@article{MTMT:34400320,
	title = {Author Correction: The medial septum controls hippocampal supra-theta oscillations},
	url = {https://m2.mtmt.hu/api/publication/34400320},
	author = {Király, Bálint and Domonkos, Andor and Jelitai, Márta and Lopes-dos-Santos, Vítor and Martínez-Bellver, Sergio and Kocsis, Barnabás and Schlingloff, Dániel and Joshi, Abhilasha and Salib, Minas and Fiáth, Richárd and Barthó, Péter and Ulbert, István and Freund, Tamás and Viney, Tim J. and Dupret, David and Varga, Viktor and Hangya, Balázs},
	doi = {10.1038/s41467-023-43190-6},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {14},
	unique-id = {34400320},
	issn = {2041-1723},
	year = {2023},
	eissn = {2041-1723},
	orcid-numbers = {Lopes-dos-Santos, Vítor/0000-0002-1858-0125; Joshi, Abhilasha/0000-0002-0511-3747; Salib, Minas/0000-0001-9938-7978; Fiáth, Richárd/0000-0001-8732-2691; Ulbert, István/0000-0001-9941-9159; Viney, Tim J./0000-0001-6444-1188; Dupret, David/0000-0002-0040-1766}
}

@article{MTMT:34188237,
	title = {The medial septum controls hippocampal supra-theta oscillations},
	url = {https://m2.mtmt.hu/api/publication/34188237},
	author = {Király, Bálint and Domonkos, Andor and Jelitai, Márta and Lopes-dos-Santos, Vítor and Martínez-Bellver, Sergio and Kocsis, Barnabás and Schlingloff, Dániel and Joshi, Abhilasha and Salib, Minas and Fiáth, Richárd and Barthó, Péter and Ulbert, István and Freund, Tamás and Viney, Tim J. and Dupret, David and Varga, Viktor and Hangya, Balázs},
	doi = {10.1038/s41467-023-41746-0},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {14},
	unique-id = {34188237},
	issn = {2041-1723},
	abstract = {Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval.},
	keywords = {NEURONS; hippocampus; Theta rhythm; ENTORHINAL CORTEX; Action Potentials; HIPPOCAMPAL; Parvalbumins; CA1 region},
	year = {2023},
	eissn = {2041-1723},
	orcid-numbers = {Király, Bálint/0000-0001-8483-8780; Lopes-dos-Santos, Vítor/0000-0002-1858-0125; Joshi, Abhilasha/0000-0002-0511-3747; Salib, Minas/0000-0001-9938-7978; Fiáth, Richárd/0000-0001-8732-2691; Ulbert, István/0000-0001-9941-9159; Viney, Tim J./0000-0001-6444-1188; Dupret, David/0000-0002-0040-1766}
}

@article{MTMT:33041472,
	title = {Huygens synchronization of medial septal pacemaker neurons generates hippocampal theta oscillation},
	url = {https://m2.mtmt.hu/api/publication/33041472},
	author = {Kocsis, Barnabás and Martínez-Bellver, Sergio and Fiáth, Richárd and Domonkos, Andor and Tóthné Sviatkó, Katalin and Schlingloff, Dániel and Barthó, Péter and Freund, Tamás and Ulbert, István and Káli, Szabolcs and Varga, Viktor and Hangya, Balázs},
	doi = {10.1016/j.celrep.2022.111149},
	journal-iso = {CELL REP},
	journal = {CELL REPORTS},
	volume = {40},
	unique-id = {33041472},
	issn = {2211-1247},
	keywords = {hippocampus; Theta; OSCILLATIONS; parvalbumin; synchrony; MEDIAL-SEPTUM},
	year = {2022},
	eissn = {2211-1247},
	orcid-numbers = {Fiáth, Richárd/0000-0001-8732-2691; Tóthné Sviatkó, Katalin/0000-0002-5104-0884; Ulbert, István/0000-0001-9941-9159}
}

@article{MTMT:32298338,
	title = {Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2},
	url = {https://m2.mtmt.hu/api/publication/32298338},
	author = {Luo, Wenshu and Egger, Matteo and Domonkos, Andor and Que, Lin and Lukacsovich, David and Cruz-Ochoa, Natalia Andrea and Szőcs, Szilárd and Seng, Charlotte and Arszovszki, Antónia and Bodóné Sipos, Eszter and Amrein, Irmgard and Winterer, Jochen and Lukacsovich, Tamás and Szabadics, János and Wolfer, David P and Varga, Csaba and Földy, Csaba},
	doi = {10.1073/pnas.2108239118},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {118},
	unique-id = {32298338},
	issn = {0027-8424},
	abstract = {Circuit formation in the central nervous system has been historically studied during development, after which cell-autonomous and nonautonomous wiring factors inactivate. In principle, balanced reactivation of such factors could enable further wiring in adults, but their relative contributions may be circuit dependent and are largely unknown. Here, we investigated hippocampal mossy fiber sprouting to gain insight into wiring mechanisms in mature circuits. We found that sole ectopic expression of Id2 in granule cells is capable of driving mossy fiber sprouting in healthy adult mouse and rat. Mice with the new mossy fiber circuit solved spatial problems equally well as controls but appeared to rely on local rather than global spatial cues. Our results demonstrate reprogrammed connectivity in mature neurons by one defined factor and an assembly of a new synaptic circuit in adult brain.},
	keywords = {mossy fiber; ID2; Single-cell RNA-seq; circuit formation; adult brain rewiring},
	year = {2021},
	eissn = {1091-6490},
	orcid-numbers = {Szabadics, János/0000-0002-4968-2562}
}

@article{MTMT:32127863,
	title = {Do not waste your electrodes - Principles of optimal electrode geometry for spike sorting},
	url = {https://m2.mtmt.hu/api/publication/32127863},
	author = {Tóth, R. and Barth, Albert and Domonkos, Andor and Varga, Viktor and Somogyvári, Zoltán},
	doi = {10.1088/1741-2552/ac0f49},
	journal-iso = {J NEURAL ENG},
	journal = {JOURNAL OF NEURAL ENGINEERING},
	volume = {18},
	unique-id = {32127863},
	issn = {1741-2560},
	year = {2021},
	eissn = {1741-2552}
}

@article{MTMT:31032708,
	title = {Broadening the phenotype of the TWNK gene associated Perrault syndrome},
	url = {https://m2.mtmt.hu/api/publication/31032708},
	author = {Fekete, Bálint András and Pentelényi, Klára and Rudas, Gábor and Gál, Anikó and Grosz, Zoltán and Illés, Anett and Jimoh, Idris János and Csukly, Gábor and Domonkos, Andor and Molnár, Mária Judit},
	doi = {10.1186/s12881-019-0934-4},
	journal-iso = {BMC MED GENET},
	journal = {BMC MEDICAL GENETICS},
	volume = {20},
	unique-id = {31032708},
	issn = {1471-2350},
	abstract = {Perrault syndrome is a genetically heterogenous, very rare disease, characterized clinically by sensorineural hearing loss, ovarian dysfunction and neurological symptoms. We present the case of a 33 years old female patient with TWNK-associated Perrault syndrome. The TWNK gene is coding the mitochondrial protein Twinkle and currently there are only two reports characterizing the phenotype of TWNK-associated Perrault syndrome. None of these publications reported about special brain MRI alterations and neuropathological changes in the muscle and peripheral nerves.Our patients with TWNK-dependent Perrault syndrome had severe bilateral hypoacusis, severe ataxia, polyneuropathy, lower limb spastic paraparesis with pyramidal signs, and gonadal dysgenesis. Psychiatric symptoms such as depression and paranoia were present as well. Brain MRI observed progressive cerebellar hyperintensive signs associated with cerebellar, medulla oblongata and cervical spinal cord atrophy. Light microscopy of the muscle biopsy detected severe neurogenic lesions. COX staining was centrally reduced in many muscle fibers. Both muscle and sural nerve electron microscopy detected slightly enlarged mitochondria with abnormal cristae surrounded by lipid vacuoles. In the sural nerve, dystrophic axons had focally uncompacted myelin lamellae present. Genetic investigation revealed multiple mtDNA deletion and compound heterozygous mutations of the TWNK gene (c.1196 A > G, c.1358 G > A).This study demonstrates that TWNK associated Perrault syndrome has a much broader phenotype as originally published. The coexistence of severe hypoacusis, spastic limb weakness, ataxia, polyneuropathy, gonadal dysgensia, hyperintense signals in the cerebellum and the presence of the mtDNA multiple deletion could indicate the impairment of the TWNK gene. This is the first report about pyramidal tract involvement and cerebellar MRI alteration associated with TWNK-related Perrault syndrome.},
	keywords = {perrault syndrome; spastic ataxia; Hyperintense cerebellar signal; TWNK},
	year = {2019},
	eissn = {1471-2350},
	orcid-numbers = {Fekete, Bálint András/0000-0002-3895-477X; Pentelényi, Klára/0000-0003-2034-5869; Gál, Anikó/0000-0002-2059-5748; Grosz, Zoltán/0000-0001-7353-1214; Illés, Anett/0000-0001-5351-9015; Jimoh, Idris János/0000-0001-7415-4836; Csukly, Gábor/0000-0002-5006-9407; Molnár, Mária Judit/0000-0001-9350-1864}
}

@article{MTMT:30725513,
	title = {Brainstem nucleus incertus controls contextual memory formation},
	url = {https://m2.mtmt.hu/api/publication/30725513},
	author = {Szőnyi, András and Sós, Katalin Eszter and Nyilas, Rita and Schlingloff, Dániel and Domonkos, Andor and Tresóné Takács, Virág and Pósfai, Balázs and Hegedüs, Panna and Priestley, James B. and Gundlach, Andrew L. and Gulyás, Attila and Varga, Viktor and Losonczy, Attila and Freund, Tamás and Nyíri, Gábor},
	doi = {10.1126/science.aaw0445},
	journal-iso = {SCIENCE},
	journal = {SCIENCE},
	volume = {364},
	unique-id = {30725513},
	issn = {0036-8075},
	abstract = {Hippocampal pyramidal cells encode memory engrams, which guide adaptive behavior. Selection of engram-forming cells is regulated by somatostatin-positive dendrite-targeting interneurons, which inhibit pyramidal cells that are not required for memory formation. Here, we found that gamma-aminobutyric acid ( GABA)-releasing neurons of the mouse nucleus incertus (NI) selectively inhibit somatostatin-positive interneurons in the hippocampus, both monosynaptically and indirectly through the inhibition of their subcortical excitatory inputs. We demonstrated that NI GABAergic neurons receive monosynaptic inputs from brain areas processing important environmental information, and their hippocampal projections are strongly activated by salient environmental inputs in vivo. Optogenetic manipulations of NI GABAergic neurons can shift hippocampal network state and bidirectionally modify the strength of contextual fear memory formation. Our results indicate that brainstem NI GABAergic cells are essential for controlling contextual memories.},
	year = {2019},
	eissn = {1095-9203},
	orcid-numbers = {Nyilas, Rita/0000-0002-9634-9535; Tresóné Takács, Virág/0000-0002-3276-4131; Pósfai, Balázs/0000-0003-1035-565X; Hegedüs, Panna/0000-0002-9984-5729; Gulyás, Attila/0000-0003-4961-636X}
}

@article{MTMT:3409634,
	title = {Hippocampal Network Dynamics during Rearing Episodes},
	url = {https://m2.mtmt.hu/api/publication/3409634},
	author = {Barth, Albert and Domonkos, Andor and Fernandez-Ruiz, A and Freund, Tamás and Varga, Viktor},
	doi = {10.1016/j.celrep.2018.04.021},
	journal-iso = {CELL REP},
	journal = {CELL REPORTS},
	volume = {23},
	unique-id = {3409634},
	issn = {2211-1247},
	abstract = {Animals build a model of their surroundings on the basis of information gathered during exploration. Rearing on the hindlimbs changes the vantage point of the animal, increasing the sampled area of the environment. This environmental knowledge is suggested to be integrated into a cognitive map stored by the hippocampus. Previous studies have found that damage to the hippocampus impairs rearing. Here, we characterize the operational state of the hippocampus during rearing episodes. We observe an increase of theta frequency paralleled by a sink in the dentate gyrus and a prominent theta-modulated fast gamma transient in the middle molecular layer. On the descending phase of rearing, a decrease of theta power is detected. Place cells stop firing during rearing, while a different subset of putative pyramidal cells is activated. Our results suggest that the hippocampus switches to a different operational state during rearing, possibly to update spatial representation with information from distant sources.},
	year = {2018},
	eissn = {2211-1247},
	pages = {1706-1715}
}

@mastersthesis{MTMT:30586535,
	title = {Glutamáterg komponens a raphe-hippocampalis kapcsolatban},
	url = {https://m2.mtmt.hu/api/publication/30586535},
	author = {Domonkos, Andor},
	doi = {10.14753/SE.2017.2067},
	unique-id = {30586535},
	year = {2017}
}

@article{MTMT:3060359,
	title = {Divergent in vivo activity of non-serotonergic and serotonergic VGluT3-neurones in the median raphe region},
	url = {https://m2.mtmt.hu/api/publication/3060359},
	author = {Domonkos, Andor and Ledri, LN and Laszlovszky, Tamás Kristóf and Cserép, Csaba and Borhegyi, Zsolt and Papp, Edit and Nyíri, Gábor and Freund, Tamás and Varga, Viktor},
	doi = {10.1113/JP272036},
	journal-iso = {J PHYSIOL-LONDON},
	journal = {JOURNAL OF PHYSIOLOGY-LONDON},
	volume = {594},
	unique-id = {3060359},
	issn = {0022-3751},
	abstract = {KEY POINTS: *Median raphe is a key subcortical modulatory centre involved in several brain functions e.g. regulation of sleep-wake cycle, emotions and memory storage. *A large proportion of median raphe neurones are glutamatergic and implement a radically different mode of communication than serotonergic cells, but their in vivo activity is unknown. *We provide the first description of the in vivo, brain state-dependent firing properties of median raphe glutamatergic neurones identified by immunopositivity for the vesicular glutamate transporter type 3 (VGluT3) and serotonin (5HT). Glutamatergic populations (VGluT3+/5HT- and VGluT3+/5HT+)were compared to the purely serotonergic (VGluT3-/5HT+) and VGluT3-/5HT- neurones. *VGluT3+/5HT+ neurones fired similar to VGluT3-/5HT+ cells, whereas significantly diverged from the VGluT3+/5HT- population. Activity of the latter subgroup resembled the spiking of VGluT3-/5HT- cells, except their diverging response to sensory stimulation. *The VGluT3+ population of the median raphe may broadcast rapidly varying signals on top of a state-dependent, tonic modulation. ABSTRACT: Subcortical modulation is crucial for information processing in the cerebral cortex. Besides the canonical neuromodulators, glutamate has recently been identified as a key cotransmitter of numerous monoaminergic projections. In the median raphe, a pure glutamatergic neurone population projecting to limbic areas was also discovered with a possibly novel, yet undetermined function. Here, we report the first functional description of the vesicular glutamate transporter type 3 (VGluT3)-expressing median raphe neurones. Since there is no appropriate genetic marker for the separation of serotonergic (5HT+) and non-serotonergic (5HT-) VGluT3+ neurones, we utilised immunohistochemistry after recording and juxtacellular labelling in anaesthetised rats. VGluT3+/5HT- neurones fired faster, more variably and were permanently activated during sensory stimulation, as opposed to the transient response of the slow firing VGluT3-/5HT+ subgroup. VGluT3+/5HT- cells were also more active during hippocampal theta. In addition, the VGluT3-/5HT- population - putative GABAergic cells - resembled the firing of VGluT3+/5HT- neurones, but without significant reaction to the sensory stimulus. Interestingly, the VGluT3+/5HT+ group - spiking slower than the VGluT3+/5HT- population - exhibited a mixed response i.e. the initial transient activation was followed by sustained elevation of firing. Phase coupling to hippocampal and prefrontal slow oscillations was found in VGluT3+/5HT- neurones, also differentiating them from the VGluT3+/5HT+ subpopulation. Taken together, glutamatergic neurones in the median raphe may implement multiple, highly divergent forms of modulation in parallel: a slow, tonic mode interrupted by sensory-evoked rapid transients and a fast one, capable of conveying complex patterns influenced by sensory inputs. This article is protected by copyright. All rights reserved.},
	year = {2016},
	eissn = {1469-7793},
	pages = {3775-3790},
	orcid-numbers = {Cserép, Csaba/0000-0001-5513-2471; Borhegyi, Zsolt/0000-0001-5556-8742}
}