@article{MTMT:34876197,
	title = {The Incidence of Recurrent and Chronic Pancreatitis after Acute Pancreatitis: A Systematic Review and Meta-Analysis},
	url = {https://m2.mtmt.hu/api/publication/34876197},
	author = {Gagyi , Endre and Teutsch, Brigitta and Veres, Dániel and Pálinkás, Dániel and Vörhendi, Nóra and Ocskay, Klementina and Márta, Katalin and Hegyi, Péter Jenő and Hegyi, Péter and Erőss, Bálint Mihály},
	journal-iso = {THER ADV GASTROENTER},
	journal = {THERAPEUTIC ADVANCES IN GASTROENTEROLOGY},
	volume = {0},
	unique-id = {34876197},
	issn = {1756-283X},
	year = {2024},
	eissn = {1756-2848},
	pages = {0},
	orcid-numbers = {Teutsch, Brigitta/0000-0002-9530-7886; Veres, Dániel/0000-0002-9687-3556; Ocskay, Klementina/0000-0001-5848-2506; Márta, Katalin/0000-0002-2213-4865; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427}
}

@article{MTMT:34852778,
	title = {Early nutrition is safe and does not increase complications after upper gastrointestinal bleeding—a systematic review and meta-analysis of randomized controlled trials},
	url = {https://m2.mtmt.hu/api/publication/34852778},
	author = {Obeidat, Mahmoud Mohammadnour Suleiman and Teutsch, Brigitta and Floria, Diana-Elena and Veres, Dániel and Hegyi, Péter and Erőss, Bálint Mihály},
	doi = {10.1038/s41598-024-61543-z},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {34852778},
	issn = {2045-2322},
	abstract = {Despite a lack of evidence, patients are often not fed for 48–96 h after upper gastrointestinal bleeding (UGIB); however, many trials have demonstrated the benefits of early nutrition (EN). We conducted a meta-analysis of randomized controlled trials (RTCs) to evaluate the outcomes of EN compared to delayed nutrition (DN) after UGIB. The protocol was registered on PROSPERO (CRD42022372306). PubMed, Embase, CENTRAL, Scopus, and Web of Science were searched on the 27th of April 2024 to identify eligible RCTs. The primary outcomes were early (within 7 days) and late (within 30–42 days) mortality and rebleeding. Pooled risk ratios (RR), mean differences (MD), and corresponding 95% confidence intervals (CI) were calculated using a random-effects model. A total of 10 trials with 1051 patients were included in the analysis. Early mortality was not significantly different between the two groups (RR 1.20, CI 0.85–1.71, I 2  = 0%), whereas late mortality was reduced to a clinically relevant extent in the EN group (RR 0.61, CI 0.35–1.06, I 2  = 0%). When comparing the two groups, we found no significant difference in terms of early and late rebleeding (RR 1.04, CI 0.66–1.63, I 2  = 0% and RR 1.16, CI 0.63–2.13, I 2  = 0%, respectively). Our analysis also showed that the length of hospital stay was reduced in the EN group compared to the DN group (MD −1.22 days, CI: −2.43 to −0.01, I 2  = 94%). In conclusion, compared with DN, EN (within 24 h) appears to be a safe intervention and could reduce the length of hospital stay without increasing the risk of complications after UGIB.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Teutsch, Brigitta/0000-0002-9530-7886; Veres, Dániel/0000-0002-9687-3556; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427}
}

@article{MTMT:34852447,
	title = {Contrast-enhanced endoscopic ultrasound likely does not improve diagnostic adequacy during endoscopic ultrasound guided tissue acquisition: A systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/34852447},
	author = {Engh, Marie Anne and Teutsch, Brigitta and Schulze, Wenning A. and Hadani, Y. and Almog, O. and Veres, Dániel and Hegyi, Péter and Erőss, Bálint Mihály},
	doi = {10.1016/j.pan.2024.04.007},
	journal-iso = {PANCREATOLOGY},
	journal = {PANCREATOLOGY},
	unique-id = {34852447},
	issn = {1424-3903},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {1424-3911},
	orcid-numbers = {Engh, Marie Anne/0000-0003-4269-5130; Teutsch, Brigitta/0000-0002-9530-7886; Veres, Dániel/0000-0002-9687-3556; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427}
}

@article{MTMT:34763940,
	title = {Morphology of the papilla can predict procedural safety and efficacy of ERCP-a systematic review and meta-analysis.},
	url = {https://m2.mtmt.hu/api/publication/34763940},
	author = {Tari, Edina and Gagyi , Endre and Rancz, Anett and Veres, Dániel and Váncsa, Szilárd and Hegyi, Péter Jenő and Hagymási, Krisztina and Hegyi, Péter and Erőss, Bálint Mihály},
	doi = {10.1038/s41598-024-57758-9},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {34763940},
	issn = {2045-2322},
	abstract = {Endoscopic Retrograde Cholangiopancreatography (ERCP) is the primary therapeutic procedure for pancreaticobiliary disorders, and studies highlighted the impact of papilla anatomy on its efficacy and safety. Our objective was to quantify the influence of papilla morphology on ERCP outcomes. We systematically searched three medical databases in September 2022, focusing on studies detailing the cannulation process or the rate of adverse events in the context of papilla morphology. The Haraldsson classification served as the primary system for papilla morphology, and a pooled event rate with a 95% confidence interval was calculated as the effect size measure. Out of 17 eligible studies, 14 were included in the quantitative synthesis. In studies using the Haraldsson classification, the rate of difficult cannulation was the lowest in type I papilla (26%), while the highest one was observed in the case of type IV papilla (41%). For post-ERCP pancreatitis, the event rate was the highest in type II papilla (11%) and the lowest in type I and III papilla (6-6%). No significant difference was observed in the cannulation failure and post-ERCP bleeding event rates between the papilla types. In conclusion, certain papilla morphologies are associated with a higher rate of difficult cannulation and post-ERCP pancreatitis.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Tari, Edina/0000-0002-8540-0614; Veres, Dániel/0000-0002-9687-3556; Váncsa, Szilárd/0000-0002-9347-8163; Hagymási, Krisztina/0000-0002-5859-1320; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427}
}

@article{MTMT:34682498,
	title = {The risk of developing splanchnic vein thrombosis in acute pancreatitis increases 3 days after symptom onset: A systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/34682498},
	author = {Borbély, Ruben Zsolt and Szalai, Eszter and Philip, Bryan Mangalath and Dobszai, Dalma and Teutsch, Brigitta and Zolcsák, Ádám and Veres, Dániel and Erőss, Bálint Mihály and Gellért, Bálint and Hegyi, Péter Jenő and Hegyi, Péter and Faluhelyi, Nándor},
	doi = {10.1002/ueg2.12550},
	journal-iso = {UEG JOURNAL},
	journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL},
	unique-id = {34682498},
	issn = {2050-6406},
	abstract = {Abstract Background Splanchnic vein thrombosis is a complication of acute pancreatitis (AP) and is likely often underdiagnosed. Objectives We aimed to understand the time course and risk factors of splanchnic vein thrombosis in the early phase of AP. Methods A systematic search was conducted using the PRISMA guidelines (PROSPERO registration CRD42022367578). Inclusion criteria were appropriate imaging techniques in adult AP patients, studies that reported splanchnic vein thrombosis data from the early phase, and reliable information on the timing of imaging in relation to the onset of pancreatitis symptoms or hospital admission. The proportion of patients with thrombosis with 95% confidence intervals (CI) was calculated using random-effects meta-analyses, and multiple subgroup analyses were performed. Results Data from 1951 patients from 14 studies were analyzed. The proportion of patients with splanchnic vein thrombosis within 12 days after symptom onset was 0.13 (CI 0.07?0.23). The occurrence was lowest at 0.06 (CI 0.03?0.1) between 0 and 3 days after symptom onset, and increased fourfold to 0.23 (CI 0.16?0.31) between 3 and 11 days. On hospital admission, the proportion of patients affected was 0.12 (CI 0.02?0.49); it was 0.17 (CI 0.03?0.58) 1?5 days after admission. The prevalence in mild, moderate, and severe AP was 0.15 (CI 0.05?0.36), 0.26 (CI 0.15?0.43), and 0.27 (CI 0.17?0.4), respectively. Alcoholic etiology (0.31, CI 0.13?0.58) and pancreatic necrosis (0.55, CI 0.29?0.78, necrosis above 30%) correlated with increased SVT prevalence. Conclusion The risk of developing splanchnic vein thrombosis is significant in the early stages of AP and may affect up to a quarter of patients. Alcoholic etiology, pancreatic necrosis, and severity may increase the prevalence of splanchnic vein thrombosis.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {2050-6414},
	orcid-numbers = {Teutsch, Brigitta/0000-0002-9530-7886; Zolcsák, Ádám/0000-0002-9128-4867; Veres, Dániel/0000-0002-9687-3556; Erőss, Bálint Mihály/0000-0003-3658-8427; Gellért, Bálint/0009-0002-7896-1541; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:34561485,
	title = {Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk},
	url = {https://m2.mtmt.hu/api/publication/34561485},
	author = {Ünal, Pelin and Lu, Ye and Bueno-de-Mesquita, Bas and van Eijck, Casper H J and Talar-Wojnarowska, Renata and Szentesi, Andrea Ildikó and Gazouli, Maria and Kreivenaite, Edita and Tavano, Francesca and Małecka-Wojciesko, Ewa and Erőss, Bálint Mihály and Oliverius, Martin and Bunduc, Stefania and Nóbrega Aoki, Mateus and Vodickova, Ludmila and Boggi, Ugo and Giaccherini, Matteo and Kondrackiene, Jurate and Chammas, Roger and Palmieri, Orazio and Theodoropoulos, George E and Bijlsma, Maarten F and Basso, Daniela and Mohelnikova-Duchonova, Beatrice and Soucek, Pavel and Izbicki, Jakob R and Kiudelis, Vytautas and Vanella, Giuseppe and Arcidiacono, Paolo Giorgio and Włodarczyk, Barbara and Hackert, Thilo and Schöttker, Ben and Uzunoglu, Faik G and Bambi, Franco and Goetz, Mara and Hlavac, Viktor and Brenner, Hermann and Perri, Francesco and Carrara, Silvia and Landi, Stefano and Hegyi, Péter and Dijk, Frederike and Maiello, Evaristo and Capretti, Giovanni and Testoni, Sabrina Gloria Giulia and Petrone, Maria Chiara and Stocker, Hannah and Ermini, Stefano and Archibugi, Livia and Gentiluomo, Manuel and Cavestro, Giulia Martina and Pezzilli, Raffaele and Di Franco, Gregorio and Milanetto, Anna Caterina and Sperti, Cosimo and Neoptolemos, John P and Morelli, Luca and Vokacova, Klara and Pasquali, Claudio and Lawlor, Rita T and Bazzocchi, Francesca and Kupcinskas, Juozas and Capurso, Gabriele and Campa, Daniele and Canzian, Federico},
	doi = {10.1186/s40246-024-00576-x},
	journal-iso = {HUM GENOMICS},
	journal = {HUMAN GENOMICS},
	volume = {18},
	unique-id = {34561485},
	issn = {1473-9542},
	abstract = {Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). However, the strict significance threshold commonly used makes it likely that many true risk loci are missed. Functional annotation of GWAS polymorphisms is a proven strategy to identify additional risk loci. We aimed to investigate single-nucleotide polymorphisms (SNP) in regulatory regions [transcription factor binding sites (TFBSs) and enhancers] that could change the expression profile of multiple genes they act upon and thereby modify PDAC risk. We analyzed a total of 12,636 PDAC cases and 43,443 controls from PanScan/PanC4 and the East Asian GWAS (discovery populations), and the PANDoRA consortium (replication population). We identified four associations that reached study-wide statistical significance in the overall meta-analysis: rs2472632(A) (enhancer variant, OR 1.10, 95%CI 1.06,1.13, p = 5.5 × 10-8), rs17358295(G) (enhancer variant, OR 1.16, 95%CI 1.10,1.22, p = 6.1 × 10-7), rs2232079(T) (TFBS variant, OR 0.88, 95%CI 0.83,0.93, p = 6.4 × 10-6) and rs10025845(A) (TFBS variant, OR 1.88, 95%CI 1.50,1.12, p = 1.32 × 10-5). The SNP with the most significant association, rs2472632, is located in an enhancer predicted to target the coiled-coil domain containing 34 oncogene. Our results provide new insights into genetic risk factors for PDAC by a focused analysis of polymorphisms in regulatory regions and demonstrating the usefulness of functional prioritization to identify loci associated with PDAC risk.},
	keywords = {single nucleotide polymorphism; ENHANCER; Pancreatic cancer; Association study; Transcription factor binding site},
	year = {2024},
	eissn = {1479-7364},
	orcid-numbers = {Szentesi, Andrea Ildikó/0000-0003-2097-6927; Erőss, Bálint Mihály/0000-0003-3658-8427; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:34530314,
	title = {Persistently High Procalcitonin and C-Reactive Protein Are Good Predictors of Infection in Acute Necrotizing Pancreatitis: A Systematic Review and Meta-Analysis},
	url = {https://m2.mtmt.hu/api/publication/34530314},
	author = {Tarján, Dorottya and Szalai, Eszter and Lipp, Mónika Bernadett and Verbói, Máté and Kói, Tamás and Erőss, Bálint Mihály and Teutsch, Brigitta and Faluhelyi, Nándor and Hegyi, Péter and Mikó, Alexandra},
	doi = {10.3390/ijms25021273},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34530314},
	issn = {1661-6596},
	abstract = {Infected necrotizing pancreatitis (INP) is associated with an increased risk of organ failure and mortality. Its early recognition and timely initiation of antibiotic therapy can save patients’ lives. We systematically searched three databases on 27 October 2022. In the eligible studies, the presence of infection in necrotizing pancreatitis was confirmed via a reference test, which involved either the identification of gas within the necrotic collection through computed tomography imaging or the examination of collected samples, which yielded positive results in Gram staining or culture. Laboratory biomarkers compared between sterile necrotizing pancreatitis and INP were used as the index test, and our outcome measures included sensitivity, specificity, the receiver operating characteristic (ROC) curve and area under the ROC curve (AUC). Within the first 72 hours (h) after admission, the AUC of C-reactive protein (CRP) was 0.69 (confidence interval (CI): 0.62–0.76), for procalcitonin (PCT), it was 0.69 (CI: 0.60–0.78), and for white blood cell count, it was 0.61 (CI: 0.47–0.75). After the first 72 h, the pooled AUC of CRP showed an elevated level of 0.88 (CI: 0.75–1.00), and for PCT, it was 0.86 (CI: 0.60–1.11). The predictive value of CRP and PCT for infection is poor within 72 h after hospital admission but seems good after the first 72 h. Based on these results, infection is likely in case of persistently high CRP and PCT, and antibiotic initiation may be recommended.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Erőss, Bálint Mihály/0000-0003-3658-8427; Teutsch, Brigitta/0000-0002-9530-7886; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:34453597,
	title = {Obesity paradox in older sarcopenic adults - a delay in aging : A systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/34453597},
	author = {Eitmann, Szimonetta and Mátrai, Péter and Hegyi, Péter and Balaskó, Márta and Erőss, Bálint Mihály and Dorogi, Kira and Pétervári, Erika},
	doi = {10.1016/j.arr.2023.102164},
	journal-iso = {AGEING RES REV},
	journal = {AGEING RESEARCH REVIEWS},
	volume = {93},
	unique-id = {34453597},
	issn = {1568-1637},
	abstract = {The prognostic significance of obesity in sarcopenic adults is controversial. This systematic review and meta-analysis aimed to investigate the effect of additional obesity on health outcomes in sarcopenia. MEDLINE, EMBASE, Scopus and CENTRAL were systematically searched for studies to compare health outcomes of adults with sarcopenic obesity (SO) to those of sarcopenic non-obese (SNO) adults. We also considered the methods of assessing obesity. Of 15060 records screened, 65 papers were included (100612 participants). Older community-dwelling SO adults had 15% lower mortality risk than the SNO group (hazard ratio, HR: 0.85, 95% confidence interval 0.76, 0.94) even when obesity was assessed by measurement of body composition. Additionally, meta-regression analysis revealed a significant negative linear correlation between the age and the HR of all-cause mortality in SO vs. SNO community-dwelling adults, but not in severely ill patients. Compared with SNO, SO patients presented lower physical performance, higher risk for metabolic syndrome, but similar cognitive function, risk of falls and cardiovascular diseases. Age-related obesity, SO and later fat loss leading to SNO represent consecutive phases of biological aging. Additional obesity could worsen the health state in sarcopenia, but above 65 years SO represents a biologically earlier phase with longer life expectancy than SNO.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {1872-9649},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427; Pétervári, Erika/0000-0002-3673-8491}
}

@article{MTMT:34227657,
	title = {One third of cases of new-onset diabetic ketosis in adults are associated with ketosis-prone type 2 diabetes-A systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/34227657},
	author = {Kovács, Adrienn Nikolett and Bunduc, Stefania and Veres, Dániel and Pálinkás, Dániel and Gagyi , Endre and Hegyi, Péter Jenő and Erőss, Bálint Mihály and Mihály, Emese and Hegyi, Péter and Hosszúfalusi, Nóra},
	doi = {10.1002/dmrr.3743},
	journal-iso = {DIABETES-METAB RES},
	journal = {DIABETES-METABOLISM RESEARCH AND REVIEWS},
	volume = {40},
	unique-id = {34227657},
	issn = {1520-7552},
	abstract = {Ketosis-prone type 2 diabetes was defined by the World Health Organization in 2019. According to the literature, the diagnosis is based on the presence of ketosis, islet autoantibody negativity and preserved insulin secretion. Our meta-analysis assessed the prevalence and clinical characteristics of ketosis-prone type 2 diabetes among patients hospitalised with diabetic ketoacidosis (DKA) or ketosis.The systematic search was performed in five main databases as of 15 October 2021 without restrictions. We calculated the pooled prevalence of ketosis-prone type 2 diabetes (exposed group) within the diabetic population under examination, patients with ketoacidosis or ketosis, to identify the clinical characteristics, and we compared it to type 1 diabetes (the comparator group). The random effects model provided pooled estimates as prevalence, odds ratio and mean difference (MD) with 95% confidence intervals.Eleven articles were eligible for meta-analysis, thus incorporating 2010 patients of various ethnic backgrounds. Among patients presenting with DKA or ketosis at the onset of diabetes, 35% (95% CI: 24%-49%) had ketosis-prone type 2 diabetes. These patients were older (MD = 11.55 years; 95% CI: 5.5-17.6) and had a significantly higher body mass index (BMI) (MD = 5.48 kg/m2 ; 95% CI: 3.25-7.72) than those with type 1 diabetes.Ketosis-prone type 2 diabetes accounts for one third of DKA or ketosis at the onset of diabetes in adults. These patients are characterised by islet autoantibody negativity and preserved insulin secretion. They are older and have a higher BMI compared with type 1 diabetes. C-peptide and diabetes-related autoantibody measurement is essential to identify this subgroup among patients with ketosis at the onset of diabetes.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {1520-7560},
	orcid-numbers = {Veres, Dániel/0000-0002-9687-3556; Erőss, Bálint Mihály/0000-0003-3658-8427; Mihály, Emese/0000-0003-3046-7341; Hegyi, Péter/0000-0003-0399-7259; Hosszúfalusi, Nóra/0000-0002-9469-372X}
}

@article{MTMT:34566520,
	title = {A MIKROSZKÓPOS COLITIS RIZIKÓ FAKTORAI: AZ IRODALOM ÖSSZEFOGLALÁSA ÉS METAANALÍZIS},
	url = {https://m2.mtmt.hu/api/publication/34566520},
	author = {Rancz, Anett and Teutsch, Brigitta and Obeidat, Mahmoud Mohammadnour Suleiman and Veres, Dániel and Weidinger, G and Erőss, Bálint Mihály and Hegyi, Péter and Mihály, Emese},
	journal-iso = {MBA},
	journal = {MAGYAR BELORVOSI ARCHIVUM},
	volume = {76},
	unique-id = {34566520},
	issn = {0133-5464},
	year = {2023},
	pages = {329-330},
	orcid-numbers = {Teutsch, Brigitta/0000-0002-9530-7886; Erőss, Bálint Mihály/0000-0003-3658-8427; Hegyi, Péter/0000-0003-0399-7259; Mihály, Emese/0000-0003-3046-7341}
}