TY - JOUR AU - Pakgohar, Naghmeh AU - Barabás, Sándor AU - Ćuk, Mirjana AU - Csecserits, Anikó AU - Gyalus, Adrienn AU - Lengyel, Attila AU - Lhotsky, Barbara AU - Mártonffy, András AU - Ónodi, Gábor AU - Rédei, Tamás AU - Botta‐Dukát, Zoltán TI - Low replicability of testing the stress–dominance hypothesis using a trait convergence/divergence pattern JF - JOURNAL OF VEGETATION SCIENCE J2 - J VEG SCI VL - 35 PY - 2024 IS - 3 SN - 1100-9233 DO - 10.1111/jvs.13260 UR - https://m2.mtmt.hu/api/publication/34836743 ID - 34836743 LA - English DB - MTMT ER - TY - JOUR AU - Reicher, Vivien AU - Kovács, Tímea AU - Csibra, Barbara AU - Gácsi, Márta TI - Potential interactive effect of positive expectancy violation and sleep on memory consolidation in dogs JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 SN - 2045-2322 DO - 10.1038/s41598-024-60166-8 UR - https://m2.mtmt.hu/api/publication/34831542 ID - 34831542 N1 - Export Date: 2 May 2024 Correspondence Address: Reicher, V.; Clinical and Developmental Neuropsychology Research Group, Hungary; email: reicher.vivien@ttk.hu AB - In dogs, as in humans, both emotional and learning pretreatment affect subsequent behaviour and sleep. Although learning often occurs in an emotional-social context, the emotion-learning interplay in such context remain mainly unknown. Aims were to assess the effects of Controlling versus Permissive (emotional factors) training (learning factors) styles on dogs’ behaviour, learning performance, and sleep. Family dogs ( N = 24) participated in two command learning sessions employing the two training styles with each session followed by assessment of learning performance, a 2-h-long non-invasive sleep EEG measurement, and a retest of learning performance. Pre- to post-sleep improvement in learning performance was evident in dogs that received the Permissive training during the second learning session, indicating that dogs that experienced a more rewarding situation than expected (positive expectancy violation) during the second training session showed improved learning success after their afternoon sleep. These results possibly indicate an interactive effect of expectancy violation and sleep on enhancing learning. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Bálint AU - Jordán, F. TI - Emergence of keystone individuals in the social networks of the ant Camponotus fellah JF - INSECTES SOCIAUX J2 - INSECT SOC PY - 2024 SN - 0020-1812 DO - 10.1007/s00040-024-00963-6 UR - https://m2.mtmt.hu/api/publication/34821684 ID - 34821684 AB - Community ecology and sociobiology share a number of problems (e.g. understanding part-to-whole relationships), so sharing methods may be beneficial. In this paper, we re-analyze a large social network database for Camponotus fellah ants, from the perspective of keystone individuals, based on methods developed in community ecology. We study different network types for six colonies, over a time series of 10 days. These include the total network of weighted interactions, the subnetworks for the castes and the subnetworks for Queen-linked and Queen-independent individuals. We perform time-independent (i.e. average values) and temporal (i.e. trends) analyses. The most commonly used global network metrics showed high variability in time but no clear trends. Yet, the variability of a network centrality index (topological importance, TI), developed earlier in community ecology, shows clear increase in each colony over time, suggesting the emergence of keystone individuals as a general tendency in all studied ant colonies. LA - English DB - MTMT ER - TY - JOUR AU - Laczi, Miklós AU - Sarkadi, Fanni AU - Herényi, Márton AU - Nagy, Gergely AU - Hegyi, Gergely AU - Jablonszky, Mónika AU - Könczey, Réka AU - Krenhardt, Katalin AU - Markó, Gábor AU - Rosivall, Balázs AU - Szász, Eszter AU - Szöllősi, Eszter AU - Tóth, László AU - Zsebők, Sándor AU - Török, János TI - Responses in the breeding parameters of the collared flycatcher to the changing climate JF - SCIENCE OF THE TOTAL ENVIRONMENT J2 - SCI TOTAL ENVIRON VL - 926 PY - 2024 SN - 0048-9697 DO - 10.1016/j.scitotenv.2024.171945 UR - https://m2.mtmt.hu/api/publication/34787582 ID - 34787582 N1 - HUN-REN–ELTE–MTM Integrative Ecology Research Group, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/C, Budapest, H-1117, Hungary Behavioural Ecology Group, Department of Systematic Zoology and Ecology, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/C, Budapest, H-1117, Hungary The Barn Owl Foundation, Temesvári út 8., Orosztony, H-8744, Hungary Doctoral School of Biology, Institute of Biology, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/C, Budapest, H-1117, Hungary Department of Zoology and Ecology, Institute for Wildlife Management and Nature Conservation, Hungarian University of Agriculture and Life Sciences, Páter Károly utca 1, Gödöllő, H-2103, Hungary Evolutionary Ecology Research Group, Institute of Ecology and Botany, Centre for Ecological Research, Alkotmány út 4., Vácrátót, H-2163, Hungary Hungarian Institute for Educational Research and Development, Eszterházy Károly University, Rákóczi út 70, Budapest, H-1074, Hungary Department of Plant Pathology, Institute of Plant Protection, Hungarian University of Agriculture and Life Sciences, Ménesi út 44., Budapest, H-1118, Hungary Institute for Rural Development and Landscape Management, Faculty of Agricultural and Rural Development, Eszterházy Károly University, Mátrai út 36., Gyöngyös, H-3200, Hungary Export Date: 15 April 2024 CODEN: STEVA Correspondence Address: Laczi, M.; HUN-REN–ELTE–MTM Integrative Ecology Research Group, Pázmány Péter sétány 1/C, Hungary; email: miklos.laczi@ttk.elte.hu LA - English DB - MTMT ER - TY - JOUR AU - Horváth, Lilla AU - Biri-Kovács, Beáta AU - Baranyai, Zsuzsa AU - Stipsicz, Bence András AU - Méhes, Előd AU - Jezsó, Bálint AU - Krátký, Martin AU - Vinšová, Jarmila AU - Bősze, Szilvia TI - New Salicylanilide Derivatives and Their Peptide Conjugates as Anticancer Compounds: Synthesis, Characterization, and In Vitro Effect on Glioblastoma JF - ACS OMEGA J2 - ACS OMEGA VL - 9 PY - 2024 IS - 15 SP - 16927 EP - 16948 PG - 22 SN - 2470-1343 DO - 10.1021/acsomega.3c05727 UR - https://m2.mtmt.hu/api/publication/34777528 ID - 34777528 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office, Hungary [VEKOP-2.3.3-15-2017-00020, TKP2020-IKA-05]; EFSA-CDN [CZ.02.1.01/0.0/0.0/16_019/0000841]; ERDF; SVV [260 661]; Hungarian Ministry for Innovation and Technology [2018-1.2.1-NKP-2018-00005, 2018-1.2.1-NKP]; National Research, Development and Innovation Office, Hungary (NKFIH); NKFIH [K142904]; New National Excellence Program of the Ministry for Culture and Innovation National Research, Development and Innovation Fund [UNKP-22-4]; Doctoral School of Biology, Institute of Biology, Eotvos Lorand University Funding text: The authors are grateful for the support of the National Research, Development and Innovation Office, Hungary (grants: VEKOP-2.3.3-15-2017-00020 and TKP2020-IKA-05). This work was supported by the EFSA-CDN (grant no. CZ.02.1.01/0.0/0.0/16_019/0000841) and cofunded by the ERDF and SVV 260 661. We are grateful for the ELTE Thematic Excellence Programme (Szint+) and the 2018-1.2.1-NKP-2018-00005 project (under the 2018-1.2.1-NKP funding scheme) provided by the Hungarian Ministry for Innovation and Technology and the National Research, Development and Innovation Office, Hungary (NKFIH). We are also grateful for the support of K142904 (PI: SB, NKFIH), and LBH is grateful for the support of the UNKP-22-4 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. BS is grateful for the support of the Doctoral School of Biology, Institute of Biology, Eotvos Lorand University. LA - English DB - MTMT ER - TY - JOUR AU - Rani, Varsha AU - Horváth, Zsófia AU - Nejstgaard, Jens C. AU - Fierpasz, Ádám AU - Pálffy, Károly AU - Vad, Csaba Ferenc TI - Food density drives diet shift of the invasive mysid shrimp, Limnomysis benedeni JF - ECOLOGY AND EVOLUTION J2 - ECOL EVOL VL - 14 PY - 2024 IS - 4 SN - 2045-7758 DO - 10.1002/ece3.11202 UR - https://m2.mtmt.hu/api/publication/34774857 ID - 34774857 N1 - Submitted to Ecology and Evolution October 04, 2023; Review(s) Completed, Editorial Evaluation Pending 22 Nov 2023. https://doi.org/10.22541/au.169642823.39376932/v1 AB - Understanding the diet preferences and food selection of invasive species is crucial to better predict their impact on community structure and ecosystem functioning. Limnomysis benedeni , a Ponto‐Caspian invasive mysid shrimp, is one of the most successful invaders in numerous European river and lake ecosystems. While existing studies suggest potentially strong trophic impact due to high predation pressure on native plankton communities, little is known of its food selectivity between phyto‐ and zooplankton, under different food concentrations. Here, we therefore investigated the feeding selectivity of L . benedeni on two commonly occurring prey organisms in freshwaters, the small rotifer zooplankton Brachionus calyciflorus together with the microphytoplankton Cryptomonas sp. present in increasing densities. Our results demonstrated a clear shift in food selection, with L. benedeni switching from B. calyciflorus to Cryptomonas sp. already when the two prey species were provided in equal biomasses. Different functional responses were observed for the two food types, indicating somewhat different foraging mechanisms for each food type. These findings provide experimental evidence on the feeding flexibility of invasive mysid shrimps and potential implications for trophic interactions in invaded ecosystems. LA - English DB - MTMT ER - TY - JOUR AU - Jacksi, Mevan Fahmi Sami AU - Schád, Éva AU - Tantos, Ágnes TI - Morphological Changes Induced by TKS4 Deficiency Can Be Reversed by EZH2 Inhibition in Colorectal Carcinoma Cells JF - BIOMOLECULES J2 - BIOMOLECULES VL - 14 PY - 2024 IS - 4 SN - 2218-273X DO - 10.3390/biom14040445 UR - https://m2.mtmt.hu/api/publication/34773735 ID - 34773735 N1 - Export Date: 7 May 2024 Correspondence Address: Tantos, A.; HUN-REN Research Centre for Natural SciencesHungary; email: tantos.agnes@ttk.hu AB - Background: The scaffold protein tyrosine kinase substrate 4 (TKS4) undergoes tyrosine phosphorylation by the epidermal growth factor receptor (EGFR) pathway via Src kinase. The TKS4 deficiency in humans is responsible for the manifestation of a genetic disorder known as Frank–Ter Haar syndrome (FTHS). Based on our earlier investigation, the absence of TKS4 triggers migration, invasion, and epithelial–mesenchymal transition (EMT)-like phenomena while concurrently suppressing cell proliferation in HCT116 colorectal carcinoma cells. This indicates that TKS4 may play a unique role in the progression of cancer. In this study, we demonstrated that the enhancer of zeste homolog 2 (EZH2) and the histone methyltransferase of polycomb repressive complex 2 (PRC2) are involved in the migration, invasion, and EMT-like changes in TKS4-deficient cells (KO). EZH2 is responsible for the maintenance of the trimethylated lysine 27 on histone H3 (H3K27me3). Methods: We performed transcriptome sequencing, chromatin immunoprecipitation, protein and RNA quantitative studies, cell mobility, invasion, and proliferation studies combined with/without the EZH2 activity inhibitor 3-deazanoplanocine (DZNep). Results: We detected an elevation of global H3K27me3 levels in the TKS4 KO cells, which could be reduced with treatment with DZNep, an EZH2 inhibitor. Inhibition of EZH2 activity reversed the phenotypic effects of the knockout of TKS4, reducing the migration speed and wound healing capacity of the cells as well as decreasing the invasion capacity, while the decrease in cell proliferation became stronger. In addition, inhibition of EZH2 activity also reversed most epithelial and mesenchymal markers. We investigated the wider impact of TKS4 deletion on the gene expression profile of colorectal cancer cells using transcriptome sequencing of wild-type and TKS4 knockout cells, particularly before and after treatment with DZNep. Additionally, we observed changes in the expression of several protein-coding genes and long non-coding RNAs that showed a recovery in expression levels following EZH2 inhibition. Conclusions: Our results indicate that the removal of TKS4 causes a notable disruption in the gene expression pattern, leading to the disruption of several signal transduction pathways. Inhibiting the activity of EZH2 can restore most of these transcriptomics and phenotypic effects in colorectal carcinoma cells. LA - English DB - MTMT ER - TY - JOUR AU - Premate, Ester AU - Fišer, Žiga AU - Biró, Anna AU - Copilaş-Ciocianu, Denis AU - Fromhage, Lutz AU - Jennions, Michael AU - Borko, Špela AU - Herczeg, Gábor AU - Balázs, Gergely AU - Kralj-Fišer, Simona AU - Fišer, Cene TI - Sexual dimorphism in subterranean amphipod crustaceans covaries with subterranean habitat type JF - JOURNAL OF EVOLUTIONARY BIOLOGY J2 - J EVOLUTION BIOL PY - 2024 SP - 1 SN - 1010-061X DO - 10.1093/jeb/voae032 UR - https://m2.mtmt.hu/api/publication/34769011 ID - 34769011 AB - Sexual dimorphism can evolve in response to sex-specific selection pressures that vary across habitats. We studied sexual differences in subterranean amphipods Niphargus living in shallow subterranean habitats (close to the surface), cave streams (intermediate), and cave lakes (deepest and most isolated). These three habitats differ because at greater depths there is lower food availability, reduced predation, and weaker seasonality. Additionally, species near the surface have a near-even adult sex ratio (ASR), whereas species from cave lakes have a female-biased ASR. We hypothesized (a) a decrease in sexual dimorphism from shallow subterranean habitats to cave lake species because of weaker sexual selection derived from changes in the ASR and (b) an increase in female body size in cave lakes because of stronger fecundity selection on account of oligotrophy, reduced predation, and weaker seasonality. We measured body size and two sexually dimorphic abdominal appendages for all 31 species and several behaviours related to male competition (activity, risk-taking, exploration) for 12 species. Species with an equal ASR that live close to the surface exhibited sexual dimorphism in all three morphological traits, but not in behaviour. The body size of females increased from the surface to cave lakes, but no such trend was observed in males. In cave lake species, males and females differed neither morphologically nor behaviourally. Our results are consistent with the possibility that sexual and fecundity selection covary across the three habitats, which indirectly and directly, respectively, shape the degree of sexual dimorphism in Niphargus species. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Attila István AU - Keserű, Dóra AU - Pethő, Máté AU - Détári, László AU - Bencsik, Norbert AU - Dobolyi, Árpád AU - Hajnik, Tünde TI - Sleep and local field potential effect of the D2 receptor agonist bromocriptine during the estrus cycle and postpartum period in female rats JF - PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR J2 - PHARMACOL BIOCHEM BE VL - 239 PY - 2024 SN - 0091-3057 DO - 10.1016/j.pbb.2024.173754 UR - https://m2.mtmt.hu/api/publication/34755849 ID - 34755849 N1 - In vivo Electrophysiology Research Group, Department of Physiology and Neurobiology, Eötvös Loránd University, Hungary Cellular Neurobiology Research Group, Department of Physiology and Neurobiology, Eötvös Loránd University, Hungary Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Eötvös Loránd University, Hungary Export Date: 23 April 2024 CODEN: PBBHA Correspondence Address: Tóth, A.; Department of Physiology and Neurobiology, Pázmány Péter sétány 1/C, Hungary; email: attila.toth@ttk.elte.hu LA - English DB - MTMT ER - TY - JOUR AU - Paczkó, Mátyás AU - Vörös, Dániel AU - Szabó, Péter AU - Jékely, Gáspár AU - Szathmáry, Eörs AU - Szilágyi, András TI - A neural network-based model framework for cell-fate decisions and development JF - COMMUNICATIONS BIOLOGY J2 - COMMUN BIOL VL - 7 PY - 2024 IS - 1 SN - 2399-3642 DO - 10.1038/s42003-024-05985-1 UR - https://m2.mtmt.hu/api/publication/34743931 ID - 34743931 N1 - Institute of Evolution, HUN-REN Centre for Ecological Research, Konkoly-Thege M. út 29-33, Budapest, 1121, Hungary Doctoral School of Biology, Institute of Biology, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/C, Budapest, 1117, Hungary Living Systems Institute, University of Exeter, Stocker Road 4QD, Exeter, EX4, United Kingdom Center for the Conceptual Foundations of Science, Parmenides Foundation, Hindenburgstr. 15, Pöcking, 82343, Germany Department of Plant Systematics, Ecology and Theoretical Biology, Eötvös Loránd University, Pázmány Péter sétány 1/C, Budapest, 1117, Hungary Export Date: 17 April 2024 Correspondence Address: Szathmáry, E.; Institute of Evolution, Konkoly-Thege M. út 29-33, Hungary; email: szathmary.eors@ecolres.hu AB - Gene regulatory networks (GRNs) fulfill the essential function of maintaining the stability of cellular differentiation states by sustaining lineage-specific gene expression, while driving the progression of development. However, accounting for the relative stability of intermediate differentiation stages and their divergent trajectories remains a major challenge for models of developmental biology. Here, we develop an empirical data-based associative GRN model (AGRN) in which regulatory networks store multilineage stage-specific gene expression profiles as associative memory patterns. These networks are capable of responding to multiple instructive signals and, depending on signal timing and identity, can dynamically drive the differentiation of multipotent cells toward different cell state attractors. The AGRN dynamics can thus generate diverse lineage-committed cell populations in a robust yet flexible manner, providing an attractor-based explanation for signal-driven cell fate decisions during differentiation and offering a readily generalizable modelling tool that can be applied to a wide variety of cell specification systems. LA - English DB - MTMT ER -