TY - JOUR AU - Kucsera, Eszter Márta AU - Csupor, Dezső TI - Egy ismeretlen betegség, a hisztaminintolerancia: okok, tünetek, kezelés JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 68 PY - 2024 IS - 5 SP - 246 EP - 253 PG - 8 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/34876112 ID - 34876112 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Mukhtar, Mahwash AU - Pannonhalminé Csóka, Ildikó AU - Martinović, Josipa AU - Šelo, Gordana AU - Bucić-Kojić, Ana AU - Orosz, László AU - Paróczai, Dóra AU - Burián, Katalin AU - Ambrus, Rita TI - Fabrication of Ciprofloxacin-Loaded Sodium Alginate Nanobeads Coated with Thiol-Anchored Chitosan Using B-390 Encapsulator Following Optimization by DoE JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 16 PY - 2024 IS - 6 PG - 16 SN - 1999-4923 DO - 10.3390/pharmaceutics16060691 UR - https://m2.mtmt.hu/api/publication/34866802 ID - 34866802 N1 - Project no. TKP2021-EGA-32 has been implemented with the support provided by the Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. The work was supported by the NKFI OTKA K_146148 project. Acknowledgments: We thank Nikolett Bagi and Anikó Vigyikánné Váradi for their excellent technical support. D.P. was supported by the ÚNKP-23-4-New National Excellence Program of the Ministry for Culture and Innovation and the National Research, Development, and Innovation Fund. ÚNKP-23-4-SZTE-380. AB - Most infectious diseases of the gastrointestinal tract can easily be treated by exploiting the already available antibiotics with the change in administration approach and delivery system. Ciprofloxacin (CIP) is used as a drug of choice for many bacterial infections; however, long-term therapy and off-site drug accumulation lead to an increased risk of tendinitis and peripheral neuropathy. To overcome this issue, nanotechnology is being exploited to encapsulate antibiotics within polymeric structures, which not only facilitates dose maintenance at the infection site but also limits off-site side effects. Here, sodium alginate (SA) and thiol-anchored chitosan (TC) were used to encapsulate CIP via a calcium chloride (CaCl2) cross-linker. For this purpose, the B-390 encapsulator was employed in the preparation of nanobeads using a simple technique. The hydrogel-like sample was then freeze-dried, using trehalose or mannitol as a lyoprotectant, to obtain a fine dry powder. Design of Experiment (DoE) was utilized to optimize the nanobead production, in which the influence of different independent variables was studied for their outcome on the polydispersity index (PDI), particle size, zeta potential, and percentage encapsulation efficiency (% EE). In vitro dissolution studies were performed in simulated saliva fluid, simulated gastric fluid, and simulated intestinal fluid. Antibacterial and anti-inflammatory studies were also performed along with cytotoxicity profiling. By and large, the study presented positive outcomes, proving the advantage of using nanotechnology in fabricating new delivery approaches using already available antibiotics. LA - English DB - MTMT ER - TY - CHAP AU - Papfalvi, Erika Piroska AU - Nacsa, Róbert AU - Matuz, Mária AU - Ruzsa, Roxána AU - Hambalek, Helga AU - Hajdú, Edit AU - Pető, Zoltán AU - Erdélyi, Péter AU - Soós, Gyöngyvér AU - Benkő, Ria ED - Zorana, Kovačević TI - Insights into antibiotic utilisation. Pilot study from an emergency department T2 - 3rd Antimicrobial Resistance – Current State and Perspectives 2024 PB - University of Novi Sad, Faculty of Agriculture CY - Novi Sad SN - 9788675206101 PY - 2024 SP - 259 EP - 261 PG - 3 UR - https://m2.mtmt.hu/api/publication/34865772 ID - 34865772 LA - English DB - MTMT ER - TY - CHAP AU - Benkő, Ria AU - Papfalvi, Erika Piroska AU - Matuz, Mária ED - Zorana, Kovačević TI - Different aspects of hungarian antibiotic use T2 - 3rd Antimicrobial Resistance – Current State and Perspectives 2024 PB - University of Novi Sad, Faculty of Agriculture CY - Novi Sad SN - 9788675206101 PY - 2024 SP - 37 EP - 38 PG - 2 UR - https://m2.mtmt.hu/api/publication/34865735 ID - 34865735 LA - English DB - MTMT ER - TY - CONF AU - Hasanpour, Feria AU - Berkó, Szilvia TI - Innovative dermal drug delivery formulation containing lidocaine compare with lidocaine ointment T2 - VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and RegulatoryAffairs, University of Szeged, Faculty of Pharmacy C1 - Szeged PY - 2024 SP - 46 EP - 46 PG - 1 DO - 10.14232/syrptbrs.2024.46 UR - https://m2.mtmt.hu/api/publication/34855660 ID - 34855660 LA - English DB - MTMT ER - TY - JOUR AU - Milenkova, Sofia AU - Ambrus, Rita AU - Mukhtar, Mahwash AU - Pilicheva, Bissera AU - Marudova, Maria TI - Spray-Dried Chitosan Hydrogel Particles as a Potential Delivery System for Benzydamine Hydrochloride JF - GELS (BASEL) J2 - GELS-BASEL VL - 10 PY - 2024 IS - 3 SP - 189 SN - 2310-2861 DO - 10.3390/gels10030189 UR - https://m2.mtmt.hu/api/publication/34854941 ID - 34854941 AB - Chitosan, being a biocompatible and mucoadhesive polysaccharide, is one of the most preferred hydrogel-forming materials for drug delivery. The objectives of the present study are to obtain spray-dried microparticles based on low-molecular-weight chitosan and study their potential application as cargo systems for the orally active drug benzydamine hydrochloride. Three types of particles are obtained: raw chitosan particles (at three different concentrations), cross-linked with sodium tripolyphosphate (NaTPP) particles (at three different chitosan:NaTPP ratios), and particles coated with mannitol (at three different chitosan:mannitol ratios), all of them in the size range between 1 and 10 µm. Based on the loading efficiency and the yields of the formulated hydrogel particles, one model of each type is chosen for further investigation of the effect of the cross-linker or the excipient on the properties of the gel structures. The morphology of both empty and benzydamine hydrochloride-loaded chitosan particles was examined by scanning electron microscopy, and it was quite regular and spherical. Interactions and composition in the samples are investigated by Fourier-transformed infrared spectroscopy. The thermal stability and phase state of the drug and drug-containing polymer matrixes were tested by differential scanning calorimetry and X-ray powdered diffraction, revealing that the drug underwent a phase transition. A drug release kinetics study of the chosen gel-based structures in simulated saliva buffer (pH = 6.8) and mathematical modeling of the process were performed, indicating the Weibull model as the most appropriate one. LA - English DB - MTMT ER - TY - JOUR AU - Perković, Gabriela AU - Martinović, Josipa AU - Šelo, Gordana AU - Bucić-Kojić, Ana AU - Planinić, Mirela AU - Ambrus, Rita TI - Characterization of Grape Pomace Extract Microcapsules: The Influence of Carbohydrate Co-Coating on the Stabilization of Goat Whey Protein as a Primary Coating JF - FOODS J2 - FOODS VL - 13 PY - 2024 IS - 9 SP - 1346 SN - 2304-8158 DO - 10.3390/foods13091346 UR - https://m2.mtmt.hu/api/publication/34854924 ID - 34854924 AB - Both grape pomace and whey are waste products from the food industry that are rich in valuable ingredients. The utilization of these two by-products is becoming increasingly possible as consumer awareness of upcycling increases. The biological activities of grape pomace extract (GPE) are diverse and depend on its bioavailability, which is influenced by processes in the digestive system. In this work, goat whey protein (GW) was used as the primary coating to protect the phenolic compounds of GPE during the spray drying process. In addition, trehalose (T), sucrose (S), xylose (X), and maltodextrin (MD) were added to the goat whey proteins as co-coatings and protein stabilizers. All spray drying experiments resulted in microcapsules (MC) with a high encapsulation efficiency (77.6–95.5%) and yield (91.5–99.0%) and almost 100% recovery of phenolic compounds during the release test. For o-coumaric acid, the GW-coated microcapsules (MC) showed a bioavailability index of up to 731.23%. A semi-crystalline structure and hydrophilicity were characteristics of the MC coated with 10% T, S, X, or 5% MD. GW alone or in combination with T, S, MD, or X proved to be a promising carrier for polyphenols from grape pomace extract and ensured good bioavailability of these natural antioxidants. LA - English DB - MTMT ER - TY - JOUR AU - Érszegi, András AU - Vámos, Máté AU - Viola, Réka AU - Csupor, Dezső AU - Vágvölgyi, Anna TI - „Agyfényesítés” vagy evidenciák nélküli gyógyszerabúzus? A piracetám alkalmazása Magyarországon [„Cognitive Enhancement" or non-evidence-based nootropic abuse? – Use of Piracetam in Hungary] JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 54 PY - 2024 IS - 2 SP - 141 EP - 149 PG - 9 SN - 0133-5596 DO - 10.26430/CHUNGARICA.2024.54.2.141 UR - https://m2.mtmt.hu/api/publication/34854390 ID - 34854390 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lambert, Maarten AU - Wonink, Anneloes AU - Benkő, Ria AU - Plejdrup Hansen, Malene AU - van Dijk, Liset AU - Taxis, Katja TI - Pharmacists combating antimicrobial resistance: A Delphi study on antibiotic dispensing JF - RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY J2 - RES SOC ADMIN PHARM PY - 2024 PG - 10 SN - 1551-7411 DO - 10.1016/j.sapharm.2024.04.006 UR - https://m2.mtmt.hu/api/publication/34849164 ID - 34849164 AB - The daily work of community pharmacists includes dispensing antibiotics, but little is known about how this should be done to ensure quality use of antibiotics.To define specific tasks of the community pharmacist when dispensing antibiotics and to assess to what extent these tasks can be implemented in practice in Europe.A Delphi study with community pharmacist experts in the European Economic Area. Statements on potential tasks for pharmacists during the antibiotic dispensing process were based on a systematic literature review. Participants rated the statements for importance and feasibility of implementation in practice in 3 rounds on a scale from 1 to 9. Consensus of importance was defined as ≥ 80 % of experts rating a statement between 7 and 9. An online expert meeting was conducted between rounds 1 and 2. Scores for all statements were analysed descriptively.Overall, 38 experts from 21 countries participated in the study. Experts reached consensus on 108 statements within 5 themes: 1) collaboration with prescribers, 2) checking prescriptions and dispensing, 3) counselling, 4) education, and 5) pharmacy services. Potential tasks included advising and collaborating with prescribers, performing safety checks, and having access to specific prescription information. Additionally, pharmacists should counsel patients related to the dispensed antibiotic and on antimicrobial resistance and infectious diseases. With few exceptions, pharmacists should not dispense antibiotics without prescriptions or prescribe antibiotics. Consensus on feasibility of implementation was only reached for statements in the categories "counselling patients" and "education". Barriers to changing practice included structure of the healthcare system, resistance to change from prescribers or pharmacy staff, lack of time and finances, legal barriers, and patient expectations.Community pharmacists have an important role when dispensing antibiotics. This study provides important steps towards better community pharmacy antibiotic dispensing practices throughout the EEA. LA - English DB - MTMT ER - TY - JOUR AU - Pintér, Dávid AU - Balogh, Andrea AU - Benkő, Ria AU - Tóth, Erika Hajnalka TI - Magyar vonatkozások egy nemzetközi kórképben. A Journal of Sleep Research által 2023-ban kiadott, az insomnia kezelését célzó terápiás irányelv áttekintése TS - A Journal of Sleep Research által 2023-ban kiadott, az insomnia kezelését célzó terápiás irányelv áttekintése JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 68 PY - 2024 IS - 4 SP - 188 EP - 197 PG - 10 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/34849152 ID - 34849152 LA - Hungarian DB - MTMT ER -