TY - JOUR AU - Kajos, Luca Fanni AU - Molics, Bálint AU - Than, Péter AU - Gőbel, Gyula AU - Elmer, Diána AU - Pónusz-Kovács, Dalma AU - Csákvári, Tímea AU - Kovács, Bettina AU - Horváth, Lilla Anita AU - Bódis, József AU - Boncz, Imre TI - Comparative analysis of the quality of life regarding patients who underwent hip replacement in public versus private hospitals in Hungary JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 14 SN - 2045-2322 DO - 10.1038/s41598-024-60720-4 UR - https://m2.mtmt.hu/api/publication/34836452 ID - 34836452 AB - The study aimed to investigate the impact of hip replacement surgery on the quality of life and to compare the outcomes by sociodemographic and surgical data in Hungarian public and private hospitals. Patients were selected at the Department of Orthopaedics (Clinical Centre, University of Pécs) and at the Da Vinci Private Clinic in Pécs. Patients completed the SF-36 and Oxford Hip Score (OHS) questionnaires before the surgery, 6 weeks and 3 months later. We also evaluated socio-demographic data, disease and surgical conditions. The research involved 128 patients, 60 patients in public, 68 patients in private hospital. Despite the different sociodemographic characteristics and surgical outcomes of public and private healthcare patients, both groups had significantly improved the quality of life 3 months after hip replacement surgery measured by OHS and SF-36 physical health scores (p < 0.001). In the mental health score, only the patients of the private health sector showed a significant improvement (p < 0.001). The extent of improvement did not differ between the two healthcare sectors according to the OHS questionnaire (p = 0.985). While the SF-36 physical health score showed a higher improvement for public patients (p = 0.027), the mental health score showed a higher improvement for private patients (p = 0.015). LA - English DB - MTMT ER - TY - JOUR AU - Horváth, Ádám AU - Steib, Anita AU - Nehr-Majoros, Andrea Kinga AU - Kántás, Boglárka AU - Király, Ágnes AU - Racskó, Márk AU - Tóth, Balázs István AU - Szánti-Pintér, Eszter AU - Kudová, Eva AU - Skodáné Földes, Rita AU - Helyes, Zsuzsanna AU - Szőke, Éva TI - Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 9 PG - 13 SN - 1661-6596 DO - 10.3390/ijms25094637 UR - https://m2.mtmt.hu/api/publication/34824919 ID - 34824919 AB - The thermo- and pain-sensitive Transient Receptor Potential Melastatin 3 and 8 (TRPM3 and TRPM8) ion channels are functionally associated in the lipid rafts of the plasma membrane. We have already described that cholesterol and sphingomyelin depletion, or inhibition of sphingolipid biosynthesis decreased the TRPM8 but not the TRPM3 channel opening on cultured sensory neurons. We aimed to test the effects of lipid raft disruptors on channel activation on TRPM3- and TRPM8-expressing HEK293T cells in vitro, as well as their potential analgesic actions in TRPM3 and TRPM8 channel activation involving acute pain models in mice. CHO cell viability was examined after lipid raft disruptor treatments and their effects on channel activation on channel expressing HEK293T cells by measurement of cytoplasmic Ca2+ concentration were monitored. The effects of treatments were investigated in Pregnenolone-Sulphate-CIM-0216-evoked and icilin-induced acute nocifensive pain models in mice. Cholesterol depletion decreased CHO cell viability. Sphingomyelinase and methyl-beta-cyclodextrin reduced the duration of icilin-evoked nocifensive behavior, while lipid raft disruptors did not inhibit the activity of recombinant TRPM3 and TRPM8. We conclude that depletion of sphingomyelin or cholesterol from rafts can modulate the function of native TRPM8 receptors. Furthermore, sphingolipid cleavage provided superiority over cholesterol depletion, and this method can open novel possibilities in the management of different pain conditions. LA - English DB - MTMT ER - TY - JOUR AU - Nörenberg, Jasper Maximilian AU - Vida, P. AU - Bösmeier, I. AU - Forró, B. AU - Nörenberg, A. AU - Buda, Á. AU - Simon, Diána AU - Erdő-Bonyár, Szabina AU - Jáksó, Pál AU - Kovács, Kálmán András AU - Mikó, Éva AU - Berki, Tímea AU - Mezősi, Emese AU - Barakonyi, Alíz TI - Decidual γδT cells of early human pregnancy produce angiogenic and immunomodulatory proteins while also possessing cytotoxic potential JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 15 PY - 2024 PG - 12 SN - 1664-3224 DO - 10.3389/fimmu.2024.1382424 UR - https://m2.mtmt.hu/api/publication/34796888 ID - 34796888 N1 - Journal Article; Research Support, Non-U.S. Gov't LA - English DB - MTMT ER - TY - JOUR AU - Abrán, Hunor AU - Kovács, Kálmán András AU - Horvát, Zalán AU - Erőss, Edina AU - Hollins Martin, Caroline J AU - Martin, Colin R TI - Translation and validation of the Hungarian version of the Birth Satisfaction Scale-Revised (BSS-R). JF - MIDWIFERY J2 - MIDWIFERY VL - 132 PY - 2024 PG - 7 SN - 0266-6138 DO - 10.1016/j.midw.2024.103983 UR - https://m2.mtmt.hu/api/publication/34786848 ID - 34786848 N1 - Export Date: 18 April 2024 CODEN: MIDWE AB - Evidence relating maternal birth experience to a range of maternal and neonatal outcomes is increasingly compelling. Consequently valid and reliable self-report of birth experience from the mothers perspective is critical.The current study sought to translate and validate a Hungarian-language version of the Birth Satisfaction Scale-Revised (BSS-R).Following forward and backwards translation into Hungarian, the Hungarian BSS-R (HU-BSS-R) was administered to women in a major Transylvanian hospital maternity unit within 72 h postpartum. Key psychometric characteristics were then examined in relation to factor structure, divergent and convergent validity, internal consistency, and known-groups discriminant validity.Two-hundred and thirty-two women completed the HU-BSS-R. Confirmatory factor analysis revealed the HU-BSS-R to offer an excellent fit to data for the established tri-dimensional measurement model. The HU-BSS-R was also found to offer excellent convergent and divergent validity and known-groups discriminant validity. No significant differences were observed between internal consistency observations between the current study and the original UK validation study.The HU-BSS-R is a valid and reliable translation of the original BSS-R, it has proved itself to have excellent psychometric properties and is suitable for use in the Hungarian maternity context. LA - English DB - MTMT ER - TY - JOUR AU - Vesztergom, Dóra AU - Téglás, Gyöngyvér AU - Bahrehmand, Kiarash AU - Török, Attila AU - Balla, Levente AU - Forgács, Vince AU - Konc, János AU - Tándor, Zoltán AU - Várnagy, Ákos AU - Boga, Péter AU - Zádori, János AU - Sipos, Miklós AU - Mánfai, Zoltán AU - Novák, Zoltán TI - Reducing radicality in fertility-sparing surgery is associated with improved in vitro fertilization outcome in early-stage cervical cancer: A national retrospective study JF - GYNECOLOGIC ONCOLOGY J2 - GYNECOL ONCOL VL - 186 PY - 2024 SP - 35 EP - 41 PG - 7 SN - 0090-8258 DO - 10.1016/j.ygyno.2024.03.024 UR - https://m2.mtmt.hu/api/publication/34769257 ID - 34769257 N1 - Export Date: 18 April 2024 CODEN: GYNOA LA - English DB - MTMT ER - TY - JOUR AU - Gödöny, Krisztina AU - Herczeg, Róbert AU - Gyenesei, Attila AU - Várnagy, Ákos AU - Bognár, Zoltán AU - Kovács, L. Gábor AU - Szekeres, Júlia AU - Mauchart, Péter AU - Nagy, Bernadett AU - Erostyák, János AU - Kovács, Kálmán András AU - Bódis, József TI - Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development JF - MEDICAL PRINCIPLES AND PRACTICE J2 - MED PRIN PRACT VL - 33 PY - 2024 IS - 2 SP - 112 EP - 121 PG - 10 SN - 1011-7571 DO - 10.1159/000536358 UR - https://m2.mtmt.hu/api/publication/34763514 ID - 34763514 N1 - National Laboratory on Human Reproduction, University of Pecs, Pecs, Hungary Department of Obstetrics and Gynecology, Medical School, University of Pecs, Pecs, Hungary HUN-REN-PTE Human Reproduction Research Group, University of Pecs, Pecs, Hungary Szentagothai Research Center, University of Pecs, Pecs, Hungary Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, University of Pecs, Pecs, Hungary Department of Laboratory Medicine, Medical School, University of Pecs, Pecs, Hungary Institute of Physics, University of Pecs, Pecs, Hungary Export Date: 6 May 2024 CODEN: MPPRE Correspondence Address: Mauchart, P.; National Laboratory on Human Reproduction, Hungary; email: mauchart.peter@pte.hu AB - Objective: Early embryonic development is characterized by rapid cell division and gene activation, making the embryo extremely sensitive to environmental influences. Light exposure can affect embryonic development through a direct toxic effect on the embryo via the generation of reactive oxygen species. In a previous study, we demonstrated the positive effect of improved light-protected embryo culture conditions implemented in our laboratory. This study aimed to investigate the changes in human embryo development under light protection during the conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Materials and Methods: We tested the potential beneficial effect of light filters to reduce the risk of toxic effects of light. IVF outcomes were compared between two experimental conditions, light protection with red light filters versus no light protection as a control. Results: Blastocyst development rate in IVF was significantly higher in the light-protected group than in the group treated under conventional conditions (46.6 vs. 26.7%). In the case of ICSI, we obtained a similar result (44.5 vs. 31.6%). The rate of cryopreservation with at least one embryo was higher in the light-protected phase (32.8%) than in the conventionally manipulated phase (26.8%). The abortion rate was also significantly lower during the light-protected period in IVF, resulting in a higher live birth rate. Conclusions: The implementation of light protection to reduce the embryotoxic wavelengths of light in IVF centers may improve the blastocyst development rate and embryo quality while maintaining embryo safety. LA - English DB - MTMT ER - TY - JOUR AU - Bokor, Szilvia AU - Csölle, Ildikó AU - Heidinger-Felső, Regina AU - Vass, Réka Anna AU - Funke Kiss, Simone AU - Ertl, Tibor AU - Molnár, Dénes TI - Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 PG - 17 SN - 1664-2392 DO - 10.3389/fendo.2024.1287255 UR - https://m2.mtmt.hu/api/publication/34729560 ID - 34729560 N1 - Department of Paediatrics, Medical School, University of Pécs, Pécs, Hungary National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary Department of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, Hungary Obstetrics and Gynecology, Magyar Imre Hospital Ajka, Ajka, Hungary Export Date: 18 March 2024 Correspondence Address: Bokor, S.; Department of Paediatrics, Hungary; email: bokor.szilvia@pte.hu AB - Growing evidence shows that maternal nutrition from preconception until lactation has an important effect on the development of non-communicable diseases in the offspring. Biological responses to environmental stress during pregnancy, including undernutrition or overnutrition of various nutrients, are transmitted in part by DNA methylation. The aim of the present narrative review is to summarize literature data on altered DNA methylation patterns caused by maternal macronutrient or vitamin intake and its association with offspring's phenotype (obesity and related metabolic changes). With our literature search, we found evidence for the association between alterations in DNA methylation pattern of different genes caused by maternal under- or overnutrition of several nutrients (protein, fructose, fat, vitamin D, methyl-group donor nutrients) during 3 critical periods of programming (preconception, pregnancy, lactation) and the development of obesity or related metabolic changes (glucose, insulin, lipid, leptin, adiponectin levels, blood pressure, non-alcoholic fatty liver disease) in offspring. The review highlights that maternal consumption of several nutrients could individually affect the development of offspring's obesity and related metabolic changes via alterations in DNA methylation. LA - English DB - MTMT ER - TY - CHAP AU - Ertl, Tibor ED - Tulassay, Tivadar TI - Necrotizáló enterocolitis és rövidbél-szindróma T2 - Klinikai gyermekgyógyászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632286673 PY - 2024 SP - 210 EP - 212 PG - 3 UR - https://m2.mtmt.hu/api/publication/34688851 ID - 34688851 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Rashidiani, Shima AU - Mamo, Gizaw AU - Farkas, Benjámin AU - Szabadi, András AU - Farkas, Bálint AU - Uszkai, Veronika AU - Császár, András AU - Brandt, Barbara AU - Kovács, Kálmán András AU - Pap, Marianna AU - Rauch, Tibor TI - Integrative Epigenetic and Molecular Analysis Reveals a Novel Promoter for a New Isoform of the Transcription Factor TEAD4 JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 4 PG - 15 SN - 1661-6596 DO - 10.3390/ijms25042223 UR - https://m2.mtmt.hu/api/publication/34684525 ID - 34684525 N1 - * Megosztott szerzőség AB - TEAD4 is a transcription factor that plays a crucial role in the Hippo pathway by regulating the expression of genes related to proliferation and apoptosis. It is also involved in the maintenance and differentiation of the trophectoderm during pre- and post-implantation embryonic development. An alternative promoter for the TEAD4 gene was identified through epigenetic profile analysis, and a new transcript from the intronic region of TEAD4 was discovered using the 5'RACE method. The transcript of the novel promoter encodes a TEAD4 isoform (TEAD4-ΔN) that lacks the DNA-binding domain but retains the C-terminal protein-protein interaction domain. Gene expression studies, including end-point PCR and Western blotting, showed that full-length TEAD4 was present in all investigated tissues. However, TEAD4-ΔN was only detectable in certain cell types. The TEAD4-ΔN promoter is conserved throughout evolution and demonstrates transcriptional activity in transient-expression experiments. Our study reveals that TEAD4 interacts with the alternative promoter and increases the expression of the truncated isoform. DNA methylation plays a crucial function in the restricted expression of the TEAD4-ΔN isoform in specific tissues, including the umbilical cord and the placenta. The data presented indicate that the DNA-methylation status of the TEAD4-ΔN promoter plays a critical role in regulating organ size, cancer development, and placenta differentiation. LA - English DB - MTMT ER - TY - CONF AU - Pónusz-Kovács, Dalma AU - Csákvári, Tímea AU - Kajos, Luca Fanni AU - Elmer, Diána AU - Pónusz, Róbert AU - Bódis, József AU - Boncz, Imre ED - Figler, Mária ED - Karamánné Pakai, Annamária ED - Tigyi, Zoltánné ED - Kajos, Luca Fanni ED - Trixler, Bettina TI - Magyarországi területi egyenlőtlenségek elemzése a női infertilitás diagnózis esetében T2 - Jubileumi Szakkollégiumi Konferencia: Absztrakt kötet PB - Pécsi Tudományegyetem Egészségtudományi Kar (PTE ETK) C1 - Pécs SN - 9789636262402 PY - 2024 SP - 20 EP - 20 PG - 1 UR - https://m2.mtmt.hu/api/publication/34667323 ID - 34667323 LA - Hungarian DB - MTMT ER -