@article{MTMT:34879649,
	title = {Kardiovaszkuláris autonóm és perifériás szenzoros neuropátia elhízott nőbetegekben = Cardiovascular autonomic and peripheral sensory neuropathy in women with obesty},
	url = {https://m2.mtmt.hu/api/publication/34879649},
	author = {Vágvölgyi, Anna and Zádori, János and Keller, Nóra and Lippai, Balázs and Szöllősi, Dalma and Márton, Virág and Wellinger, Károly and Lada, Szilvia and Szűcs, Mónika and Menyhárt, Adrienn and Kempler, Péter and Baczkó, István and Várkonyi, Tamás and Lengyel, Csaba Attila},
	journal-iso = {DIABETOLOGIA HUNGARICA},
	journal = {DIABETOLOGIA HUNGARICA},
	volume = {32},
	unique-id = {34879649},
	issn = {1217-372X},
	year = {2024},
	eissn = {2560-0168},
	pages = {87-88},
	orcid-numbers = {Vágvölgyi, Anna/0000-0002-8810-700X; Baczkó, István/0000-0002-9588-0797; Várkonyi, Tamás/0000-0001-6833-3563; Lengyel, Csaba Attila/0000-0002-0434-0067}
}

@article{MTMT:34879506,
	title = {Az autonóm neuropátia, a mentális funkció és a szénhidrát-anyagcsere paramétereinek összefüggése 1-es típusú és inzulinnal kezelt 2-es típusú diabéteszes betegekben = Association between autonomic neuropathy, mental function and carbohydrate metabolism parameters in patients with type 1 and insulin-treated type 2 diabetes},
	url = {https://m2.mtmt.hu/api/publication/34879506},
	author = {Nyiraty, Szabolcs and Vágvölgyi, Anna and Várkonyi, Ákos and Tóth, Bettina and Pesei, Fruzsina and Bordács, Barbara Anikó and Kupai, Krisztina and Orosz, Andrea and Lengyel, Csaba Attila and Kempler, Péter and Várkonyi, Tamás},
	journal-iso = {DIABETOLOGIA HUNGARICA},
	journal = {DIABETOLOGIA HUNGARICA},
	volume = {32},
	unique-id = {34879506},
	issn = {1217-372X},
	year = {2024},
	eissn = {2560-0168},
	pages = {57-58},
	orcid-numbers = {Vágvölgyi, Anna/0000-0002-8810-700X; Kupai, Krisztina/0000-0002-0644-1718; Lengyel, Csaba Attila/0000-0002-0434-0067; Várkonyi, Tamás/0000-0001-6833-3563}
}

@article{MTMT:34867079,
	title = {Physiology and Pharmacology The Role of Aquaporin 4 in Lacrimal Gland Ductal Fluid Secretion in Mice},
	url = {https://m2.mtmt.hu/api/publication/34867079},
	author = {Elekes, Gréta and Virág, Csapó and Szarka, Dóra and Szalay, László and Korsós, Marietta Margaréta and Dorottya, Tálosi and Török, Dénes and Tóth-Molnár, Edit},
	doi = {10.1167/iovs.65.5.30},
	journal-iso = {INVEST OPHTH VIS SCI},
	journal = {INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE},
	volume = {65},
	unique-id = {34867079},
	issn = {0146-0404},
	year = {2024},
	eissn = {1552-5783},
	orcid-numbers = {Szarka, Dóra/0000-0002-5117-2131; Szalay, László/0000-0002-8797-4291; Tóth-Molnár, Edit/0000-0001-7989-1616}
}

@article{MTMT:34857518,
	title = {Kardiovaszkuláris adaptációs mechanizmusok vizsgálata fi atal élsportolóknál = Cardiovascular adaptation mechanisms in young elite athletes},
	url = {https://m2.mtmt.hu/api/publication/34857518},
	author = {Polyák, Alexandra Júlia and Vágvölgyi, Anna and Ágoston, Gergely and Orosz, Andrea and Kapornai, Krisztina and Kiss, Enikő and Varró, András and Farkas, András and Lengyel, Csaba Attila and Szili-Török, Tamás and Farkas, Attila},
	journal-iso = {CARDIOL HUNG},
	journal = {CARDIOLOGIA HUNGARICA},
	volume = {54},
	unique-id = {34857518},
	issn = {0133-5596},
	year = {2024},
	eissn = {1588-0230},
	pages = {C440-C440},
	orcid-numbers = {Vágvölgyi, Anna/0000-0002-8810-700X; Varró, András/0000-0003-0745-3603; Lengyel, Csaba Attila/0000-0002-0434-0067; Szili-Török, Tamás/0000-0002-7165-8243}
}

@article{MTMT:34855145,
	title = {Effect of Orkambi on the course of acute pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/34855145},
	author = {Venglovecz, Viktória and Grassalkovich, A and Tóth, E and Ébert, Attila and Gál, Eleonóra and Korsós, Marietta Margaréta and Maléth, József and Rakonczay, Zoltán and Galla, Zsolt and Monostori, Péter and Hegyi, P},
	journal-iso = {CENT EUR J GASTRO HEPATOL},
	journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE},
	volume = {10},
	unique-id = {34855145},
	year = {2024},
	eissn = {2415-9107},
	pages = {137-138},
	orcid-numbers = {Venglovecz, Viktória/0000-0002-2316-7247; Maléth, József/0000-0001-5768-3090; Rakonczay, Zoltán/0000-0002-1499-3416; Galla, Zsolt/0000-0002-9166-1212; Monostori, Péter/0000-0003-3591-6054}
}

@article{MTMT:34855059,
	title = {INVESTIGATION OF HUMAN FOETAL PANCREATIC DUCTS AND DUCTAL ORGANOIDS FOR THE APPLICATION AS MODEL SYSTEMS},
	url = {https://m2.mtmt.hu/api/publication/34855059},
	author = {Dágó, Á and Mihalekné, Fűr G and Orján, E and Balla, Z and Bálint, E and Kormányos, E and Csendes, A and Batka, B and Pallagi, Petra and Pásztor, N and Kaizer, L and Venglovecz, Viktória and Maléth, József and Hegyi, P and Kozinszky, Z and Kiss, L and Rakonczay, Z},
	journal-iso = {CENT EUR J GASTRO HEPATOL},
	journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE},
	volume = {10},
	unique-id = {34855059},
	year = {2024},
	eissn = {2415-9107},
	pages = {84-85},
	orcid-numbers = {Pallagi, Petra/0000-0001-8906-0840; Venglovecz, Viktória/0000-0002-2316-7247; Maléth, József/0000-0001-5768-3090}
}

@article{MTMT:34850170,
	title = {Elucidating the Benefit of Perforated vs Non-Perforated Membranes in Guided Bone Regeneration: An in Vivo Histologic Evaluation and Histomorphometric Analysis},
	url = {https://m2.mtmt.hu/api/publication/34850170},
	author = {Urbán, István András and Mirsky, Nicholas and Serroni, Matteo and Tovar, Nick and Nayak, Vasudev Vivekanand and Witek, Lukasz and Marin, Charles and Saleh, Muhammed and Ravidà, Andrea and Baczkó, István and Párkányi, László and Nagy, Katalin and Coelho, Paulo G},
	doi = {10.11607/prd.7110},
	journal-iso = {INT J PERIODONT REST},
	journal = {INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY},
	unique-id = {34850170},
	issn = {0198-7569},
	abstract = {Background: Non-perforated Polytetrafluoroethylene (PTFE) membranes are effectively utilized in guided bone regeneration (GBR) but may hinder cell migration due to limited interaction with the periosteum. This study compared bone regeneration using occlusive or perforated membranes combined with acellular collagen sponge (ACS) and recombinant human bone morphogenic protein-2 (rhBMP-2) in a canine mandibular model. Material and Methods: Male beagle dogs (n=3) received two mandibular defects each to compare ACS/rhBMP-2 with experimental (perforated group) and control (non-perforated group) membranes (n=3 defects/group). Tissue healing was assessed histomorphologically, histomorphometrically and through volumetric reconstruction using microcomputed tomography. Results: The perforated group showed increased bone formation and reduced soft tissue formation compared to the non-perforated group. For the primary outcome, histomorphometric analysis revealed significantly greater total regenerated bone in the perforated group (67.08 ± 6.86%) relative to the nonperforated group (25.18 ± 22.44%) (p = 0.036). Perforated membranes had less soft tissue infiltration (32.91 ± 6.86%) compared to non-perforated membranes (74.82 ± 22.44%) (p = 0.036). Conclusion: The increased permeability of membranes in the perforated group potentially enabled periosteal precursor cells greater accessibility to rhBMP-2. The availability may have accelerated their differentiation into mature bone-forming cells, contributing to the stimulation of new bone production, relative to the non-perforated group.},
	keywords = {IMPLANTS; Osteogenesis; Bone regeneration; Polytetrafluoroethylene; periosteum},
	year = {2024},
	eissn = {1945-3388},
	orcid-numbers = {Baczkó, István/0000-0002-9588-0797; Nagy, Katalin/0000-0001-9383-5952}
}

@article{MTMT:34786266,
	title = {Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies},
	url = {https://m2.mtmt.hu/api/publication/34786266},
	author = {Grandits, Thomas and Augustin, Christoph M and Haase, Gundolf and Jost, Norbert László and Mirams, Gary R and Niederer, Steven A and Plank, Gernot and Varró, András and Virág, László and Jung, Alexander},
	doi = {10.7554/eLife.91911},
	journal-iso = {ELIFE},
	journal = {ELIFE},
	volume = {12},
	unique-id = {34786266},
	issn = {2050-084X},
	abstract = {Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models with experimental data can become a significant computational burden. To mitigate the computational burden, the present study introduces a neural network (NN) that emulates the AP for given maximum conductances of selected ion channels, pumps, and exchangers. Its applicability in pharmacological studies was tested on synthetic and experimental data. The NN emulator potentially enables massive speed-ups compared to regular simulations and the forward problem (find drugged AP for pharmacological parameters defined as scaling factors of control maximum conductances) on synthetic data could be solved with average root-mean-square errors (RMSE) of 0.47 mV in normal APs and of 14.5 mV in abnormal APs exhibiting early afterdepolarizations (72.5% of the emulated APs were alining with the abnormality, and the substantial majority of the remaining APs demonstrated pronounced proximity). This demonstrates not only very fast and mostly very accurate AP emulations but also the capability of accounting for discontinuities, a major advantage over existing emulation strategies. Furthermore, the inverse problem (find pharmacological parameters for control and drugged APs through optimization) on synthetic data could be solved with high accuracy shown by a maximum RMSE of 0.22 in the estimated pharmacological parameters. However, notable mismatches were observed between pharmacological parameters estimated from experimental data and distributions obtained from the Comprehensive in vitro Proarrhythmia Assay initiative. This reveals larger inaccuracies which can be attributed particularly to the fact that small tissue preparations were studied while the emulator was trained on single cardiomyocyte data. Overall, our study highlights the potential of NN emulators as powerful tool for an increased efficiency in future quantitative systems pharmacology studies.},
	keywords = {human; computer simulation; machine learning; Systems biology; Computational Biology; Computer modeling; CELL BIOLOGY; Cardiac electrophysiology; surrogate modeling},
	year = {2024},
	eissn = {2050-084X},
	orcid-numbers = {Varró, András/0000-0003-0745-3603}
}

@article{MTMT:34778284,
	title = {Autonomic function and specific right atrial functions - Is there a relationship? Correlations from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study},
	url = {https://m2.mtmt.hu/api/publication/34778284},
	author = {Nemes, Attila and Kormányos, Árpád and Orosz, Andrea and Ambrus, Nóra and Várkonyi, Tamás and Lengyel, Csaba Attila},
	doi = {10.1002/jcu.23672},
	journal-iso = {J CLIN ULTRASOUND},
	journal = {JOURNAL OF CLINICAL ULTRASOUND},
	unique-id = {34778284},
	issn = {0091-2751},
	abstract = {Similarly to the ventricles, the atria are under sympathetic/parasympathetic neural regulation. Accordingly, correlations were investigated between Ewing's standard cardiovascular reflex tests (SCRTs) and three-dimensional speckle-tracking echocardiography (3DSTE)-derived right atrial (RA) volumes and strains in healthy subjects.The study comprised 45 healthy adults, but 5 subjects were excluded due to inferior image quality for 3DSTE-derived RA assessments. The remaining 40 individuals being in sinus rhythm had a mean age of 35.1 ± 3.5 years (20 men). Two-dimensional, Doppler, 3DSTE and SCRTs were performed in all cases.RA maximum volume and total and passive RA stroke volumes correlated with the Valsalva ratio. Active RA stroke volume and emptying fraction showed correlations with 30/15 ratio. Peak global and mean segmental RA circumferential (CS) and longitudinal strains (LS) showed correlation with the Valsalva ratio. At atrial contraction, global RA-LS and mean segmental RA-CS showed correlations with the Valsalva ratio. Moreover, mean segmental RA-CS correlated with 30/15 ratio and mean segmental RA radial strain showed correlations with systolic blood pressure in response to standing. Autonomic neuropathy score correlated with peak global RA-LS.Autonomic function parameters have significant associations with specific RA functions in healthy adults, making the latter possible indicators of autonomic dysregulation.},
	keywords = {Echocardiography; Correlation; three-dimensional; Autonomic; Speckle-tracking; Right atrial},
	year = {2024},
	eissn = {1097-0096},
	orcid-numbers = {Nemes, Attila/0000-0002-7570-6214; Kormányos, Árpád/0000-0002-7052-2184; Várkonyi, Tamás/0000-0001-6833-3563; Lengyel, Csaba Attila/0000-0002-0434-0067}
}

@article{MTMT:34763568,
	title = {Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations},
	url = {https://m2.mtmt.hu/api/publication/34763568},
	author = {Mohammed, Aiman and Mohácsi, Gábor  and Naveed, Muhammad and Prorok, János and Jost, Norbert László and Virág, László and Baczkó, István and Topal, Leila and Varró, András},
	doi = {10.1038/s41598-024-57828-y},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {34763568},
	issn = {2045-2322},
	abstract = {Recent experimental data shows that hesperetin, a citrus flavonoid, affects potassium channels and can prolong the QT c interval in humans. Therefore, in the present study we investigated the effects of hesperetin on various transmembrane ionic currents and on ventricular action potentials. Transmembrane current measurements and action potential recordings were performed by patch-clamp and the conventional microelectrode techniques in dog and rabbit ventricular preparations. At 10 µM concentration hesperetin did not, however, at 30 µM significantly decreased the amplitude of the I K1 , I to , I Kr potassium currents. Hesperetin at 3–30 µM significantly and in a concentration-dependent manner reduced the amplitude of the I Ks current. The drug significantly decreased the amplitudes of the I NaL and I CaL currents at 30 µM. Hesperetin (10 and 30 µM) did not change the action potential duration in normal preparations, however, in preparations where the repolarization reserve had been previously attenuated by 100 nM dofetilide and 1 µg/ml veratrine, caused a moderate but significant prolongation of repolarization. These results suggest that hesperetin at close to relevant concentrations inhibits the I Ks outward potassium current and thereby reduces repolarization reserve. This effect in certain specific situations may prolong the QT interval and consequently may enhance proarrhythmic risk.},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Prorok, János/0000-0001-8419-8859; Baczkó, István/0000-0002-9588-0797; Varró, András/0000-0003-0745-3603}
}