TY - JOUR AU - Vágvölgyi, Anna AU - Zádori, János AU - Keller, Nóra AU - Lippai, Balázs AU - Szöllősi, Dalma AU - Márton, Virág AU - Wellinger, Károly AU - Lada, Szilvia AU - Szűcs, Mónika AU - Menyhárt, Adrienn AU - Kempler, Péter AU - Baczkó, István AU - Várkonyi, Tamás AU - Lengyel, Csaba Attila TI - Kardiovaszkuláris autonóm és perifériás szenzoros neuropátia elhízott nőbetegekben = Cardiovascular autonomic and peripheral sensory neuropathy in women with obesty JF - DIABETOLOGIA HUNGARICA J2 - DIABETOLOGIA HUNGARICA VL - 32 PY - 2024 IS - Suppl 1 SP - 87 EP - 88 PG - 2 SN - 1217-372X UR - https://m2.mtmt.hu/api/publication/34879649 ID - 34879649 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Nyiraty, Szabolcs AU - Vágvölgyi, Anna AU - Várkonyi, Ákos AU - Tóth, Bettina AU - Pesei, Fruzsina AU - Bordács, Barbara Anikó AU - Kupai, Krisztina AU - Orosz, Andrea AU - Lengyel, Csaba Attila AU - Kempler, Péter AU - Várkonyi, Tamás TI - Az autonóm neuropátia, a mentális funkció és a szénhidrát-anyagcsere paramétereinek összefüggése 1-es típusú és inzulinnal kezelt 2-es típusú diabéteszes betegekben = Association between autonomic neuropathy, mental function and carbohydrate metabolism parameters in patients with type 1 and insulin-treated type 2 diabetes JF - DIABETOLOGIA HUNGARICA J2 - DIABETOLOGIA HUNGARICA VL - 32 PY - 2024 IS - Suppl 2 SP - 57 EP - 58 PG - 2 SN - 1217-372X UR - https://m2.mtmt.hu/api/publication/34879506 ID - 34879506 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Elekes, Gréta AU - Virág, Csapó AU - Szarka, Dóra AU - Szalay, László AU - Korsós, Marietta Margaréta AU - Dorottya, Tálosi AU - Török, Dénes AU - Tóth-Molnár, Edit TI - Physiology and Pharmacology The Role of Aquaporin 4 in Lacrimal Gland Ductal Fluid Secretion in Mice JF - INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE J2 - INVEST OPHTH VIS SCI VL - 65 PY - 2024 IS - 5 PG - 8 SN - 0146-0404 DO - 10.1167/iovs.65.5.30 UR - https://m2.mtmt.hu/api/publication/34867079 ID - 34867079 LA - English DB - MTMT ER - TY - JOUR AU - Polyák, Alexandra Júlia AU - Vágvölgyi, Anna AU - Ágoston, Gergely AU - Orosz, Andrea AU - Kapornai, Krisztina AU - Kiss, Enikő AU - Varró, András AU - Farkas, András AU - Lengyel, Csaba Attila AU - Szili-Török, Tamás AU - Farkas, Attila TI - Kardiovaszkuláris adaptációs mechanizmusok vizsgálata fi atal élsportolóknál = Cardiovascular adaptation mechanisms in young elite athletes JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 54 PY - 2024 IS - Suppl C SP - C440 EP - C440 PG - 1 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/34857518 ID - 34857518 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Venglovecz, Viktória AU - Grassalkovich, A AU - Tóth, E AU - Ébert, Attila AU - Gál, Eleonóra AU - Korsós, Marietta Margaréta AU - Maléth, József AU - Rakonczay, Zoltán AU - Galla, Zsolt AU - Monostori, Péter AU - Hegyi, P TI - Effect of Orkambi on the course of acute pancreatitis JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 10 PY - 2024 IS - Suppl 1 SP - 137 EP - 138 PG - 2 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/34855145 ID - 34855145 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Dágó, Á AU - Mihalekné, Fűr G AU - Orján, E AU - Balla, Z AU - Bálint, E AU - Kormányos, E AU - Csendes, A AU - Batka, B AU - Pallagi, Petra AU - Pásztor, N AU - Kaizer, L AU - Venglovecz, Viktória AU - Maléth, József AU - Hegyi, P AU - Kozinszky, Z AU - Kiss, L AU - Rakonczay, Z TI - INVESTIGATION OF HUMAN FOETAL PANCREATIC DUCTS AND DUCTAL ORGANOIDS FOR THE APPLICATION AS MODEL SYSTEMS JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 10 PY - 2024 IS - Suppl 1 SP - 84 EP - 85 PG - 2 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/34855059 ID - 34855059 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Urbán, István András AU - Mirsky, Nicholas AU - Serroni, Matteo AU - Tovar, Nick AU - Nayak, Vasudev Vivekanand AU - Witek, Lukasz AU - Marin, Charles AU - Saleh, Muhammed AU - Ravidà, Andrea AU - Baczkó, István AU - Párkányi, László AU - Nagy, Katalin AU - Coelho, Paulo G TI - Elucidating the Benefit of Perforated vs Non-Perforated Membranes in Guided Bone Regeneration: An in Vivo Histologic Evaluation and Histomorphometric Analysis JF - INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY J2 - INT J PERIODONT REST PY - 2024 SN - 0198-7569 DO - 10.11607/prd.7110 UR - https://m2.mtmt.hu/api/publication/34850170 ID - 34850170 AB - Background: Non-perforated Polytetrafluoroethylene (PTFE) membranes are effectively utilized in guided bone regeneration (GBR) but may hinder cell migration due to limited interaction with the periosteum. This study compared bone regeneration using occlusive or perforated membranes combined with acellular collagen sponge (ACS) and recombinant human bone morphogenic protein-2 (rhBMP-2) in a canine mandibular model. Material and Methods: Male beagle dogs (n=3) received two mandibular defects each to compare ACS/rhBMP-2 with experimental (perforated group) and control (non-perforated group) membranes (n=3 defects/group). Tissue healing was assessed histomorphologically, histomorphometrically and through volumetric reconstruction using microcomputed tomography. Results: The perforated group showed increased bone formation and reduced soft tissue formation compared to the non-perforated group. For the primary outcome, histomorphometric analysis revealed significantly greater total regenerated bone in the perforated group (67.08 ± 6.86%) relative to the nonperforated group (25.18 ± 22.44%) (p = 0.036). Perforated membranes had less soft tissue infiltration (32.91 ± 6.86%) compared to non-perforated membranes (74.82 ± 22.44%) (p = 0.036). Conclusion: The increased permeability of membranes in the perforated group potentially enabled periosteal precursor cells greater accessibility to rhBMP-2. The availability may have accelerated their differentiation into mature bone-forming cells, contributing to the stimulation of new bone production, relative to the non-perforated group. LA - English DB - MTMT ER - TY - JOUR AU - Grandits, Thomas AU - Augustin, Christoph M AU - Haase, Gundolf AU - Jost, Norbert László AU - Mirams, Gary R AU - Niederer, Steven A AU - Plank, Gernot AU - Varró, András AU - Virág, László AU - Jung, Alexander TI - Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies JF - ELIFE J2 - ELIFE VL - 12 PY - 2024 PG - 27 SN - 2050-084X DO - 10.7554/eLife.91911 UR - https://m2.mtmt.hu/api/publication/34786266 ID - 34786266 N1 - Funding Agency and Grant Number: Austrian Science Fund; Austrian Science Fund (FWF); German Research Foundation (DFG); National Institutes of Health; National Research, Development and Innovation Office (NRDI); Hungarian Research Network (HUN-REN); Wellcome Trust Funding text: This research was funded by the Austrian Science Fund (FWF), the German Research Foundation (DFG), the National Institutes of Health, the National Research, Development and Innovation Office (NRDI), the Hungarian Research Network (HUN-REN), and the Wellcome Trust. For the purpose of open access, the authors have applied a CC-BY public copyright licence to any Author Accepted Manuscript version arising from this submission. AB - Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models with experimental data can become a significant computational burden. To mitigate the computational burden, the present study introduces a neural network (NN) that emulates the AP for given maximum conductances of selected ion channels, pumps, and exchangers. Its applicability in pharmacological studies was tested on synthetic and experimental data. The NN emulator potentially enables massive speed-ups compared to regular simulations and the forward problem (find drugged AP for pharmacological parameters defined as scaling factors of control maximum conductances) on synthetic data could be solved with average root-mean-square errors (RMSE) of 0.47 mV in normal APs and of 14.5 mV in abnormal APs exhibiting early afterdepolarizations (72.5% of the emulated APs were alining with the abnormality, and the substantial majority of the remaining APs demonstrated pronounced proximity). This demonstrates not only very fast and mostly very accurate AP emulations but also the capability of accounting for discontinuities, a major advantage over existing emulation strategies. Furthermore, the inverse problem (find pharmacological parameters for control and drugged APs through optimization) on synthetic data could be solved with high accuracy shown by a maximum RMSE of 0.22 in the estimated pharmacological parameters. However, notable mismatches were observed between pharmacological parameters estimated from experimental data and distributions obtained from the Comprehensive in vitro Proarrhythmia Assay initiative. This reveals larger inaccuracies which can be attributed particularly to the fact that small tissue preparations were studied while the emulator was trained on single cardiomyocyte data. Overall, our study highlights the potential of NN emulators as powerful tool for an increased efficiency in future quantitative systems pharmacology studies. LA - English DB - MTMT ER - TY - JOUR AU - Nemes, Attila AU - Kormányos, Árpád AU - Orosz, Andrea AU - Ambrus, Nóra AU - Várkonyi, Tamás AU - Lengyel, Csaba Attila TI - Autonomic function and specific right atrial functions - Is there a relationship? Correlations from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study JF - JOURNAL OF CLINICAL ULTRASOUND J2 - J CLIN ULTRASOUND PY - 2024 PG - 8 SN - 0091-2751 DO - 10.1002/jcu.23672 UR - https://m2.mtmt.hu/api/publication/34778284 ID - 34778284 N1 - Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Export Date: 23 April 2024 CODEN: JCULD Correspondence Address: Nemes, A.; Department of Medicine, H-6725 Szeged, emmelweis street 8, P.O. Box 427, Hungary; email: nemes.attila@med.u-szeged.hu AB - Similarly to the ventricles, the atria are under sympathetic/parasympathetic neural regulation. Accordingly, correlations were investigated between Ewing's standard cardiovascular reflex tests (SCRTs) and three-dimensional speckle-tracking echocardiography (3DSTE)-derived right atrial (RA) volumes and strains in healthy subjects.The study comprised 45 healthy adults, but 5 subjects were excluded due to inferior image quality for 3DSTE-derived RA assessments. The remaining 40 individuals being in sinus rhythm had a mean age of 35.1 ± 3.5 years (20 men). Two-dimensional, Doppler, 3DSTE and SCRTs were performed in all cases.RA maximum volume and total and passive RA stroke volumes correlated with the Valsalva ratio. Active RA stroke volume and emptying fraction showed correlations with 30/15 ratio. Peak global and mean segmental RA circumferential (CS) and longitudinal strains (LS) showed correlation with the Valsalva ratio. At atrial contraction, global RA-LS and mean segmental RA-CS showed correlations with the Valsalva ratio. Moreover, mean segmental RA-CS correlated with 30/15 ratio and mean segmental RA radial strain showed correlations with systolic blood pressure in response to standing. Autonomic neuropathy score correlated with peak global RA-LS.Autonomic function parameters have significant associations with specific RA functions in healthy adults, making the latter possible indicators of autonomic dysregulation. LA - English DB - MTMT ER - TY - JOUR AU - Mohammed, Aiman AU - Mohácsi, Gábor AU - Naveed, Muhammad AU - Prorok, János AU - Jost, Norbert László AU - Virág, László AU - Baczkó, István AU - Topal, Leila AU - Varró, András TI - Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 10 SN - 2045-2322 DO - 10.1038/s41598-024-57828-y UR - https://m2.mtmt.hu/api/publication/34763568 ID - 34763568 N1 - Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi School of Medicine, University of Szeged, Szeged, Hungary HUN-REN-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Research Network, Szeged, Hungary Export Date: 17 April 2024 Correspondence Address: Baczkó, I.; Department of Pharmacology and Pharmacotherapy, Hungary; email: baczko.istvan@med.u-szeged.hu Correspondence Address: Varró, A.; Department of Pharmacology and Pharmacotherapy, Hungary; email: varro.andras@med.u-szeged.hu AB - Recent experimental data shows that hesperetin, a citrus flavonoid, affects potassium channels and can prolong the QT c interval in humans. Therefore, in the present study we investigated the effects of hesperetin on various transmembrane ionic currents and on ventricular action potentials. Transmembrane current measurements and action potential recordings were performed by patch-clamp and the conventional microelectrode techniques in dog and rabbit ventricular preparations. At 10 µM concentration hesperetin did not, however, at 30 µM significantly decreased the amplitude of the I K1 , I to , I Kr potassium currents. Hesperetin at 3–30 µM significantly and in a concentration-dependent manner reduced the amplitude of the I Ks current. The drug significantly decreased the amplitudes of the I NaL and I CaL currents at 30 µM. Hesperetin (10 and 30 µM) did not change the action potential duration in normal preparations, however, in preparations where the repolarization reserve had been previously attenuated by 100 nM dofetilide and 1 µg/ml veratrine, caused a moderate but significant prolongation of repolarization. These results suggest that hesperetin at close to relevant concentrations inhibits the I Ks outward potassium current and thereby reduces repolarization reserve. This effect in certain specific situations may prolong the QT interval and consequently may enhance proarrhythmic risk. LA - English DB - MTMT ER -