TY - JOUR AU - Orosz, János Máté AU - Rávai, Bettina AU - Mátravölgyi, Béla AU - Bálint, Erika TI - Flow Synthesis of Capsaicin and Capsaicinoid Analogues JF - ACS SUSTAINABLE CHEMISTRY & ENGINEERING J2 - ACS SUSTAIN CHEM ENG PY - 2024 SN - 2168-0485 DO - 10.1021/acssuschemeng.4c01839 UR - https://m2.mtmt.hu/api/publication/34852442 ID - 34852442 LA - English DB - MTMT ER - TY - JOUR AU - Hargittai, István TI - José Elguero – an introduction and tribute JF - STRUCTURAL CHEMISTRY J2 - STRUCT CHEM PY - 2024 PG - 2 SN - 1040-0400 DO - 10.1007/s11224-024-02334-0 UR - https://m2.mtmt.hu/api/publication/34846758 ID - 34846758 N1 - Export Date: 10 May 2024 CODEN: STCHE Correspondence Address: Hargittai, I.; Budapest University of Technology and EconomicsHungary; email: stuceditor@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Ficzere, Máté AU - Mészáros, Lilla Alexandra AU - Diószegi, Anna AU - Bánrévi, Zoltán AU - Farkas, Attila AU - Lenk, Sándor AU - Galata, Dorián László AU - Nagy, Zsombor Kristóf TI - UV imaging for the rapid at-line content determination of different colourless APIs in their tablets with artificial neural networks JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 657 PY - 2024 PG - 10 SN - 0378-5173 DO - 10.1016/j.ijpharm.2024.124174 UR - https://m2.mtmt.hu/api/publication/34845147 ID - 34845147 N1 - Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp 3., Budapest, H-1111, Hungary Department of Atomic Physics, Budapest University of Technology and Economics, Műegyetem rkp 3., Budapest, H-1111, Hungary Export Date: 17 May 2024 CODEN: IJPHD Correspondence Address: Kristóf Nagy, Z.; Department of Organic Chemistry and Technology, Műegyetem rkp 3., Hungary; email: zsknagy@oct.bme.hu Funding details: Budapesti Műszaki és Gazdaságtudományi Egyetem, BME Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH Funding details: Magyar Tudományos Akadémia, MTA Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding details: European Commission, EC, ÚNKP-23-3-I-BME-23, ÚNKP-23-5- BME-448 Funding text 1: Project no. RRF-2.3.1-21-2022-00015 has been implemented with the support provided by the European Union. This project was supported by the \\u00DANKP-23-3-I-BME-23 and \\u00DANKP-23-5- BME-448 New National Excellence Program of the Ministry of Human Capacities. The project supported by the Doctoral Excellence Fellowship Programme (DCEP) is funded by the National Research Development and Innovation Fund of the Ministry of Culture and Innovation and the Budapest University of Technology and Economics, under a grant agreement with the National Research, Development and Innovation Office. This paper was supported by the J\\u00E1nos Bolyai Scholarship of the Hungarian Academy of Sciences. LA - English DB - MTMT ER - TY - JOUR AU - Keglevich, György AU - Varga, Petra Regina AU - Dinnyesi, Emoke AU - Szalai, Zsuzsanna AU - Bősze, Szilvia AU - Szabó, Rita (Oláhné) AU - Drahos, Laszlo AU - Karaghiosoff, Konstantin TI - N-Functionalization of β-aminophosphonates: cytotoxic effects of the new derivatives JF - ORGANIC & BIOMOLECULAR CHEMISTRY J2 - ORG BIOMOL CHEM PY - 2024 PG - 11 SN - 1477-0520 DO - 10.1039/d4ob00243a UR - https://m2.mtmt.hu/api/publication/34845070 ID - 34845070 N1 - Funding Agency and Grant Number: European Commission [K134318, RRF-2.3.1-21-2022-00015]; National Research, Development and Innovation Office; European Union Funding text: This project was supported by the National Research, Development and Innovation Office (K134318). Project no. RRF-2.3.1-21-2022-00015 has been implemented with the support provided by the European Union. AB - beta-Aminophosphonates obtained by the Michael addition of primary amines to the double bond of diethyl vinylphosphonate proved to be suitable starting materials (amine components) in the Kabachnik-Fields reaction with formaldehyde and dialkyl phosphites or secondary phosphine oxides to afford N-phosphonylmethyl- and N-phosphinoylmethyl-beta-aminophosphonates. On the other hand, the starting aminophosphonates were modified by N-acylation using acid chlorides. The N-acyl products were found to exist in a dynamic equilibrium of two conformers as suggested by the broad NMR signals. At 26 degrees C, there may be rotation around the N-C axis of the acylamide function. At the same time, low-temperature NMR measurements at -5 degrees C revealed the presence of two distinct rotamers that could be characterized by P-31, C-13 and H-1 NMR data. The modified beta-aminophosphonic derivatives were subjected to a comparative structure-activity analysis on MDA-MB-231, PC-3, A431 and Ebc-1 tumor cell lines, and in a few cases, significant activity was detected. LA - English DB - MTMT ER - TY - JOUR AU - Kádár, Szabina AU - Kennedy, Andrew AU - Lee, Samuel AU - Ruiz, Rebeca AU - Farkas, Attila AU - Tőzsér, Petra AU - Csicsák, Dóra AU - Tóth, Gergő AU - Sinkó, Bálint AU - Borbás, Enikő TI - Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus—An aripiprazole case study JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 198 PY - 2024 PG - 11 SN - 0928-0987 DO - 10.1016/j.ejps.2024.106782 UR - https://m2.mtmt.hu/api/publication/34845067 ID - 34845067 N1 - Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, 3 Műegyetem rkp, Budapest, H-1111, Hungary Pion Inc UK Ltd., Forest Row Business Park, Forest RowRH18 5DW, United Kingdom Pion Inc., 10 Cook Street, Billerica, MA 01821, United States Department of Pharmaceutical Chemistry, Semmelweis University, 9 Hőgyes Endre Street, Budapest, 1092, Hungary Export Date: 17 May 2024 CODEN: EPSCE Correspondence Address: Sinkó, B.; Pion Inc., 10 Cook Street, United States; email: bsinko@pion-inc.com Funding details: European Commission, EC Funding details: Magyar Tudományos Akadémia, MTA Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, NKFIH FK 146930, ÚNKP-23-3-II-BME-88 Funding text 1: This work was financially supported by the J\\u00E1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences (EB). This work was funded by the National Research, Development and Innovation Office, Hungary (grant: NKFIH FK 146930). This project was supported by the \\u00DANKP-23-3-II-BME-88 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund (SK). Project no. RRF-2.3.1-21-2022-00015 has been implemented with the support provided by the European Union. LA - English DB - MTMT ER - TY - CONF AU - Do Thi, Huyen Trang AU - Tóth, András József TI - A desztillációs eljárás környezeti értékelése az illékony- és szerves halogénvegyületek eltávolítására a technológiai hulladékvizek esetében T2 - Műszaki Kémiai Napok 2024 PY - 2024 SP - 2 UR - https://m2.mtmt.hu/api/publication/34833665 ID - 34833665 LA - Hungarian DB - MTMT ER - TY - CONF AU - Somogyvári, Erik AU - Tóth, András József TI - Komplex, erősen nem-ideális négykomponensű elegyek elválasztása desztillációval – modellezés és optimalizálás folyamatszimulátorban T2 - Műszaki Kémiai Napok 2024 PY - 2024 SP - 1 UR - https://m2.mtmt.hu/api/publication/34833652 ID - 34833652 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Benkő, Beáta Mária AU - Tóth, Gergő AU - Moldvai, Dorottya AU - Kádár, Szabina AU - Szabó, Edina AU - Szabó, Zoltán-István AU - Mazákné Kraszni, Márta AU - Szente, Lajos AU - Fiser, Béla AU - Sebestyén, Anna AU - Zelkó, Romána AU - Sebe, István TI - Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation, analytical and in vitro biological characterization of the inclusion complexes JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 657 PY - 2024 PG - 14 SN - 0378-5173 DO - 10.1016/j.ijpharm.2024.124187 UR - https://m2.mtmt.hu/api/publication/34830527 ID - 34830527 LA - English DB - MTMT ER - TY - JOUR AU - Molnár, Zsófia Klára AU - Koplányi, Gábor AU - Farkas, Réka AU - Péli, Noémi AU - Kenéz, Balázs AU - Decsi, Balázs AU - Katona, Gábor AU - Balogh, György Tibor AU - Vértessy, Beáta (Grolmuszné) AU - Balogh Weiser, Diána TI - Immobilization of human tyrosine hydroxylase onto magnetic nanoparticles – A novel formulation of a therapeutic enzyme JF - INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES J2 - INT J BIOL MACROMOL VL - 268 PY - 2024 IS - Part 2 PG - 11 SN - 0141-8130 DO - 10.1016/j.ijbiomac.2024.131939 UR - https://m2.mtmt.hu/api/publication/34830192 ID - 34830192 AB - Human tyrosine hydroxylase (hTH) has key role in the production of catecholamine neurotransmitters. The structure, function and regulation of hTH has been extensively researched area and the possibility of enzyme replacement therapy (ERT) involving hTH through nanocarriers has been raised as well. However, our understanding on how hTH may interact with nanocarriers is still lacking. In this work, we attempted to investigate the immobilization of hTH on magnetic nanoparticles (MNPs) with various surface linkers in quantitative and mechanistic detail. Our results showed that the activity of hTH was retained after immobilization via secondary and covalent interactions as well. The colloidal stability of hTH could be also enhanced proved by Dynamic light scattering and Zeta potential analysis and a homogenous enzyme layer could be achieved, which was investigated by Raman mapping. The covalent attachment of hTH on MNPs via aldehyde or epoxy linkers provide irreversible immobilization and 38.1 % and 16.5 % recovery (ER). The hTH-MNPs catalyst had 25 % ER in average in simulated nasal electrolyte solution (SNES). This outcome highlights the relevance of immobilization applying MNPs as a potential formulation tool of sensitive therapeutic enzymes offering new opportunities for ERT related to neurodegenerative disorders. © 2024 The Author(s) LA - English DB - MTMT ER - TY - CHAP AU - Mika, László Tamás AU - Árvai, Csaba ED - Reedijk, J. TI - Catalysis in Biomass-Based Solvents T2 - Reference Module in Chemistry, Molecular Sciences and Chemical Engineering PB - Elsevier CY - Waltham (MA) SN - 9780124095472 PY - 2024 SP - 10.1016/B978-0-443-15742-4.00041-7 DO - 10.1016/B978-0-443-15742-4.00041-7 UR - https://m2.mtmt.hu/api/publication/34827493 ID - 34827493 AB - Replacing fossil resources with renewables is one of the most pressing challenges in developing a cleaner chemical industry. It is a fact that the chemical industry utilizes enormous amounts of solvents, which undoubtedly contribute to the release of millions of tons of organic compounds into the environment. The research activities on biomass conversion have identified promising alternatives that could be introduced as non-fossil reaction media into various catalytic processes, lowering their environmental impacts. Herein, the application of g-valerolactone, 2-methyltetrahydrofuran, ethanol, glycerol, methyl- and ethyl levulinate, ethyl lactate, limonene and p- cymene as well as selected designer solvents i.e. choline chloride/urea deep eutectic solvent as biomass-based alternative reaction media for catalytic transformation were overviewed. LA - English DB - MTMT ER -