@article{MTMT:33712712,
	title = {Structural Adaptation of the Single-Stranded DNA-Binding Protein C-Terminal to DNA Metabolizing Partners Guides Inhibitor Design},
	url = {https://m2.mtmt.hu/api/publication/33712712},
	author = {Tököli, Attila and Bodnár, Brigitta and Bogár, Ferenc and Paragi, Gábor and Hetényi, Anasztázia and Bartus, Éva and Wéber, Edit and Hegedüs, Zsófia and Szabó, Zoltán and Kecskeméti, Gábor and Szakonyi, Gerda and Martinek, Tamás},
	doi = {10.3390/pharmaceutics15041032},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {33712712},
	issn = {1999-4923},
	abstract = {Single-stranded DNA-binding protein (SSB) is a bacterial interaction hub and an appealing target for antimicrobial therapy. Understanding the structural adaptation of the disordered SSB C-terminus (SSB-Ct) to DNA metabolizing enzymes (e.g., ExoI and RecO) is essential for designing high-affinity SSB mimetic inhibitors. Molecular dynamics simulations revealed the transient interactions of SSB-Ct with two hot spots on ExoI and RecO. The residual flexibility of the peptide–protein complexes allows adaptive molecular recognition. Scanning with non-canonical amino acids revealed that modifications at both termini of SSB-Ct could increase the affinity, supporting the two-hot-spot binding model. Combining unnatural amino acid substitutions on both segments of the peptide resulted in enthalpy-enhanced affinity, accompanied by enthalpy–entropy compensation, as determined by isothermal calorimetry. NMR data and molecular modeling confirmed the reduced flexibility of the improved affinity complexes. Our results highlight that the SSB-Ct mimetics bind to the DNA metabolizing targets through the hot spots, interacting with both of segments of the ligands.},
	year = {2023},
	eissn = {1999-4923},
	orcid-numbers = {Tököli, Attila/0000-0001-8413-3182; Bogár, Ferenc/0000-0002-0611-1452; Paragi, Gábor/0000-0001-5408-1748; Hetényi, Anasztázia/0000-0001-8080-6992; Bartus, Éva/0000-0001-9976-6978; Wéber, Edit/0000-0002-5904-0619; Hegedüs, Zsófia/0000-0002-5546-8167; Szabó, Zoltán/0000-0001-8278-8038; Kecskeméti, Gábor/0000-0002-5584-6869; Szakonyi, Gerda/0000-0002-4366-4283; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:32570862,
	title = {Fehérje méretű molekulák humán sejtekbe juttatása lipid-raft mediált endocitózissal},
	url = {https://m2.mtmt.hu/api/publication/32570862},
	author = {Hetényi, Anasztázia and Imre, Norbert and Szabó, Enikő and Bodnár, Brigitta and Szkalisity, Ábel and Gróf, Ilona and Bocsik, Alexandra and Deli, Mária Anna and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Martinek, Tamás},
	journal-iso = {BIOKÉMIA},
	journal = {BIOKÉMIA: A MAGYAR BIOKÉMIAI EGYESÜLET FOLYÓIRATA},
	volume = {45},
	unique-id = {32570862},
	issn = {0133-8455},
	year = {2021},
	eissn = {2060-8152},
	pages = {67-83},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Deli, Mária Anna/0000-0001-6084-6524; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Martinek, Tamás/0000-0003-3168-8066}
}

@{MTMT:32024174,
	title = {Endocytosis routing sequence peptide for cell delivery systems},
	url = {https://m2.mtmt.hu/api/publication/32024174},
	author = {Imre, Norbert and Martinek, Tamás and Hetényi, Anasztázia and Bodnár, Brigitta and Monostori, Eva and Czibula, Agnes and Szabo, Eniko and Deli, Mária Anna and Horvath, Peter},
	unique-id = {32024174},
	abstract = {The present invention relates to cell delivery systems. The present invention specifically relates to new methods of intracellular delivery by endocytosis routing sequence peptides having the sequence of WYKYV or analogs thereof, by caveloar/lipid raft-mediated endocytosis and uses of such peptides. The invention also relates to conjugates comprising said peptides and uses thereof in therapies wherein intracellular delivery of a therapeutically active mol. is required.},
	keywords = {endocytosis routing peptide sequence cell delivery drugs},
	year = {2020},
	orcid-numbers = {Martinek, Tamás/0000-0003-3168-8066; Hetényi, Anasztázia/0000-0001-8080-6992; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:31126947,
	title = {Routing Nanomolar Protein Cargoes to Lipid Raft‐Mediated/Caveolar Endocytosis through a Ganglioside GM1‐Specific Recognition Tag},
	url = {https://m2.mtmt.hu/api/publication/31126947},
	author = {Imre, Norbert and Hetényi, Anasztázia and Szabó, Enikő and Bodnár, Brigitta and Szkalisity, Ábel and Gróf, Ilona and Bocsik, Alexandra and Deli, Mária Anna and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Martinek, Tamás},
	doi = {10.1002/advs.201902621},
	journal-iso = {ADV SCI},
	journal = {ADVANCED SCIENCE},
	volume = {7},
	unique-id = {31126947},
	year = {2020},
	eissn = {2198-3844},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Deli, Mária Anna/0000-0001-6084-6524; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Martinek, Tamás/0000-0003-3168-8066}
}

@misc{MTMT:31624665,
	title = {IgG bejuttatása specifikus GM1 gangliozid felismerő szekvenciával},
	url = {https://m2.mtmt.hu/api/publication/31624665},
	author = {Imre, Norbert and Hetényi, Anasztázia and Szabó, Enikő and Bodnár, Brigitta and Szkalisity, Ábel and Gróf, Ilona and Bocsik, Alexandra and Deli, A. Mária and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Martinek, Tamás},
	unique-id = {31624665},
	year = {2019},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Martinek, Tamás/0000-0003-3168-8066}
}

@mastersthesis{MTMT:3402058,
	title = {Synthesis of monosaccharide and nucleoside conjugates of estrone derivatives},
	url = {https://m2.mtmt.hu/api/publication/3402058},
	author = {Bodnár, Brigitta},
	doi = {10.14232/phd.9761},
	publisher = {SZTE},
	unique-id = {3402058},
	year = {2018}
}

@misc{MTMT:3337576,
	title = {Synthesis of 5'-azidonucleosides as building blocks for the preparation of biologically active bioconjugates},
	url = {https://m2.mtmt.hu/api/publication/3337576},
	author = {Bodnár, Brigitta and Kovács, Lajos and Zoltán, Kupihár},
	unique-id = {3337576},
	year = {2017},
	orcid-numbers = {Kovács, Lajos/0000-0002-0331-3980}
}

@misc{MTMT:3337573,
	title = {5'-Azidonukleozidok előállítása},
	url = {https://m2.mtmt.hu/api/publication/3337573},
	author = {Bodnár, Brigitta},
	unique-id = {3337573},
	year = {2017}
}

@misc{MTMT:3337568,
	title = {The synthesis of 5'-azido-5'-deoxynucleosides and homologues thereof},
	url = {https://m2.mtmt.hu/api/publication/3337568},
	author = {Bodnár, Brigitta and Kovács, Lajos and Zoltán, Kupihár},
	unique-id = {3337568},
	year = {2017},
	orcid-numbers = {Kovács, Lajos/0000-0002-0331-3980}
}

@{MTMT:3327529,
	title = {5'-linkerrel módosított nukleozidok},
	url = {https://m2.mtmt.hu/api/publication/3327529},
	author = {Kupihár, Zoltán and Bodnár, Brigitta and Kovács, Lajos},
	unique-id = {3327529},
	year = {2017},
	orcid-numbers = {Kupihár, Zoltán/0000-0001-5499-7617; Kovács, Lajos/0000-0002-0331-3980}
}