TY - CONF AU - Balogh-Hartmann, Fruzsina AU - Páger, Csilla AU - Bufa, Anita AU - Madarászné Horváth, Ibolya AU - Marosvölgyi, Tamás AU - Makszin, Lilla ED - Kovács, Bettina ED - Glázer-Kniesz, Adrienn ED - Tislér, Ádám TI - Adalékanyagtartalmú növényi eredetű tejhelyettesítő italok fehérjetartalmának profilozása mikrofluidikai eljárással T2 - Absztraktkötet: XII. Interdiszciplináris Doktorandusz Konferencia = Book of Abstract: XII. Interdisciplinary Doctoral Conference PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat C1 - Pécs SN - 9789636262457 PY - 2024 SP - 117 EP - 117 PG - 1 UR - https://m2.mtmt.hu/api/publication/34846032 ID - 34846032 LA - Hungarian DB - MTMT ER - TY - CONF AU - Kaçar, Ömer Furkan AU - Szentes, T AU - Verzár, Zsófia AU - Poór, Viktória AU - Marosvölgyi, Tamás AU - Szabó, Éva ED - Kovács, Bettina ED - Glázer-Kniesz, Adrienn ED - Tislér, Ádám TI - Comparison of Quality Parameters and Fatty Acid Content of Fish Oil Supplements Across Countries T2 - Absztraktkötet: XII. Interdiszciplináris Doktorandusz Konferencia = Book of Abstract: XII. Interdisciplinary Doctoral Conference PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat C1 - Pécs SN - 9789636262457 PY - 2024 SP - 17 EP - 17 PG - 1 UR - https://m2.mtmt.hu/api/publication/34813000 ID - 34813000 LA - English DB - MTMT ER - TY - JOUR AU - Marosvölgyi, Tamás AU - Mintál, Kitti AU - Borbásné Farkas, Kornélia AU - Sipos, Zoltán AU - Makszin, Lilla AU - Szabó, Éva AU - Tóth, Attila AU - Kocsis, Béla AU - Kovács, Krisztina AU - Hormay, Edina AU - Lénárd, László AU - Karádi, Zoltán György AU - Bufa, Anita TI - Antibiotics and probiotics-induced effects on the total fatty acid composition of feces in a rat model JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-024-57046-6 UR - https://m2.mtmt.hu/api/publication/34745300 ID - 34745300 N1 - * Megosztott szerzőség AB - Fatty acids (FAs) play important roles as membrane components and signal transduction molecules. Changes in short chain FA (SCFA) composition are associated with gut microbiota modifications. However, the effect of bacteria-driven changes on the detailed FA spectrum has not been explored yet. We investigated the effect of antibiotics (ABx) and/or probiotics, in four treatment groups on rat stool FA composition. Principal component analysis indicated that the chromatogram profiles of the treatment groups differ, which was also observed at different time points. Linear mixed effects models showed that in the parameters compared (sampling times, treatments. and their interactions), both the weight percentage and the concentration of FAs were affected by ABx and probiotic administration. This study found that the gut microbiome defines trans and branched saturated FAs, most saturated FAs, and unsaturated FAs with less carbon atoms. These results are among the first ones to demonstrate the restoring effects of a probiotic mixture on a substantial part of the altered total FA spectrum, and also revealed a previously unknown relationship between gut bacteria and a larger group of FAs. These findings suggest that intestinal bacteria produce not only SCFAs but also other FAs that may affect the host’s physiological processes. LA - English DB - MTMT ER - TY - JOUR AU - Hatem, Okba AU - Kaçar, Ömer Furkan AU - Kaçar, Hüsna Kaya AU - Szentpéteri, József László (Joe Petersburger) AU - Marosvölgyi, Tamás AU - Szabó, Éva TI - Trans isomeric fatty acids in human milk and their role in infant health and development JF - FRONTIERS IN NUTRITION J2 - FRONT NUTR VL - 11 PY - 2024 PG - 17 SN - 2296-861X DO - 10.3389/fnut.2024.1379772 UR - https://m2.mtmt.hu/api/publication/34724787 ID - 34724787 N1 - * Megosztott szerzőség AB - It is well known that long chain polyunsaturated fatty acids (LCPUFAs) play an important role in neurodevelopment in the perinatal life. The most important source of these fatty acids is the diet, however, they can also be formed in the human body from their shorter chain precursors, the essential fatty acids. Since the WHO recommends exclusive breastfeeding for the first six months after birth, the exclusive source of these fatty acids for breastfed infants is human milk, which can be influenced by the mother’s diet. Unsaturated fatty acids can have either cis or trans configuration double bond in their chain with distinct physiological effects. Cis isomeric unsaturated fatty acids have several beneficial effects, while trans isomers are mostly detrimental, because of their similar structure to saturated fatty acids. Trans fatty acids (TFAs) can be further subdivided into industrial (iTFA) and ruminant-derived trans fatty acids (rTFA). However, the physiological effects of these two TFA subgroups may differ. In adults, dietary intake of iTFA has been linked to atherosclerosis, insulin resistance, obesity, chronic inflammation, and increased development of certain cancers, among other diseases. However, iTFAs can have a negative impact on health not only in adulthood but in childhood too. Results from previous studies have shown that iTFAs have a significant negative effect on LCPUFA levels in the blood of newborns and infants. In addition, iTFAs can affect the growth and development of infants, and animal studies suggest that they might even have lasting negative effects later in life. Since the only source of TFAs in the human body is the diet, the TFA content of breast milk may determine the TFA supply of breastfed infants and thus affect the levels of LCPUFAs important for neurodevelopment and the health of infants. In this review, we aim to provide an overview of the TFA content in human milk available in the literature and their potential effects on infant health and development. LA - English DB - MTMT ER - TY - CONF AU - Marosvölgyi, Tamás AU - Mintál, Kitti AU - Borbásné Farkas, Kornélia AU - Makszin, Lilla AU - Szabó, Éva AU - Attila, Toth AU - Béla, Kocsis AU - Zoltan, Karadi AU - Bufa, Anita TI - Antibiotic-induced effects on the fatty acid composition of faeces in a rat model T2 - 2023 15th International ISSFAL Congress PY - 2023 SP - 269 UR - https://m2.mtmt.hu/api/publication/34797768 ID - 34797768 LA - English DB - MTMT ER - TY - CONF AU - Szabó, Éva AU - Okba, Hatem AU - Zoltán, Szabó AU - Madarászné Horváth, Ibolya AU - Tamás, Decsi AU - Marosvölgyi, Tamás TI - Plant-based drinks as nutritional sources of fatty acids T2 - 2023 15th International ISSFAL Congress PY - 2023 SP - 258 UR - https://m2.mtmt.hu/api/publication/34797759 ID - 34797759 LA - English DB - MTMT ER - TY - CONF AU - Balogh-Hartmann, Fruzsina AU - Páger, Csilla AU - Bufa, Anita AU - Madarászné Horváth, Ibolya AU - Marosvölgyi, Tamás AU - Makszin, Lilla TI - Microfluidic-based protein quantification in plant- based drinks derived from nuts T2 - 13th Balaton Symposium on High-Performance Separation Methods Book of Abstracts PY - 2023 PG - 1 UR - https://m2.mtmt.hu/api/publication/34186807 ID - 34186807 LA - English DB - MTMT ER - TY - CONF AU - Balogh-Hartmann, Fruzsina AU - Páger, Csilla AU - Bufa, Anita AU - Madarászné Horváth, Ibolya AU - Marosvölgyi, Tamás AU - Makszin, Lilla TI - Microfluidic analysis for determination of the protein content in legume-based plant drinks T2 - 13th Balaton Symposium on High-Performance Separation Methods Book of Abstracts PY - 2023 UR - https://m2.mtmt.hu/api/publication/34186786 ID - 34186786 LA - English DB - MTMT ER - TY - JOUR AU - Balogh-Hartmann, Fruzsina AU - Páger, Csilla AU - Bufa, Anita AU - Madarászné Horváth, Ibolya AU - Verzár, Zsófia AU - Marosvölgyi, Tamás AU - Makszin, Lilla TI - Microfluidic Analysis for the Determination of Protein Content in Different Types of Plant-Based Drinks JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 18 PG - 19 SN - 1420-3049 DO - 10.3390/molecules28186684 UR - https://m2.mtmt.hu/api/publication/34167332 ID - 34167332 N1 - Institute of Bioanalysis, Medical School, Szentágothai Research Center, University of Pécs, Pécs, 7622, Hungary Institute of Nutritional Sciences and Dietetics, Faculty of Health Sciences, University of Pécs, Pécs, 7621, Hungary Export Date: 9 October 2023 CODEN: MOLEF Correspondence Address: Makszin, L.; Institute of Bioanalysis, Hungary; email: lilla.makszin@aok.pte.hu AB - The widespread consumption of plant-based drinks, driven by health and dietary reasons (including cow's milk allergy, lactose intolerance, milk protein intolerance, following a vegetarian or vegan diet) necessitates automated and accurate test methods. Our study demonstrates the simultaneous determination of protein components and total protein concentrations in plant-based milk alternatives using a rapid and reproducible microchip gel electrophoretic method. As expected, the electrophoretic profiles of each plant-based drink differed. Based on our analyses and statistical evaluation, it can be determined that the protein profiles of different plant-based beverages do not differ significantly between different manufacturers or different expiry dates. The measured total protein content was compared with the nominal values, i.e., the values stated on the beverage labels. As the number of consumers of functional and specialized plant-based milk alternatives continues to rise, it is important to prioritize methods that provide qualitative and quantitative information on protein composition and other nutrients. LA - English DB - MTMT ER - TY - JOUR AU - Ordnung, Madeleine AU - Mank, Marko AU - Stahl, Bernd AU - Kurz, Deborah AU - Marosvölgyi, Tamás AU - Decsi, Tamás AU - Rothenbacher, Dietrich AU - Genuneit, Jon AU - Siziba, Linda P. TI - Potential sex differences in human milk fatty acids and their association with atopic dermatitis: Results of the Ulm SPATZ health study JF - PEDIATRIC ALLERGY AND IMMUNOLOGY J2 - PEDIATR ALLERGY IMMU VL - 34 PY - 2023 IS - 7 PG - 10 SN - 0905-6157 DO - 10.1111/pai.13992 UR - https://m2.mtmt.hu/api/publication/34077794 ID - 34077794 N1 - Funding Agency and Grant Number: Danone Nutricia Research; Medizinische Fakultaet, Universitaet Leipzig; Medizinische Fakultaet, Universitaet Ulm Funding text: Danone Nutricia Research; Medizinische Fakultaet, Universitaet Leipzig; Medizinische Fakultaet, Universitaet Ulm AB - BackgroundPolyunsaturated fatty acids (PUFAs) in human milk are essential in immune system maturation and might play a role in the development of allergic conditions, such as atopic dermatitis (AD) in infants. Immune system responses are modulated by sex, but data on the sex-specific associations with PUFAs are limited. We therefore explored sex-specific differences in human milk PUFAs and their association with AD up to 2 years. MethodsPUFAs were measured in human milk samples from the Ulm SPATZ Health Study at 6 weeks (n = 512) and 6 months (n = 367). Associations with AD up to 2 years were evaluated using crude and multivariable logistic regression. Interactions between infant sex and PUFAs were explored by including the product term. ResultsNo significant associations were observed with 6-week data. At 6 months, the median relative proportion of docosahexaenoic acid (DHA) was significantly higher in milk for female than male infants (p = .001). Female infants whose milk was lower in quintile proportions of alpha-linolenic acid (ALA) at 6 months had lower odds of AD compared to males [first vs. fifth quintile OR (95% confidence interval): 0.13 (0.02, 0.66), p = .02]. This interaction was not significant when correcting for multiple testing (& alpha; threshold: p = .004). No other statistically significant associations were observed. ConclusionIndividual quintile PUFA proportions in human milk were not associated with AD, overall and in a sex-specific manner. More comprehensive and statistically powered longitudinal studies are needed to determine whether potential sex differences in human milk, if any, could be of clinical relevance for infants including the investigation of mediating factors. LA - English DB - MTMT ER -