@article{MTMT:34866258,
	title = {Optimizing cardiopulmonary rehabilitation duration for long COVID patients: an exercise physiology monitoring approach},
	url = {https://m2.mtmt.hu/api/publication/34866258},
	author = {Szarvas, Zsófia and Fekete, Mónika and Szőllősi, Gergő József and Kup, Katica Anna and Horvath, Rita and Shimizu, Maya and Tsuhiya, Fuko and Choi, Ha Eun and Wu, Huang-Tzu and Fazekas-Pongor, Vince and Pete, Kinga Nedda and Cserjesi, Renata and Bakos, Regina and Gőbel, Orsolya and Gyongyosi, Kata and Pinter, Renata and Kolozsvari, Dora and Jáky-Kováts, Zsuzsanna Ágnes and Yabluchanskiy, Andriy and Owens, Cameron D. and Ungvári, Zoltán István and Tarantini, Stefano and Horváth, Gábor and Müller, Veronika and Varga, János Tamás},
	doi = {10.1007/s11357-024-01179-z},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {in press},
	unique-id = {34866258},
	issn = {2509-2715},
	abstract = {The presence of prolonged symptoms after COVID infection worsens the workability and quality of life. 200 adults with long COVID syndrome were enrolled after medical, physical, and mental screening, and were divided into two groups based on their performance. The intervention group ( n  = 100) received supervised rehabilitation at Department of Pulmonology, Semmelweis University with the registration number 160/2021 between 01/APR/2021–31/DEC/2022, while an age-matched control group ( n  = 100) received a single check-up. To evaluate the long-term effects of the rehabilitation, the intervention group was involved in a 2- and 3-month follow-up, carrying out cardiopulmonary exercise test. Our study contributes understanding long COVID rehabilitation, emphasizing the potential benefits of structured cardiopulmonary rehabilitation in enhancing patient outcomes and well-being. Significant difference was found between intervention group and control group at baseline visit in pulmonary parameters, as forced vital capacity, forced expiratory volume, forced expiratory volume, transfer factor for carbon monoxide, transfer coefficient for carbon monoxide, and oxygen saturation (all p  < 0.05). Our follow-up study proved that a 2-week long, patient-centered pulmonary rehabilitation program has a positive long-term effect on people with symptomatic long COVID syndrome. Our data showed significant improvement between two and three months in maximal oxygen consumption ( p  < 0.05). Multidisciplinary, individualized approach may be a key element of a successful cardiopulmonary rehabilitation in long COVID conditions, which improves workload, quality of life, respiratory function, and status of patients with long COVID syndrome.},
	year = {2024},
	eissn = {2509-2723},
	pages = {in press},
	orcid-numbers = {Szarvas, Zsófia/0000-0002-0022-5053; Fekete, Mónika/0000-0001-8632-2120; Fazekas-Pongor, Vince/0000-0002-6405-4003; Gőbel, Orsolya/0000-0002-7648-9362; Jáky-Kováts, Zsuzsanna Ágnes/0000-0001-6145-6595; Ungvári, Zoltán István/0000-0002-6035-6039; Tarantini, Stefano/0000-0001-5627-1430; Horváth, Gábor/0000-0003-4079-1698; Müller, Veronika/0000-0002-1398-3187; Varga, János Tamás/0000-0002-8552-1336}
}

@article{MTMT:34864803,
	title = {Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain},
	url = {https://m2.mtmt.hu/api/publication/34864803},
	author = {Gulej, R. and Nyúl-Tóth, Ádám and Csik, B. and Patai, R. and Petersen, B. and Negri, S. and Chandragiri, S.S. and Shanmugarama, S. and Mukli, Péter and Yabluchanskiy, A. and Conley, S. and Huffman, D. and Tarantini, Stefano and Csiszar, Anna and Ungvári, Zoltán István},
	doi = {10.1007/s11357-024-01154-8},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	unique-id = {34864803},
	issn = {2509-2715},
	year = {2024},
	eissn = {2509-2723},
	orcid-numbers = {Mukli, Péter/0000-0003-4355-8103; Tarantini, Stefano/0000-0001-5627-1430; Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:34853080,
	title = {Acute neuroendocrine changes after traumatic brain injury},
	url = {https://m2.mtmt.hu/api/publication/34853080},
	author = {Magyar-Sümegi, Zsófia Dina and Stankovics, Levente and Lendvai-Emmert, Dominika and Czigler, András and Hegedüs, Emőke and Csendes, Márk Lajos and Tóth, Luca and Ungvári, Zoltán István and Büki, András and Tóth, Péter József},
	doi = {10.1016/j.bas.2024.102830},
	journal-iso = {BRAIN SPINE},
	journal = {BRAIN AND SPINE},
	volume = {4},
	unique-id = {34853080},
	issn = {2772-5294},
	year = {2024},
	orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:34842957,
	title = {Age-related shifts in mental health determinants from a deprived area in the European Union: informing the national healthy aging program of Hungary},
	url = {https://m2.mtmt.hu/api/publication/34842957},
	author = {Kovács, Nóra and Bíró, Éva and Pikó, Péter and Ungvári, Zoltán István and Ádány, Róza},
	doi = {10.1007/s11357-024-01182-4},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	unique-id = {34842957},
	issn = {2509-2715},
	abstract = {Mental disorders are among the leading causes of disability worldwide, disproportionately affecting older people. This study aims to assess the mental health of elderly individuals living in a deprived region of Hungary, and to identify and estimate the weight of different determinants of mental health across different age groups. A cross-sectional study was conducted with randomly selected samples of individuals (n = 860) aged 18 years and older in Northeast Hungary. The World Health Organization Well-Being Index (WHO-5), the single-item Life Satisfaction Scale, and the 12-item General Health Questionnaire (GHQ-12) were used to measure mental health of the participants. Multiple linear regression analysis was performed to measure the association between sociodemographic and health-related variables and mental health. Overall, the mean WHO-5 score was 69.2 ± 18.1 and it showed a significant decrease by age ( p  < 0.001), with the lowest score observed in aged 75 years and above ( p  < 0.001). The mean life satisfaction score was 7.5 ± 1.9 and it showed a significant decreasing trend over the life course ( p  < 0.001). The highest level of psychological distress as assessed by GHQ-12 was observed in the group aged 75 years or older (11.5 ± 6.0, p  < 0.001). Multiple linear regression indicated that self-reported financial status, social support, sense of control over their health, activity limitation and pain intensity were the most important determinants of mental health among older adults. Interventions to improve the mental health of older adults should focus on the positive impact of social support, the reduction of financial insecurity and the use of effective pain relief medications.},
	year = {2024},
	eissn = {2509-2723},
	orcid-numbers = {Bíró, Éva/0000-0002-0131-8147; Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:34830215,
	title = {Diagnosis rates, therapeutic characteristics, lifestyle, and cancer screening habits of patients with diabetes mellitus in a highly deprived region in Hungary: a cross-sectional analysis},
	url = {https://m2.mtmt.hu/api/publication/34830215},
	author = {Pártos, Katalin and Major, Dávid and Dósa, Norbert Sándor and Fazekas-Pongor, Vince and Tabák, Ádám and Ungvári, Zoltán István and Horváth, Ildikó and Barta, Ildikó and Pozsgai, Éva and Bodnár, Tamás and Fehér, Gergely and Lenkey, Zsófia and Fekete, Mónika and Springó, Zsolt},
	doi = {10.3389/fendo.2024.1299148},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34830215},
	issn = {1664-2392},
	year = {2024},
	eissn = {1664-2392},
	orcid-numbers = {Major, Dávid/0000-0002-6108-9745; Fazekas-Pongor, Vince/0000-0002-6405-4003; Tabák, Ádám/0000-0002-6234-3936; Ungvári, Zoltán István/0000-0002-6035-6039; Horváth, Ildikó/0000-0001-6891-1044; Fekete, Mónika/0000-0001-8632-2120}
}

@article{MTMT:34825015,
	title = {Prognostic significance of a signature based on senescence-related genes in colorectal cancer},
	url = {https://m2.mtmt.hu/api/publication/34825015},
	author = {Ungvári, Zoltán István and Ungvári, Anna Sára and Bianchini, Giampaolo and Győrffy, Balázs},
	doi = {10.1007/s11357-024-01164-6},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	unique-id = {34825015},
	issn = {2509-2715},
	abstract = {Colorectal cancer, recognized as a quintessential age-related disease, underscores the intricate interplay between aging mechanisms and disease pathogenesis. Cellular senescence, a DNA damage-induced cellular stress response, is characterized by cell cycle arrest, the expression of an inflammatory senescence-associated secretory phenotype, and alterations in extracellular matrix metabolism. It is widely recognized as a fundamental and evolutionarily conserved mechanism of aging. Guided by geroscience principles, which assert that the pathogenesis of age-related diseases involves cellular mechanisms of aging, this study delves into the role of senescence-related genes in colon cancer progression. Leveraging a gene set reflective of senescence-associated pathways, we employed uni- and multivariate Cox proportional hazards survival analysis combined with the determination of the false discovery rate to analyze correlations between gene expression and survival. The integrated database of 1130 colon cancer specimens with available relapse-free survival time and relapse event data from ten independent cohorts provided a robust platform for survival analyses. We identified senescence-related genes associated with differential expression levels linked to shorter survival. Our findings unveil a prognostic signature utilizing cellular senescence-related genes (hazard ratio: 2.73, 95% CI 2.12-3.52, p = 6.4E - 16), offering valuable insights into survival prediction in colon cancer. Multivariate analysis underscored the independence of the senescence-related signature from available epidemiological and pathological variables. This study highlights the potential of senescence-related genes as prognostic biomarkers. Overall, our results underscore the pivotal role of cellular senescence, a fundamental mechanism of aging, in colon cancer progression.},
	keywords = {CANCER; Aging; colorectal cancer; senescence; Gerooncology},
	year = {2024},
	eissn = {2509-2723},
	orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Győrffy, Balázs/0000-0002-5772-3766}
}

@article{MTMT:34804161,
	title = {Atherosclerotic burden and cerebral small vessel disease : exploring the link through microvascular aging and cerebral microhemorrhages},
	url = {https://m2.mtmt.hu/api/publication/34804161},
	author = {Csiszar, Anna and Ungvári, Anna Sára and Patai, Roland and Gulej, Rafal and Yabluchanskiy, Andriy and Benyó, Zoltán and Kovács, Illés and Sótonyi, Péter and Kirkpartrick, Angelia C and Prodan, Calin I and Liotta, Eric M and Zhang, Xin A and Tóth, Péter József and Tarantini, Stefano and Sorond, Farzaneh A and Ungvári, Zoltán István},
	doi = {10.1007/s11357-024-01139-7},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {in press},
	unique-id = {34804161},
	issn = {2509-2715},
	abstract = {Cerebral microhemorrhages (CMHs, also known as cerebral microbleeds) are a critical but frequently underestimated aspect of cerebral small vessel disease (CSVD), bearing substantial clinical consequences. Detectable through sensitive neuroimaging techniques, CMHs reveal an extensive pathological landscape. They are prevalent in the aging population, with multiple CMHs often being observed in a given individual. CMHs are closely associated with accelerated cognitive decline and are increasingly recognized as key contributors to the pathogenesis of vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). This review paper delves into the hypothesis that atherosclerosis, a prevalent age-related large vessel disease, extends its pathological influence into the cerebral microcirculation, thereby contributing to the development and progression of CSVD, with a specific focus on CMHs. We explore the concept of vascular aging as a continuum, bridging macrovascular pathologies like atherosclerosis with microvascular abnormalities characteristic of CSVD. We posit that the same risk factors precipitating accelerated aging in large vessels (i.e., atherogenesis), primarily through oxidative stress and inflammatory pathways, similarly instigate accelerated microvascular aging. Accelerated microvascular aging leads to increased microvascular fragility, which in turn predisposes to the formation of CMHs. The presence of hypertension and amyloid pathology further intensifies this process. We comprehensively overview the current body of evidence supporting this interconnected vascular hypothesis. Our review includes an examination of epidemiological data, which provides insights into the prevalence and impact of CMHs in the context of atherosclerosis and CSVD. Furthermore, we explore the shared mechanisms between large vessel aging, atherogenesis, microvascular aging, and CSVD, particularly focusing on how these intertwined processes contribute to the genesis of CMHs. By highlighting the role of vascular aging in the pathophysiology of CMHs, this review seeks to enhance the understanding of CSVD and its links to systemic vascular disorders. Our aim is to provide insights that could inform future therapeutic approaches and research directions in the realm of neurovascular health.},
	keywords = {ATHEROSCLEROSIS; Aging; Blood-Brain Barrier; Arteriosclerosis; stroke; Leukoaraiosis; Peripheral artery disease; VASCULAR DEMENTIA; Microbleed; White matter hyperintensities; white matter injury},
	year = {2024},
	eissn = {2509-2723},
	orcid-numbers = {Benyó, Zoltán/0000-0001-6015-0359; Kovács, Illés/0000-0001-5763-0482; Sótonyi, Péter/0000-0002-2216-4298; Tarantini, Stefano/0000-0001-5627-1430; Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:34803971,
	title = {Predictive factors of basic palliative and hospice care among patients with cancer visiting the emergency department in a Hungarian tertiary care center},
	url = {https://m2.mtmt.hu/api/publication/34803971},
	author = {Varga, Csaba and Springó, Zsolt and Koch, M. and Prenek, L. and Porcsa, L. and Bellyei, Szabolcs and Rumi, L. and Szabó, É. and Ungvári, Zoltán István and Girán, K. and Kiss, I. and Pozsgai, É.},
	doi = {10.1016/j.heliyon.2024.e29348},
	journal-iso = {HELIYON},
	journal = {HELIYON},
	volume = {10},
	unique-id = {34803971},
	year = {2024},
	eissn = {2405-8440},
	orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:34773870,
	title = {Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence},
	url = {https://m2.mtmt.hu/api/publication/34773870},
	author = {Balasubramanian, Priya and Kiss, Tamás and Gulej, Rafal and Nyúl-Tóth, Ádám and Tarantini, Stefano and Yabluchanskiy, Andriy and Ungvári, Zoltán István and Csiszar, Anna},
	doi = {10.3390/nu16070952},
	journal-iso = {NUTRIENTS},
	journal = {NUTRIENTS},
	volume = {16},
	unique-id = {34773870},
	abstract = {High-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive saturated fat content and low nutritional value. Epidemiological studies have compellingly linked HFD consumption to obesity and the development of type 2 diabetes mellitus. Moreover, the synergistic interplay of HFD, obesity, and diabetes expedites the aging process and prematurely fosters age-related diseases. However, the underlying mechanisms driving these associations remain enigmatic. One of the most conspicuous hallmarks of aging is the accumulation of highly inflammatory senescent cells, with mounting evidence implicating increased cellular senescence in the pathogenesis of age-related diseases. Our hypothesis posits that HFD consumption amplifies senescence burden across multiple organs. To scrutinize this hypothesis, we subjected mice to a 6-month HFD regimen, assessing senescence biomarker expression in the liver, white adipose tissue, and the brain. Aging is intrinsically linked to impaired cellular stress resilience, driven by dysfunction in Nrf2-mediated cytoprotective pathways that safeguard cells against oxidative stress-induced senescence. To ascertain whether Nrf2-mediated pathways shield against senescence induction in response to HFD consumption, we explored senescence burden in a novel model of aging: Nrf2-deficient (Nrf2+/−) mice, emulating the aging phenotype. Our initial findings unveiled significant Nrf2 dysfunction in Nrf2+/− mice, mirroring aging-related alterations. HFD led to substantial obesity, hyperglycemia, and impaired insulin sensitivity in both Nrf2+/− and Nrf2+/+ mice. In control mice, HFD primarily heightened senescence burden in white adipose tissue, evidenced by increased Cdkn2a senescence biomarker expression. In Nrf2+/− mice, HFD elicited a significant surge in senescence burden across the liver, white adipose tissue, and the brain. We postulate that HFD-induced augmentation of senescence burden may be a pivotal contributor to accelerated organismal aging and the premature onset of age-related diseases.},
	year = {2024},
	eissn = {2072-6643},
	orcid-numbers = {Kiss, Tamás/0000-0001-5339-5227; Gulej, Rafal/0000-0002-9958-707X; Tarantini, Stefano/0000-0001-5627-1430; Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:34760823,
	title = {Editorial: Endocrine regulation of aging: impacts of humoral factors and circulating mediators},
	url = {https://m2.mtmt.hu/api/publication/34760823},
	author = {Petersen, B. and Negri, S. and Milan, M. and Reyff, Z. and Ballard, C. and Ihuoma, J. and Ungvári, Zoltán István and Tarantini, Stefano},
	doi = {10.3389/fendo.2024.1387435},
	journal-iso = {FRONT ENDOCRINOL},
	journal = {FRONTIERS IN ENDOCRINOLOGY},
	volume = {15},
	unique-id = {34760823},
	issn = {1664-2392},
	year = {2024},
	eissn = {1664-2392},
	orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Tarantini, Stefano/0000-0001-5627-1430}
}