TY - THES AU - Szabó-Halász, Adrienn TI - Challenges in the treatment and follow up of acute pancreatitis [Kihívások az akut pancreatitis kezelésében és utánkövetésében] PB - Szegedi Tudományegyetem (SZTE) PY - 2022 SP - 56 DO - 10.14232/phd.11073 UR - https://m2.mtmt.hu/api/publication/32860647 ID - 32860647 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Szabolcs AU - Pintér, József AU - Molontay, Roland AU - Nagy, Marcell AU - Borbásné Farkas, Kornélia AU - Sipos, Zoltán AU - Fehérvári, Péter AU - Pecze, László AU - Földi, Mária AU - Vincze, Áron AU - Takács, Tamás AU - Czakó, László AU - Szabó-Halász, Adrienn AU - Boros, Eszter AU - Hamvas, József AU - Varga, Márta AU - Mickevicius, Artautas AU - Faluhelyi, Nándor AU - Farkas, Orsolya AU - Váncsa, Szilárd AU - Nagy, Rita AU - Bunduc, Stefania AU - Hegyi, Péter Jenő AU - Márta, Katalin AU - Borka, Katalin AU - Doros, Attila AU - Hosszúfalusi, Nóra AU - Zubek, László AU - Erőss, Bálint Mihály AU - Molnár, Zsolt AU - Párniczky, Andrea AU - Hegyi, Péter AU - Szentesi, Andrea Ildikó ED - Kiss, Szabolcs / Collaborator ED - Farkas, Nelli / Collaborator ED - Sipos, Zoltán / Collaborator ED - Fehérvári, Péter / Collaborator ED - Pecze, László / Collaborator ED - Földi, Mária / Collaborator ED - Vincze, Áron / Collaborator ED - Takács, Tamás / Collaborator ED - Czakó, László / Collaborator ED - Halász, Adrienn / Collaborator ED - Boros, Eszter / Collaborator ED - Hamvas, József / Collaborator ED - Varga, Márta / Collaborator ED - Mickevicius, Artautas / Collaborator ED - Faluhelyi, Nándor / Collaborator ED - Farkas, Orsolya / Collaborator ED - Váncsa, Szilárd / Collaborator ED - Nagy, Rita / Collaborator ED - Bunduc, Stefania / Collaborator ED - Hegyi, Péter Jenő / Collaborator ED - Márta, Katalin / Collaborator ED - Borka, Katalin / Collaborator ED - Doros, Attila / Collaborator ED - Hosszúfalusi, Nóra / Collaborator ED - Zubek, László / Collaborator ED - Erőss, Bálint / Collaborator ED - Molnár, Zsolt / Collaborator ED - Párniczky, Andrea / Collaborator ED - Hegyi, Péter / Collaborator ED - Szentesi, Andrea / Collaborator ED - Bajor, Judit / Collaborator ED - Gódi, Szilárd / Collaborator ED - Sarlós, Patrícia / Collaborator ED - Czimmer, József / Collaborator ED - Szabó, Imre / Collaborator ED - Pár, Gabriella / Collaborator ED - Illés, Anita / Collaborator ED - Hágendorn, Roland / Collaborator ED - Németh, Balázs / Collaborator ED - Kui, Balázs / Collaborator ED - Illés, Dóra / Collaborator ED - Gajdán, László / Collaborator ED - Dunás-Varga, Veronika / Collaborator ED - Fejes, Roland / Collaborator ED - Papp, Mária / Collaborator ED - Vitális, Zsuzsanna / Collaborator ED - Novák, János / Collaborator ED - Török, Imola / Collaborator ED - Macarie, Melania / Collaborator ED - Ramírez-Maldonado, Elena / Collaborator ED - Sallinen, Ville / Collaborator ED - Galeev, Shamil / Collaborator ED - Bod, Barnabás / Collaborator ED - Ince, Ali Tüzün / Collaborator ED - Pécsi, Dániel / Collaborator ED - Varjú, Péter / Collaborator ED - Juhász, Márk Félix / Collaborator ED - Ocskay, Klementina / Collaborator ED - Mikó, Alexandra / Collaborator ED - Szakács, Zsolt / Collaborator AU - Izbéki, Ferenc TI - Early prediction of acute necrotizing pancreatitis by artificial intelligence : a prospective cohort-analysis of 2387 cases JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 11 SN - 2045-2322 DO - 10.1038/s41598-022-11517-w UR - https://m2.mtmt.hu/api/publication/32823615 ID - 32823615 N1 - * Megosztott szerzőség AB - Pancreatic necrosis is a consistent prognostic factor in acute pancreatitis (AP). However, the clinical scores currently in use are either too complicated or require data that are unavailable on admission or lack sufficient predictive value. We therefore aimed to develop a tool to aid in necrosis prediction. The XGBoost machine learning algorithm processed data from 2387 patients with AP. The confidence of the model was estimated by a bootstrapping method and interpreted via the 10th and the 90th percentiles of the prediction scores. Shapley Additive exPlanations (SHAP) values were calculated to quantify the contribution of each variable provided. Finally, the model was implemented as an online application using the Streamlit Python-based framework. The XGBoost classifier provided an AUC value of 0.757. Glucose, C-reactive protein, alkaline phosphatase, gender and total white blood cell count have the most impact on prediction based on the SHAP values. The relationship between the size of the training dataset and model performance shows that prediction performance can be improved. This study combines necrosis prediction and artificial intelligence. The predictive potential of this model is comparable to the current clinical scoring systems and has several advantages over them. LA - English DB - MTMT ER - TY - JOUR AU - Hegyi, Péter Jenő AU - Soós, Alexandra AU - Tóth, Emese AU - Ébert, Attila AU - Venglovecz, Viktória AU - Márta, Katalin AU - Mátrai, Péter AU - Mikó, Alexandra AU - Bajor, Judit AU - Sarlós, Patrícia AU - Vincze, Áron AU - Szabó-Halász, Adrienn AU - Izbéki, Ferenc AU - Szepes, Zoltán AU - Czakó, László AU - Kovács, György AU - Papp, Mária AU - Dubravcsik, Zsolt AU - Varga, Márta AU - Hamvas, József AU - Németh, Balázs AU - Macarie, Melania AU - Ince, Ali Tüzün AU - Bordin, Dmitry S AU - Dubtsova, Elena A AU - Kiryukova, Mariya A AU - Khatkov, Igor E AU - Bideeva, Tanya AU - Mickevicius, Artautas AU - Ramírez-Maldonado, Elena AU - Sallinen, Ville AU - Erőss, Bálint Mihály AU - Pécsi, Dániel AU - Szentesi, Andrea Ildikó AU - Párniczky, Andrea AU - Tiszlavicz, László AU - Hegyi, Péter TI - Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 11 PY - 2021 IS - 1 PG - 14 SN - 2045-2322 DO - 10.1038/s41598-020-80532-6 UR - https://m2.mtmt.hu/api/publication/31815619 ID - 31815619 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office [K116634, FK131864, FK124632, K128222]; Economic Development and Innovation Operative Programme Grant from the National Research, Development and Innovation Office [GINOP 2.3.2-15-2016-00048]; Human Resources Development Operational Programme Grant from the National Research, Development and Innovation Office [EFOP-3.6.2-16-2017-00006]; Hungarian Academy of Sciences [LP2014-10/2014]; Hungarian Academy of Sciences; Ministry for Innovation and Technology [UNKP-20-5] Funding text: The study was funded by Project Grants (K116634 to PH, FK131864 to AM, FK124632 to BCN and K128222 to LC), an Economic Development and Innovation Operative Programme Grant (GINOP 2.3.2-15-2016-00048 to PH) and a Human Resources Development Operational Programme Grant (EFOP-3.6.2-16-2017-00006 to PH) from the National Research, Development and Innovation Office, as well as a Momentum Grant from the Hungarian Academy of Sciences (LP2014-10/2014 to PH). Supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (to AM) and by the UNKP-20-5 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (to AM). AB - Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare. LA - English DB - MTMT ER - TY - JOUR AU - Hegyi, P AU - Soós, A AU - Tóth, Emese AU - Ébert, Attila AU - Venglovecz, Viktória AU - Márta, K AU - Mátrai, P AU - Mikó, A AU - Bajor, Judit AU - Sarlós, P AU - Szabó-Halász, Adrienn AU - Izbéki, F AU - Szepes, Zoltán AU - Czakó, László AU - Kovács, G AU - Papp, M AU - Dubravcsik, Zsolt AU - Varga, M AU - Hamvas, J AU - Németh, Balázs AU - Macarie, Mq AU - Tüzün, A AU - Bordin, D AU - Kiryukova, M AU - Khatkov, I AU - Bideeva, T AU - Mickevicius, A AU - Ramírez-Maldonado, E AU - Sallinen, V AU - ErÖss, B AU - Pécsi, Dániel AU - Szentesi, Andrea Ildikó AU - Párniczky, A AU - Hegyi, Péter TI - The new definition of early chronic pancreatitis JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 20 PY - 2020 IS - Suppl. 1 SP - S56 EP - S58 PG - 3 SN - 1424-3903 DO - 10.1016/j.pan.2020.07.071 UR - https://m2.mtmt.hu/api/publication/31822032 ID - 31822032 LA - English DB - MTMT ER - TY - JOUR AU - Kui, Balázs AU - Gódi, S AU - Bajor, J AU - Török, I AU - Macaria, M AU - Farkas, H AU - Mickevicius, A AU - Sallinen, V AU - Maldonado, E AU - Papp, M AU - Kovács, G AU - Fehér, E AU - Sarlós, P AU - Galeev, S AU - Németh, Balázs AU - Vincze, Á AU - Pencik, P AU - Ozola-Zalite, I AU - Pukitis, A AU - Litvin, A AU - Kovalskaya, I AU - Czimmer, J AU - Pár, G AU - Hritz, István AU - Illés, Dóra AU - Szentesi, Andrea Ildikó AU - Lakatos, L AU - Capurso, G AU - Patai, Á AU - Stilidi, E AU - Peserico, G AU - Zadorozhna, K AU - Sonmez, E AU - Tüzün, Ince A AU - Vishalkumar, S AU - Horibe, M AU - Ihász, M AU - Erőss, B AU - Márta, K AU - Szakács, Zsolt AU - Farkas, N AU - Gede, N AU - Szabó-Halász, Adrienn AU - Gajdán, L AU - Izbéki, F AU - Poropat, G AU - Robu, G AU - Jinga, M AU - Hegyi, Péter TI - The use of early achievable severity (EASY) index is beneficial for rapid risk stratification in acute pancreatitis at hospital admission JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 6 PY - 2020 IS - Suppl 2 SP - 62 EP - 63 PG - 2 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/31819813 ID - 31819813 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Szabolcs AU - Farkas, N AU - Fehérvári, P AU - Pecze, L AU - Földi, Mária AU - Vincze, Á AU - Gódi, S AU - Bajor, J AU - Czimmer, J AU - Sarlós, P AU - Hágendorn, R AU - Takács, Tamás AU - Izbéki, F AU - Szabó-Halász, Adrienn AU - Hamvas, J AU - Varga, M AU - Crai, S AU - Mickevicius, A AU - Patai, Á AU - Ihász, M AU - Varjú, P AU - Faluhelyi, N AU - Farkas, O AU - Miseta, A AU - Kelemen, Dezső AU - Papp, R AU - Hegyi, P AU - Szentesi, Andrea Ildikó AU - Párniczky, A AU - Hegyi, Péter TI - Risk prediction model for developing pancreatic necrosis JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 6 PY - 2020 IS - Suppl 1 SP - 61 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/31819695 ID - 31819695 LA - English DB - MTMT ER - TY - JOUR AU - Hegyi, P AU - Soós, A AU - Tóth, Emese AU - Ébert, Attila AU - Venglovecz, Viktória AU - Márta, K AU - Mikó, A AU - Bajor, J AU - Sarlós, P AU - Vincze, Á AU - Szabó-Halász, Adrienn AU - Izbéki, F AU - Szepes, Zoltán AU - Czakó, László AU - Kovács, L. Gábor AU - Papp, Mária AU - Dubravcsik, Zsolt AU - Varga, M AU - Hamvas, J AU - Németh, Balázs AU - Erőss, B AU - Pécsi, D AU - Szentesi, Andrea Ildikó AU - Párniczky, A AU - Hegyi, Péter TI - The new definition of early chronic pancreatitis JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 6 PY - 2020 IS - Suppl 2 SP - 54 EP - 54 PG - 1 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/31784556 ID - 31784556 LA - English DB - MTMT ER - TY - JOUR AU - Mosztbacher, Dóra AU - Hanák, Lilla AU - Borbásné Farkas, Kornélia AU - Szentesi, Andrea Ildikó AU - Mikó, Alexandra AU - Bajor, Judit AU - Sarlós, Patrícia AU - Czimmer, József AU - Vincze, Áron AU - Hegyi, Péter Jenő AU - Erőss, Bálint Mihály AU - Takács, Tamás AU - Czakó, László AU - Németh, Balázs AU - Izbéki, Ferenc AU - Szabó-Halász, Adrienn AU - Gajdán, László AU - Hamvas, József AU - Papp, Mária AU - Földi, Ildikó AU - Fehér, Krisztina Eszter AU - Varga, Márta AU - Csefkó, Klára AU - Török, Imola AU - Farkas, Hunor Pál AU - Mickevicius, Artautas AU - Maldonado, Elena Ramirez AU - Sallinen, Ville AU - Novák, János AU - Ince, Ali Tüzün AU - Galeev, Shamil AU - Bod, Barnabás AU - Sümegi, János AU - Pencik, Petr AU - Dubravcsik, Zsolt AU - Illés, Dóra AU - Gódi, Szilárd AU - Kui, Balázs AU - Márta, Katalin AU - Pécsi, Dániel AU - Varjú, Péter AU - Szakács, Zsolt AU - Darvasi, Erika AU - Párniczky, Andrea AU - Hegyi, Péter TI - Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 20 PY - 2020 IS - 4 SP - 608 EP - 616 PG - 9 SN - 1424-3903 DO - 10.1016/j.pan.2020.03.018 UR - https://m2.mtmt.hu/api/publication/31280739 ID - 31280739 N1 - * Megosztott szerzőség AB - Background Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are inadequate and contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP. Methods AP patients over 18 years old who underwent triglyceride measurement within the initial three days were included into our cohort analysis from a prospective international, multicenter AP registry operated by the Hungarian Pancreatic Study Group. Data on 716 AP cases were analyzed. Six groups were created based on the highest triglyceride level (<1.7 mmol/l, 1.7–2.19 mmol/l, 2.2–5.59 mmol/l, 5.6–11.29 mmol/l, 11.3–22.59 mmol/l, ≥22.6 mmol/l). Results Hypertriglyceridemia (≥1.7 mmol/l) presented in 30.6% of the patients and was significantly and dose-dependently associated with younger age and male gender. In 7.7% of AP cases, hypertriglyceridemia (≥11.3 mmol/l) was considered as a causative etiological factor; however, 43.6% of these cases were associated with other etiologies (alcohol and biliary). Hypertriglyceridemia was significantly and dose-dependently related to obesity and diabetes. The rates of local complications, organ failure and maximum CRP level were significantly and dose-dependently raised by hypertriglyceridemia. Triglyceride above 11.3 mmol/l was linked to a significantly higher incidence of moderately severe AP and longer hospital stay, whereas triglyceride over 22.6 mmol/l was significantly associated with severe AP as well. Conclusion Hypertriglyceridemia dose-dependently aggravates the severity and related complications of AP. Diagnostic workup for hypertriglyceridemia requires better awareness regardless of the etiology of AP. LA - English DB - MTMT ER - TY - JOUR AU - Párniczky, Andrea AU - Lantos, Tamás AU - Tóth, Eszter Margit AU - Szakács, Zsolt AU - Gódi, Szilárd AU - Hágendorn, Roland AU - Illés, Dóra AU - Koncz, Balázs AU - Márta, Kata AU - Mikó, Alexandra AU - Mosztbacher, Dora AU - Németh, Balázs AU - Pécsi, Dániel AU - Szabó, Anikó AU - Szűcs, Ákos AU - Varjú, Péter AU - Szentesi, Andrea AU - Darvasi, Erika AU - Erőss, Bálint AU - Izbéki, Ferenc AU - Gajdán, László AU - Szabó-Halász, Adrienn AU - Vincze, Aron AU - Szabó, Imre AU - Pár, Gabriella AU - Bajor, Judit AU - Sarlós, Patrícia AU - Czimmer, József AU - Hamvas, József AU - Takács, Tamás AU - Szepes, Zoltán AU - Czakó, László AU - Varga, Márta AU - Novák, János AU - Bod, Barnabás AU - Szepes, Attila AU - Sümegi, János AU - Papp, Mária AU - Góg, Csaba AU - Török, Imola AU - Huang, Wei AU - Xia, Qing AU - Xue, Ping AU - Li, Weiqin AU - Chen, Weiwei AU - Shirinskaya, Natalia V. AU - Poluektov, Vladimir L. AU - Shirinskaya, Anna V. AU - Hegyi, Péter AU - Bátovsky, Marian AU - Rodriguez-Oballe, Juan A. AU - Salas, Isabel Miguel AU - Lopez-Diaz, Javier AU - Dominguez-Munoz, J Enrique AU - Molero, Xavier AU - Pando, Elizabeth AU - Ruiz-Rebollo, Maria Lourdes AU - Burgueño-Gómez, Beatriz AU - Chang, Yu-Ting AU - Chang, Ming-Chu AU - Sud, Ajay AU - Moore, Danielle AU - Sutton, Robert AU - Gougol, Amir AU - Papachristou, Georgios AU - Susak, Yaroslav Mykhailovych AU - Tiuliukin, Illia Olehovych AU - Gomes, António P. AU - Oliveira, Maria Jesus AU - Aparício, Davis Joao AU - Tantau, Marcell AU - Kurti, Floreta AU - Kovacheva-Slavova, Mila AU - Strecher, Stephanie-Susanne AU - Mayerle, Julia AU - Poporat, Goran AU - Das, Kshaunish AU - Marino, Marco Vito AU - Capurso, Gabriele AU - Małecka-Panas, Ewa AU - Zatorski, Hubert AU - Gasiorowska, Anita AU - Fabisiak, Natalia AU - Ceranowicz, Piotr AU - Kuśnierz-Cabala, Beata AU - Carvalho, Johana Rita AU - Fernandes, Samuel Raimundo AU - Chang, Jae Hyuck AU - Choi, Eun Kwang AU - Han, Jimin AU - Bertilsson, Sara AU - Jumaa, Hanaz AU - Sandblom, Gabriel AU - Kacar, Sabite AU - Baltatzis, Minas AU - Varabei, Aliaksandr Vladimir AU - Yeshi, Vizhynis AU - Chooklin, Serge AU - Kozachenko, Andriy AU - Veligotsky, Nikolay AU - Hegyi, Péter TI - Antibiotic therapy in acute pancreatitis: from global overuse to evidence based recommendations JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 19 PY - 2019 IS - Suppl 1 SP - S148 EP - S150 PG - 3 SN - 1424-3903 DO - 10.1016/j.pan.2019.05.401 UR - https://m2.mtmt.hu/api/publication/31627571 ID - 31627571 LA - English DB - MTMT ER - TY - JOUR AU - Erőss, Bálint AU - Farkas, Nelli AU - Hanák, Lilla AU - Mikó, Alexandra AU - Vincze, Aron AU - Gódi, Szilárd AU - Sarlós, Patrícia AU - Czimmer, József AU - Bajor, Judit AU - Pécsi, Dániel AU - Varjú, Péter AU - Márta, Kata AU - Hegyi, Péter AU - Szentesi, Andrea AU - Párniczky, Andrea AU - Hamvas, József AU - Bod, Barnabás AU - Török, Imola AU - Hunor-Pál, Farkas AU - Izbéki, Ferenc AU - Szabó-Halász, Adrienn AU - Dunás, Veronika AU - Gajdán, László AU - Czakó, László AU - Illés, Dóra AU - Takács, Tamás AU - Németh, Balázs AU - Kui, Balázs AU - Darvasi, Erika AU - Papp, Mária AU - Földi, Ildikó AU - Fehér, Eszter AU - Varga, Márta AU - Csefkó, Klára AU - Novák, János AU - Sümegi, János AU - Szepes, Attila AU - Mickevicius, Artautas AU - Maldonado, Elena Ramirez AU - Sallinen, Ville AU - Ince, Ali Tüzün AU - Galeev, Shamil AU - Pencik, Petr AU - Hegyi, Péter TI - A Multicenter, International Cohort Analysis of 1435 Patients to Support Clinical Trial Design in Acute Pancreatitis JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 19 PY - 2019 IS - Suppl 1 SP - S147 EP - S148 SN - 1424-3903 DO - 10.1016/j.pan.2019.05.399 UR - https://m2.mtmt.hu/api/publication/31627542 ID - 31627542 LA - English DB - MTMT ER -