@article{MTMT:34720451,
	title = {A carvedilolterápia jelentősége a kardiovaszkuláris betegségek kezelésében},
	url = {https://m2.mtmt.hu/api/publication/34720451},
	author = {Ábrahám, György and Gajdán, Nikolett},
	journal-iso = {METABOLIZMUS},
	journal = {METABOLIZMUS},
	volume = {22},
	unique-id = {34720451},
	issn = {1589-7311},
	year = {2025},
	pages = {82-85},
	orcid-numbers = {Ábrahám, György/0000-0002-2272-2317}
}

@article{MTMT:34828644,
	title = {Az anémia etiopatológiája, diagnózisa és kezelése gyulladásos bélbetegségekben [Etiopathology, diagnosis, and management of anaemia in inflammatory bowel disease]},
	url = {https://m2.mtmt.hu/api/publication/34828644},
	author = {Resál, Tamás and Molnár, Tamás},
	doi = {10.33570/CEUJGH.10.1.13},
	journal-iso = {CENT EUR J GASTRO HEPATOL},
	journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE},
	volume = {10},
	unique-id = {34828644},
	abstract = {Az anémia az egyik leggyakoribb komorbiditás gyulladásos bélbetegeknél (IBD), amelynek a hátterében leggyakrabban a vasháztartás zavara áll. Bár az anémia prevalenciája kifejezetten magas, és az életminőséget is jelentősen rontja, a pontos etiológia tisztázása és a kezelés is gyakran elmarad IBD-ben. Jelen összefoglaló közlemény célja, hogy bemutassa az anémia epidemiológiai adatait, segítse a fennálló vérszegénység etiopatológiai tisztázását, és ezáltal segítse a megfelelő terápia választását az anémia és a vasháztartás rendezésére.},
	year = {2024},
	eissn = {2415-9107},
	pages = {13-17},
	orcid-numbers = {Resál, Tamás/0000-0002-3842-9094; Molnár, Tamás/0000-0002-4913-7599}
}

@article{MTMT:34828410,
	title = {Insights into treatment of complex Crohn's perianal fistulas},
	url = {https://m2.mtmt.hu/api/publication/34828410},
	author = {Norčič, Gregor and Smrekar, Nataša and Marković, Srđan and Barišić, Goran and Kiudelis, Gediminas and Paužas, Henrikas and Molnár, Tamás and Szijártó, Attila and Šerclová, Zuzana and Roblek, Tina and Uršič, Viktor and White, Ian},
	doi = {10.1186/s12919-024-00291-4},
	journal-iso = {BMC PROCEEDINGS},
	journal = {BMC PROCEEDINGS},
	volume = {18},
	unique-id = {34828410},
	abstract = {Complex perianal fistula is a common complication of Crohn's disease (CD) which leads to negative impact on patient's quality of life. Successful management of the disease requires a multidisciplinary approach, including a gastroenterologist and a colorectal surgeon, applying combined surgical and medical therapy. One of frequently practiced surgical procedures is seton placement in the fistula tract, which is used to control perianal sepsis and drain the fistula, while preventing recurrent abscess formation.Darvadstrocel, a suspension of expanded, allogeneic, adipose-derived, mesenchymal stem cells, is safe and effective for treatment-refractory complex perianal fistulas in patients with Crohn's disease. Following approval of darvadstrocel, the INSPIRE registry is being conducted in order to evaluate long-term safety and effectiveness of the drug on a large, heterogenous population.An online expert meeting was held from March 20 to March 30, 2023, which provided relevant insights into the decision-making process regarding seton use and obtained feedback on the first experiences with darvadstrocel. The aim of this article is to present the perspectives from gastroenterologists and colorectal surgeons practicing in Czechia, Hungary, Israel, Lithuania, Serbia, and Slovenia in topics such as diagnosis and treatment options for patients with complex Crohn's perianal fistulas (CPF), specifically focusing on the use of setons and darvadstrocel.During this virtual session, unavailability of comprehensive data on safety and efficacy of available treatment procedures was emphasized as an important obstacle towards development of standardized recommendations and improvement of outcomes in treatment of (CPF). Furthermore, achieving consensus in seton use, duration of its placement, and frequency of change is recognized as one of CPF treatments major challenges. Despite these issues, it is important to promote better understanding and treatment of complex perianal fistulas in order to improve the quality of life of those affected by this condition.},
	keywords = {Crohn's disease; Multidisciplinary management; Surgical procedures; Perianal fistulas; long-term safety evaluation; treatment challenges; Darvadstrocel Therapy},
	year = {2024},
	eissn = {1753-6561},
	orcid-numbers = {Molnár, Tamás/0000-0002-4913-7599}
}

@article{MTMT:34825468,
	title = {Incident Cancer Risk in Patients with Incident Type 2 Diabetes Mellitus in Hungary (Part 1)},
	url = {https://m2.mtmt.hu/api/publication/34825468},
	author = {Abonyi-Tóth, Zsolt and Rokszin, György Aurél and Bajcsayné Fábián, Ibolya and Kiss, Zoltán and Jermendy, György and Kempler, Péter and Lengyel, Csaba Attila and Wittmann, István and Molnár, Gergő Attila and Sütő, Gábor},
	doi = {10.3390/cancers16091745},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {16},
	unique-id = {34825468},
	abstract = {Abstract
		(1) Background: Patients with type 2 diabetes mellitus (T2DM) are at higher risk of cancer but how these two diseases associate is still debated. The goal of this study was the assessment of the overall incidence of cancer among patients with newly diagnosed T2DM in Hungary. (2) Methods: A nationwide, retrospective, longitudinal study was performed using a Hungarian database. After exclusion of cases of age < 18 years, with gestational diabetes, with polycystic ovary syndrome, and with type 1 and prevalent type 2 diabetes mellitus, the incident T2DM (approx. 50,000 cases yearly) and for comparison, the diabetes-free Hungarian adult population (approx. 7,000,000 cases yearly) was included in the study. The primary endpoints were the overall and site-specific incidence and annual percentage change of the incidence of cancer in both populations. (3) Results: The overall incidence of cancer in patients amounted to 29.4/1000 and 6.6/1000 with or without T2DM, respectively, and the OR (95%CI) of cancer of the T2DM group was 4.32 (4.14–4.53), p < 0.0001. The risk of having cancer was age dependent. The incidence of cancer was declining in the non-diabetic but was unchanged in the T2DM population. The average lag time of diagnosing cancer after the detection of T2DM was 3.86 months. (4) Conclusions: Incident T2DM is associated with a significantly higher overall risk of incident cancer, with a reverse correlation of age. Newly registered T2DM patients were suggested to be screened for cancer within 6 months.},
	year = {2024},
	eissn = {2072-6694},
	orcid-numbers = {Abonyi-Tóth, Zsolt/0000-0002-5585-3313; Kiss, Zoltán/0000-0002-4752-8529; Kempler, Péter/0000-0002-6072-8832; Lengyel, Csaba Attila/0000-0002-0434-0067; Molnár, Gergő Attila/0000-0001-6052-5907}
}

@article{MTMT:34824744,
	title = {Speckle-tracking echocardiography-derived left ventricular global longitudinal strain – 2D, 3D, manual or automated?},
	url = {https://m2.mtmt.hu/api/publication/34824744},
	author = {Nemes, Attila},
	doi = {10.1016/j.ijcard.2024.132096},
	journal-iso = {INT J CARDIOL},
	journal = {INTERNATIONAL JOURNAL OF CARDIOLOGY},
	volume = {406},
	unique-id = {34824744},
	issn = {0167-5273},
	year = {2024},
	eissn = {1874-1754},
	orcid-numbers = {Nemes, Attila/0000-0002-7570-6214}
}

@article{MTMT:34824739,
	title = {AI-assisted capsule endoscopy reading in suspected small bowel bleeding. a multicentre prospective study},
	url = {https://m2.mtmt.hu/api/publication/34824739},
	author = {Spada, Cristiano and Piccirelli, Stefania and Hassan, Cesare and Ferrari, Clarissa and Toth, Ervin and González-Suárez, Begoña and Keuchel, Martin and McAlindon, Marc and Finta, Ádám and Rosztóczy, András and Dray, Xavier and Salvi, Daniele and Riccioni, Maria Elena and Benamouzig, Robert and Chattree, Amit and Humphries, Adam and Saurin, Jean-Christophe and Despott, Edward J and Murino, Alberto and Johansson, Gabriele Wurm and Giordano, Antonio and Baltes, Peter and Sidhu, Reena and Szalai, Milan and Helle, Krisztina and Nemeth, Artur and Nowak, Tanja and Lin, Rong and Costamagna, Guido},
	doi = {10.1016/S2589-7500(24)00048-7},
	journal-iso = {LANCET DIGIT HEALTH},
	journal = {LANCET DIGITAL HEALTH},
	volume = {6},
	unique-id = {34824739},
	abstract = {Capsule endoscopy reading is time consuming, and readers are required to maintain attention so as not to miss significant findings. Deep convolutional neural networks can recognise relevant findings, possibly exceeding human performances and reducing the reading time of capsule endoscopy. Our primary aim was to assess the non-inferiority of artificial intelligence (AI)-assisted reading versus standard reading for potentially small bowel bleeding lesions (high P2, moderate P1; Saurin classification) at per-patient analysis. The mean reading time in both reading modalities was evaluated among the secondary endpoints.Patients aged 18 years or older with suspected small bowel bleeding (with anaemia with or without melena or haematochezia, and negative bidirectional endoscopy) were prospectively enrolled at 14 European centres. Patients underwent small bowel capsule endoscopy with the Navicam SB system (Ankon, China), which is provided with a deep neural network-based AI system (ProScan) for automatic detection of lesions. Initial reading was performed in standard reading mode. Second blinded reading was performed with AI assistance (the AI operated a first-automated reading, and only AI-selected images were assessed by human readers). The primary endpoint was to assess the non-inferiority of AI-assisted reading versus standard reading in the detection (diagnostic yield) of potentially small bowel bleeding P1 and P2 lesions in a per-patient analysis. This study is registered with ClinicalTrials.gov, NCT04821349.From Feb 17, 2021 to Dec 29, 2021, 137 patients were prospectively enrolled. 133 patients were included in the final analysis (73 [55%] female, mean age 66·5 years [SD 14·4]; 112 [84%] completed capsule endoscopy). At per-patient analysis, the diagnostic yield of P1 and P2 lesions in AI-assisted reading (98 [73·7%] of 133 lesions) was non-inferior (p<0·0001) and superior (p=0·0213) to standard reading (82 [62·4%] of 133; 95% CI 3·6-19·0). Mean small bowel reading time was 33·7 min (SD 22·9) in standard reading and 3·8 min (3·3) in AI-assisted reading (p<0·0001).AI-assisted reading might provide more accurate and faster detection of clinically relevant small bowel bleeding lesions than standard reading.ANKON Technologies, China and AnX Robotica, USA provided the NaviCam SB system.},
	year = {2024},
	eissn = {2589-7500},
	pages = {e345-e353},
	orcid-numbers = {Rosztóczy, András/0000-0002-8597-8934}
}

@article{MTMT:34824725,
	title = {Trends and regional differences in antidiabetic medication use: a nationwide retrospective observational study},
	url = {https://m2.mtmt.hu/api/publication/34824725},
	author = {Csatordai, Márta and Benkő, Ria and Matuz, Mária and Engi, Zsófia and Csupor, Dezső and Lengyel, Csaba Attila and Doró, Péter},
	doi = {10.1186/s13098-024-01334-8},
	journal-iso = {DIABETOL METAB SYNDR},
	journal = {DIABETOLOGY AND METABOLIC SYNDROME},
	volume = {16},
	unique-id = {34824725},
	issn = {1758-5996},
	year = {2024},
	eissn = {1758-5996},
	orcid-numbers = {Benkő, Ria/0000-0002-8009-8962; Matuz, Mária/0000-0002-7877-2399; Csupor, Dezső/0000-0002-4088-3333; Lengyel, Csaba Attila/0000-0002-0434-0067; Doró, Péter/0000-0001-7784-6010}
}

@article{MTMT:34803172,
	title = {Left atrial strains in cardiac amyloidosis -does its subtype matter?},
	url = {https://m2.mtmt.hu/api/publication/34803172},
	author = {Nemes, Attila},
	doi = {10.1016/j.ijcard.2024.132078},
	journal-iso = {INT J CARDIOL},
	journal = {INTERNATIONAL JOURNAL OF CARDIOLOGY},
	volume = {406},
	unique-id = {34803172},
	issn = {0167-5273},
	year = {2024},
	eissn = {1874-1754},
	orcid-numbers = {Nemes, Attila/0000-0002-7570-6214}
}

@article{MTMT:34797929,
	title = {A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma},
	url = {https://m2.mtmt.hu/api/publication/34797929},
	author = {Giaccherini, M and Rende, M and Gentiluomo, M and Corradi, C and Archibugi, L and Ermini, S and Maiello, E and Morelli, L and van Eijck, C H J and Cavestro, G M and Schneider, M and Mickevicius, A and Adamonis, K and Basso, D and Hlavac, V and Gioffreda, D and Talar-Wojnarowska, R and Schöttker, B and Lovecek, M and Vanella, G and Gazouli, M and Uno, M and Malecka-Wojciesko, E and Vodicka, P and Goetz, M and Bijlsma, M F and Petrone, M C and Bazzocchi, F and Kiudelis, M and Szentesi, Andrea Ildikó and Carrara, S and Nappo, G and Brenner, H and Milanetto, A C and Soucek, P and Katzke, V and Peduzzi, G and Rizzato, C and Pasquali, C and Chen, X and Capurso, G and Hackert, T and Bueno-de-Mesquita, B and Uzunoglu, F G G and Hegyi, Péter and Greenhalf, W and Theodoropoulos, G E E and Sperti, C and Perri, F and Oliverius, M and Mambrini, A and Tavano, F and Farinella, R and Arcidiacono, P G and Lucchesi, M and Bunduc, Stefania and Kupcinskas, J and Di Franco, G and Stocker, S and Neoptolemos, J P and Bambi, F and Jamroziak, K and Testoni, S G G and Aoki, M N and Mohelnikova-Duchonova, B and Izbicki, J R and Pezzilli, R and Lawlor, R T and Kauffmann, E F and López de Maturana, E and Malats, N and Canzian, F and Campa, D},
	doi = {10.1093/mutage/geae012},
	journal-iso = {MUTAGENESIS},
	journal = {MUTAGENESIS},
	unique-id = {34797929},
	issn = {0267-8357},
	abstract = {Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted ten years ago in relation to pancreatic ductal adenocarcinoma susceptibility. However, in the last decade, genetic association studies performed on several human traits have greatly increased the number of known pleiotropic variants. Based on the hypothesis that variants already associated with a least one trait have a higher probability of association with other traits, 61,052 variants reported to be associated by at least one genome wide association study (GWAS) with at least one human trait were tested in the present study consisting of two phases (discovery and validation), comprising a total of 16,055 pancreatic ductal adenocarcinoma (PDAC) cases and 212,149 controls. The meta-analysis of the two phases showed two loci (10q21.1-rs4948550 (P=6.52×10-5) and 7q36.3-rs288762 (P=3.03×10-5) potentially associated with PDAC risk. 10q21.1-rs4948550 shows a high degree of pleiotropy and it is also associated with colorectal cancer risk while 7q36.3-rs288762 is situated 28,558 base pairs upstream of the Sonic Hedgehog (SHH) gene, which is involved in the cell differentiation process and PDAC etiopathogenesis. In conclusion, none of the single nucleotide polymorphisms (SNPs) showed a formally statistically significant association after correction for multiple testing. However, given their pleiotropic nature and association with various human traits including colorectal cancer, the two SNPs showing the best associations with PDAC risk merit further investigation through fine mapping and ad hoc functional studies.},
	keywords = {single nucleotide polymorphism; genetic susceptibility; Pancreatic cancer; Pleiotropy},
	year = {2024},
	eissn = {1464-3804},
	orcid-numbers = {Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:34796471,
	title = {Favipiravir does not improve viral clearance in mild to moderate COVID-19 – a systematic review and meta-analysis of randomized controlled trials},
	url = {https://m2.mtmt.hu/api/publication/34796471},
	author = {Bahar, Muhammad Akbar and Kusuma, Ikhwan Yuda and Visnyovszki, Ádám and Matuz, Mária and Benkő, Ria and Ferenci, Tamás and Szabó, Bálint Gergely and Hajdú, Edit and Pető, Zoltán and Csupor, Dezső},
	doi = {10.1016/j.heliyon.2024.e29808},
	journal-iso = {HELIYON},
	journal = {HELIYON},
	volume = {10},
	unique-id = {34796471},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {2405-8440},
	orcid-numbers = {Matuz, Mária/0000-0002-7877-2399; Benkő, Ria/0000-0002-8009-8962; Ferenci, Tamás/0000-0001-6791-3080; Szabó, Bálint Gergely/0000-0003-1775-1356; Csupor, Dezső/0000-0002-4088-3333}
}