@article{MTMT:34883229,
	title = {LINE-1 ORF1p is a Promising Biomarker in Cervical Intraepithelial Neoplasia Degree Assessment},
	url = {https://m2.mtmt.hu/api/publication/34883229},
	author = {Karkas, Réka and Abdullah, Khaldoon Sadiq Ahmed and Kaizer, László and Ürmös, A and Raya, May and Tiszlavicz, Lilla Györgyi and Pankotai, Tibor and Nagy, István and Mátés, Lajos and Sükösd, Farkas},
	doi = {10.1097/PGP.0000000000001035},
	journal-iso = {INT J GYNECOL PATHOL},
	journal = {INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY},
	volume = {44},
	unique-id = {34883229},
	issn = {0277-1691},
	abstract = {Cervical intraepithelial neoplasia (CIN) represents a spectrum of preinvasive squamous lesions within the cervical epithelium, whose identification is a diagnostic challenge due to subtle histomorphological differences among its categories. This study explores ORF1p, a nucleic acid-binding protein derived from long interspersed nuclear element-1 (LINE-1), as a potential biomarker for enhancing CIN diagnosis. A comprehensive analysis of 143 cervical specimens, encompassing CIN I (n=20), CIN II (n=46), CIN III (n=14), invasive cancer (n=32), and nondysplastic cases (normal cervical epithelia (n=24) and atrophy (n=7) were conducted. ORF1p, Ki67, and p16 expressions were evaluated using immunohistochemistry. ORF1p immunopositivity was detected in the vast majority [110/112 (98.2%)] of dysplastic and neoplastic (CIN and invasive cancer) specimens, whereas 19/24 (79.2%) of normal cervical specimens lacked ORF1p expression. The observed pattern of ORF1p expression showed a progressively increasing extent and intensity with advancing CIN grades. CIN I exhibited mild ORF1p expression in the lower one or two-thirds of the cervical epithelium [14/16 (87.5%)], whereas CIN II demonstrated moderate to strong ORF1p expression spanning the lower two-thirds [29/46 (63.0%)]. Pronounced transepithelial ORF1p immunopositivity characterized CIN III cases [13/14 (92.8%)] and cervical cancer [30/32 (93.8%)]. These findings propose ORF1p as a valuable indicator even for detecting CIN I, effectively discerning them from normal cervical tissue (p < 0.0001). Our findings underscore the potential of ORF1p as an early diagnostic marker for cervical neoplasia.},
	year = {2025},
	eissn = {1538-7151},
	pages = {22-30},
	orcid-numbers = {Pankotai, Tibor/0000-0001-9810-5465}
}

@article{MTMT:33708483,
	title = {Prolonged activity of the transposase helper may raise safety concerns during DNA transposon-based gene therapy},
	url = {https://m2.mtmt.hu/api/publication/33708483},
	author = {Imre, Gergely and Takács, Bertalan Vilmos and Czipa, Erik and Drubi, Andrea and Jaksa, Gábor and Latinovics, Dóra and Nagy, Andrea and Karkas, Réka and Hudoba, Liza and Vásárhelyi, Bálint Márk and Pankotai-Bodó, Gabriella and Blastyák, András and Hegedűs, Zoltán and Germán, Péter and Bálint, Balázs and Abdullah, Khaldoon Sadiq Ahmed and Kopasz, Anna Georgina and Kovács, Anita Kármen and Nagy, László and Sükösd, Farkas and Pintér, Lajos and Rülicke, Thomas and Barta, Endre and Nagy, István and Haracska, Lajos and Mátés, Lajos},
	doi = {10.1016/j.omtm.2023.03.003},
	journal-iso = {MOL THER-METH CLIN D},
	journal = {MOLECULAR THERAPY-METHODS AND CLINICAL DEVELOPMENT},
	volume = {29},
	unique-id = {33708483},
	year = {2023},
	eissn = {2329-0501},
	pages = {145-159},
	orcid-numbers = {Vásárhelyi, Bálint Márk/0000-0003-1782-8691; Kovács, Anita Kármen/0000-0001-9805-1647}
}

@article{MTMT:32773206,
	title = {A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver},
	url = {https://m2.mtmt.hu/api/publication/32773206},
	author = {Kopasz, Anna Georgina and Pusztai, Dávid and Karkas, Réka and Hudoba, Liza and Abdullah, Khaldoon Sadiq Ahmed and Imre, Gergely and Pankotai-Bodó, Gabriella and Migh, Ede and Nagy, Andrea and Kriston, András and Germán, Péter and Drubi, Andrea and Molnár, Anna and Fekete, Ildikó and Dani, Virág Éva and Ocsovszki, Imre and Puskás, László and Horváth, Péter and Sükösd, Farkas and Mátés, Lajos},
	doi = {10.1186/s12915-022-01262-x},
	journal-iso = {BMC BIOL},
	journal = {BMC BIOLOGY},
	volume = {20},
	unique-id = {32773206},
	issn = {1741-7007},
	year = {2022},
	eissn = {1741-7007},
	orcid-numbers = {Abdullah, Khaldoon Sadiq Ahmed/0000-0001-9980-3724; Dani, Virág Éva/0000-0001-9715-2569; Ocsovszki, Imre/0000-0003-1290-996X}
}