@article{MTMT:32548543,
	title = {Survival Comes at a Cost: A Coevolution of Phage and Its Host Leads to Phage Resistance and Antibiotic Sensitivity of Pseudomonas aeruginosa Multidrug Resistant Strains},
	url = {https://m2.mtmt.hu/api/publication/32548543},
	author = {Koderi Valappil, Sarshad and Shetty, Prateek and Deim, Zoltán and Terhes, Gabriella and Zsoldiné Urbán, Edit and Váczi, Sándor and Patai, Roland and Polgár, Tamás Ferenc and Pertics, Botond Zsombor and Schneider, György and Kovács, Tamás and Rákhely, Gábor},
	doi = {10.3389/fmicb.2021.783722},
	journal-iso = {FRONT MICROBIOL},
	journal = {FRONTIERS IN MICROBIOLOGY},
	volume = {12},
	unique-id = {32548543},
	issn = {1664-302X},
	abstract = {The increasing ineffectiveness of traditional antibiotics and the rise of multidrug resistant (MDR) bacteria have necessitated the revival of bacteriophage (phage) therapy. However, bacteria might also evolve resistance against phages. Phages and their bacterial hosts coexist in nature, resulting in a continuous coevolutionary competition for survival. We have isolated several clinical strains of Pseudomonas aeruginosa and phages that infect them. Among these, the PIAS (Phage Induced Antibiotic Sensitivity) phage belonging to the Myoviridae family can induce multistep genomic deletion in drug-resistant clinical strains of P. aeruginosa, producing a compromised drug efflux system in the bacterial host. We identified two types of mutant lines in the process: green mutants with SNPs (single nucleotide polymorphisms) and smaller deletions and brown mutants with large (∼250 kbp) genomic deletion. We demonstrated that PIAS used the MexXY-OprM system to initiate the infection. P. aeruginosa clogged PIAS phage infection by either modifying or deleting these receptors. The green mutant gaining phage resistance by SNPs could be overcome by evolved PIASs (E-PIASs) with a mutation in its tail-fiber protein. Characterization of the mutant phages will provide a deeper understanding of phage-host interaction. The coevolutionary process continued with large deletions in the same regions of the bacterial genomes to block the (E-)PIAS infection. These mutants gained phage resistance via either complete loss or substantial modifications of the phage receptor, MexXY-OprM, negating its essential role in antibiotic resistance. In vitro and in vivo studies indicated that combined use of PIAS and antibiotics could effectively inhibit P. aeruginosa growth. The phage can either eradicate bacteria or induce antibiotic sensitivity in MDR-resistant clinical strains. We have explored the potential use of combination therapy as an alternative approach against MDR P. aeruginosa infection.},
	keywords = {Combined treatment; bacteriophage therapy; phage resistance; MexXY-OprM efflux system; phage-provoked sequential genomic mutation/deletion},
	year = {2021},
	eissn = {1664-302X},
	orcid-numbers = {Deim, Zoltán/0000-0003-3925-5564; Terhes, Gabriella/0000-0002-7301-9672; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Váczi, Sándor/0000-0002-9642-7126; Pertics, Botond Zsombor/0000-0002-1734-1632; Rákhely, Gábor/0000-0003-2557-3641}
}

@mastersthesis{MTMT:32477085,
	title = {Streptococcus agalactiae screening of pregnant women and detection of methicillin-resistant Staphylococcus aureus using MALDI-TOF mass spectrometry: application and improvement of the method [Várandós nők Streptococcus agalactiae szűrése és methicillin-rezisztens Staphylococcus aureus törzsek kimutatása MALDI-TOF tömegspektrometriával: alkalmazás és módszerfejlesztés]},
	url = {https://m2.mtmt.hu/api/publication/32477085},
	author = {Pappné Ábrók, Marianna},
	doi = {10.14232/phd.10598},
	publisher = {SZTE},
	unique-id = {32477085},
	year = {2021},
	orcid-numbers = {Pappné Ábrók, Marianna/0000-0002-9812-4778}
}

@article{MTMT:32471601,
	title = {Tuning Genomics for Highly Heterozygous and Polyploid Saccharomyces Genomes: Where did our Commercial and Clinical Yeasts come from?},
	url = {https://m2.mtmt.hu/api/publication/32471601},
	author = {Alexandra, Imre and Hanna, Viktória Rácz and Péter, Oláh and Zsuzsa, Antunovics and Csányiné Dóczi, Ilona and Kovács, Renátó and László, Majoros and István, Pócsi and Ksenija, Lopandic and Devin, Bendixsen and Rike, Stelkens and Walter, P. Pfiegler},
	journal-iso = {ACTA MICROBIOL IMMUNOL HUNG},
	journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA},
	volume = {68},
	unique-id = {32471601},
	issn = {1217-8950},
	year = {2021},
	eissn = {1588-2640},
	pages = {73}
}

@article{MTMT:32471568,
	title = {Virulence Factors and In-Host Selection of Phenotypes in Infectious Probiotic Yeast Isolates},
	url = {https://m2.mtmt.hu/api/publication/32471568},
	author = {Imre, Alexandra and Kovács, Renátó and Pázmándi, Kitti and Jakab, Ágnes and V. Rácz, Hanna and Nemes, Dániel and Csányiné Dóczi, Ilona and Bácskay, Ildikó and Gácser, Attila and Farkas, Zoltán and Kovács, Károly and Majoros, László and Pócsi, István and P. Pflieger, Walter},
	journal-iso = {ACTA MICROBIOL IMMUNOL HUNG},
	journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA},
	volume = {68},
	unique-id = {32471568},
	issn = {1217-8950},
	year = {2021},
	eissn = {1588-2640},
	pages = {73},
	orcid-numbers = {Nemes, Dániel/0000-0002-5477-0540}
}

@article{MTMT:32471534,
	title = {Phage-Induced Antibiotic Sensitivity of Multidrug Resistant Pseudomonas Aeruginosa: A Perspective on Combined Phage-Antibiotic Therapy},
	url = {https://m2.mtmt.hu/api/publication/32471534},
	author = {Koderi Valappil, Sarshad and Deim, Zoltán and Terhes, Gabriella and Zsoldiné Urbán, Edit and Prateek, Shetty and Roland, Patai and György, Schneider and Tamás, Kovács and Rákhely, Gábor},
	journal-iso = {ACTA MICROBIOL IMMUNOL HUNG},
	journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA},
	volume = {68},
	unique-id = {32471534},
	issn = {1217-8950},
	year = {2021},
	eissn = {1588-2640},
	pages = {47-47},
	orcid-numbers = {Deim, Zoltán/0000-0003-3925-5564; Terhes, Gabriella/0000-0002-7301-9672; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Rákhely, Gábor/0000-0003-2557-3641}
}

@article{MTMT:32471530,
	title = {Epidemiological Characterization of HEV Infection, in Hungary},
	url = {https://m2.mtmt.hu/api/publication/32471530},
	author = {Ulbert, Áron and Anett, Magyari and Hajdú, Edit and Zita, Túri and Burián, Katalin and Terhes, Gabriella},
	journal-iso = {ACTA MICROBIOL IMMUNOL HUNG},
	journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA},
	volume = {68},
	unique-id = {32471530},
	issn = {1217-8950},
	year = {2021},
	eissn = {1588-2640},
	pages = {47-47},
	orcid-numbers = {Burián, Katalin/0000-0003-1300-2374; Terhes, Gabriella/0000-0002-7301-9672}
}

@article{MTMT:32471522,
	title = {Description of a Novel Carbapenemase From Bacteroides Xylanisolvens},
	url = {https://m2.mtmt.hu/api/publication/32471522},
	author = {Sóki, József and Ulrike, Schumacher and Balázs, Horváth and Ágnes, Berényi and István, Nagy and Nagy, Erzsébet},
	journal-iso = {ACTA MICROBIOL IMMUNOL HUNG},
	journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA},
	volume = {68},
	unique-id = {32471522},
	issn = {1217-8950},
	year = {2021},
	eissn = {1588-2640},
	pages = {38},
	orcid-numbers = {Sóki, József/0000-0001-9230-8907}
}

@article{MTMT:32471464,
	title = {Phenotypic and Molecular Characterization of Carbapenem Heteroresistant Bacteroides Fragilis strains},
	url = {https://m2.mtmt.hu/api/publication/32471464},
	author = {Baaity, Zain and Nagy, Erzsébet and Sóki, József},
	journal-iso = {ACTA MICROBIOL IMMUNOL HUNG},
	journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA},
	volume = {68},
	unique-id = {32471464},
	issn = {1217-8950},
	year = {2021},
	eissn = {1588-2640},
	pages = {6},
	orcid-numbers = {Baaity, Zain/0000-0001-6411-382X; Sóki, József/0000-0001-9230-8907}
}

@article{MTMT:32471444,
	title = {Metronidazole-resistant Bacteroidesstrains from Kuwait: A Molecular Study},
	url = {https://m2.mtmt.hu/api/publication/32471444},
	author = {Baaity, Zain and Wafaa, Jamal and Vincent, O. Rotimi and Burián, Katalin and Nagy, Erzsébet and Somogyvári, Ferenc and Sóki, József},
	journal-iso = {ACTA MICROBIOL IMMUNOL HUNG},
	journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA},
	volume = {68},
	unique-id = {32471444},
	issn = {1217-8950},
	year = {2021},
	eissn = {1588-2640},
	pages = {5},
	orcid-numbers = {Baaity, Zain/0000-0001-6411-382X; Burián, Katalin/0000-0003-1300-2374; Sóki, József/0000-0001-9230-8907}
}

@CONFERENCE{MTMT:32118834,
	title = {Development and pilot testing of a questionnaire to assess the knowledge-level and attitudes of junior doctors on infectious diseases and antimicrobial resistance},
	url = {https://m2.mtmt.hu/api/publication/32118834},
	author = {Gajdács, Márió and Klaudia, Komáry and Burián, Katalin and Hajdú, Edit and Paulik, Edit and Szabó, Andrea},
	booktitle = {Proceedings of the 1st International Electronic Conference on Antibiotics},
	doi = {10.3390/ECA2021-09881},
	unique-id = {32118834},
	year = {2021},
	orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Burián, Katalin/0000-0003-1300-2374; Paulik, Edit/0000-0002-3446-4327}
}