@article{MTMT:32781700,
	title = {Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study},
	url = {https://m2.mtmt.hu/api/publication/32781700},
	author = {Dreier, Jens P. and Winkler, Maren K. L. and Major, Sebastian and Horst, Viktor and Lublinsky, Svetlana and Kola, Vasilis and Lemale, Coline L. and Kang, Eun-Jeung and Maslarova, Anna and Salur, Irmak and Lückl, János and Platz, Johannes and Jorks, Devi and Oliveira-Ferreira, Ana I. and Schoknecht, Karl and Reiffurth, Clemens and Milakara, Denny and Wiesenthal, Dirk and Hecht, Nils and Dengler, Nora F. and Liotta, Agustin and Wolf, Stefan and Kowoll, Christina M. and Schulte, André P. and Santos, Edgar and Güresir, Erdem and Unterberg, Andreas W. and Sarrafzadeh, Asita and Sakowitz, Oliver W. and Vatter, Hartmut and Reiner, Michael and Brinker, Gerrit and Dohmen, Christian and Shelef, Ilan and Bohner, Georg and Scheel, Michael and Vajkoczy, Peter and Hartings, Jed A. and Friedman, Alon and Martus, Peter and Woitzik, Johannes},
	doi = {10.1093/brain/awab457},
	journal-iso = {BRAIN},
	journal = {BRAIN},
	volume = {145},
	unique-id = {32781700},
	issn = {0006-8950},
	abstract = {Focal brain damage after aneurysmal subarachnoid haemorrhage predominantly results from intracerebral haemorrhage, and early and delayed cerebral ischaemia. The prospective, observational, multicentre, cohort, diagnostic phase III trial, DISCHARGE-1, primarily investigated whether the peak total spreading depolarization-induced depression duration of a recording day during delayed neuromonitoring (delayed depression duration) indicates delayed ipsilateral infarction. Consecutive patients (n = 205) who required neurosurgery were enrolled in six university hospitals from September 2009 to April 2018. Subdural electrodes for electrocorticography were implanted. Participants were excluded on the basis of exclusion criteria, technical problems in data quality, missing neuroimages or patient withdrawal (n = 25). Evaluators were blinded to other measures. Longitudinal MRI, and CT studies if clinically indicated, revealed that 162/180 patients developed focal brain damage during the first 2 weeks. During 4.5 years of cumulative recording, 6777 spreading depolarizations occurred in 161/180 patients and 238 electrographic seizures in 14/180. Ten patients died early; 90/170 developed delayed infarction ipsilateral to the electrodes. Primary objective was to investigate whether a 60-min delayed depression duration cut-off in a 24-h window predicts delayed infarction with >0.60 sensitivity and >0.80 specificity, and to estimate a new cut-off. The 60-min cut-off was too short. Sensitivity was sufficient [= 0.76 (95% confidence interval: 0.65-0.84), P = 0.0014] but specificity was 0.59 (0.47-0.70), i.e. <0.80 (P < 0.0001). Nevertheless, the area under the receiver operating characteristic (AUROC) curve of delayed depression duration was 0.76 (0.69-0.83, P < 0.0001) for delayed infarction and 0.88 (0.81-0.94, P < 0.0001) for delayed ischaemia (reversible delayed neurological deficit or infarction). In secondary analysis, a new 180-min cut-off indicated delayed infarction with a targeted 0.62 sensitivity and 0.83 specificity. In awake patients, the AUROC curve of delayed depression duration was 0.84 (0.70-0.97, P = 0.001) and the prespecified 60-min cut-off showed 0.71 sensitivity and 0.82 specificity for reversible neurological deficits. In multivariate analysis, delayed depression duration (beta = 0.474, P < 0.001), delayed median Glasgow Coma Score (beta = -0.201, P = 0.005) and peak transcranial Doppler (beta = 0.169, P = 0.016) explained 35% of variance in delayed infarction. Another key finding was that spreading depolarization-variables were included in every multiple regression model of early, delayed and total brain damage, patient outcome and death, strongly suggesting that they are an independent biomarker of progressive brain injury. While the 60-min cut-off of cumulative depression in a 24-h window indicated reversible delayed neurological deficit, only a 180-min cut-off indicated new infarction with >0.60 sensitivity and >0.80 specificity. Although spontaneous resolution of the neurological deficit is still possible, we recommend initiating rescue treatment at the 60-min rather than the 180-min cut-off if progression of injury to infarction is to be prevented.Focal damage after subarachnoid haemorrhage results from intracerebral haemorrhage and cerebral ischaemia. In a prospective, observational, multicentre, diagnostic phase III trial, DISCHARGE-1, Dreier et al. examine whether monitoring cortical spreading depolarizations can predict delayed infarction-and thus poor outcomes.},
	year = {2022},
	eissn = {1460-2156},
	pages = {1264-1284},
	orcid-numbers = {Dreier, Jens P./0000-0001-7459-2828; Major, Sebastian/0000-0003-0970-1308; Lückl, János/0000-0001-8094-771X; Milakara, Denny/0000-0003-3148-6122; Hecht, Nils/0000-0001-9989-649X; Brinker, Gerrit/0000-0002-0184-0680; Shelef, Ilan/0000-0002-8398-6455; Friedman, Alon/0000-0001-6907-1040}
}

@article{MTMT:32663200,
	title = {Migraine Aura, Transient Ischemic Attacks, Stroke, and Dying of the Brain Share the Same Key Pathophysiological Process in Neurons Driven by Gibbs–Donnan Forces, Namely Spreading Depolarization},
	url = {https://m2.mtmt.hu/api/publication/32663200},
	author = {Lemale, Coline L. and Lückl, János and Horst, Viktor and Reiffurth, Clemens and Major, Sebastian and Hecht, Nils and Woitzik, Johannes and Dreier, Jens P.},
	doi = {10.3389/fncel.2022.837650},
	journal-iso = {FRONT CELL NEUROSCI},
	journal = {FRONTIERS IN CELLULAR NEUROSCIENCE},
	volume = {16},
	unique-id = {32663200},
	issn = {1662-5102},
	year = {2022},
	eissn = {1662-5102},
	orcid-numbers = {Lückl, János/0000-0001-8094-771X}
}

@mastersthesis{MTMT:2995653,
	title = {Investigation of the risk factors of preterm birth and infant mortality in Hungary – epidemiological and cost-effectiveness analyses},
	url = {https://m2.mtmt.hu/api/publication/2995653},
	author = {Nyári, Csaba},
	doi = {10.14232/phd.2521},
	publisher = {SZTE},
	unique-id = {2995653},
	year = {2015}
}

@mastersthesis{MTMT:2993027,
	title = {Fotoszintetizáló baktériumok fluoreszcenciájának indukciója és relaxációja},
	url = {https://m2.mtmt.hu/api/publication/2993027},
	author = {Asztalos, Emese},
	doi = {10.14232/phd.2392},
	publisher = {SZTE},
	unique-id = {2993027},
	year = {2015}
}

@article{MTMT:2925398,
	title = {Purple non-sulfur photosynthetic bacteria monitor environmental stresses},
	url = {https://m2.mtmt.hu/api/publication/2925398},
	author = {Kis, Mariann and Sipka, Gábor and Asztalos, Emese and Rázga, Zsolt and Maróti, Péter},
	doi = {10.1016/j.jphotobiol.2015.07.017},
	journal-iso = {J PHOTOCH PHOTOBIO B},
	journal = {JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY},
	volume = {151},
	unique-id = {2925398},
	issn = {1011-1344},
	year = {2015},
	eissn = {1873-2682},
	pages = {110-117},
	orcid-numbers = {Kis, Mariann/0000-0001-6678-4344; Sipka, Gábor/0000-0002-8553-4890; Rázga, Zsolt/0000-0003-4717-8482}
}

@article{MTMT:2865767,
	title = {Protonated rhodosemiquinone at the QB binding site of M265IT mutant reaction center of photosynthetic bacterium Rhodobacter sphaeroides},
	url = {https://m2.mtmt.hu/api/publication/2865767},
	author = {Maróti, Ágnes and Wraight, CA and Maróti, Péter},
	doi = {10.1021/bi501553t},
	journal-iso = {BIOCHEMISTRY-US},
	journal = {BIOCHEMISTRY},
	volume = {54},
	unique-id = {2865767},
	issn = {0006-2960},
	abstract = {The 2nd electron transfer from the primary ubiquinone QA to the secondary ubiquinone QB in the reaction center (RC) from Rhodobacter sphaeroides involves protonated QB- intermediate state whose low pKa makes the direct observation impossible. Here, we replaced the native ubiquinone by low potential rhodoquinone at the QB binding site of the M265IT mutant RC. Because the in situ midpoint redox potential of QA of this mutant was lowered about the same extent ( approximately 100 mV) as that of QB upon exchange of ubiquinone by low potential rhodoquinone, the interquinone (QA-->QB) electron transfer became energetically favorable. After subsequent saturating flash excitations, a period of two damped oscillation of the protonated rhodosemiquinone was observed. The QBH* was identified by 1) the characteristic band at 420 nm of the absorption spectrum after the 2nd flash and 2) smaller damping of the oscillation at 420 nm (due to the neutral form) than at 460 nm (attributed to the anionic form). The appearance of the neutral semiquinone was restricted to the acidic pH range indicating a functional pKa of less than 5.5, slightly higher than that of the native ubisemiquinone (pKa < 4.5) at pH 7. The analysis of the pH- and temperature dependences of the rates of the 2nd electron transfer supports the concept of pH-dependent pKa of the semiquinone at the QB binding site. The local electrostatic potential is severely modified by the strongly interacting neighboring acidic cluster and the pKa of the semiquinone is in the middle of the pH range of the complex titration. The kinetic and thermodynamic data are discussed according to the proton-activated electron transfer mechanism combined with pH-dependent functional pKa of the semiquinone at the QB site of the RC.},
	year = {2015},
	eissn = {1520-4995},
	pages = {2095-2103}
}

@article{MTMT:2814951,
	title = {A kék LED fizikai Nobel-díjat érdemelt},
	url = {https://m2.mtmt.hu/api/publication/2814951},
	author = {Maróti, Péter},
	journal-iso = {MAGY KEM LAP},
	journal = {MAGYAR KÉMIKUSOK LAPJA},
	volume = {70},
	unique-id = {2814951},
	issn = {0025-0163},
	year = {2015},
	eissn = {1588-1199},
	pages = {37-38}
}

@article{MTMT:2814945,
	title = {Stigmatellin probes the electrostatic potential in the QB site of photosynthetic reaction center},
	url = {https://m2.mtmt.hu/api/publication/2814945},
	author = {Gerencsér, László and Boros, Bogáta and Derrien, V and Hanson, DH and Wraight, CA and Sebban, P and Maróti, Péter},
	doi = {10.1016/j.bpj.2014.11.3463},
	journal-iso = {BIOPHYS J},
	journal = {BIOPHYSICAL JOURNAL},
	volume = {108},
	unique-id = {2814945},
	issn = {0006-3495},
	year = {2015},
	eissn = {1542-0086},
	pages = {379-394}
}

@article{MTMT:2814940,
	title = {Fluorescence relaxation in intact cells of photosynthetic bacteria: donor and acceptor side limitations of reopening of the reaction center},
	url = {https://m2.mtmt.hu/api/publication/2814940},
	author = {Asztalos, Emese and Sipka, Gábor and Maróti, Péter},
	doi = {10.1007/s11120-014-0070-0},
	journal-iso = {PHOTOSYNTH RES},
	journal = {PHOTOSYNTHESIS RESEARCH},
	volume = {124},
	unique-id = {2814940},
	issn = {0166-8595},
	year = {2015},
	eissn = {1573-5079},
	pages = {31-44},
	orcid-numbers = {Sipka, Gábor/0000-0002-8553-4890}
}

@article{MTMT:2780613,
	title = {The rate of second electron transfer to QB− in bacterial reaction center of impaired proton delivery shows hydrogen-isotope effect},
	url = {https://m2.mtmt.hu/api/publication/2780613},
	author = {Maróti, Ágnes and Wraight, Colin A and Maróti, Péter},
	doi = {10.1016/j.bbabio.2014.11.002},
	journal-iso = {BBA-BIOENERGETICS},
	journal = {BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS},
	volume = {1847},
	unique-id = {2780613},
	issn = {0005-2728},
	abstract = {Abstract The 2nd electron transfer in reaction center of photosynthetic bacterium Rhodobacter sphaeroides is a two step process in which protonation of QB− precedes interquinone electron transfer. The thermal activation and pH dependence of the overall rate constants of different RC variants were measured and compared in solvents of water (H2O) and heavy water (D2O). The electron transfer variants where the electron transfer is rate limiting (wild type and M17DN, L210DN and H173EQ mutants) do not show solvent isotope effect and the significant decrease of the rate constant of the second electron transfer in these mutants is due to lowering the operational pKa of QB−/QBH: 4.5 (native), 3.9 (L210DN), 3.7 (M17DN) and 3.1 (H173EQ) at pH 7. On the other hand, the proton transfer variants where the proton transfer is rate limiting demonstrate solvent isotope effect of pH-independent moderate magnitude (2.11 ± 0.26 (WT + Ni2 +), 2.16 ± 0.35 (WT + Cd2 +) and 2.34 ± 0.44 (L210DN/M17DN)) or pH-dependent large magnitude (5.7 at pH 4 (L213DN)). Upon deuteration, the free energy and the enthalpy of activation increase in all proton transfer variants by about 1 kcal/mol and the entropy of activation becomes negligible in L210DN/M17DN mutant. The results are interpreted as manifestation of equilibrium and kinetic solvent isotope effects and the structural, energetic and kinetic possibility of alternate proton delivery pathways are discussed.},
	keywords = {reaction center protein; bacterial photosynthesis; Solvent isotope effect; Protonation mutant; Flash-induced proton delivery},
	year = {2015},
	eissn = {1879-2650},
	pages = {223-230}
}