@article{MTMT:33870536,
	title = {PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related factor 2 (NRF2) affecting NRF2 subcellular localization},
	url = {https://m2.mtmt.hu/api/publication/33870536},
	author = {Jankó, Laura and Tóth, Emese and Laczik, Miklós and Rauch, Boglárka and Janka, Eszter and Bálint, Bálint László and Bay, Péter},
	doi = {10.1038/s41598-023-35076-w},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {33870536},
	issn = {2045-2322},
	abstract = {PARP2 is a member of the PARP enzyme family. Although, PARP2 plays role in DNA repair, it has regulatory roles in mitochondrial and lipid metabolism, it has pivotal role in bringing about the adverse effects of pharmacological PARP inhibitors. Previously, we showed that the ablation of PARP2 induces oxidative stress and, consequently, mitochondrial fragmentation. In attempt to identify the source of the reactive species we assessed the possible role of a central regulator of cellular antioxidant defense, nuclear factor erythroid 2-related factor 2 (NRF2). The silencing of PARP2 did not alter either the mRNA or the protein expression of NRF2, but changed its subcellular localization, decreasing the proportion of nuclear, active fraction of NRF2. Pharmacological inhibition of PARP2 partially restored the normal localization pattern of NRF2 and in line with that, we showed that NRF2 is PARylated that is absent in the cells in which PARP2 was silenced. Apparently, the PARylation of NRF2 by PARP2 has pivotal role in regulating the subcellular (nuclear) localization of NRF2. The silencing of PARP2 rearranged the expression of genes encoding proteins with antioxidant function, among these a subset of NRF2-dependent genes.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Bálint, Bálint László/0000-0002-6163-7190}
}

@article{MTMT:32058440,
	title = {Silencing of Poly(ADP-Ribose) Polymerase-2 Induces Mitochondrial Reactive Species Production and Mitochondrial Fragmentation},
	url = {https://m2.mtmt.hu/api/publication/32058440},
	author = {Jankó, Laura and Kovács, Tünde and Laczik, Miklós and Sári, Zsanett Mercédesz and Ujlaki, Gyula and Kis, Nikoletta Gréta and Horváth, Ibolya and Antal, Miklós and Vigh, László and Bálint, Bálint László and Uray (Davis), Karen L. and Bay, Péter},
	doi = {10.3390/cells10061387},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {10},
	unique-id = {32058440},
	year = {2021},
	eissn = {2073-4409},
	orcid-numbers = {Bálint, Bálint László/0000-0002-6163-7190; Uray (Davis), Karen L./0000-0001-6997-459X; Bay, Péter/0000-0002-6191-6616}
}

@article{MTMT:31627406,
	title = {Indoxylsulfate, a metabolite of the microbiome, has cytostatic effects in breast cancer via activation of AHR and PXR receptors and induction of oxidative stress},
	url = {https://m2.mtmt.hu/api/publication/31627406},
	author = {Sári, Zsanett Mercédesz and Mikó, Edit and Kovács, Tünde and Boratkó, Anita and Ujlaki, Gyula and Jankó, Laura and Kiss, Borbála Katalin and Uray (Davis), Karen L. and Bay, Péter},
	doi = {10.3390/cancers12102915},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {12},
	unique-id = {31627406},
	year = {2020},
	eissn = {2072-6694}
}

@article{MTMT:31408725,
	title = {Indolepropionic acid, a metabolite of the microbiome, has cytostatic properties in breast cancer by activating AHR and PXR receptors and inducing oxidative stress},
	url = {https://m2.mtmt.hu/api/publication/31408725},
	author = {Sári, Zsanett Mercédesz and Mikó, Edit and Kovács, Tünde and Jankó, Laura and Csonka, Tamás and Lente, G and Sebő, É and Toth, J and Tóth, Dezső and Árkosy, Péter and Boratkó, Anita and Ujlaki, Gyula and Török, M and Kovács, Ilona and Szabó, Judit and Kiss, Borbála Katalin and Méhes, Gábor and Goedert, JJ and Bay, Péter},
	doi = {10.3390/cancers12092411},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {12},
	unique-id = {31408725},
	year = {2020},
	eissn = {2072-6694}
}

@article{MTMT:31156819,
	title = {Silencing of PARP2 blocks autophagic degradation},
	url = {https://m2.mtmt.hu/api/publication/31156819},
	author = {Jankó, Laura and Sári, Zsanett Mercédesz and Kovács, Tünde and Kis, Nikoletta Gréta and Szántó, Magdolna and Antal, Miklós and Juhász, Gábor and Bay, Péter},
	doi = {10.3390/cells9020380},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {9},
	unique-id = {31156819},
	year = {2020},
	eissn = {2073-4409},
	orcid-numbers = {Juhász, Gábor/0000-0001-8548-8874}
}

@article{MTMT:31123558,
	title = {PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes—Implications for UV-Induced DNA Repair and Photocarcinogenesis},
	url = {https://m2.mtmt.hu/api/publication/31123558},
	author = {Hegedűs, Csaba and Boros, Gábor and Fidrus, Eszter and Kis, Gréta Nikoletta and Antal, Miklós and Juhász, Tamás and Janka, Eszter Anna and Jankó, Laura and Paragh, György and Emri, Gabriella and Bay, Péter and Remenyik, Éva},
	doi = {10.3390/cancers12010005},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {12},
	unique-id = {31123558},
	year = {2020},
	eissn = {2072-6694},
	orcid-numbers = {Janka, Eszter Anna/0000-0003-0724-5281}
}

@article{MTMT:30774202,
	title = {Lithocholic acid, a metabolite of the microbiome, increases oxidative stress in breast cancer},
	url = {https://m2.mtmt.hu/api/publication/30774202},
	author = {Kovács, Patrik Bence and Csonka, Tamás and Kovács, Tünde and Sári, Zsanett Mercédesz and Ujlaki, Gyula and Sipos, Adrienn and Karányi, Zsolt and Szeőcs, Dóra and Hegedűs, Csaba and Uray (Davis), Karen L. and Jankó, Laura and Kiss, M and Kiss, Borbála Katalin and Laoui, D and Virág, László and Méhes, Gábor and Bay, Péter and Mikó, Edit},
	doi = {10.3390/cancers11091255},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {11},
	unique-id = {30774202},
	year = {2019},
	eissn = {2072-6694}
}

@article{MTMT:30385388,
	title = {Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of muscular lipid homeostasis},
	url = {https://m2.mtmt.hu/api/publication/30385388},
	author = {Márton, Judit and Péter, Mária and Balogh, Gábor and Bódi, Beáta and Vida, András and Szántó, Magdolna and Bojcsuk, Dóra and Jankó, Laura and Bhattoa Harjit, Pál and Gombos, Imre and Uray (Davis), Karen L. and Horváth, Ibolya and Török, Zsolt and Bálint, Bálint László and Papp, Zoltán and Vigh, László and Bay, Péter},
	doi = {10.1016/j.bbalip.2018.07.013},
	journal-iso = {BBA-MOL CELL BIOL L},
	journal = {BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS},
	volume = {1863},
	unique-id = {30385388},
	issn = {1388-1981},
	abstract = {There is a growing body of evidence that poly(ADP-ribose) polymerase-2 (PARP2), although originally described as a DNA repair protein, has a widespread role as a metabolic regulator. We show that the ablation of PARP2 induced characteristic changes in the lipidome. The silencing of PARP2 induced the expression of sterol regulatory element-binding protein-1 and -2 and initiated de novo cholesterol biosynthesis in skeletal muscle. Increased muscular cholesterol was shunted to muscular biosynthesis of dihydrotestosterone, an anabolic steroid. Thus, skeletal muscle fibers in PARP2(-/-) mice were stronger compared to those of their wild-type littermates. In addition, we detected changes in the dynamics of the cell membrane, suggesting that lipidome changes also affect the biophysical characteristics of the cell membrane. In in silico and wet chemistry studies, we identified lipid species that can decrease the expression of PARP2 and potentially phenocopy the genetic abruption of PARP2, including artificial steroids. In view of these observations, we propose a new role for PARP2 as a lipid-modulated regulator of lipid metabolism.},
	year = {2018},
	eissn = {1879-2618},
	pages = {1399-1412},
	orcid-numbers = {Bojcsuk, Dóra/0000-0001-5091-7237; Bhattoa Harjit, Pál/0000-0002-4909-0065; Bálint, Bálint László/0000-0002-6163-7190}
}