@article{MTMT:32733913,
	title = {α/β-Peptides as Nanomolar Triggers of Lipid Raft-Mediated Endocytosis through GM1 Ganglioside Recognition},
	url = {https://m2.mtmt.hu/api/publication/32733913},
	author = {Hetényi, Anasztázia and Szabó, Enikő and Imre, Norbert and Nath Bhaumik, Kaushik and Tököli, Attila and Füzesi, Tamás and Hollandi, Réka and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Deli, Mária Anna and Martinek, Tamás},
	doi = {10.3390/pharmaceutics14030580},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {14},
	unique-id = {32733913},
	issn = {1999-4923},
	abstract = {Cell delivery of therapeutic macromolecules and nanoparticles is a critical drug development challenge. Translocation through lipid raft-mediated endocytic mechanisms is being sought, as it can avoid rapid lysosomal degradation. Here, we present a set of short alpha/beta-peptide tags with high affinity to the lipid raft-associated ganglioside GM1. These sequences induce effective internalization of the attached immunoglobulin cargo. The structural requirements of the GM1-peptide interaction are presented, and the importance of the membrane components are shown. The results contribute to the development of a receptor-based cell delivery platform.},
	year = {2022},
	eissn = {1999-4923},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Tököli, Attila/0000-0001-8413-3182; Monostori, Éva/0000-0002-7442-3562; Deli, Mária Anna/0000-0001-6084-6524; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:32570862,
	title = {Fehérje méretű molekulák humán sejtekbe juttatása lipid-raft mediált endocitózissal},
	url = {https://m2.mtmt.hu/api/publication/32570862},
	author = {Hetényi, Anasztázia and Imre, Norbert and Szabó, Enikő and Bodnár, Brigitta and Szkalisity, Ábel and Gróf, Ilona and Bocsik, Alexandra and Deli, Mária Anna and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Martinek, Tamás},
	journal-iso = {BIOKÉMIA},
	journal = {BIOKÉMIA: A MAGYAR BIOKÉMIAI EGYESÜLET FOLYÓIRATA},
	volume = {45},
	unique-id = {32570862},
	issn = {0133-8455},
	year = {2021},
	eissn = {2060-8152},
	pages = {67-83},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Deli, Mária Anna/0000-0001-6084-6524; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Martinek, Tamás/0000-0003-3168-8066}
}

@mastersthesis{MTMT:32476788,
	title = {Intracellular protein delivery with the use of endocytosis routing sequences [Fehérjék sejtbe juttatása endocitózis útvonalra irányító szekvenciákkal]},
	url = {https://m2.mtmt.hu/api/publication/32476788},
	author = {Imre, Norbert},
	doi = {10.14232/phd.10645},
	publisher = {SZTE},
	unique-id = {32476788},
	year = {2021}
}

@{MTMT:32024174,
	title = {Endocytosis routing sequence peptide for cell delivery systems},
	url = {https://m2.mtmt.hu/api/publication/32024174},
	author = {Imre, Norbert and Martinek, Tamás and Hetényi, Anasztázia and Bodnár, Brigitta and Monostori, Eva and Czibula, Agnes and Szabo, Eniko and Deli, Mária Anna and Horvath, Peter},
	unique-id = {32024174},
	abstract = {The present invention relates to cell delivery systems. The present invention specifically relates to new methods of intracellular delivery by endocytosis routing sequence peptides having the sequence of WYKYV or analogs thereof, by caveloar/lipid raft-mediated endocytosis and uses of such peptides. The invention also relates to conjugates comprising said peptides and uses thereof in therapies wherein intracellular delivery of a therapeutically active mol. is required.},
	keywords = {endocytosis routing peptide sequence cell delivery drugs},
	year = {2020},
	orcid-numbers = {Martinek, Tamás/0000-0003-3168-8066; Hetényi, Anasztázia/0000-0001-8080-6992; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:31126947,
	title = {Routing Nanomolar Protein Cargoes to Lipid Raft‐Mediated/Caveolar Endocytosis through a Ganglioside GM1‐Specific Recognition Tag},
	url = {https://m2.mtmt.hu/api/publication/31126947},
	author = {Imre, Norbert and Hetényi, Anasztázia and Szabó, Enikő and Bodnár, Brigitta and Szkalisity, Ábel and Gróf, Ilona and Bocsik, Alexandra and Deli, Mária Anna and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Martinek, Tamás},
	doi = {10.1002/advs.201902621},
	journal-iso = {ADV SCI},
	journal = {ADVANCED SCIENCE},
	volume = {7},
	unique-id = {31126947},
	year = {2020},
	eissn = {2198-3844},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Deli, Mária Anna/0000-0001-6084-6524; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Martinek, Tamás/0000-0003-3168-8066}
}

@misc{MTMT:31624665,
	title = {IgG bejuttatása specifikus GM1 gangliozid felismerő szekvenciával},
	url = {https://m2.mtmt.hu/api/publication/31624665},
	author = {Imre, Norbert and Hetényi, Anasztázia and Szabó, Enikő and Bodnár, Brigitta and Szkalisity, Ábel and Gróf, Ilona and Bocsik, Alexandra and Deli, A. Mária and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Martinek, Tamás},
	unique-id = {31624665},
	year = {2019},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:30679490,
	title = {Synthesis and Statistical Optimization of Poly (Lactic-Co-Glycolic Acid) Nanoparticles Encapsulating GLP1 Analog Designed for Oral Delivery},
	url = {https://m2.mtmt.hu/api/publication/30679490},
	author = {Ismail, Ruba and Sovány, Tamás and Gácsi, Attila and Ambrus, Rita and Katona, Gábor and Imre, Norbert and Pannonhalminé Csóka, Ildikó},
	doi = {10.1007/s11095-019-2620-9},
	journal-iso = {PHAR RES},
	journal = {PHARMACEUTICAL RESEARCH},
	volume = {36},
	unique-id = {30679490},
	issn = {0724-8741},
	year = {2019},
	eissn = {1573-904X},
	orcid-numbers = {Ismail, Ruba/0000-0002-5122-9513; Sovány, Tamás/0000-0003-3392-7788; Katona, Gábor/0000-0003-1564-4813; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:30434125,
	title = {Dual Action of the PN159/KLAL/MAP Peptide. Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability.},
	url = {https://m2.mtmt.hu/api/publication/30434125},
	author = {Bocsik, Alexandra and Gróf, Ilona and Kiss, Lóránd and Ötvös, Ferenc and Zsíros, Ottó and Daruka, Lejla and Fülöp, Lívia and Vastag, Monika and Kittel, Ágnes and Imre, Norbert and Martinek, Tamás and Pál, Csaba and Révész, Piroska and Deli, Mária Anna},
	doi = {10.3390/pharmaceutics11020073},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {11},
	unique-id = {30434125},
	issn = {1999-4923},
	abstract = {The absorption of drugs is limited by the epithelial barriers of the gastrointestinal tract. One of the strategies to improve drug delivery is the modulation of barrier function by the targeted opening of epithelial tight junctions. In our previous study the 18-mer amphiphilic PN159 peptide was found to be an effective tight junction modulator on intestinal epithelial and blood⁻brain barrier models. PN159, also known as KLAL or MAP, was described to interact with biological membranes as a cell-penetrating peptide. In the present work we demonstrated that the PN159 peptide as a penetration enhancer has a dual action on intestinal epithelial cells. The peptide safely and reversibly enhanced the permeability of Caco-2 monolayers by opening the intercellular junctions. The penetration of dextran molecules with different size and four efflux pump substrate drugs was increased several folds. We identified claudin-4 and -7 junctional proteins by docking studies as potential binding partners and targets of PN159 in the opening of the paracellular pathway. In addition to the tight junction modulator action, the peptide showed cell membrane permeabilizing and antimicrobial effects. This dual action is not general for cell-penetrating peptides (CPPs), since the other three CPPs tested did not show barrier opening effects.},
	keywords = {Drug delivery; Claudin; Caco-2; Antimicrobial peptide; KLAL; PN159; absorption enhancer; cell-penetrating peptide (CPP); intestinal epithelial cells; tight junction modulator},
	year = {2019},
	eissn = {1999-4923},
	orcid-numbers = {Fülöp, Lívia/0000-0002-8010-0129; Martinek, Tamás/0000-0003-3168-8066; Révész, Piroska/0000-0002-5336-6052; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:2993079,
	title = {Foldameric probes for membrane interactions by induced β-sheet folding},
	url = {https://m2.mtmt.hu/api/publication/2993079},
	author = {Hegedüs, Zsófia and Makra, Ildikó and Imre, Norbert and Hetényi, Anasztázia and Mándity, István and Monostori, Éva and Martinek, Tamás},
	doi = {10.1039/C5CC09257D},
	journal-iso = {CHEM COMMUN},
	journal = {CHEMICAL COMMUNICATIONS},
	volume = {52},
	unique-id = {2993079},
	issn = {1359-7345},
	abstract = {Design strategies were devised for alpha/beta-peptide foldameric analogues of the antiangiogenic anginex with the goal of mimicking the diverse structural features from the unordered conformation to a folded beta-sheet in response to membrane interactions. Structure-activity relationships were investigated in the light of different beta-sheet folding levels.},
	keywords = {PROTEIN; ACID; DESIGN; SECONDARY STRUCTURE; ANGIOGENESIS; CIRCULAR-DICHROISM; Practical guide; HAIRPIN; PEPTIDE ANGINEX},
	year = {2016},
	eissn = {1364-548X},
	pages = {1891-1894},
	orcid-numbers = {Hegedüs, Zsófia/0000-0002-5546-8167; Hetényi, Anasztázia/0000-0001-8080-6992; Mándity, István/0000-0003-2865-6143; Monostori, Éva/0000-0002-7442-3562; Martinek, Tamás/0000-0003-3168-8066}
}