@article{MTMT:34863613, title = {Bilastine for the treatment of allergic rhinoconjunctivitis and urticaria. results from an international Delphi study}, url = {https://m2.mtmt.hu/api/publication/34863613}, author = {Canonica, Giorgio Walter and Kuna, Piotr and Maurer, Marcus and Mösges, Ralph and Novák, Zoltán and Papadopoulos, Nikolaus and Del Rio, Pablo Rodriguez}, doi = {10.7573/dic.2024-2-3}, journal-iso = {DRUGS CONTEXT}, journal = {DRUGS IN CONTEXT}, volume = {13}, unique-id = {34863613}, issn = {1745-1981}, abstract = {Second-generation oral H1-antihistamines, including bilastine, represent the emerging treatments of allergic rhinitis (including rhinoconjunctivitis) and chronic urticaria in both adults and children. This study analyses available evidence supporting the use of bilastine amongst second-generation antihistamines for the symptomatic treatment of allergic rhinitis and urticaria in adults and children.Consensus amongst experts from 17 countries on the ideal treatment of rhinitis and urticaria, and the specific role of bilastine was measured by means of a modified Delphi process. A total of 12 statements were voted on by the experts using a five-point Likert scale (1 = strongly disagree; 2 = disagree; 3 = undecided; 4 = agree; 5 = strongly agree). The definition of consensus was set at a minimum of 80% concordance for 4+5 scores (agree or strongly agree).All proposed statements reached consensus, with a concordance of ≥98% for five statements and ≥96% for seven.The wide consensus obtained for the proposed statements suggests a prominent role for bilastine in the management of allergic rhinitis and urticaria.}, keywords = {allergic rhinitis; urticaria; Allergy; allergic rhinoconjunctivitis; Antihistamines; bilastine; Delphi process}, year = {2024}, eissn = {1740-4398}, orcid-numbers = {Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743} } @article{MTMT:34856761, title = {Új szemlélet, új utak az asztma kezelésében}, url = {https://m2.mtmt.hu/api/publication/34856761}, author = {Novák, Zoltán}, journal-iso = {GYERMEKORVOS TOVÁBBKÉPZÉS}, journal = {GYERMEKORVOS TOVÁBBKÉPZÉS}, volume = {23}, unique-id = {34856761}, issn = {1589-0309}, year = {2024}, pages = {8-10} } @article{MTMT:34855145, title = {Effect of Orkambi on the course of acute pancreatitis}, url = {https://m2.mtmt.hu/api/publication/34855145}, author = {Venglovecz, Viktória and Grassalkovich, A and Tóth, E and Ébert, Attila and Gál, Eleonóra and Korsós, Marietta Margaréta and Maléth, József and Rakonczay, Zoltán and Galla, Zsolt and Monostori, Péter and Hegyi, P}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {10}, unique-id = {34855145}, year = {2024}, eissn = {2415-9107}, pages = {137-138}, orcid-numbers = {Venglovecz, Viktória/0000-0002-2316-7247; Maléth, József/0000-0001-5768-3090; Rakonczay, Zoltán/0000-0002-1499-3416; Galla, Zsolt/0000-0002-9166-1212; Monostori, Péter/0000-0003-3591-6054} } @article{MTMT:34851786, title = {Validation of the Meditech ABPM-06 24-hour blood pressure monitoring system in a pediatric population according to International Organization for Standardization Protocol 81060-2:2018}, url = {https://m2.mtmt.hu/api/publication/34851786}, author = {Jakab, Andrea Emese and Horváth, Edit and Molnár, Dorottya and Bukva, Mátyás and Bereczki, Csaba}, doi = {10.1097/MBP.0000000000000701}, journal-iso = {BLOOD PRESS MONIT}, journal = {BLOOD PRESSURE MONITORING}, unique-id = {34851786}, issn = {1359-5237}, abstract = {Ambulatory blood pressure monitoring (ABPM) devices play a crucial role in diagnosing hypertension, not only in adults but also in pediatric patients. ABPM-06, the latest oscillometric device from Meditech Ltd. (Budapest, Hungary), is the focus of this study. The objective was to validate the ABPM-06 device using the International Organization for Standardization (ISO) 81060-2 : 2018 standard.A total of 86 healthy patients, consisting of 34 males and 52 females, aged between 3 and 17 years, were enrolled in this study. During the ambulatory phase, a total of 50 patients were enrolled, with 35 patients falling within the 3- to 12-year-old age range and 15 patients aged between 12 and 17 years. Additionally, for the dynamic test, 36 patients were selected, comprising of 10 individuals aged 3-12 years and 26 patients aged 12-17 years. These patients were recruited from the outpatient clinics of the Department of Pediatrics at Albert Szent-Györgyi University in Szeged, Hungary. The validation process involved utilizing the same-arm sequence protocol, both in resting positions and during stress testing.The ABPM-06 performed well in both clinical and ambulatory validations. In terms of validation criterion 1, the mean ± SD of the differences between the test device and reference blood pressure readings was -1.3 ± 3.5 mmHg for systolic and -0.1 ± 2.3 mmHg for diastolic, in children under the age of 12 years. For those over the age of 12 years, the mean ± SD of the differences was -2.8 ± 4.6 mmHg for systolic and -0.5 ± 2.7 mmHg for diastolic. Regarding the ambulatory validation, for children under 12 years old, the mean ± SD of the differences was -1.3 ± 3.5 mmHg for systolic and -0.1 ± 2.3 mmHg for diastolic. In the age group above 12 years, the mean ± SD of the differences was -2.8 ± 4.6 mmHg for systolic and -0.5 ± 2.7 mmHg for diastolic. Both tests successfully met the established criteria regarding the mean and SD values of the differences between the device readings and the observed SBP and DBP measurements.The ABPM-06 oscillometric device fully adheres to the ISO 81060-2 : 2018 standard requirements for ABPM determination in the pediatric population (ages 3-17 years). Consequently, this ABPM device proves to be suitable for effectively managing hypertension in children and adolescents.}, year = {2024}, eissn = {1473-5725}, orcid-numbers = {Jakab, Andrea Emese/0000-0003-4350-3460; Bereczki, Csaba/0000-0003-0091-3558} } @article{MTMT:34851784, title = {Recommendations for asthma monitoring in children. A PeARL document endorsed by APAPARI, EAACI, INTERASMA, REG, and WAO}, url = {https://m2.mtmt.hu/api/publication/34851784}, author = {Papadopoulos, Nikolaos G and Custovic, Adnan and Deschildre, Antoine and Gern, James E and Nieto Garcia, Antonio and Miligkos, Michael and Phipatanakul, Wanda and Wong, Gary and Xepapadaki, Paraskevi and Agache, Ioana and Arasi, Stefania and Awad El-Sayed, Zeinab and Bacharier, Leonard B and Bonini, Matteo and Braido, Fulvio and Caimmi, Davide and Castro-Rodriguez, Jose A and Chen, Zhimin and Clausen, Michael and Craig, Timothy and Diamant, Zuzana and Ducharme, Francine M and Ebisawa, Motohiro and Eigenmann, Philippe and Feleszko, Wojciech and Fierro, Vincezo and Fiocchi, Alessandro and Garcia-Marcos, Luis and Goh, Anne and Gómez, René Maximiliano and Gotua, Maia and Hamelmann, Eckard and Hedlin, Gunilla and Hossny, Elham M and Ispayeva, Zhanat and Jackson, Daniel J and Jartti, Tuomas and Jeseňák, Miloš and Kalayci, Omer and Kaplan, Alan and Konradsen, Jon R and Kuna, Piotr and Lau, Susanne and Le Souef, Peter and Lemanske, Robert F and Levin, Michael and Makela, Mika J and Mathioudakis, Alexander G and Mazulov, Oleksandr and Morais-Almeida, Mário and Murray, Clare and Nagaraju, Karthik and Novák, Zoltán and Pawankar, Ruby and Pijnenburg, Marielle W and Pite, Helena and Pitrez, Paulo M and Pohunek, Petr and Price, David and Priftanji, Alfred and Ramiconi, Valeria and Rivero Yeverino, Daniela and Roberts, Graham and Sheikh, Aziz and Shen, Kun-Ling and Szepfalusi, Zsolt and Tsiligianni, Ioanna and Turkalj, Mirjana and Turner, Steve and Umanets, Tetiana and Valiulis, Arunas and Vijveberg, Susanne and Wang, Jiu-Yao and Winders, Tonya and Yon, Dong Keon and Yusuf, Osman M and Zar, Heather J}, doi = {10.1111/pai.14129}, journal-iso = {PEDIATR ALLERGY IMMU}, journal = {PEDIATRIC ALLERGY AND IMMUNOLOGY}, volume = {35}, unique-id = {34851784}, issn = {0905-6157}, abstract = {Monitoring is a major component of asthma management in children. Regular monitoring allows for diagnosis confirmation, treatment optimization, and natural history review. Numerous factors that may affect disease activity and patient well-being need to be monitored: response and adherence to treatment, disease control, disease progression, comorbidities, quality of life, medication side-effects, allergen and irritant exposures, diet and more. However, the prioritization of such factors and the selection of relevant assessment tools is an unmet need. Furthermore, rapidly developing technologies promise new opportunities for closer, or even "real-time," monitoring between visits. Following an approach that included needs assessment, evidence appraisal, and Delphi consensus, the PeARL Think Tank, in collaboration with major international professional and patient organizations, has developed a set of 24 recommendations on pediatric asthma monitoring, to support healthcare professionals in decision-making and care pathway design.}, keywords = {Biomarkers; Therapy; diagnosis; Consensus; childhood; GUIDELINES; asthma management}, year = {2024}, eissn = {1399-3038} } @article{MTMT:34779925, title = {Personalized analysis of pain–weather associations: a pilot study}, url = {https://m2.mtmt.hu/api/publication/34779925}, author = {Tuboly, Gábor and Horváth, Gyöngyi and Nagy, Kamilla and Nagy, Edit}, doi = {10.18071/isz.77.0077}, journal-iso = {IDEGGYOGY SZEMLE}, journal = {IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE}, volume = {77}, unique-id = {34779925}, issn = {0019-1442}, abstract = {Background and purpose – It is a wellknown belief that weather can influence human health, including pain sensation. However, the current data are controversial, which might be due to the wide range of interindividual differences. The present study aimed to characterize the individual pain– weather associations during chronic pain by utilizing several data analytical methods. Methods – The study included 3-3 patients with (P1, P3, and P4) or without (P2, P5, P6) diabetes mellitus and signs of trigeminal neuralgia or low back pain. Subjective pain scores (0–10) and 12 weather parameters (terrestrial, geomagnetic, and solar) were recorded for one month repeated three times daily. Nonparametric Spearman’s correlation (Sp), multiple regression (Mx), and principal component (PCA) analyses were performed to evaluate associations between pain and meteorological factors obtained at the day of recorded pain value, 2 days before and 2 days after the recorded pain, and the changes in these parameters (5 × 12 parameters). Complex scores were calculated based on the results of these analyses. Results – While the temperature had the highest effects on the pain levels in most of the participants, huge interindividual dif­ferences in the degree and the direction of the associations between pain and weather parameters could be obtained. The analytic methods also revealed subjectspecific results, and the synthesis of different statistical methods as total scores provided a personalized map for each patient, which showed disparate patterns across the study participants. Thus, Participants 2 and 5 had higher scores for Mx compared to Sp; furthermore, certain factors showed opposite direction in their associations with the pain level depending on the type of analysis (Sp vs Mx). In contrast, P3 had a lower score for Mx compared to Sp, which might suggest a low level of weather sensitivity on the association between the different weather parameters in this subject. Furthermore, participants P4 and P6 had a very high level of weather sensitivity, while P1 had an opposite pattern. Regarding the time point-related effects on the pain level, most patients were sensitive to parameters obtained at the same day or two days before, except the P1 subject, who had the highest sensitivity to weather parameters detected two days after. Conclusion – The present study highlights the importance of integrating different data analysis approaches to elucidate the individual connections between pain and most of the weather parameters. In conclusion, complex personalized profiling should be considered for the characterization of pain–weather associations by applying different data analytical approaches, which may provide feedback to physicians and patients.}, year = {2024}, eissn = {2498-6208}, pages = {77-87}, orcid-numbers = {Horváth, Gyöngyi/0000-0002-6025-4577; Nagy, Edit/0000-0002-2485-6618} } @article{MTMT:34756390, title = {Blood pressure in preterm infants with bronchopulmonary dysplasia in the first three months of life}, url = {https://m2.mtmt.hu/api/publication/34756390}, author = {Kiss, Judit Klára and Gajda , Anna and Mari, Judit and Bereczki, Csaba}, doi = {10.1007/s00467-024-06354-0}, journal-iso = {PEDIATR NEPHROL}, journal = {PEDIATRIC NEPHROLOGY}, unique-id = {34756390}, issn = {0931-041X}, year = {2024}, eissn = {1432-198X}, orcid-numbers = {Mari, Judit/0000-0003-3176-6116; Bereczki, Csaba/0000-0003-0091-3558} } @article{MTMT:34749104, title = {A Turner-szindróma áttekintése az újabb genetikai ismeretek és a multidiszciplináris beteggondozás tekintetében}, url = {https://m2.mtmt.hu/api/publication/34749104}, author = {Beniczky, Nikolett Jusztina and Szücs, Nikolette and Gellén, Balázs and Bertalan, Rita}, doi = {10.1556/650.2024.32998}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {34749104}, issn = {0030-6002}, abstract = {A Turner-szindróma női fenotípussal járó komplex betegség, melynek oka az egyik X-kromoszóma teljes vagy részleges hiánya. Előfordulási gyakorisága leány újszülött esetén 1/2000–2500. A legújabb diagnosztikus kritériumok, a genetikai háttér egyre pontosabb ismerete, a terápiás lehetőségek fejlődése és az egyre részletesebb gondozási protokollok segítséget nyújtanak a betegség minél korábbi felismeréséhez és a betegek életminőségének nagy fokú javításához. A beteggondozás legfontosabb eleme minden életkorban a multidiszciplináris ellátás, mivel a Turner-szindrómás pácienseknél a különböző életszakaszokban más és más, de egyszerre akár több tünet, illetve betegség vagy szövődmény manifesztálódása is várható. A szindrómához társuló fenotípusbeli eltérések nagy variációt mutatnak. Leggyakoribb tünete az alacsony termet, a petefészek dysgenesise által okozott hypogonadismus és következményes késői vagy elmaradt pubertas. Graviditás csupán 4,8–7,6%-ban fordul elő. A testi elváltozások mellett több szervrendszer érintett, így várható különböző, Turner-szindrómával összefüggő betegségek – úgymint veleszületett szív- és vesefejlődési rendellenességek, vérnyomáseltérés, fülészeti, szemészeti, pajzsmirigy-, ortopéd betegségek, neurokognitív diszfunkció, a csont-ásványianyag csökkenése és autoimmun betegségek – előfordulása is. Összefoglalónk célja, hogy segítséget nyújtson a Turner-szindrómás betegek minél korábbi diagnosztizálásához és az élethosszig tartó teljes körű beteggondozáshoz, különös tekintettel endokrinológiai és kardiológiai ellátásukra. Orv Hetil. 2024; 165(11): 416–423.}, year = {2024}, eissn = {1788-6120}, pages = {416-423}, orcid-numbers = {Szücs, Nikolette/0000-0002-6614-1311; Bertalan, Rita/0000-0003-4700-4167} } @article{MTMT:34683154, title = {A hereleszállási zavarok kezelése Magyarországon – hol tartunk most?}, url = {https://m2.mtmt.hu/api/publication/34683154}, author = {Varga, Alexandra and Tardi, Réka and Kovács, Tamás}, doi = {10.1556/650.2024.32957}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {34683154}, issn = {0030-6002}, abstract = {Bevezetés: A hereleszállási zavarok korszerű gyermekkori kezelése nélkülözhetetlen a hosszú távú morbiditás – infertilitás, malignus heretumorok – kialakulásának elkerüléséhez. Célkitűzés: Az ellátási gyakorlat fejlesztése érdekében vizsgálatunkban fel kívántuk tárni, hogy a kórkép magyarországi ellátása megfelel-e az aktuális hazai és főbb nemzetközi, elsősorban európai irányelveknek. Módszer: és szakellátás felméréséhez 2023-ban online kérdőíves vizsgálatot végeztünk a Házi Gyermekorvosok Egyesületének, valamint a Magyar Gyermeksebész Társaság tagjainak körében. A válaszokat leíró statisztikai módszerekkel elemeztük. Eredmények: A hereleszállási zavarok kezelését a felmérésben részt vevő alapellátók (n = 69) esetében elsősorban a szakképzésük során tanultak (65,2%), míg a szakellátás képviselőinek körében (n = 56) döntően a nemzetközi irányelvek (66,1%) befolyásolják. A kérdőívet kitöltő házi gyermekorvosok 98,6%-a ellenőrzi a herék újszülöttkori helyzetét, és eltérés észlelésekor 88,4%-uk megfelelő időben utalja szakrendelésre a gyermeket. Az orchidopexia optimális idejét 66,6%-uk ismeri. A retraktilis herék kezelése 59,4%-uk ismeretei szerint elsősorban konzervatív, és 60,8%-uk végzi a pubertáskorig utánkövetésüket. Orchidopexiát követően 39,1%-uk végzi kamaszkorig a gondozást. A szakellátás képviselői (98,2%) az orchidopexiát a megfelelő életkorra időzítik, nem tapintható herék észlelésekor azonban 28,6%-uk kér preoperatív ultrahangvizsgálatot. A magas hasüregi herék kezelése elsősorban (82,1%) a minimálinvazív Shehata-műtéttel történik. Megbeszélés: A hereleszállási zavarok hazai kezelése döntően az aktuális irányelvek szerint zajlik, mindemellett az alapellátás képviselőinek ismeretei néhány fontos kérdésben – a műtéti ellátás optimális időzítése, retraktilis herék és orchidopexián átesett gyermekek gondozása – hiányosak. A gyermeksebészeti szakellátás modern szemléletű, korszerű minimálinvazív technikák alkalmazásával zajlik, ultrahangvizsgálat azonban sok esetben feleslegesen történik. Következtetés: A hereleszállási zavarok kezelésére vonatkozó ismeretek szélesebb körű terjesztése szükséges az országos szintű, minden tekintetben korszerű ellátás megvalósulásához és a hosszú távú morbiditás csökkentéséhez. Orv Hetil. 2024; 165(4): 138–146.}, year = {2024}, eissn = {1788-6120}, pages = {138-146}, orcid-numbers = {Varga, Alexandra/0000-0001-7057-5983} } @article{MTMT:34554028, title = {The Impact of Qualification and Hospice Education on Staff Attitudes during Palliative Care in Pediatric Oncology Wards—A National Survey}, url = {https://m2.mtmt.hu/api/publication/34554028}, author = {Salamon, Eszter and Fodor, Éva and Földesi, Enikő and Hauser, Péter and Kriván, Gergely and Csanádi, Krisztina and Garami, Miklós and Kovács, Gábor and Csóka, Monika and Tiszlavicz, Lilla Györgyi and Kiss, Csongor and Dergez, Tímea and Ottóffy, Gábor}, doi = {10.3390/children11020178}, journal-iso = {CHILDREN-BASEL}, journal = {CHILDREN (BASEL)}, volume = {11}, unique-id = {34554028}, abstract = {Background: Our knowledge about the attitudes of healthcare staff to palliative care in pediatric oncology is scarce. We aimed to assess their perceptions of palliative care in Hungary and find answers to the question of how to provide good palliative care for children. Method: Physicians (n = 30) and nurses (n = 43) working in the field of pediatric oncology (12 of them specialized in hospice care) were interviewed. Palliative care practice (communication, integration of palliative care, professionals’ feelings and attitudes, and opportunities for improvement) was assessed by semi-structured interviews evaluated in a mixed quantitative and qualitative way by narrative categorical content analysis and thematic analysis. Results: All providers displayed high negative emotions, positive evaluations, and used many active verbs. Nurses showed higher levels of denial, more self-references, and were more likely to highlight loss. Physicians emphasized the importance of communication regarding adequate or inadequate palliative care. Hospice specialists showed a higher passive verb rate, a lower self-reference, a lower need for psychological support, and a greater emphasis on teamwork and professional aspects. Conclusion: Our results show that nurses are more emotionally stressed than doctors in palliative care in pediatric oncology. To our knowledge, a study comparing doctors and nurses in this field has yet to be carried out. Our results suggest that pediatric oncological staff can positively evaluate a child’s palliative care despite the emotional strain. Regarding hospices, professional practice in palliative care may be a protective factor in reducing emotional distress and achieving professional well-being.}, year = {2024}, eissn = {2227-9067}, orcid-numbers = {Hauser, Péter/0000-0002-8307-8975; Garami, Miklós/0000-0003-4298-2746; Kovács, Gábor/0000-0001-9924-1645; Csóka, Monika/0000-0003-4202-891X; Kiss, Csongor/0000-0001-5170-5965; Ottóffy, Gábor/0000-0002-8990-6620} }