TY - JOUR AU - Fábián, Anna AU - Bor, Renáta AU - Vasas, Béla AU - Szűcs, Mónika AU - Tóth, Tibor AU - Bősze, Zsófia AU - Szántó, Kata Judit AU - Bacsur, Péter AU - Bálint, Anita AU - Farkas, Bernadett AU - Farkas, Klaudia AU - Milassin, Ágnes AU - Rutka, Mariann AU - Resál, Tamás AU - Molnár, Tamás AU - Szepes, Zoltán TI - Long-term outcomes after endoscopic removal of malignant colorectal polyps. Results from a 10-year cohort TS - Results from a 10-year cohort JF - WORLD JOURNAL OF GASTROINTESTINAL ENDOSCOPY J2 - WORLD J GASTROINTEST ENDOSC VL - 16 PY - 2024 IS - 4 SP - 193 EP - 205 PG - 13 SN - 1948-5190 DO - 10.4253/wjge.v16.i4.193 UR - https://m2.mtmt.hu/api/publication/34852892 ID - 34852892 AB - Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging, and evidence regarding a surveillance-only strategy is limited.To evaluate long-term outcomes after endoscopic removal of malignant colorectal polyps.A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and 2020. Residual disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were investigated. Event rates for categorical variables and means for continuous variables with 95% confidence intervals were calculated, and Fisher's exact test and Mann-Whitney test were performed. Potential risk factors of adverse outcomes were determined with univariate and multivariate logistic regression models.In total, 135 lesions (mean size: 22.1 mm; location: 42% rectal) from 129 patients (mean age: 67.7 years; 56% male) were enrolled. The proportion of pedunculated and non-pedunculated lesions was similar, with en bloc resection in 82% and 47% of lesions, respectively. Tumor differentiation, distance from resection margins, depth of submucosal invasion, lymphovascular invasion, and budding were reported at 89.6%, 45.2%, 58.5%, 31.9%, and 25.2%, respectively. Residual tumor was found in 10 patients, and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical resection. Univariate analysis identified piecemeal resection as a risk factor for residual malignancy (odds ratio: 1.74; P = 0.042). At least 1 year of follow-up was available for 117 lesions from 111 patients (mean follow-up period: 5.59 years). Overall, 54%, 30%, 30%, 11%, and 16% of patients presented at the 1-year, 3-year, 5-year, 7-year, and 9-10-year surveillance examinations. Adverse outcomes occurred in 9.0% (local recurrence and dissemination in 4 patients and 9 patients, respectively), with no difference between patients undergoing secondary surgery and surveillance only.Reporting of histological features and adherence to surveillance colonoscopy needs improvement. Long-term adverse outcome rates might be higher than previously reported, irrespective of whether secondary surgery was performed. LA - English DB - MTMT ER - TY - GEN AU - Leticia, Szadai AU - Aron, Bartha AU - Indira, Pla Parada AU - Lakatos, Alexandra AU - Pál, Dorottya AU - Anna, Sára Lengyel AU - Natália, Pinto de Almeida AU - Ágnes, Judit Jánosi AU - Fábio, Nogueira AU - Beata, Szeitz AU - Viktória, Doma AU - Nicole, Woldmar AU - Jéssica, Guedes AU - Zsuzsanna, Ujfaludi AU - Zoltán, Gábor Pahi AU - Pankotai, Tibor AU - Yonghyo, Kim AU - Győrffy, Balázs AU - Bo, Baldetorp AU - Charlotte, Welinder AU - A., Marcell Szasz AU - Lazaro, Betancourt AU - Jeovanis, Gil AU - Roger, Appelqvist AU - Ho-Jeong, Kwon AU - Sarolta, Kárpáti AU - Magdalena, Kuras AU - Jimmy, Rodriguez Murillo AU - István, Balázs Németh AU - Johan, Malm AU - David, Fenyö AU - Krzysztof, Pawłowski AU - Peter, Horvatovich AU - Elisabet, Wieslander AU - Kemény, Lajos Vince AU - Gilberto, Domont AU - György, MarkoVarga AU - Aniel, Sanchez TI - Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts PY - 2024 UR - https://m2.mtmt.hu/api/publication/34842721 ID - 34842721 LA - English DB - MTMT ER - TY - JOUR AU - Fazekas, Fruzsina AU - Újfaludi, Zsuzsanna AU - Bíró, Krisztina AU - Páhi, Zoltán Gábor AU - Buzogány, István AU - Sükösd, Farkas AU - Pankotai, Tibor AU - Beöthe, Tamás TI - Complex treatment of residual metastatic germ cell cancer. a single center experience. TS - a single center experience. JF - JOURNAL OF BIOTECHNOLOGY J2 - J BIOTECHNOL VL - Apr 29 PY - 2024 SN - 0168-1656 DO - 10.1016/j.jbiotec.2024.04.018 UR - https://m2.mtmt.hu/api/publication/34839173 ID - 34839173 AB - Testicular cancer is the most common solid malignancy among men aged 15-35. Radical orchiectomy and platinum-based chemotherapy (BEP) are curative in the majority of patients, including advanced, metastatic cases. According to current urooncology guidelines all non-seminoma patients harbouring post-chemotherapy residual masses of ≥ 1cm should undergo salvage retroperitoneal lymph node dissection (RPLND). However, only 10% of residual tumors contain viable disease.To assess patient outcomes and complications considering different treatment regimens and clinical characteristics.In a retrospective cross-sectional study patients (n=127) who underwent postchemotherapy RPLND between 2007 and 2023 at our referral center were evaluated. The patients received systemic treatment at various oncology centers. The number of BEP cycles received were occasionally different from standard. Only patients with normal postchemotherapy serum tumor markers and primary testicular or extragonadal germ cell neoplasms were included. Treatment groups were established according to the number of BEP cycles received, and the extent of RPLND (bilateral or modified template). Treatment outcomes and complications were assessed.Standard 3-4 courses of BEP were received by 100 (78,7%) patients, while 11 (8,7%) patients underwent less, and 16 (12,6%) more courses than standard. On histopathologic evaluation viable germ cell tumor, teratoma, and necrosis/fibrosis was present in 26 (20,5%), 67 (52,7%) and 34 (26,8%) of specimen, respectively. In the 5-6 BEP series subgroup high rate of viable disease (37,5%) was found and significantly more nephrectomies were performed, than other chemotherapy subgroups. Extratesticular GCT, viable disease in residual mass or progression after RPLND indicated lower survival. Mild (Clavien-Dindo I-II) or no postoperative complications were reported in 93,7% of cases.The study suggests no significant benefit from exceeding 3-4 courses of BEP. Timely salvage RPLND should be performed in high volume centers for optimal treatment outcomes with acceptable complication rates. Adherence to the Heidenreich criteria is advisable where practical. LA - English DB - MTMT ER - TY - JOUR AU - Cserni, Gábor AU - Bori, Rita AU - Ambrózay, Éva AU - Serfőző, Orsolya TI - Histological Patterns and Mammographic Presentation of Invasive Lobular Carcinoma Show No Obvious Associations JF - CANCERS J2 - CANCERS VL - 16 PY - 2024 IS - 9 PG - 17 SN - 2072-6694 DO - 10.3390/cancers16091640 UR - https://m2.mtmt.hu/api/publication/34821848 ID - 34821848 AB - Invasive lobular carcinoma of the breast has different mammographic appearances, including spiculated or lobulated masses, architectural distortion, increased breast density, and the possibility of also being occult. Histologically, the morphology is also variable, as several patterns have been described beside the classical one, including the solid, the alveolar, the trabecular, the one with tubular elements, and others. Of 146 ILC cases, 141 were reviewed for mammographic appearance and 136 for histological patterns by two radiologist and two pathologists, respectively; 132 common cases were analyzed for possible associations between mammographic presentation and the histological patterns. Interobserver agreement on the presence or absence of a given mammographic morphology ranged from 45% (increased density) to 95% (occult lesion); the most common radiomorphology was that of a spiculated mass. Interobserver agreement on the presence or absence of a given histological pattern ranged between 79% (solid) and 99% (classical) but was worse when semi-quantification was also included. The mammography–pathology correlation was less than optimal. Multifocality was more commonly detected by histology. The identification of a mammographic mass lesion often coincided with a mass-like lesion on the histological slides and vice versa, but nearly half of the mammographically occult lesions were felt to have masses on histological slides assessed grossly. Histological patterns showed no obvious associations with one or the other mammographic appearance. LA - English DB - MTMT ER - TY - JOUR AU - Faragó, Anna AU - Zvara, Ágnes AU - Tiszlavicz, László AU - Hunyadi-Gulyás Éva, Csilla AU - Darula, Zsuzsanna AU - Hegedűs, Zoltán AU - Szabó, Enikő AU - Surguta, Sára Eszter AU - Tóvári, József AU - Puskás, László AU - Szebeni, Gábor TI - Lectin-Based Immunophenotyping and Whole Proteomic Profiling of CT-26 Colon Carcinoma Murine Model JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 7 PG - 21 SN - 1661-6596 DO - 10.3390/ijms25074022 UR - https://m2.mtmt.hu/api/publication/34790193 ID - 34790193 N1 - * Megosztott szerzőség AB - A murine colorectal carcinoma (CRC) model was established. CT26 colon carcinoma cells were injected into BALB/c mice's spleen to study the primary tumor and the mechanisms of cell spread of colon cancer to the liver. The CRC was verified by the immunohistochemistry of Pan Cytokeratin and Vimentin expression. Immunophenotyping of leukocytes isolated from CRC-bearing BALB/c mice or healthy controls, such as CD19+ B cells, CD11+ myeloid cells, and CD3+ T cells, was carried out using fluorochrome-labeled lectins. The binding of six lectins to white blood cells, such as galectin-1 (Gal1), siglec-1 (Sig1), Sambucus nigra lectin (SNA), Aleuria aurantia lectin (AAL), Phytolacca americana lectin (PWM), and galectin-3 (Gal3), was assayed. Flow cytometric analysis of the splenocytes revealed the increased binding of SNA, and AAL to CD3 + T cells and CD11b myeloid cells; and increased siglec-1 and AAL binding to CD19 B cells of the tumor-bearing mice. The whole proteomic analysis of the established CRC-bearing liver and spleen versus healthy tissues identified differentially expressed proteins, characteristic of the primary or secondary CRC tissues. KEGG Gene Ontology bioinformatic analysis delineated the established murine CRC characteristic protein interaction networks, biological pathways, and cellular processes involved in CRC. Galectin-1 and S100A4 were identified as upregulated proteins in the primary and secondary CT26 tumor tissues, and these were previously reported to contribute to the poor prognosis of CRC patients. Modelling the development of liver colonization of CRC by the injection of CT26 cells into the spleen may facilitate the understanding of carcinogenesis in human CRC and contribute to the development of novel therapeutic strategies. LA - English DB - MTMT ER - TY - JOUR AU - Ferenczi, Ádám AU - Kuthi, Levente AU - Sejben, István AU - Sejben, Anita TI - Colonic tubular adenoma with clear cell change – case report with whole exome sequencing and updated review of the literature JF - PATHOBIOLOGY J2 - PATHOBIOLOGY VL - & PY - 2024 SP - & SN - 1015-2008 DO - 10.1159/000538705 UR - https://m2.mtmt.hu/api/publication/34774854 ID - 34774854 AB - Introduction: Colorectal tubular adenomas displaying clear cell change are rare entities, with unknown clinical relevance, prognosis, immunohistochemical, and molecular features. Case presentation: Hereby we report a case of a 43-year-old female patient with a rectosigmoid polyp. Histologically, conventional dysplasia was visible with scattered areas displaying clear cell change. Whole exome sequencing (WES) was carried out and revealed high tumour mutation burden, and 7 pathogenic mutations, including TP53, APC, FGFR4, EHBP1, IL4R, TYR, and ACTN3.Conclusion: Clear cell change may only be present in less than 0,1% of adenomas. Aetiology is not well understood, additionally, few authors suggest autolysis or fixation problems. Our WES resulted in newly found pathogenic mutations, and high mutation burden, proving the lesion’s neoplastic origin. Hitherto, neither special stainings, nor immunohistochemical markers proved to be useful in the diagnostic process. From a differential diagnostic perspective, enteroblastic differentiation, primary and secondary clear cell adenocarcinoma has to be excluded. LA - English DB - MTMT ER - TY - GEN AU - Indira, Pla AU - Botond, L. Szabolcs AU - Petra, Nikolett Péter AU - Zsuzsanna, Ujfaludi AU - Yonghyo, Kim AU - Peter, Horvatovich AU - Aniel Sanchez, Krzysztof Pawlowski AU - Elisabet, Wieslander AU - Jéssica, Guedes AU - Pál, Dorottya AU - Anna A. Ascsillán, Lazaro Hiram Betancourt AU - István, Balázs Németh AU - Jeovanis, Gil AU - Natália, Pinto de Almeida, Beáta Szeitz, Leticia Szadai AU - Viktória, Doma AU - Nicole, Woldmar AU - Áron, Bartha AU - Zoltan, Pahi AU - Pankotai, Tibor AU - Balázs, Győrffy AU - A., Marcell Szasz AU - Gilberto, Domont AU - Fábio, Nogueira AU - Ho, Jeong Kwon AU - Roger, Appelqvist AU - Sarolta, Kárpáti AU - David, Fenyö AU - Johan, Malm AU - György, Marko-Varga AU - Kemény, Lajos Vince TI - Identifying Ferroptosis Inducers, HDAC,and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction PY - 2024 UR - https://m2.mtmt.hu/api/publication/34758494 ID - 34758494 LA - English DB - MTMT ER - TY - JOUR AU - Szűcs, Diána AU - Monostori, Tamás AU - Vanda, Miklós AU - Páhi, Zoltán Gábor AU - Szilard, Poliska AU - Kemény, Lajos AU - Veréb, Zoltán TI - Licensing effects of inflammatory factors and TLR ligands on the regenerative capacity of adipose-derived mesenchymal stem cells JF - FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY J2 - FRONT CELL DEV BIOL VL - 12 PY - 2024 PG - 15 SN - 2296-634X DO - 10.3389/fcell.2024.1367242 UR - https://m2.mtmt.hu/api/publication/34757445 ID - 34757445 N1 - Regenerative Medicine and Cellular Pharmacology Laboratory, Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged, Szeged, Hungary Biobank, University of Szeged, Szeged, Hungary Genome Integrity and DNA Repair Core Group, Hungarian Centre of Excellence for Molecular Medicine (HCEMM), University of Szeged, Szeged, Hungary Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Genomic Medicine and Bioinformatics Core Facility, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Hungarian Centre of Excellence for Molecular Medicine-USz Skin Research Group, University of Szeged, Szeged, Hungary Export Date: 26 April 2024 Correspondence Address: Veréb, Z.; Regenerative Medicine and Cellular Pharmacology Laboratory, Hungary; email: vereb.zoltan@med.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Bacsur, Péter AU - Wetwittayakhlang, Panu AU - Resál, Tamás AU - Földi, Emese AU - Vasas, Béla AU - Farkas, Bernadett AU - Rutka, Mariann AU - Bessissow, Talat AU - Afif, Waqqas AU - Bálint, Anita AU - Fábián, Anna AU - Bor, Renáta AU - Szepes, Zoltán AU - Farkas, Klaudia AU - Lakatos, Péter László AU - Molnár, Tamás TI - Accuracy of the Pancolonic Modified Mayo Score in predicting the long-term outcomes of ulcerative colitis: a promising scoring system JF - THERAPEUTIC ADVANCES IN GASTROENTEROLOGY J2 - THER ADV GASTROENTER VL - 17 PY - 2024 PG - 11 SN - 1756-283X DO - 10.1177/17562848241239606 UR - https://m2.mtmt.hu/api/publication/34752035 ID - 34752035 N1 - First published online March 21, 2024 LA - English DB - MTMT ER - TY - JOUR AU - Ébert, Attila AU - Gál, Eleonóra AU - Tóth, Emese AU - Szögi, Titanilla AU - Hegyi, Péter AU - Venglovecz, Viktória TI - Role of CFTR in diabetes‐induced pancreatic ductal fluid and HCO 3 − secretion JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 602 PY - 2024 IS - 6 SP - 1065 EP - 1083 PG - 19 SN - 0022-3751 DO - 10.1113/JP285702 UR - https://m2.mtmt.hu/api/publication/34677129 ID - 34677129 N1 - Funding Agency and Grant Number: CF-Trust CFRD-SRC [SRC 007]; National Research, Development and Innovation Office [SNN134497]; New National Excellence Program Of The Ministry Of Human Capacities [UNKP-18-4] Funding text: We are grateful for support for this study provided by the CF-Trust CFRD-SRC Grant (No.: SRC 007) and the National Research, Development and Innovation Office (SNN134497) and New National Excellence Program Of The Ministry Of Human Capacities (UNKP-18-4 to VV). LA - English DB - MTMT ER -