@article{MTMT:34879391,
	title = {Analysis of AlphaMissense data in different protein groups and structural context},
	url = {https://m2.mtmt.hu/api/publication/34879391},
	author = {Tordai, Hedvig and Torres, O. and Csepi, M. and Padányi, Rita and Lukács, G.L. and Hegedűs, Tamás},
	doi = {10.1038/s41597-024-03327-8},
	journal-iso = {SCI DATA},
	journal = {SCIENTIFIC DATA},
	volume = {11},
	unique-id = {34879391},
	year = {2024},
	eissn = {2052-4463},
	orcid-numbers = {Tordai, Hedvig/0000-0002-0875-5569; Padányi, Rita/0000-0001-7798-0463; Hegedűs, Tamás/0000-0002-0331-9629}
}

@article{MTMT:34871745,
	title = {Prediabetes and Poorly Controlled Type-2 Diabetes as Risk Indicators for Peri-implant Diseases:A Systematic Review and Meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/34871745},
	author = {Bencze, Bulcsú and Golzio Navarro Cavalcante, Bianca and Romandini, Mario and Barabás-Róna, Virág and Váncsa, Szilárd and Varga, Gábor and Kivovics, Márton and Szabó, Bence and Agócs, Gergely and Géczi, Zoltán and Hermann, Péter and Hegyi, Péter and Végh, Dániel},
	doi = {10.1016/j.jdent.2024.105094},
	journal-iso = {J DENTISTRY},
	journal = {JOURNAL OF DENTISTRY},
	volume = {146},
	unique-id = {34871745},
	issn = {0300-5712},
	abstract = {ABSTRACT Objective The study answers the PECO question: “In adults with dental implants (P), do subjects suffering from type-2 diabetes or prediabetes (E) have worse peri-implant conditions (O) than subjects without type-2 diabetes and prediabetes (C)?”. Prediabetes (5.7-6.4% HbA1c), and the different qualities of glycemic control in type-2 diabetes; well-controlled (>8% HbA1c), and poorly controlled (>8% HbA1c) individuals; were classified according to the recommendations of the American Diabetes Association. Data Predefined search keys were used with search terms including: Dental implant, diabetes mellitus, glycemic control and HbA1c. Sources An electronic search in the MEDLINE, Embase, and Cochrane libraries were conducted without any filters or language restrictions. Additionally, manual search of the reference lists were carried out to identify all relevant articles. Study Selection Eligibility criteria were cohort, case-control and cross-sectional studies that answerd our PECO question with at least 1 year of follow-up. From a total of 2660 records, 35 articles (1761 individuals) were included in the analysis. Meta-analytic difference in means for crestal bone loss was 1.2 mm [95% CI=0.4; 2.1] in patients with prediabetes, 1.8 mm [CI=1.0; 2.7] in poorly controlled patients, whereas 0.4 mm [CI=-0.3; 1.1] in well-controlled individuals. Meta-regression showed that 1% increase in HbA1c increased crestal bone loss by 0.24 mm. Conclusions Within the limitations of the study, patients with poorly controlled type-2 diabetes or prediabetes may have worse peri-implant conditions compared to patients without diabetes and well-controlled type-2 diabetes. Well-controlled type-2 diabetes is not a risk indicator for peri-implant diseases. Clinical Significance Clinicians should measure blood HbA1c levels when planning implant-supported restorations, thus patients with undiagnosed or poorly controlled type-2 diabetes can be identified, that allows for glycemic level adjustment by the diabetologist specialist prior to dental implant surgery, ensuring peri-implant health. Protocol registration number (CRD42022375263)},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {1879-176X},
	orcid-numbers = {Golzio Navarro Cavalcante, Bianca/0000-0002-2804-6524; Váncsa, Szilárd/0000-0002-9347-8163; Varga, Gábor/0000-0002-5506-8198; Kivovics, Márton/0000-0003-0728-7027; Agócs, Gergely/0000-0003-2489-3790; Géczi, Zoltán/0000-0003-3799-9535; Hermann, Péter/0000-0002-9148-0139; Hegyi, Péter/0000-0003-0399-7259; Végh, Dániel/0000-0002-2836-6747}
}

@article{MTMT:34866835,
	title = {Very Young and Advanced Maternal Age Strongly Elevates the Occurrence of Non-Chromosomal Congenital Anomalies : A Systematic Review and Meta-Analysis of Population-Based Studies},
	url = {https://m2.mtmt.hu/api/publication/34866835},
	author = {Pethő, Boglárka and Váncsa, Szilárd and Váradi, Alex and Agócs, Gergely and Mátrai, Ákos and Zászkaliczky-Iker, Franciska and Balogh, Zita and Bánhidy, Ferenc and Hegyi, Péter and Ács, Nándor},
	doi = {10.1016/j.ajog.2024.05.010},
	journal-iso = {AM J OBSTET GYNECOL},
	journal = {AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY},
	unique-id = {34866835},
	issn = {0002-9378},
	abstract = {To evaluate the role of maternal age in the incidence of non-chromosomal congenital anomalies (NCAs) and to pinpoint age groups at higher risk to refine screening protocols.Search performed on October 19, 2021, across MEDLINE (via PubMed), Cochrane Library (CENTRAL), and Embase.Included were population-based studies assessing the impact of maternal age on the incidence of NCAs in pregnant women, without restrictions on age range, country, or comorbidities.The PRISMA 2020 guideline and Cochrane Handbook informed the systematic review and meta-analysis. A random-effects model was used for pooling effect sizes, considering the heterogeneity across studies.From 15,547 studies, 72 were synthesized. Maternal age >35 showed an increased NCA risk (RR 1.31, CI: 1.07-1.61), rising notably after >40 (RR 1.44, CI: 1.25-1.66). The latter changes to 1.25 (CI: 1.08-1.46) if the co-occurrence of chromosomal aberrations is excluded. Specific anomalies like cleft lip/palate (>40, RR 1.57, CI: 1.11-2.20) and circulatory system defects (>40, RR 1.94, CI: 1.28-2.93) were significantly associated with advanced maternal age. Conversely, gastroschisis was linked to mothers <20 (RR 3.08, CI: 2.74-3.47).The study confirms that both very young and advanced maternal ages significantly increase the risk of NCAs. There's a pressing need for age-specific prenatal screening protocols to better detect these anomalies, especially considering the current trend of delayed childbearing. Further research is required to fully understand the impact of maternal age on the prevalence of rarer NCAs.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {1097-6868},
	orcid-numbers = {Pethő, Boglárka/0000-0002-0020-5781; Váncsa, Szilárd/0000-0002-9347-8163; Váradi, Alex/0000-0001-8229-6340; Agócs, Gergely/0000-0003-2489-3790; Bánhidy, Ferenc/0000-0001-8910-1964; Hegyi, Péter/0000-0003-0399-7259; Ács, Nándor/0000-0002-1919-1869}
}

@article{MTMT:34865157,
	title = {Effect of temperature, pH and calcium phosphate concentration on the properties of reassembled casein micelles},
	url = {https://m2.mtmt.hu/api/publication/34865157},
	author = {Fan, Zekun and Fehér, Bence and Hettinga, Kasper and Voets, Ilja K. and Bijl, Etske},
	doi = {10.1016/j.foodhyd.2023.109592},
	journal-iso = {FOOD HYDROCOLLOID},
	journal = {FOOD HYDROCOLLOIDS},
	volume = {149},
	unique-id = {34865157},
	issn = {0268-005X},
	year = {2024},
	eissn = {1873-7137},
	pages = {109592},
	orcid-numbers = {Hettinga, Kasper/0000-0002-9017-4447; Voets, Ilja K./0000-0003-3543-4821; Bijl, Etske/0000-0002-7363-5387}
}

@article{MTMT:34863489,
	title = {No evidence for the superiority of 3 T MRI over 1.5 T MRI for diagnosing wrist ligamentous lesions : a systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/34863489},
	author = {Hergár, Luca and Kovács, Norbert and Agócs, Gergely and Weninger, Viktor and Skaliczki, Gábor and Lutz, Elmar and Hegyi, Péter and Kovács, Balázs Krisztián and Hetthéssy, Judit},
	doi = {10.1016/j.arthro.2024.04.029},
	journal-iso = {ARTHROSCOPY},
	journal = {ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY},
	unique-id = {34863489},
	issn = {0749-8063},
	abstract = {Our aim was to determine the diagnostic accuracy of native MRI regarding different ligamentous lesions of the wrist and to analyze the influence of technical characteristics, such as field strength, application of fat saturation, 3D sequences, and wrist coils.The systematic search was performed using MEDLINE, Embase, and CENTRAL databases. Studies that were published before the 12th of February 2024 were included. All studies comparing the diagnostic accuracy of native wrist MRI to that of wrist arthroscopy for suspected ligamentous lesions were included. Results were analyzed by anatomic localization and technical aspects of the MRI. To assess the quality of included studies, we used the revised QUADAS-2 tool.The systematic search revealed 5,181 articles. Thirty-seven studies, reporting 3893 ligamentous lesions, were eligible for inclusion. The studies displayed heterogeneity in terms of technical conditions, such as field strength, the use of wrist coils, the application of 3D sequences and fat saturation. Research methods also varied. Overall sensitivity and specificity were 0.78 (0.66 - 0.86) and 0.81 (0.70 - 0.89) for 1.5T MRI, while sensitivity was 0.73 (0.68 - 0.78) and specificity was 0.90 (0.59 - 0.98) for 3T MRI. There was no significant difference between the two subgroups (p=0,3807 and p=0,4248). Sensitivity was 0.82 (0.75 - 0.87) for triangular fibrocartilage complex (TFCC) lesions, 0.63 (0.50 - 0.74) for scapholunate ligament (SL) tears, and 0.41 (0.25 - 0.60) for lunotriquetral ligament (LT) lesions. Specificity for TFCC lesions was 0.82 (0.73 - 0.89), for SL tears 0.86 (0.73 - 0.93), and for LT lesions 0.93 (0.81 - 0.98).The sensitivity and specificity of MRI is influenced by the anatomic location of the lesion and technical conditions. In terms of diagnostic accuracy, no significant difference was found between 1.5T and 3T MRI.III. Systematic review of Level II. - III.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {1526-3231},
	orcid-numbers = {Agócs, Gergely/0000-0003-2489-3790; Weninger, Viktor/0000-0001-8192-4632; Skaliczki, Gábor/0000-0002-8555-5114; Hegyi, Péter/0000-0003-0399-7259; Hetthéssy, Judit/0000-0001-8274-5257}
}

@article{MTMT:34852778,
	title = {Early nutrition is safe and does not increase complications after upper gastrointestinal bleeding—a systematic review and meta-analysis of randomized controlled trials},
	url = {https://m2.mtmt.hu/api/publication/34852778},
	author = {Obeidat, Mahmoud Mohammadnour Suleiman and Teutsch, Brigitta and Floria, Diana-Elena and Veres, Dániel and Hegyi, Péter and Erőss, Bálint Mihály},
	doi = {10.1038/s41598-024-61543-z},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {34852778},
	issn = {2045-2322},
	abstract = {Despite a lack of evidence, patients are often not fed for 48–96 h after upper gastrointestinal bleeding (UGIB); however, many trials have demonstrated the benefits of early nutrition (EN). We conducted a meta-analysis of randomized controlled trials (RTCs) to evaluate the outcomes of EN compared to delayed nutrition (DN) after UGIB. The protocol was registered on PROSPERO (CRD42022372306). PubMed, Embase, CENTRAL, Scopus, and Web of Science were searched on the 27th of April 2024 to identify eligible RCTs. The primary outcomes were early (within 7 days) and late (within 30–42 days) mortality and rebleeding. Pooled risk ratios (RR), mean differences (MD), and corresponding 95% confidence intervals (CI) were calculated using a random-effects model. A total of 10 trials with 1051 patients were included in the analysis. Early mortality was not significantly different between the two groups (RR 1.20, CI 0.85–1.71, I 2  = 0%), whereas late mortality was reduced to a clinically relevant extent in the EN group (RR 0.61, CI 0.35–1.06, I 2  = 0%). When comparing the two groups, we found no significant difference in terms of early and late rebleeding (RR 1.04, CI 0.66–1.63, I 2  = 0% and RR 1.16, CI 0.63–2.13, I 2  = 0%, respectively). Our analysis also showed that the length of hospital stay was reduced in the EN group compared to the DN group (MD −1.22 days, CI: −2.43 to −0.01, I 2  = 94%). In conclusion, compared with DN, EN (within 24 h) appears to be a safe intervention and could reduce the length of hospital stay without increasing the risk of complications after UGIB.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Teutsch, Brigitta/0000-0002-9530-7886; Veres, Dániel/0000-0002-9687-3556; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427}
}

@article{MTMT:34852447,
	title = {Contrast-enhanced endoscopic ultrasound likely does not improve diagnostic adequacy during endoscopic ultrasound guided tissue acquisition: A systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/34852447},
	author = {Engh, Marie Anne and Teutsch, Brigitta and Schulze, Wenning A. and Hadani, Y. and Almog, O. and Veres, Dániel and Hegyi, Péter and Erőss, Bálint Mihály},
	doi = {10.1016/j.pan.2024.04.007},
	journal-iso = {PANCREATOLOGY},
	journal = {PANCREATOLOGY},
	unique-id = {34852447},
	issn = {1424-3903},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {1424-3911},
	orcid-numbers = {Engh, Marie Anne/0000-0003-4269-5130; Teutsch, Brigitta/0000-0002-9530-7886; Veres, Dániel/0000-0002-9687-3556; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427}
}

@article{MTMT:34797745,
	title = {RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma},
	url = {https://m2.mtmt.hu/api/publication/34797745},
	author = {Saleh, H.A. and Mitwasi, N. and R., Loureiro L. and Kegler, A. and Soto, K.E.G. and Hoffmann, L. and Crespo, E. and Arndt, C. and Bergmann, Ralf Konrad and Bachmann, M. and Feldmann, A.},
	doi = {10.1038/s41417-024-00766-8},
	journal-iso = {CANCER GENE THER},
	journal = {CANCER GENE THERAPY},
	unique-id = {34797745},
	issn = {0929-1903},
	year = {2024},
	eissn = {1476-5500}
}

@article{MTMT:34794477,
	title = {A meta-analysis on first-trimester blood count parameters—is the neutrophil-to-lymphocyte ratio a potentially novel method for first-trimester preeclampsia screening?},
	url = {https://m2.mtmt.hu/api/publication/34794477},
	author = {Mészáros, Balázs and Veres, Dániel and Nagyistók, Luca and Kovács, Bence Géza and Kukor, Zoltán and Valent, Sándor},
	doi = {10.3389/fmed.2024.1336764},
	journal-iso = {FRONT MED},
	journal = {FRONTIERS IN MEDICINE},
	volume = {11},
	unique-id = {34794477},
	year = {2024},
	eissn = {2296-858X},
	orcid-numbers = {Veres, Dániel/0000-0002-9687-3556; Kovács, Bence Géza/0000-0002-5578-1858; Kukor, Zoltán/0000-0002-7250-2160; Valent, Sándor/0000-0003-1098-1861}
}

@article{MTMT:34789637,
	title = {Water-Insoluble, Thermostable, Crosslinked Gelatin Matrix for Soft Tissue Implant Development},
	url = {https://m2.mtmt.hu/api/publication/34789637},
	author = {Varga, Viktória Dóra and Smeller, László and Várdai, Róbert and Kocsis, Bence and Zsoldos, Ibolya and Cruciani, Sara and Pala, Renzo and Hornyák, István},
	doi = {10.3390/ijms25084336},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34789637},
	issn = {1661-6596},
	abstract = {In this present study, the material science background of crosslinked gelatin (GEL) was investigated. The aim was to assess the optimal reaction parameters for the production of a water-insoluble crosslinked gelatin matrix suitable for heat sterilization. Matrices were subjected to enzymatic degradation assessments, and their ability to withstand heat sterilization was evaluated. The impact of different crosslinkers on matrix properties was analyzed. It was found that matrices crosslinked with butanediol diglycidyl ether (BDDE) and poly(ethylene glycol) diglycidyl ether (PEGDE) were resistant to enzymatic degradation and heat sterilization. Additionally, at 1 v/v % crosslinker concentration, the crosslinked weight was lower than the starting weight, suggesting simultaneous degradation and crosslinking. The crosslinked weight and swelling ratio were optimal in the case of the matrices that were crosslinked with 3% and 5% v/v BDDE and PEGDE. FTIR analysis confirmed crosslinking, and the reduction of free primary amino groups indicated effective crosslinking even at a 1% v/v crosslinker concentration. Moreover, stress–strain and compression characteristics of the 5% v/v BDDE crosslinked matrix were comparable to native gelatin. Based on material science measurements, the crosslinked matrices may be promising candidates for scaffold development, including properties such as resistance to enzymatic degradation and heat sterilization.},
	keywords = {Biomaterials; Material science; crosslinked gelatin; scaffold development},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Varga, Viktória Dóra/0009-0005-8769-1653; Smeller, László/0000-0002-3643-3268; Hornyák, István/0000-0002-7183-8973}
}