TY - JOUR AU - Molnár, Tihamér AU - Lehoczki, Andrea Marianna AU - Fekete, Mónika AU - Várnai, Réka AU - Zavori, Laszlo AU - Erdő-Bonyár, Szabina AU - Simon, Diána AU - Berki, Tímea AU - Csécsei, Péter AU - Ezer, Erzsébet TI - Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - In press PY - 2024 SN - 2509-2715 DO - 10.1007/s11357-024-01165-5 UR - https://m2.mtmt.hu/api/publication/34824081 ID - 34824081 N1 - * Megosztott szerzőség AB - The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced the medical community to the phenomenon of long COVID, a condition characterized by persistent symptoms following the resolution of the acute phase of infection. Among the myriad of symptoms reported by long COVID sufferers, chronic fatigue, cognitive disturbances, and exercise intolerance are predominant, suggesting systemic alterations beyond the initial viral pathology. Emerging evidence has pointed to mitochondrial dysfunction as a potential underpinning mechanism contributing to the persistence and diversity of long COVID symptoms. This review aims to synthesize current findings related to mitochondrial dysfunction in long COVID, exploring its implications for cellular energy deficits, oxidative stress, immune dysregulation, metabolic disturbances, and endothelial dysfunction. Through a comprehensive analysis of the literature, we highlight the significance of mitochondrial health in the pathophysiology of long COVID, drawing parallels with similar clinical syndromes linked to post-infectious states in other diseases where mitochondrial impairment has been implicated. We discuss potential therapeutic strategies targeting mitochondrial function, including pharmacological interventions, lifestyle modifications, exercise, and dietary approaches, and emphasize the need for further research and collaborative efforts to advance our understanding and management of long COVID. This review underscores the critical role of mitochondrial dysfunction in long COVID and calls for a multidisciplinary approach to address the gaps in our knowledge and treatment options for those affected by this condition. LA - English DB - MTMT ER - TY - CHAP AU - Stankovics, Levente ED - Vámos, Zoltán TI - A tromboembólia profilaxisa T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó Zrt. CY - Budapest SN - 9789632269177 PY - 2024 SP - 170 EP - 171 PG - 2 UR - https://m2.mtmt.hu/api/publication/34823723 ID - 34823723 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Dóczi, Tamás Péter ED - Vámos, Zoltán TI - Agyödéma T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó Zrt. CY - Budapest SN - 9789632269177 PY - 2024 SP - 67 EP - 74 PG - 1 UR - https://m2.mtmt.hu/api/publication/34823698 ID - 34823698 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Czeiter, Endre AU - Amrein, Krisztina ED - Vámos, Zoltán TI - Az agyi neurobiomarkerek diagnosztikus és prognosztikus értéke T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó Zrt. CY - Budapest SN - 9789632269177 PY - 2024 SP - 63 EP - 66 PG - 1 UR - https://m2.mtmt.hu/api/publication/34823697 ID - 34823697 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Tóth, Péter József ED - Vámos, Zoltán TI - Az agy véráramlásának autoregulációja T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó Zrt. CY - Budapest SN - 9789632269177 PY - 2024 SP - 49 EP - 49 PG - 1 UR - https://m2.mtmt.hu/api/publication/34823693 ID - 34823693 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Tóth, Péter József ED - Vámos, Zoltán TI - Az agy keringésszabályozása T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó Zrt. CY - Budapest SN - 9789632269177 PY - 2024 SP - 47 EP - 47 PG - 1 UR - https://m2.mtmt.hu/api/publication/34823691 ID - 34823691 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Czeiter, Endre AU - Fazekas, Bálint AU - Amrein, Krisztina ED - Vámos, Zoltán TI - Az agysérülés neuroanatómiája T2 - Súlyos baleseti agysérültek ellátása PB - Medicina Könyvkiadó Zrt. CY - Budapest SN - 9789632269177 PY - 2024 SP - 33 EP - 46 PG - 14 UR - https://m2.mtmt.hu/api/publication/34823375 ID - 34823375 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csiszar, Anna AU - Ungvári, Anna Sára AU - Patai, Roland AU - Gulej, Rafal AU - Yabluchanskiy, Andriy AU - Benyó, Zoltán AU - Kovács, Illés AU - Sótonyi, Péter AU - Kirkpartrick, Angelia C AU - Prodan, Calin I AU - Liotta, Eric M AU - Zhang, Xin A AU - Tóth, Péter József AU - Tarantini, Stefano AU - Sorond, Farzaneh A AU - Ungvári, Zoltán István TI - Atherosclerotic burden and cerebral small vessel disease : exploring the link through microvascular aging and cerebral microhemorrhages JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - in press PY - 2024 PG - 30 SN - 2509-2715 DO - 10.1007/s11357-024-01139-7 UR - https://m2.mtmt.hu/api/publication/34804161 ID - 34804161 N1 - * Megosztott szerzőség AB - Cerebral microhemorrhages (CMHs, also known as cerebral microbleeds) are a critical but frequently underestimated aspect of cerebral small vessel disease (CSVD), bearing substantial clinical consequences. Detectable through sensitive neuroimaging techniques, CMHs reveal an extensive pathological landscape. They are prevalent in the aging population, with multiple CMHs often being observed in a given individual. CMHs are closely associated with accelerated cognitive decline and are increasingly recognized as key contributors to the pathogenesis of vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). This review paper delves into the hypothesis that atherosclerosis, a prevalent age-related large vessel disease, extends its pathological influence into the cerebral microcirculation, thereby contributing to the development and progression of CSVD, with a specific focus on CMHs. We explore the concept of vascular aging as a continuum, bridging macrovascular pathologies like atherosclerosis with microvascular abnormalities characteristic of CSVD. We posit that the same risk factors precipitating accelerated aging in large vessels (i.e., atherogenesis), primarily through oxidative stress and inflammatory pathways, similarly instigate accelerated microvascular aging. Accelerated microvascular aging leads to increased microvascular fragility, which in turn predisposes to the formation of CMHs. The presence of hypertension and amyloid pathology further intensifies this process. We comprehensively overview the current body of evidence supporting this interconnected vascular hypothesis. Our review includes an examination of epidemiological data, which provides insights into the prevalence and impact of CMHs in the context of atherosclerosis and CSVD. Furthermore, we explore the shared mechanisms between large vessel aging, atherogenesis, microvascular aging, and CSVD, particularly focusing on how these intertwined processes contribute to the genesis of CMHs. By highlighting the role of vascular aging in the pathophysiology of CMHs, this review seeks to enhance the understanding of CSVD and its links to systemic vascular disorders. Our aim is to provide insights that could inform future therapeutic approaches and research directions in the realm of neurovascular health. LA - English DB - MTMT ER - TY - GEN AU - Rendes, Réka AU - Orsi, Gergely AU - Perlaki, Gábor AU - Bereczkei, Tamás AU - Deák, Anita TI - Neural correlates of valence and arousal ratings responding to socio-emotional stimuli. PY - 2024 UR - https://m2.mtmt.hu/api/publication/34794821 ID - 34794821 N1 - Z3-Poster 3-9002 LA - English DB - MTMT ER - TY - CHAP AU - Maróti, Péter AU - Schlégl, Ádám Tibor AU - Nagy, Bálint AU - Tóth, Luca AU - Bogár, Péter Zoltán AU - Józsa, Gergő AU - Rendeki, Szilárd AU - Mallakpour, Shadpour AU - Hussain, Chaudhery Mustansar TI - Additive manufacturing in limb prosthetics and orthotics: the past, present and future of 3D printing orthopedic assistive devices T2 - Medical Additive Manufacturing PB - Elsevier SN - 9780323953832 PY - 2024 SP - 179 EP - 207 PG - 29 DO - 10.1016/B978-0-323-95383-2.00028-7 UR - https://m2.mtmt.hu/api/publication/34774903 ID - 34774903 LA - English DB - MTMT ER -