TY - JOUR AU - Király, Bálint AU - Domonkos, Andor AU - Jelitai, Márta AU - Lopes-dos-Santos, Vítor AU - Martínez-Bellver, Sergio AU - Kocsis, Barnabás AU - Schlingloff, Dániel AU - Joshi, Abhilasha AU - Salib, Minas AU - Fiáth, Richárd AU - Barthó, Péter AU - Ulbert, István AU - Freund, Tamás AU - Viney, Tim J. AU - Dupret, David AU - Varga, Viktor AU - Hangya, Balázs TI - Author Correction: The medial septum controls hippocampal supra-theta oscillations JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 14 PY - 2023 IS - 1 PG - 1 SN - 2041-1723 DO - 10.1038/s41467-023-43190-6 UR - https://m2.mtmt.hu/api/publication/34400320 ID - 34400320 LA - English DB - MTMT ER - TY - JOUR AU - Király, Bálint AU - Domonkos, Andor AU - Jelitai, Márta AU - Lopes-dos-Santos, Vítor AU - Martínez-Bellver, Sergio AU - Kocsis, Barnabás AU - Schlingloff, Dániel AU - Joshi, Abhilasha AU - Salib, Minas AU - Fiáth, Richárd AU - Barthó, Péter AU - Ulbert, István AU - Freund, Tamás AU - Viney, Tim J. AU - Dupret, David AU - Varga, Viktor AU - Hangya, Balázs TI - The medial septum controls hippocampal supra-theta oscillations JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 14 PY - 2023 IS - 1 PG - 25 SN - 2041-1723 DO - 10.1038/s41467-023-41746-0 UR - https://m2.mtmt.hu/api/publication/34188237 ID - 34188237 AB - Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval. LA - English DB - MTMT ER - TY - JOUR AU - Kocsis, Barnabás AU - Martínez-Bellver, Sergio AU - Fiáth, Richárd AU - Domonkos, Andor AU - Tóthné Sviatkó, Katalin AU - Schlingloff, Dániel AU - Barthó, Péter AU - Freund, Tamás AU - Ulbert, István AU - Káli, Szabolcs AU - Varga, Viktor AU - Hangya, Balázs TI - Huygens synchronization of medial septal pacemaker neurons generates hippocampal theta oscillation JF - CELL REPORTS J2 - CELL REP VL - 40 PY - 2022 IS - 5 PG - 29 SN - 2211-1247 DO - 10.1016/j.celrep.2022.111149 UR - https://m2.mtmt.hu/api/publication/33041472 ID - 33041472 N1 - Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, 1083, Hungary Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, 1117, Hungary Roska Tamás Doctoral School of Sciences and Technology, Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, 1083, Hungary Department of Anatomy and Human Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, 46010, Spain Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, 1083, Hungary Cerebral Cortex Research Group, Institute of Experimental Medicine, Budapest, 1083, Hungary János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, 1085, Hungary Sleep Oscillations Research Group, Research Centre for Natural Sciences, Budapest, 1117, Hungary Subcortical Modulation Research Group, Institute of Experimental Medicine, Budapest, 1083, Hungary Cited By :5 Export Date: 1 February 2024 Correspondence Address: Hangya, B.; Lendület Laboratory of Systems Neuroscience, Hungary; email: hangya.balazs@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins Tradenames: DM2500, Leica Microsystems Manufacturers: Leica Microsystems Funding details: ELKH KEP-4/5/2021, ELKH KÖ-39/2021, K119650, NKFIH PD124175, PD134196, RRF-2.3.1-21-2022-00004, TUDFO/51757-1/2019-ITM Funding details: APOSTD/2019/003 Funding details: European Research Council, ERC, 715043 Funding details: Magyar Tudományos Akadémia, MTA, K135561, KH125294, LP2015-2/2015 Funding details: Kyoto University Funding details: Innovációs és Technológiai Minisztérium Funding text 1: The authors thank Katalin Lengyel for technical assistance and Drs. Tim Viney and Peter Somogyi for helpful comments on the manuscript. This work was supported by the “Lendület” Program of the Hungarian Academy of Sciences (LP2015-2/2015), NKFIH KH125294, NKFIH K135561, the ERC Starting Grant no. 715043 and SPIRITS 2020 of Kyoto University to B.H.; the NRDI Office of Hungary within the framework of the Artificial Intelligence National Laboratory Program (RRF-2.3.1-21-2022-00004) to B.H. V.V. and S.K.; NKFIH K119650 to P.B.; National Brain Research Program 1.2.1-NKP-2017-00002 to P.B. R.F. and I.U.; NKFIH PD124175 and PD134196 to R.F.; NKFIH TUDFO/51757-1/2019-ITM, ELKH KEP-4/5/2021, and ELKH KÖ-39/2021 to I.U.; the ÚNKP-20-3 New National Excellence Program of the Ministry for Innovation and Technology to B.K.; and the Generalitat Valenciana Postdoctoral Fellowship Program (APOSTD/2019/003) to S.M.B. We acknowledge the help of the Nikon Center of Excellence at the Institute of Experimental Medicine (IEM), Nikon Europe, Nikon Austria, and Auro-Science Consulting for kindly providing microscopy support and the supportive help of the Central Virus Laboratory of IEM. We thank Luigi Petrucco for open access science art at SciDraw (https://doi.org/10.5281/zenodo.3925903). B.H. developed the idea and conceptualized the manuscript. S.M.B. R.F. A.D. B.H. and P.B. performed the experiments, supervised by T.F.F. I.U. V.V. and B.H. B.K. S.M.B. and P.B. performed the data analysis. B.K. K.S. and D.S. generated the figures. D.S. performed immunocytochemistry. B.K. performed the modeling, supervised by S.K. B.H. wrote the manuscript with input from all authors. The authors declare no competing financial interests. Funding text 2: The authors thank Katalin Lengyel for technical assistance and Drs. Tim Viney and Peter Somogyi for helpful comments on the manuscript. This work was supported by the “Lendület” Program of the Hungarian Academy of Sciences ( LP2015-2/2015 ), NKFIH KH125294 , NKFIH K135561 , the ERC Starting Grant no. 715043 and SPIRITS 2020 of Kyoto University to B.H.; the NRDI Office of Hungary within the framework of the Artificial Intelligence National Laboratory Program ( RRF-2.3.1-21-2022-00004 ) to B.H., V.V., and S.K.; NKFIH K119650 to P.B.; National Brain Research Program 1.2.1-NKP-2017-00002 to P.B., R.F., and I.U.; NKFIH PD124175 and PD134196 to R.F.; NKFIH TUDFO/51757-1/2019-ITM , ELKH KEP-4/5/2021 , and ELKH KÖ-39/2021 to I.U.; the ÚNKP-20-3 New National Excellence Program of the Ministry for Innovation and Technology to B.K.; and the Generalitat Valenciana Postdoctoral Fellowship Program ( APOSTD/2019/003 ) to S.M.B. We acknowledge the help of the Nikon Center of Excellence at the Institute of Experimental Medicine (IEM) , Nikon Europe , Nikon Austria , and Auro-Science Consulting for kindly providing microscopy support and the supportive help of the Central Virus Laboratory of IEM. We thank Luigi Petrucco for open access science art at SciDraw ( https://doi.org/10.5281/zenodo.3925903 ). LA - English DB - MTMT ER - TY - JOUR AU - Luo, Wenshu AU - Egger, Matteo AU - Domonkos, Andor AU - Que, Lin AU - Lukacsovich, David AU - Cruz-Ochoa, Natalia Andrea AU - Szőcs, Szilárd AU - Seng, Charlotte AU - Arszovszki, Antónia AU - Bodóné Sipos, Eszter AU - Amrein, Irmgard AU - Winterer, Jochen AU - Lukacsovich, Tamás AU - Szabadics, János AU - Wolfer, David P AU - Varga, Csaba AU - Földy, Csaba TI - Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2 JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 118 PY - 2021 IS - 40 PG - 11 SN - 0027-8424 DO - 10.1073/pnas.2108239118 UR - https://m2.mtmt.hu/api/publication/32298338 ID - 32298338 N1 - Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich, 8057, Switzerland Szentágothai Research Center, Department of Physiology, Medical School, University of Pécs, Pécs, 7624, Hungary Laboratory of Cellular Neuropharmacology, Institute of Experimental Medicine, Budapest, 1083, Hungary Institute of Anatomy, Faculty of Medicine, University of Zürich, Zürich, 8057, Switzerland Institute of Human Movement Sciences and Sport, D-HEST, ETH Zürich, Zürich, 8057, Switzerland Cited By :5 Export Date: 2 November 2023 CODEN: PNASA Correspondence Address: Földy, C.; Laboratory of Neural Connectivity, Switzerland; email: foldy@hifo.uzh.ch Chemicals/CAS: Idb2 protein, mouse; Inhibitor of Differentiation Protein 2 Funding details: Z?rich/ETH Z?rich Funding details: European Research Council, ERC, 772452 Funding details: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, SNF, 310030_188506 Funding details: Novartis Stiftung für Medizinisch-Biologische Forschung, 20765-3/2018/FEKUTSTRAT, EFOP-3.6.2-16-2017-00008 Funding text 1: ACKNOWLEDGMENTS. This study was supported by the Swiss National Science Foundation grant (310030_188506 to C.F.), Dr. Eric Slack-Gyr-Stiftung award (to C.F.), Novartis Stiftung für medizinisch-biologische Forschung grant (to C.F.), 20017-1.2.1-NKP-2017-00002 grant (to C.V.), EFOP-3.6.2-16-2017-00008 grant (to C.V.), 20765-3/2018/FEKUTSTRAT grant (to C.V.), ERC Consolidator Grant (nanoAXON #772452 to J.S.), and University of Zürich Forschungskredit fellowship (to W.L.). We thank Drs. Jean-Charles Paterna and Melanie Rauch (Viral Vector Facility, University of Zürich/ETH Zürich) for discussions and virus production and the Functional Genomics Center Zürich for RNA-seq support. Funding text 2: This study was supported by the Swiss National Science Foundation grant (310030_188506 to C.F.), Dr. Eric Slack-Gyr-Stiftung award (to C.F.), Novartis Stiftung f?r medizinisch-biologische Forschung grant (to C.F.), 20017-1.2.1-NKP-2017-00002 grant (to C.V.), EFOP-3.6.2-16-2017-00008 grant (to C.V.), 20765-3/2018/FEKUTSTRAT grant (to C.V.), ERC Consolidator Grant (nanoAXON #772452 to J.S.), and University of Z?rich Forschungskredit fellowship (to W.L.). We thank Drs. Jean-Charles Paterna and Melanie Rauch (Viral Vector Facility, University of Z?rich/ETH Z?rich) for discussions and virus production and the Functional Genomics Center Z?rich for RNA-seq support. AB - Circuit formation in the central nervous system has been historically studied during development, after which cell-autonomous and nonautonomous wiring factors inactivate. In principle, balanced reactivation of such factors could enable further wiring in adults, but their relative contributions may be circuit dependent and are largely unknown. Here, we investigated hippocampal mossy fiber sprouting to gain insight into wiring mechanisms in mature circuits. We found that sole ectopic expression of Id2 in granule cells is capable of driving mossy fiber sprouting in healthy adult mouse and rat. Mice with the new mossy fiber circuit solved spatial problems equally well as controls but appeared to rely on local rather than global spatial cues. Our results demonstrate reprogrammed connectivity in mature neurons by one defined factor and an assembly of a new synaptic circuit in adult brain. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, R. AU - Barth, Albert AU - Domonkos, Andor AU - Varga, Viktor AU - Somogyvári, Zoltán TI - Do not waste your electrodes - Principles of optimal electrode geometry for spike sorting JF - JOURNAL OF NEURAL ENGINEERING J2 - J NEURAL ENG VL - 18 PY - 2021 IS - 4 PG - 19 SN - 1741-2560 DO - 10.1088/1741-2552/ac0f49 UR - https://m2.mtmt.hu/api/publication/32127863 ID - 32127863 LA - English DB - MTMT ER - TY - JOUR AU - Fekete, Bálint András AU - Pentelényi, Klára AU - Rudas, Gábor AU - Gál, Anikó AU - Grosz, Zoltán AU - Illés, Anett AU - Jimoh, Idris János AU - Csukly, Gábor AU - Domonkos, Andor AU - Molnár, Mária Judit TI - Broadening the phenotype of the TWNK gene associated Perrault syndrome JF - BMC MEDICAL GENETICS J2 - BMC MED GENET VL - 20 PY - 2019 IS - 1 PG - 8 SN - 1471-2350 DO - 10.1186/s12881-019-0934-4 UR - https://m2.mtmt.hu/api/publication/31032708 ID - 31032708 AB - Perrault syndrome is a genetically heterogenous, very rare disease, characterized clinically by sensorineural hearing loss, ovarian dysfunction and neurological symptoms. We present the case of a 33 years old female patient with TWNK-associated Perrault syndrome. The TWNK gene is coding the mitochondrial protein Twinkle and currently there are only two reports characterizing the phenotype of TWNK-associated Perrault syndrome. None of these publications reported about special brain MRI alterations and neuropathological changes in the muscle and peripheral nerves.Our patients with TWNK-dependent Perrault syndrome had severe bilateral hypoacusis, severe ataxia, polyneuropathy, lower limb spastic paraparesis with pyramidal signs, and gonadal dysgenesis. Psychiatric symptoms such as depression and paranoia were present as well. Brain MRI observed progressive cerebellar hyperintensive signs associated with cerebellar, medulla oblongata and cervical spinal cord atrophy. Light microscopy of the muscle biopsy detected severe neurogenic lesions. COX staining was centrally reduced in many muscle fibers. Both muscle and sural nerve electron microscopy detected slightly enlarged mitochondria with abnormal cristae surrounded by lipid vacuoles. In the sural nerve, dystrophic axons had focally uncompacted myelin lamellae present. Genetic investigation revealed multiple mtDNA deletion and compound heterozygous mutations of the TWNK gene (c.1196 A > G, c.1358 G > A).This study demonstrates that TWNK associated Perrault syndrome has a much broader phenotype as originally published. The coexistence of severe hypoacusis, spastic limb weakness, ataxia, polyneuropathy, gonadal dysgensia, hyperintense signals in the cerebellum and the presence of the mtDNA multiple deletion could indicate the impairment of the TWNK gene. This is the first report about pyramidal tract involvement and cerebellar MRI alteration associated with TWNK-related Perrault syndrome. LA - English DB - MTMT ER - TY - JOUR AU - Szőnyi, András AU - Sós, Katalin Eszter AU - Nyilas, Rita AU - Schlingloff, Dániel AU - Domonkos, Andor AU - Tresóné Takács, Virág AU - Pósfai, Balázs AU - Hegedüs, Panna AU - Priestley, James B. AU - Gundlach, Andrew L. AU - Gulyás, Attila AU - Varga, Viktor AU - Losonczy, Attila AU - Freund, Tamás AU - Nyíri, Gábor TI - Brainstem nucleus incertus controls contextual memory formation JF - SCIENCE J2 - SCIENCE VL - 364 PY - 2019 IS - 6442 PG - 13 SN - 0036-8075 DO - 10.1126/science.aaw0445 UR - https://m2.mtmt.hu/api/publication/30725513 ID - 30725513 AB - Hippocampal pyramidal cells encode memory engrams, which guide adaptive behavior. Selection of engram-forming cells is regulated by somatostatin-positive dendrite-targeting interneurons, which inhibit pyramidal cells that are not required for memory formation. Here, we found that gamma-aminobutyric acid ( GABA)-releasing neurons of the mouse nucleus incertus (NI) selectively inhibit somatostatin-positive interneurons in the hippocampus, both monosynaptically and indirectly through the inhibition of their subcortical excitatory inputs. We demonstrated that NI GABAergic neurons receive monosynaptic inputs from brain areas processing important environmental information, and their hippocampal projections are strongly activated by salient environmental inputs in vivo. Optogenetic manipulations of NI GABAergic neurons can shift hippocampal network state and bidirectionally modify the strength of contextual fear memory formation. Our results indicate that brainstem NI GABAergic cells are essential for controlling contextual memories. LA - English DB - MTMT ER - TY - JOUR AU - Barth, Albert AU - Domonkos, Andor AU - Fernandez-Ruiz, A AU - Freund, Tamás AU - Varga, Viktor TI - Hippocampal Network Dynamics during Rearing Episodes JF - CELL REPORTS J2 - CELL REP VL - 23 PY - 2018 IS - 6 SP - 1706 EP - 1715 PG - 10 SN - 2211-1247 DO - 10.1016/j.celrep.2018.04.021 UR - https://m2.mtmt.hu/api/publication/3409634 ID - 3409634 AB - Animals build a model of their surroundings on the basis of information gathered during exploration. Rearing on the hindlimbs changes the vantage point of the animal, increasing the sampled area of the environment. This environmental knowledge is suggested to be integrated into a cognitive map stored by the hippocampus. Previous studies have found that damage to the hippocampus impairs rearing. Here, we characterize the operational state of the hippocampus during rearing episodes. We observe an increase of theta frequency paralleled by a sink in the dentate gyrus and a prominent theta-modulated fast gamma transient in the middle molecular layer. On the descending phase of rearing, a decrease of theta power is detected. Place cells stop firing during rearing, while a different subset of putative pyramidal cells is activated. Our results suggest that the hippocampus switches to a different operational state during rearing, possibly to update spatial representation with information from distant sources. LA - English DB - MTMT ER - TY - THES AU - Domonkos, Andor TI - Glutamáterg komponens a raphe-hippocampalis kapcsolatban PY - 2017 DO - 10.14753/SE.2017.2067 UR - https://m2.mtmt.hu/api/publication/30586535 ID - 30586535 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Domonkos, Andor AU - Ledri, LN AU - Laszlovszky, Tamás Kristóf AU - Cserép, Csaba AU - Borhegyi, Zsolt AU - Papp, Edit AU - Nyíri, Gábor AU - Freund, Tamás AU - Varga, Viktor TI - Divergent in vivo activity of non-serotonergic and serotonergic VGluT3-neurones in the median raphe region JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 594 PY - 2016 IS - 13 SP - 3775 EP - 3790 PG - 16 SN - 0022-3751 DO - 10.1113/JP272036 UR - https://m2.mtmt.hu/api/publication/3060359 ID - 3060359 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary Present address: MTA-ELTE-NAP B-Opto-Neuropharmacology Group, Eötvös Loránd University, Budapest, Hungary Cited By :14 Export Date: 18 February 2023 CODEN: JPHYA Correspondence Address: Varga, V.; Institute of Experimental Medicine, Hungary; email: vargav@koki.mta.hu Chemicals/CAS: glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; serotonin, 50-67-9 Funding details: Seventh Framework Programme, FP7, 294313 AB - KEY POINTS: *Median raphe is a key subcortical modulatory centre involved in several brain functions e.g. regulation of sleep-wake cycle, emotions and memory storage. *A large proportion of median raphe neurones are glutamatergic and implement a radically different mode of communication than serotonergic cells, but their in vivo activity is unknown. *We provide the first description of the in vivo, brain state-dependent firing properties of median raphe glutamatergic neurones identified by immunopositivity for the vesicular glutamate transporter type 3 (VGluT3) and serotonin (5HT). Glutamatergic populations (VGluT3+/5HT- and VGluT3+/5HT+)were compared to the purely serotonergic (VGluT3-/5HT+) and VGluT3-/5HT- neurones. *VGluT3+/5HT+ neurones fired similar to VGluT3-/5HT+ cells, whereas significantly diverged from the VGluT3+/5HT- population. Activity of the latter subgroup resembled the spiking of VGluT3-/5HT- cells, except their diverging response to sensory stimulation. *The VGluT3+ population of the median raphe may broadcast rapidly varying signals on top of a state-dependent, tonic modulation. ABSTRACT: Subcortical modulation is crucial for information processing in the cerebral cortex. Besides the canonical neuromodulators, glutamate has recently been identified as a key cotransmitter of numerous monoaminergic projections. In the median raphe, a pure glutamatergic neurone population projecting to limbic areas was also discovered with a possibly novel, yet undetermined function. Here, we report the first functional description of the vesicular glutamate transporter type 3 (VGluT3)-expressing median raphe neurones. Since there is no appropriate genetic marker for the separation of serotonergic (5HT+) and non-serotonergic (5HT-) VGluT3+ neurones, we utilised immunohistochemistry after recording and juxtacellular labelling in anaesthetised rats. VGluT3+/5HT- neurones fired faster, more variably and were permanently activated during sensory stimulation, as opposed to the transient response of the slow firing VGluT3-/5HT+ subgroup. VGluT3+/5HT- cells were also more active during hippocampal theta. In addition, the VGluT3-/5HT- population - putative GABAergic cells - resembled the firing of VGluT3+/5HT- neurones, but without significant reaction to the sensory stimulus. Interestingly, the VGluT3+/5HT+ group - spiking slower than the VGluT3+/5HT- population - exhibited a mixed response i.e. the initial transient activation was followed by sustained elevation of firing. Phase coupling to hippocampal and prefrontal slow oscillations was found in VGluT3+/5HT- neurones, also differentiating them from the VGluT3+/5HT+ subpopulation. Taken together, glutamatergic neurones in the median raphe may implement multiple, highly divergent forms of modulation in parallel: a slow, tonic mode interrupted by sensory-evoked rapid transients and a fast one, capable of conveying complex patterns influenced by sensory inputs. This article is protected by copyright. All rights reserved. LA - English DB - MTMT ER -