@mastersthesis{MTMT:31395525, title = {Ubikvitin formák és az ubikvitináció vizsgálata Drosophila melanogasterben [Examination of ubiquitin forms and ubiquitination in Drosophila melanogaster]}, url = {https://m2.mtmt.hu/api/publication/31395525}, author = {Nagy, Ágota}, doi = {10.14232/phd.10251}, publisher = {SZTE}, unique-id = {31395525}, year = {2020} } @article{MTMT:31158977, title = {Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster.}, url = {https://m2.mtmt.hu/api/publication/31158977}, author = {Kovács, Levente and Nagy, Ágota and Pál, Margit and Deák, Péter}, doi = {10.1242/jcs.237511}, journal-iso = {J CELL SCI}, journal = {JOURNAL OF CELL SCIENCE}, volume = {133}, unique-id = {31158977}, issn = {0021-9533}, abstract = {Deubiquitylating (DUB) enzymes free covalently linked ubiquitin moieties from ubiquitin-ubiquitin and ubiquitin-protein conjugates, and thereby maintain the equilibrium between free and conjugated ubiquitin moieties and regulate ubiquitin-mediated cellular processes. Here, we performed genetic analyses of mutant phenotypes in Drosophila melanogaster and demonstrate that loss of Usp14 function results in male sterility, with defects in spermatid individualization and reduced testicular free monoubiquitin levels. These phenotypes were rescued by germline-specific overexpression of wild-type Usp14. Synergistic genetic interactions with Ubi-p63E and cycloheximide sensitivity suggest that ubiquitin shortage is a primary cause of male sterility. In addition, Usp14 is predominantly expressed in testes in Drosophila, indicating a higher demand for this DUB in testes that is also reflected by testis-specific loss-of-function Usp14 phenotypes. Collectively, these results suggest a major role of Usp14 in maintaining normal steady state free monoubiquitin levels during the later stages of Drosophila spermatogenesis.This article has an associated First Person interview with the first author of the paper.}, keywords = {deubiquitination; USP14; Deubiquitylaton; Drosophila spermatogenesis; Ubiquitin equilibrium}, year = {2020}, eissn = {1477-9137}, orcid-numbers = {Kovács, Levente/0000-0002-3226-3740} } @article{MTMT:30343721, title = {Developmental- and tissue-specific changes of ubiquitin forms in Drosophila melanogaster}, url = {https://m2.mtmt.hu/api/publication/30343721}, author = {Nagy, Ágota and Kovács, Levente and Lipinszki, Zoltán and Pál, Margit and Deák, Péter}, doi = {10.20944/preprints201806.0431.v1}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {13}, unique-id = {30343721}, issn = {1932-6203}, year = {2018}, eissn = {1932-6203}, orcid-numbers = {Kovács, Levente/0000-0002-3226-3740; Lipinszki, Zoltán/0000-0002-2067-0832} } @{MTMT:3208417, title = {Developmental stage- and tissue-specific ubiquitin levels in Drosophila melanogaster}, url = {https://m2.mtmt.hu/api/publication/3208417}, author = {Nagy, Ágota and Zoltán, Lipinszki and Kovács, Levente and Margit, Pál and Deák, Péter}, booktitle = {Hungarian Molecular Life Sciences 2017}, unique-id = {3208417}, year = {2017}, pages = {59-60}, orcid-numbers = {Kovács, Levente/0000-0002-3226-3740} } @CONFERENCE{MTMT:3081790, title = {A Drosophila APC/C egyedi sajátossága = [A unique feature of the Drosophila APC/C]}, url = {https://m2.mtmt.hu/api/publication/3081790}, author = {Nagy, Ágota and Horváth, Judit and Nagy, Olga Mária and Pál, Margit and Kovács, Levente and Deák, Péter}, booktitle = {17. Kolozsvári Biológus Napok}, unique-id = {3081790}, year = {2016}, pages = {61-61}, orcid-numbers = {Nagy, Olga Mária/0000-0003-1471-5165; Kovács, Levente/0000-0002-3226-3740} } @CONFERENCE{MTMT:3081837, title = {A Drosophila APC/C érdekes új alegységei}, url = {https://m2.mtmt.hu/api/publication/3081837}, author = {Nagy, Ágota}, booktitle = {Genetikai mühelyek magyarországon XIV.}, unique-id = {3081837}, year = {2015} } @CONFERENCE{MTMT:3081798, title = {A Drosophila APC/C érdekes új alegységei = [Interesting new APC/C subunits in Drosophila]}, url = {https://m2.mtmt.hu/api/publication/3081798}, author = {Nagy, Ágota and Horváth, Judit and Nagy, Olga Mária and Pál, Margit and Kovács, Levente and Deák, Péter}, booktitle = {16. Kolozsvári Biológus Napok : Kolozsvár, 2015 április 16–18. : kivonatfüzet = [16th Biology Days : Cluj-Napoca, April 16-18 2015 : abstracts]}, unique-id = {3081798}, year = {2015}, pages = {36-36}, orcid-numbers = {Nagy, Olga Mária/0000-0003-1471-5165; Kovács, Levente/0000-0002-3226-3740} } @CONFERENCE{MTMT:2960466, title = {Characterization of a new APC/C subunit in Drosophila melanogaster}, url = {https://m2.mtmt.hu/api/publication/2960466}, author = {Nagy, Ágota and Pal, M and Nagy, Olga Mária and Kovacs, L and Deák, Péter}, booktitle = {16 th European Cell Cycle Workshop and EMBO Workshop on the Cell Cycle}, unique-id = {2960466}, year = {2015}, pages = {100}, orcid-numbers = {Nagy, Olga Mária/0000-0003-1471-5165} } @{MTMT:2960444, title = {Anaphase promoting complex subunits with unusual characteristics}, url = {https://m2.mtmt.hu/api/publication/2960444}, author = {Nagy, Ágota and Horvath, J and Nagy, Olga Mária and Pal, M and Deák, Péter}, booktitle = {Hungarian Molecular Life Sciences 2015}, unique-id = {2960444}, year = {2015}, pages = {216}, orcid-numbers = {Nagy, Olga Mária/0000-0003-1471-5165} }