TY  - JOUR
AU  - Ábrahám, György
AU  - Gajdán, Nikolett
TI  - A carvedilolterápia jelentősége a kardiovaszkuláris betegségek kezelésében
JF  - METABOLIZMUS
J2  - METABOLIZMUS
VL  - 22
PY  - 2025
IS  - 2
SP  - 82
EP  - 85
PG  - 4
SN  - 1589-7311
UR  - https://m2.mtmt.hu/api/publication/34720451
ID  - 34720451
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Nemes, Attila
TI  - Left atrial strains in cardiac amyloidosis -does its subtype matter?
JF  - INTERNATIONAL JOURNAL OF CARDIOLOGY
J2  - INT J CARDIOL
PY  - 2024
SN  - 0167-5273
DO  - 10.1016/j.ijcard.2024.132078
UR  - https://m2.mtmt.hu/api/publication/34803172
ID  - 34803172
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Giaccherini, M
AU  - Rende, M
AU  - Gentiluomo, M
AU  - Corradi, C
AU  - Archibugi, L
AU  - Ermini, S
AU  - Maiello, E
AU  - Morelli, L
AU  - van Eijck, C H J
AU  - Cavestro, G M
AU  - Schneider, M
AU  - Mickevicius, A
AU  - Adamonis, K
AU  - Basso, D
AU  - Hlavac, V
AU  - Gioffreda, D
AU  - Talar-Wojnarowska, R
AU  - Schöttker, B
AU  - Lovecek, M
AU  - Vanella, G
AU  - Gazouli, M
AU  - Uno, M
AU  - Malecka-Wojciesko, E
AU  - Vodicka, P
AU  - Goetz, M
AU  - Bijlsma, M F
AU  - Petrone, M C
AU  - Bazzocchi, F
AU  - Kiudelis, M
AU  - Szentesi, Andrea Ildikó
AU  - Carrara, S
AU  - Nappo, G
AU  - Brenner, H
AU  - Milanetto, A C
AU  - Soucek, P
AU  - Katzke, V
AU  - Peduzzi, G
AU  - Rizzato, C
AU  - Pasquali, C
AU  - Chen, X
AU  - Capurso, G
AU  - Hackert, T
AU  - Bueno-de-Mesquita, B
AU  - Uzunoglu, F G G
AU  - Hegyi, Péter
AU  - Greenhalf, W
AU  - Theodoropoulos, G E E
AU  - Sperti, C
AU  - Perri, F
AU  - Oliverius, M
AU  - Mambrini, A
AU  - Tavano, F
AU  - Farinella, R
AU  - Arcidiacono, P G
AU  - Lucchesi, M
AU  - Bunduc, Stefania
AU  - Kupcinskas, J
AU  - Di Franco, G
AU  - Stocker, S
AU  - Neoptolemos, J P
AU  - Bambi, F
AU  - Jamroziak, K
AU  - Testoni, S G G
AU  - Aoki, M N
AU  - Mohelnikova-Duchonova, B
AU  - Izbicki, J R
AU  - Pezzilli, R
AU  - Lawlor, R T
AU  - Kauffmann, E F
AU  - López de Maturana, E
AU  - Malats, N
AU  - Canzian, F
AU  - Campa, D
TI  - A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma
JF  - MUTAGENESIS
J2  - MUTAGENESIS
PY  - 2024
SN  - 0267-8357
DO  - 10.1093/mutage/geae012
UR  - https://m2.mtmt.hu/api/publication/34797929
ID  - 34797929
AB  - Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted ten years ago in relation to pancreatic ductal adenocarcinoma susceptibility. However, in the last decade, genetic association studies performed on several human traits have greatly increased the number of known pleiotropic variants. Based on the hypothesis that variants already associated with a least one trait have a higher probability of association with other traits, 61,052 variants reported to be associated by at least one genome wide association study (GWAS) with at least one human trait were tested in the present study consisting of two phases (discovery and validation), comprising a total of 16,055 pancreatic ductal adenocarcinoma (PDAC) cases and 212,149 controls. The meta-analysis of the two phases showed two loci (10q21.1-rs4948550 (P=6.52×10-5) and 7q36.3-rs288762 (P=3.03×10-5) potentially associated with PDAC risk. 10q21.1-rs4948550 shows a high degree of pleiotropy and it is also associated with colorectal cancer risk while 7q36.3-rs288762 is situated 28,558 base pairs upstream of the Sonic Hedgehog (SHH) gene, which is involved in the cell differentiation process and PDAC etiopathogenesis. In conclusion, none of the single nucleotide polymorphisms (SNPs) showed a formally statistically significant association after correction for multiple testing. However, given their pleiotropic nature and association with various human traits including colorectal cancer, the two SNPs showing the best associations with PDAC risk merit further investigation through fine mapping and ad hoc functional studies.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bahar, Muhammad Akbar
AU  - Kusuma, Ikhwan Yuda
AU  - Visnyovszki, Ádám
AU  - Matuz, Mária
AU  - Benkő, Ria
AU  - Ferenci, Tamás
AU  - Szabó, Bálint Gergely
AU  - Hajdú, Edit
AU  - Pető, Zoltán
AU  - Csupor, Dezső
TI  - Favipiravir does not improve viral clearance in mild to moderate COVID-19 – a systematic review and meta-analysis of randomized controlled trials
JF  - HELIYON
J2  - HELIYON
PY  - 2024
SN  - 2405-8440
DO  - 10.1016/j.heliyon.2024.e29808
UR  - https://m2.mtmt.hu/api/publication/34796471
ID  - 34796471
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Nemes, Attila
TI  - Are there Disease-Specific Functional Features of Cardiac Mechanics?
JF  - REVIEWS IN CARDIOVASCULAR MEDICINE
J2  - REV CARDIOVASC MED
VL  - 25
PY  - 2024
IS  - 4
PG  - 2
SN  - 1530-6550
DO  - 10.31083/j.rcm2504137
UR  - https://m2.mtmt.hu/api/publication/34788779
ID  - 34788779
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Obeid, Rima
AU  - Andrès, Emmanuel
AU  - Češka, Richard
AU  - Hooshmand, Babak
AU  - Guéant-Rodriguez, Rosa-Maria
AU  - Prada, Gabriel Ioan
AU  - Sławek, Jarosław
AU  - Traykov, Latchezar
AU  - Ta Van, Binh
AU  - Várkonyi, Tamás
AU  - Reiners, Karlheinz
ED  - Agata, Sobczynska-Malefora / Collaborator
ED  - Aleksandra, Araszkiewicz / Collaborator
ED  - Andrew, McCaddon / Collaborator
ED  - Anne, M Molloy / Collaborator
ED  - Bruce, H.R. Wolffenbuttel / Collaborator
ED  - Bruno, Annibale / Collaborator
ED  - Christine, A.F. von Arnim / Collaborator
ED  - Christy, C Tangney / Collaborator
ED  - David, Smith / Collaborator
ED  - Dongming, Zheng / Collaborator
ED  - Edith, Lahner / Collaborator
ED  - Gabriela, Spulber / Collaborator
ED  - Georgeta, Daniela Georgescu / Collaborator
ED  - Francesca, Mangialasche / Collaborator
ED  - Hendrika, (H.J.M.) Smelt / Collaborator
ED  - Janet, B McGill / Collaborator
ED  - J., David Spence / Collaborator
ED  - John, Killen / Collaborator
ED  - P, Julian Owen / Collaborator
ED  - Lisette, CPGM de Groot / Collaborator
ED  - Michelle, Murphy / Collaborator
ED  - G, Bhanuprakash Reddy / Collaborator
ED  - Pradeepa, Rajendra / Collaborator
ED  - Ralph, Green / Collaborator
ED  - Sadanand, Naik / Collaborator
ED  - Tsvetalina, Tankova / Collaborator
ED  - William, Huynh / Collaborator
ED  - Wolfgang, N. Löscher / Collaborator
ED  - Zyta, Beata Wojszel / Collaborator
TI  - Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus
JF  - JOURNAL OF CLINICAL MEDICINE
J2  - J CLIN MED
VL  - 13
PY  - 2024
IS  - 8
PG  - 18
SN  - 2077-0383
DO  - 10.3390/jcm13082176
UR  - https://m2.mtmt.hu/api/publication/34788761
ID  - 34788761
AB  - Background/Objectives: Vitamin B12 deficiency can cause variable symptoms, which may be irreversible if not diagnosed and treated in a timely manner. We aimed to develop a widely accepted expert consensus to guide the practice of diagnosing and treating B12 deficiency. Methods: We conducted a scoping review of the literature published in PubMed since January 2003. Data were used to design a two-round Delphi survey to study the level of consensus among 42 experts. Results: The panelists agreed on the need for educational and organizational changes in the current medical practices for diagnosing and treating B12 deficiency. Recognition of clinical symptoms should receive the highest priority in establishing the diagnosis. There is agreement that the serum B12 concentration is useful as a screening marker and methylmalonic acid or homocysteine can support the diagnosis. Patient lifestyle, disease history, and medications can provide clues to the cause of B12 deficiency. Regardless of the cause of the deficiency, initial treatment with parenteral B12 was regarded as the first choice for patients with acute and severe manifestations of B12 deficiency. The use of high-dose oral B12 at different frequencies may be considered for long-term treatment. Prophylactic B12 supplementation should be considered for specific high-risk groups. Conclusions: There is a consensus that clinical symptoms need to receive more attention in establishing the diagnosis of B12 deficiency. B12 laboratory markers can support the diagnosis. The severity of clinical symptoms, the causes of B12 deficiency, and the treatment goals govern decisions regarding the route and dose of B12 therapy.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Nemes, Attila
AU  - Kormányos, Árpád
AU  - Orosz, Andrea
AU  - Ambrus, Nóra
AU  - Várkonyi, Tamás
AU  - Lengyel, Csaba Attila
TI  - Autonomic function and specific right atrial functions - Is there a relationship? Correlations from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study
JF  - JOURNAL OF CLINICAL ULTRASOUND
J2  - J CLIN ULTRASOUND
PY  - 2024
PG  - 8
SN  - 0091-2751
DO  - 10.1002/jcu.23672
UR  - https://m2.mtmt.hu/api/publication/34778284
ID  - 34778284
N1  - Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary            
            Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary            
            Export Date: 23 April 2024            
            CODEN: JCULD            
            Correspondence Address: Nemes, A.; Department of Medicine, H-6725 Szeged, emmelweis street 8, P.O. Box 427, Hungary; email: nemes.attila@med.u-szeged.hu
AB  - Similarly to the ventricles, the atria are under sympathetic/parasympathetic neural regulation. Accordingly, correlations were investigated between Ewing's standard cardiovascular reflex tests (SCRTs) and three-dimensional speckle-tracking echocardiography (3DSTE)-derived right atrial (RA) volumes and strains in healthy subjects.The study comprised 45 healthy adults, but 5 subjects were excluded due to inferior image quality for 3DSTE-derived RA assessments. The remaining 40 individuals being in sinus rhythm had a mean age of 35.1 ± 3.5 years (20 men). Two-dimensional, Doppler, 3DSTE and SCRTs were performed in all cases.RA maximum volume and total and passive RA stroke volumes correlated with the Valsalva ratio. Active RA stroke volume and emptying fraction showed correlations with 30/15 ratio. Peak global and mean segmental RA circumferential (CS) and longitudinal strains (LS) showed correlation with the Valsalva ratio. At atrial contraction, global RA-LS and mean segmental RA-CS showed correlations with the Valsalva ratio. Moreover, mean segmental RA-CS correlated with 30/15 ratio and mean segmental RA radial strain showed correlations with systolic blood pressure in response to standing. Autonomic neuropathy score correlated with peak global RA-LS.Autonomic function parameters have significant associations with specific RA functions in healthy adults, making the latter possible indicators of autonomic dysregulation.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vedelek, Viktor
AU  - Petra, Bicskei
AU  - Mariann, Tábi
AU  - Biróné Lajkó, Noémi
AU  - Csaba, Ékes
AU  - Bereczki, Kristóf
AU  - Zsófia, Meixner-Csáti
AU  - Rita, Sinka
AU  - Vágvölgyi, Anna
AU  - Zádori, János
TI  - Endometrium development patterns and BMI groups among in vitro fertilization patients; prognostic aspects
JF  - FRONTIERS IN ENDOCRINOLOGY
J2  - FRONT ENDOCRINOL
VL  - 15
PY  - 2024
SN  - 1664-2392
DO  - 10.3389/fendo.2024.1379109
UR  - https://m2.mtmt.hu/api/publication/34772955
ID  - 34772955
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Nemes, Attila
AU  - Rácz, Gergely
AU  - Kormányos, Árpád
AU  - Ruzsa, Zoltán
AU  - Achim, Alexandru
AU  - Lengyel, Csaba Attila
ED  - Cristiana, Bustea
ED  - Delia, Mirela Tit
TI  - The Relationship between Tricuspid Annular Longitudinal and Sphincter-Like Features of Its Function in Healthy Adults: Insights from the MAGYAR-Healthy Study
T2  - Cardiovascular Diseases: From Basic Research to Clinical Application
PB  - MDPI
CY  - Basel
SN  - 9783725806126
PY  - 2024
SP  - 155
EP  - 164
PG  - 10
UR  - https://m2.mtmt.hu/api/publication/34768899
ID  - 34768899
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bérczi, Bálint
AU  - Borbásné Farkas, Kornélia
AU  - Hegyi, Péter
AU  - Tóth, Barbara
AU  - Csupor, Dezső
AU  - Németh, Balázs
AU  - Lukács, Anita
AU  - Czumbel, László Márk
AU  - Kerémi, Beáta
AU  - Kiss, István
AU  - Szabó, Andrea
AU  - Varga, Gábor
AU  - Gerber, Gábor
AU  - Gyöngyi, Zoltán
TI  - Aromatase Inhibitors and Plasma Lipid Changes in Postmenopausal Women with Breast Cancer: A Systematic Review and Meta-Analysis
JF  - JOURNAL OF CLINICAL MEDICINE
J2  - J CLIN MED
VL  - 13
PY  - 2024
IS  - 6
PG  - 20
SN  - 2077-0383
DO  - 10.3390/jcm13061818
UR  - https://m2.mtmt.hu/api/publication/34760472
ID  - 34760472
N1  - Journal Article; Review
AB  - Background: Women are typically diagnosed with estrogen receptor-positive breast cancer around the postmenopausal period when declining estrogen levels initiate changes in lipid profiles. Aromatase inhibitors (AI) are used to prevent the progression of cancer; however, a further reduction in estrogen levels may have detrimental effects on lipid levels, which was our working hypothesis. Methods: Our meta-analysis was conducted on the lipid profiles of postmenopausal breast cancer patients at baseline and at different treatment time points. Results: We identified 15 studies, including 1708 patients. Studies using anastrozole (ANA), exemestane (EXE), letrozole (LET), and tamoxifen (TMX) were involved. Subgroup analyses revealed that 3- and 12-month administrations of LET and EXE lead to negative changes in lipid profiles that tend to alter the lipid profile undesirably, unlike ANA and TMX. Conclusions: Our results suggest that, despite statistically significant results, EXE and LET may not be sufficient to cause severe dyslipidemia in patients without cardiovascular comorbidities according to the AHA/ACC Guideline on the Management of Blood Cholesterol. However, the results may raise the question of monitoring the effects of AIs in patients, especially those with pre-existing cardiovascular risk factors such as dyslipidemia.
LA  - English
DB  - MTMT
ER  -