@mastersthesis{MTMT:34753785, title = {Az alternatív hipertrófia módszerek molekuláris hatásai}, url = {https://m2.mtmt.hu/api/publication/34753785}, author = {Gombos, Zoltán}, unique-id = {34753785}, year = {2024} } @article{MTMT:33866054, title = {DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation}, url = {https://m2.mtmt.hu/api/publication/33866054}, author = {Jókai, Mátyás and Torma, Ferenc Gergely and McGreevy, Kristen M. and Koltai, Erika and Bori, Zoltán and Bábszky, Gergely and Bakonyi, Péter and Gombos, Zoltán and György, Bernadett and Aczél, Dóra Tímea and Tóth, László and Osváth, Péter and Fridvalszki, Marcell Norbert and Téglás, Tímea and Pósa, Anikó and Kujach, Sylwester and Olek, Robert and Kawamura, Takuji and Seki, Yasuhiro and Suzuki, Katsuhiko and Tanisawa, Kumpei and Goto, Sataro and Kerepesi, Csaba and Boldogh, Istvan and Ba, Xueqing and Davies, Kelvin J. A. and Horvath, Steve and Radák, Zsolt}, doi = {10.1007/s11357-023-00826-1}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {45}, unique-id = {33866054}, issn = {2509-2715}, abstract = {DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO 2 max ( ρ = 0.2, p = 6.4E − 4, r = 0.19, p = 1.2E − 3), Jumpmax ( p = 0.11, p = 5.5E − 2, r = 0.13, p = 2.8E − 2), Gripmax ( ρ = 0.17, p = 3.5E − 3, r = 0.16, p = 5.6E − 3), and HDL levels ( ρ = 0.18, p = 1.95E − 3, r = 0.19, p = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration ( ρ : − 0.18, p = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life.}, year = {2023}, eissn = {2509-2723}, pages = {2805-2817}, orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Bori, Zoltán/0000-0003-1253-060X; Bábszky, Gergely/0000-0002-5939-8434; Bakonyi, Péter/0000-0002-6120-3384; György, Bernadett/0000-0002-3787-7338; Tóth, László/0000-0001-9650-1202; Fridvalszki, Marcell Norbert/0000-0001-9445-9397; Pósa, Anikó/0000-0003-2167-2888; Kerepesi, Csaba/0000-0001-9541-246X; Radák, Zsolt/0000-0003-1297-6804} } @CONFERENCE{MTMT:33022291, title = {Testedzés hatása a humán mikrobiomra: élsportolók vizsgálata a koronavírus függvényében}, url = {https://m2.mtmt.hu/api/publication/33022291}, author = {Bábszky, Gergely and Torma, Ferenc Gergely and Aczél, Dóra Tímea and Bakonyi, Péter and Gombos, Zoltán and Radák, Zsolt}, booktitle = {VII. SPORTTUDOMÁNYI PHD SZIMPÓZIUM - PROGRAM- ÉS ABSZTRAKTFÜZET}, unique-id = {33022291}, year = {2022}, pages = {15-15}, orcid-numbers = {Bábszky, Gergely/0000-0002-5939-8434; Bakonyi, Péter/0000-0002-6120-3384} } @article{MTMT:33807683, title = {A premenstruációs tünetegyüttes hatása a maximális és robbanékony erőre női felnőtt jégkorongozók esetében}, url = {https://m2.mtmt.hu/api/publication/33807683}, author = {Katrics, Petra and Laczkó, Attila and Gombos, Zoltán and Béres, Sándor and Tóth, László and Bogár, Lilla and Márton, Laura and Benczenleitner, Ottó}, journal-iso = {ACTA Universitatis: Sectio Sport}, journal = {ACTA UNIVERSITATIS DE CAROLO ESZTERHÁZY NOMINATAE: SECTIO SPORT}, volume = {51}, unique-id = {33807683}, issn = {2677-0105}, year = {2021}, pages = {7-18}, orcid-numbers = {Tóth, László/0000-0001-9650-1202} } @article{MTMT:32547313, title = {A több évtizeden át tartó testedzés hatása az irizin hormon szintjére. the effect of decades long training on the irisin hormone}, url = {https://m2.mtmt.hu/api/publication/32547313}, author = {Gombos, Zoltán and Torma, Ferenc Gergely and Kolonics, Attila and Radák, Zsolt}, journal-iso = {M SPORTTUD SZLE}, journal = {MAGYAR SPORTTUDOMÁNYI SZEMLE}, volume = {22}, unique-id = {32547313}, issn = {1586-5428}, year = {2021}, pages = {10-16}, orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:32318905, title = {COVID-19 Infection Alters the Microbiome: Elite Athletes and Sedentary Patients Have Similar Bacterial Flora}, url = {https://m2.mtmt.hu/api/publication/32318905}, author = {Bábszky, Gergely and Torma, Ferenc Gergely and Aczél, Dóra Tímea and Bakonyi, Péter and Gombos, Zoltán and Feher, Janos and Szabó, Dóra and Ligeti, Balázs and Pongor, Sándor and Balogh, László and Pósa, Anikó and Radák, Zsolt}, doi = {10.3390/genes12101577}, journal-iso = {GENES-BASEL}, journal = {GENES}, volume = {12}, unique-id = {32318905}, issn = {2073-4425}, year = {2021}, eissn = {2073-4425}, orcid-numbers = {Bábszky, Gergely/0000-0002-5939-8434; Bakonyi, Péter/0000-0002-6120-3384; Szabó, Dóra/0000-0002-8601-3923; Pósa, Anikó/0000-0003-2167-2888; Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:32113803, title = {Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels.}, url = {https://m2.mtmt.hu/api/publication/32113803}, author = {Gombos, Zoltán and Koltai, Erika and Torma, Ferenc Gergely and Bakonyi, Péter and Kolonics, Attila and Aczél, Dóra Tímea and Ditrói, Tamás and Nagy, Péter and Kawamura, Takuji and Radák, Zsolt}, doi = {10.3390/ijms22147588}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {22}, unique-id = {32113803}, issn = {1661-6596}, abstract = {Despite the intensive investigation of the molecular mechanism of skeletal muscle hypertrophy, the underlying signaling processes are not completely understood. Therefore, we used an overload model, in which the main synergist muscles (gastrocnemius, soleus) of the plantaris muscle were surgically removed, to cause a significant overload in the remaining plantaris muscle of 8-month-old Wistar male rats. SIRT1-associated pro-anabolic, pro-catabolic molecular signaling pathways, NAD and H2S levels of this overload-induced hypertrophy were studied. Fourteen days of overload resulted in a significant 43% (p < 0.01) increase in the mass of plantaris muscle compared to sham operated animals. Cystathionine-β-synthase (CBS) activities and bioavailable H2S levels were not modified by overload. On the other hand, overload-induced hypertrophy of skeletal muscle was associated with increased SIRT1 (p < 0.01), Akt (p < 0.01), mTOR, S6 (p < 0.01) and suppressed sestrin 2 levels (p < 0.01), which are mostly responsible for anabolic signaling. Decreased FOXO1 and SIRT3 signaling (p < 0.01) suggest downregulation of protein breakdown and mitophagy. Decreased levels of NAD+, sestrin2, OGG1 (p < 0.01) indicate that the redox milieu of skeletal muscle after 14 days of overloading is reduced. The present investigation revealed novel cellular interactions that regulate anabolic and catabolic processes in the hypertrophy of skeletal muscle.}, keywords = {skeletal muscle; Redox regulation; anabolic signaling pathways; overload-induced hypertrophy}, year = {2021}, eissn = {1422-0067}, orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Bakonyi, Péter/0000-0002-6120-3384; Kolonics, Attila/0000-0003-3990-5336; Nagy, Péter/0000-0003-3393-235X; Radák, Zsolt/0000-0003-1297-6804} } @CONFERENCE{MTMT:32092019, title = {A kompenzatórikus hipertrófia molekuláris hatásai}, url = {https://m2.mtmt.hu/api/publication/32092019}, author = {Gombos, Zoltán and Koltai, Erika and Torma, Ferenc Gergely and Radák, Zsolt}, booktitle = {VI. SPORTTUDOMÁNYI PHD SZIMPÓZIUM PROGRAM- ÉS ABSZTRAKTFÜZET}, unique-id = {32092019}, year = {2021}, pages = {27-27}, orcid-numbers = {Koltai, Erika/0000-0002-1370-2955} } @CONFERENCE{MTMT:32091974, title = {Testedzés hatása a humán mikrobiomra: élsportolók vizsgálata a koronavírus függvényében}, url = {https://m2.mtmt.hu/api/publication/32091974}, author = {Bábszky, Gergely and Torma, Ferenc Gergely and Aczél, Dóra Tímea and Bakonyi, Péter and Gombos, Zoltán and Radák, Zsolt}, booktitle = {VI. SPORTTUDOMÁNYI PHD SZIMPÓZIUM PROGRAM- ÉS ABSZTRAKTFÜZET}, unique-id = {32091974}, year = {2021}, pages = {18-18}, orcid-numbers = {Bábszky, Gergely/0000-0002-5939-8434; Bakonyi, Péter/0000-0002-6120-3384} } @CONFERENCE{MTMT:32091922, title = {Az élethosszon át tartó edzés hatása a vér irizin szintjére}, url = {https://m2.mtmt.hu/api/publication/32091922}, author = {Gombos, Zoltán and Koltai, Erika and Torma, Ferenc Gergely and Radák, Zsolt}, booktitle = {VI. SPORTTUDOMÁNYI PHD SZIMPÓZIUM PROGRAM- ÉS ABSZTRAKTFÜZET}, unique-id = {32091922}, year = {2021}, pages = {12-12}, orcid-numbers = {Koltai, Erika/0000-0002-1370-2955} }