(NGR) and 2-[18F]FDG uptake was observed from post-intervention day 1 to 7 in the ischaemic hindlimbs, which was followed by a drop on day 10. Conforming pronounced angiogenic recovery, the NGR accretion of the ischaemic extremities differed significantly from the controls 5, 7, and 10 days after ischaemia induction (p ≤ 0.05), which correlated with the Western blot and immunohistochemical results. No remarkable radioactivity was depicted between the normally perfused hindlimbs of either the ischaemic or the control groups. Conclusions: The PET-based longitudinal assessment of angiogenesis-associated APN/CD13 expression and glucose metabolism during ischaemia may continue to broaden our knowledge on the pathophysiology of PAD.},
	year = {2024},
	eissn = {1999-4923},
	pages = {542},
	orcid-numbers = {Mező, Gábor/0000-0002-7618-7954; Képes, Zita/0000-0003-2889-8521; Trencsényi, György/0000-0001-6456-6212}
}

@article{MTMT:34820283,
	title = {Efficacy and safety of avacopan in patients with ANCA-associated vasculitis receiving rituximab in a randomised trial},
	url = {https://m2.mtmt.hu/api/publication/34820283},
	author = {Geetha, Duvuru and Dua, Anisha and Yue, Huibin and Springer, Jason and Salvarani, Carlo and Jayne, David and Merkel, Peter and Szűcs, Gabriella},
	doi = {10.1136/ard-2023-224816},
	journal-iso = {ANN RHEUM DIS},
	journal = {ANNALS OF THE RHEUMATIC DISEASES},
	volume = {83},
	unique-id = {34820283},
	issn = {0003-4967},
	year = {2024},
	eissn = {1468-2060},
	pages = {223-232},
	orcid-numbers = {Geetha, Duvuru/0000-0001-8353-5542; Dua, Anisha/0000-0002-3508-9290; Springer, Jason/0000-0002-3903-6049; Salvarani, Carlo/0000-0001-5426-5133; Jayne, David/0000-0002-1712-0637; Merkel, Peter/0000-0001-9284-7345}
}

@article{MTMT:34820104,
	title = {Quantifying antibody-dependent cellular cytotoxicity in a tumor spheroid model : application for drug discovery},
	url = {https://m2.mtmt.hu/api/publication/34820104},
	author = {Isotta, Sturniolo and Csongor, Váróczy and Ákos, Máté Bede and Hegedűs, Csaba and Demény, Máté Ágoston and Virág, László},
	journal-iso = {JOVE-J VIS EXP},
	journal = {JOVE-JOURNAL OF VISUALIZED EXPERIMENTS},
	unique-id = {34820104},
	issn = {1940-087X},
	year = {2024},
	eissn = {1940-087X}
}